9618 results
Cited 20 times since 2012 (1.6 per year)
source: EuropePMC
Journal of immunology (Baltimore, Md. : 1950),
Volume 190, Issue 3, 31 5 2013, Pages 1180-1191
Pro-apoptotic protein Noxa regulates memory T cell population size and protects against lethal immunopathology.
Wensveen FM, Klarenbeek PL, van Gisbergen KP, Pascutti MF, Derks IA, van Schaik BD, Ten Brinke A, de Vries N, Cekinovic D, Jonjic S, van Lier RA, Eldering E
Memory T cells form a highly specific defense layer against reinfection with previously encountered pathogens. In addition, memory T cells provide protection against pathogens that are similar, but not identical to the original infectious agent. This is because each T cell response harbors multiple clones with slightly different affinities, thereby creating T cell memory with a certain degree of diversity. Currently, the mechanisms that control size, diversity, and cross-reactivity of the memory...
Abstract
Cited 5 times since 2012 (0.4 per year)
source: EuropePMC
Journal of neurology,
Volume 260, Issue 6, 30 5 2013, Pages 1511-1517
Examination of cardiovascular and peripheral autonomic function in the ICU: a pilot study.
Wieske L, Kiszer ER, Schultz MJ, Verhamme C, van Schaik IN, Horn J
Unlabelled: Critical illness may affect the autonomic nervous system. Decreased cardiovascular autonomic function measured by heart rate variability (HRV) has been reported in critically ill patients but limited information exists about other autonomic functions. The cold face test (CFT) and skin wrinkle test (SWT) have never been investigated in critically ill patients. Feasibility and safety of the CFT and SWT were investigated in critically ill patients. Exclusion criteria: polyneuropathy, au...
Abstract
Cited 11 times since 2012 (0.9 per year)
source: EuropePMC
Journal of molecular and cellular cardiology,
Volume 56, 26 4 2012, Pages 116-128
Lack of haptoglobin results in unbalanced VEGFα/angiopoietin-1 expression, intramural hemorrhage and impaired wound healing after myocardial infarction.
Arslan F, Smeets MB, Buttari B, Profumo E, Riganò R, Akeroyd L, Kara E, Timmers L, Sluijter JP, van Middelaar B, den Ouden K, Pasterkamp G, Lim SK, de Kleijn DP
Decreased haptoglobin (Hp) functionality due to allelic variations is associated with worsened outcome in patients after myocardial infarction (MI). However, mechanisms through which haptoglobin deficiency impairs cardiac repair remain to be elucidated. In the present study, we identified novel molecular alterations mediated by Hp involved in early and late cardiac repair responses after left coronary artery ligation in Hp(-/-) and wild-type (WT) mice. We observed a higher mortality rate in Hp(-...
Abstract
Cited 20 times since 2012 (1.6 per year)
source: EuropePMC
Atherosclerosis,
Volume 227, Issue 1, 24 4 2012, Pages 95-99
Determinants of calcification growth in atherosclerotic carotid arteries; a serial multi-detector CT angiography study.
van Gils MJ, Bodde MC, Cremers LG, Dippel DW, van der Lugt A
Background: Little is known about the natural course of atherosclerotic plaque in the carotid artery bifurcation. This study investigated the growth pattern of calcifications in atherosclerotic carotid arteries and its determinants using serial multi-detector CT angiography (MDCTA). Methods: From a cohort of consecutive patients with TIA or ischemic stroke and a baseline MCDTA scan of the carotid arteries, subjects were invited for a follow-up scan after 4-6 years. Calcification volumes were sco...
Abstract
Cited 57 times since 2012 (4.5 per year)
source: EuropePMC
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Volume 53, 21 3 2012, Pages 359-363
Radioprotection by two phenolic compounds: chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro.
Cinkilic N, Cetintas SK, Zorlu T, Vatan O, Yilmaz D, Cavas T, Tunc S, Ozkan L, Bilaloglu R
The present study was designed to determine the radioprotective effect of two phytochemicals, namely, quinic acid and chlorogenic acid, against X-ray irradiation-induced genomic instability in non-tumorigenic human blood lymphocytes. The protective ability of two phenolic acids against radiation-induced DNA damage was assessed using the alkaline comet assay in human blood lymphocytes isolated from two healthy human donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was use...
Abstract
Cited 53 times since 2012 (4.2 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 12, 20 3 2012, Pages e52438
Blood pressure variability and cardiovascular risk in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER).
Poortvliet RK, Ford I, Lloyd SM, Sattar N, Mooijaart SP, de Craen AJ, Westendorp RG, Jukema JW, Packard CJ, Gussekloo J, de Ruijter W, Stott DJ
Variability in blood pressure predicts cardiovascular disease in young- and middle-aged subjects, but relevant data for older individuals are sparse. We analysed data from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) study of 5804 participants aged 70-82 years with a history of, or risk factors for cardiovascular disease. Visit-to-visit variability in blood pressure (standard deviation) was determined using a minimum of five measurements over 1 year; an inception cohort...
Abstract
Cited 10 times since 2012 (0.8 per year)
source: EuropePMC
Physiological measurement,
Volume 34, Issue 1, 18 3 2012, Pages N1-7
Towards true unipolar bio-potential recording: a preliminary result for ECG.
Gargiulo GD, McEwan AL, Bifulco P, Cesarelli M, Jin C, Tapson J, Thiagalingam A, van Schaik A
We present a bio-potential front-end capable of recording unipolar ECG leads without making use of the Wilson central terminal (WCT). The information contained in the new unipolar recordings may yield unique diagnostic information as it avoids the need to essentially subtract data or make use of the averaging effect imposed by the WCT. The system also allows a direct, real-time software calculation of signals corresponding to standard ECG leads for standard diagnosis. These calculated standard E...
Abstract
Cited 48 times since 2012 (3.8 per year)
source: EuropePMC
European journal of heart failure,
Volume 15, Issue 5, 18 3 2012, Pages 581-588
Resting heart rate and incident heart failure and cardiovascular mortality in older adults: role of inflammation and endothelial dysfunction: the PROSPER study.
Nanchen D, Stott DJ, Gussekloo J, Mooijaart SP, Westendorp RG, Jukema JW, Macfarlane PW, Cornuz J, Rodondi N, Buckley BM, Ford I, Sattar N, de Craen AJ, PROSPER Group
Aims: Resting heart rate is a promising modifiable cardiovascular risk marker in older adults, but the mechanisms linking heart rate to cardiovascular disease are not fully understood. We aimed to assess the association between resting heart rate and incident heart failure (HF) and cardiovascular