9618 results
Cited 41 times since 2013 (3.2 per year)
source: EuropePMC
Pharmacogenomics,
Volume 14, Issue 2, 1 1 2013, Pages 137-149
CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin.
Elens L, Nieuweboer A, Clarke SJ, Charles KA, de Graan AJ, Haufroid V, Mathijssen RH, van Schaik RH
Aim: The CYP3A4*22 allele was recently reported to be associated with reduced CYP3A4 activity. We investigated the impact of this allele on the metabolism of the CYP3A-phenotyping probes, midazolam (MDZ) and erythromycin. Patients & methods: Genomic DNA from 108 cancer patients receiving intravenous MDZ and 45 undergoing the erythromycin breath test was analyzed for CYP3A4*22 (rs35599367 C>T) and CYP3A5*3. Results: The MDZ metabolic ratio (1´-OH-MDZ:MDZ) was 20.7% (95% CI: -36.2 to -6.2)...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 157, Issue 20, 1 1 2013, Pages A6275
[High time for cerebral rehabilitation following stroke: discrepancies between guidelines and practice].
van Schaik SM, van den Berg-Vos RM, Weinstein HC
Cardiac rehabilitation programmes reduce mortality in patients following myocardial infarction. Patients with a history of transient ischaemic attack (TIA) or ischemic stroke have a high risk of recurrent stroke or other cardiovascular events, comparable with the risk that myocardial infarction patients show for recurrence. Evidence for the effectiveness of secondary prevention strategies following TIA and ischemic stroke is compelling. Despite this convincing evidence, secondary prevention in t...
Abstract
Cited 146 times since 2013 (11.6 per year)
source: EuropePMC
Pharmacogenomics,
Volume 14, Issue 1, 1 1 2013, Pages 47-62
CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy.
Elens L, van Gelder T, Hesselink DA, Haufroid V, van Schaik RH
Many studies have attempted to explain the interindividual variability observed in drug metabolism by assessing the impact of SNPs in genes implicated in drug absorption, distribution, metabolism and excretion pathways. Particular attention has been paid to the CYP450s. CYP3A4 is the main CYP isoform in human liver and intestine and is involved in the metabolism of many drugs. Its activity, however, is characterized by widespread variation in the general population, which is thought to have a ge...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Methods in molecular biology (Clifton, N.J.),
Volume 1015, 1 1 2013, Pages 293-310
A guide to the current Web-based resources in pharmacogenomics.
Glubb DM, Paugh SW, van Schaik RH, Innocenti F
Human genomics research has produced vast amounts of data that can be applied to or used to inform pharmacogenomic studies. The Internet is an extremely useful resource for pharmacogenomics as many Web sites provide access to data from genomic and clinical studies or host tools which can be used to interpret findings or generate hypotheses. Human genetic variation can now easily be explored or visualized through genome browsers and Web-based repositories which store the details of millions of hu...
Abstract
Cited 5 times since 2013 (0.4 per year)
source: EuropePMC
Methods in molecular biology (Clifton, N.J.),
Volume 1015, 1 1 2013, Pages 345-354
Evidence based drug dosing and pharmacotherapeutic recommendations per genotype.
Deneer VH, van Schaik RH
Implementing pharmacogenetics in daily clinical practice has the potential to improve patient care. The translation of results of pharmacogenetic studies into practical pharmacotherapeutic recommendations is essential. These recommendations are preferably available at the time of drug prescribing and drug dispensing. This chapter describes a process of developing evidence based drug dosing and pharmacotherapeutic guidelines per genotype by the Dutch Pharmacogenetics Working Group. It is aimed to...
Abstract
Drug metabolism and drug interactions,
Volume 28, Issue 4, 1 1 2013, Pages 191-192
New challenges for pharmacogenomics.
van Schaik RH
Abstract
Cited 60 times since 2013 (4.7 per year)
source: EuropePMC
Genome biology and evolution,
Volume 5, Issue 8, 1 1 2013, Pages 1524-1535
Recent recombination events in the core genome are associated with adaptive evolution in Enterococcus faecium.
de Been M, van Schaik W, Cheng L, Corander J, Willems RJ
Reasons for the rising clinical impact of the bacterium Enterococcus faecium include the species' rapid acquisition of adaptive genetic elements. Here, we focused on the impact of recombination on the evolution of E. faecium. We used the recently developed BratNextGen algorithm to detect recombinant regions in the core genome of 34 E. faecium strains, including three newly sequenced clinical strains. Recombination was found to have a significant impact on the E. faecium genome: of the origi...
Abstract
Cited 16 times since 2013 (1.3 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 21, Issue 1, 1 1 2013, Pages 6-13
Myocardial bridging: what have we learned in the past and will new diagnostic modalities provide new insights?
Bruschke AV, Veltman CE, de Graaf MA, Vliegen HW
The clinical significance of myocardial bridging has been a subject of discussion and controversy since the introduction of coronary arteriography (CAG) in the early 1960s. More recently computed tomography coronary angiography (CTCA) has made it possible to visualise the overlying muscular bands and appears to have a higher sensitivity for detecting myocardial bridging than CAG. Combining CTCA with invasive techniques such as CAG should make it possible to improve our understanding of the patho...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 157, Issue 23, 1 1 2013, Pages A6354
[Feedback during laparoscopic training].
Spruit EN, Band GP, Hamming JF
A recent Danish study showed that instructor feedback significantly reduced the duration of training time needed for acquiring laparoscopic skills. While there is a clear advantage to trainees reaching a predetermined expert level of performance more rapidly, this does not necessarily imply that the skills were also acquired more efficiently. Experiencing continual feedback while undergoing a training task could reduce the level of difficulty in performing it; the presence of an instructor can a...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Nederlands tijdschrift voor geneeskunde,
Volume 157, Issue 7, 1 1 2013, Pages A5928
[Adhesiolysis during abdominal surgery: substantial risks].
Hamming JF, Bonsing BA
Surgeons from the Dutch St. Radboud University Medical Centre recently presented the results of a prospective study on adhesiolysis in abdominal surgery. In this methodologically sound study, the authors provided substantial data on the consequences of adhesiolysis. Most patients who have undergone an abdominal operation in the past appear to have adhesions. During an adhesiolysis procedure, 10% of patients suffer intestinal damage, the operating time is prolonged and blood loss is more severe....
Abstract
Cited 25 times since 2013 (2 per year)
source: EuropePMC
Thrombosis research,
Volume 131 Suppl 1, 1 1 2013, Pages S39-41
Venous thromboembolism in neonates and children--update 2013.
Nowak-Göttl U, Janssen V, Manner D, Kenet G
Thromboses (VTE) in children were associated with medical diseases with and without acquired or inherited thrombophilic risk factors (IT). Disease recurrence rates vary between 3% in children with a first event during the neonatal period and 21% in children with idiopathic VTE. Recently reported systematic reviews showed significant associations between VTE and factor V G1691A or factor II G20210A mutations, protein C, protein S and antithrombin deficiency, more pronounced when combined IT were...
Abstract
Cited 46 times since 2013 (3.6 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 6, Issue 1, 1 1 2013, Pages 42-52
Real-time integration of MDCT-derived coronary anatomy and epicardial fat: impact on epicardial electroanatomic mapping and ablation for ventricular arrhythmias.
van Huls van Taxis CF, Wijnmaalen AP, Piers SR, van der Geest RJ, Schalij MJ, Zeppenfeld K
Objectives: This study aimed to evaluate the feasibility and accuracy of real-time integration of multidetector computed tomography (MDCT) derived coronary anatomy and epicardial fat distribution and its impact on electroanatomical mapping and ablation. Background: Epicardial catheter ablation for ventricular arrhythmias (VA) is an important therapeutic option in patients after endocardial ablation failure. However, epicardial mapping and ablation are limited by the presence of coronary arteries...
Abstract
Cited 26 times since 2013 (2.1 per year)
source: EuropePMC
The journal of gene medicine,
Volume 15, Issue 1, 1 1 2013, Pages 1-11
Development of an AdEasy-based system to produce first- and second-generation adenoviral vectors with tropism for CAR- or CD46-positive cells.
Janssen JM, Liu J, Skokan J, Gonçalves MA, de Vries AA
Background: The AdEasy system has acquired preeminence amongst the various methods for producing first-generation, early region 1 (E1)-deleted human adenovirus (HAdV) vectors (AdVs) as a result of the fast and reproducible recovery of full-length AdV genomes via homologous recombination in Escherichia coli. Methods: From the classical AdEasy system, a new production platform was derived to assemble first- and second-generation [i.e. E1- plus early region 2A (E2A)-deleted] AdVs displaying on thei...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 157, Issue 51, 1 1 2013, Pages A7059
[The bionic heart patient: care about aftercare].
Schalij MJ
During the last few decades, care for heart patients has significantly improved. The enormous increase in the number of diagnostic and therapeutic options has resulted in a much better prognosis for many patients with cardiovascular disorders. Implantable cardioverter defibrillators (ICDs) and resynchronization therapy combined with ICDs decrease the risk of sudden death due to ventricular arrhythmias and improve symptoms related to cardiovascular failure. Percutaneous valve implants and percuta...
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
Kardiologia polska,
Volume 71 Suppl 11, 1 1 2013, Pages S319-94
[ESC guidelines on diabetes, pre-diabetes and diseases of the cardiovascular system developed in cooperation with the EASD].
Grupa Robocza Europejskiego Towarzystwa Kardiologicznego (ESC), Rydén L, Grant PJ, Anker SD, Berne C, Cosentino F, Danchin N, Deaton C, Escaned J, Hammes HP, Huikuri H, Marre M, Marx N, Mellbin L, Ostergren J, Patrono C, Seferovic P, Sousa Uva M, Taskinen MR, Tendera M, Tuomilehto J, Valensi P, Zamorano JL, European Association for the Study of Diabetes (EASD)
Abstract
Cited 24 times since 2013 (1.9 per year)
source: EuropePMC
Asian Pacific journal of cancer prevention : APJCP,
Volume 14, Issue 5, 1 1 2013, Pages 3281-3288
Determining the awareness of and compliance with breast cancer screening among Turkish residential women.
Yilmaz D, Bebis H, Ortabag T
Background: Breast cancer is the leading cause of cancer-related deaths in women. Despite being associated with high morbidity and mortality, breast cancer is a disease that can be diagnosed and treated early. Materials and methods: In this cross-sectional study of 321 women, data were collected by Questionnaire, Breast Cancer Risk Assessment Form and Champion's Health Belief Model Scale. Mann-Whitney U, Kruskal-Wallis, Chi- squared tests and logistic regression were used in the statistical...
Abstract
Cited 55 times since 2013 (4.4 per year)
source: EuropePMC
The British journal of dermatology,
Volume 168, Issue 1, 1 1 2013, Pages 93-98
Dose optimization for near-infrared fluorescence sentinel lymph node mapping in patients with melanoma.
van der Vorst JR, Schaafsma BE, Verbeek FP, Swijnenburg RJ, Hutteman M, Liefers GJ, van de Velde CJ, Frangioni JV, Vahrmeijer AL
Background: Regional lymph node involvement is the most important prognostic factor in cutaneous melanoma. As only 20% of patients with melanoma have occult nodal disease and would benefit from a regional lymphadenectomy, the sentinel lymph node (SLN) biopsy was introduced. Near-infrared (NIR) fluorescence has been hypothesized to improve SLN mapping. Objectives: To assess the potential of intraoperative NIR fluorescence imaging to improve SLN mapping in patients with melanoma and to examine t...
Abstract
Cited 76 times since 2013 (6 per year)
source: EuropePMC
Journal of the American Society of Nephrology : JASN,
Volume 24, Issue 1, 1 1 2013, Pages 149-159
Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome.
Teeninga N, Kist-van Holthe JE, van Rijswijk N, de Mos NI, Hop WC, Wetzels JF, van der Heijden AJ, Nauta J
Prolonged prednisolone treatment for the initial episode of childhood nephrotic syndrome may reduce relapse rate, but whether this results from the increased duration of treatment or a higher cumulative dose remains unclear. We conducted a randomized, double-blind, placebo-controlled trial in 69 hospitals in The Netherlands. We randomly assigned 150 children (9 months to 17 years) presenting with nephrotic syndrome to either 3 months of prednisolone followed by 3 months of placebo (n=74) or 6 mo...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention,
Volume 16, Issue Pt 3, 1 1 2013, Pages 147-154
Improved myocardial scar characterization by super-resolution reconstruction in late gadolinium enhanced MRI.
Dzyubachyk O, Tao Q, Poot DH, Lamb H, Zeppenfeld K, Lelieveldt BP, van der Geest RJ
Image resolution is an important factor for accurate myocardial scar assessment from late gadolinium enhanced (LGE) MR. It has been shown that the conventionally used short-axis (SA) LGE acquisition with anisotropic resolution may overestimate the scar size due to partial volume effect, undermining the prognostic and diagnostic accuracy of LGE MRI in critical clinical applications. In this work, we present a method for combining three complementary anisotropic orthogonal LGE sequences of the hea...
Abstract
Cited 22 times since 2013 (1.7 per year)
source: EuropePMC
Indian pacing and electrophysiology journal,
Volume 13, Issue 1, 1 1 2013, Pages 14-33
Radiofrequency catheter ablation of idiopathic right ventricular outflow tract arrhythmias.
Calvo N, Jongbloed M, Zeppenfeld K
Idiopathic ventricular arrhythmias (VA) consist of various subtypes of VA that occur in the absence of clinically apparent structural heart disease. Affected patients account for approximately 10% of all patients referred for evaluation of ventricular tachycardia (VT). Arrhythmias arising from the outflow tract (OT) are the most common subtype of idiopathic VA and more than 70-80% of idiopathic VTs or premature ventricular contractions (PVCs) originate from the right ventricular (RV) OT. Idiopat...
Abstract
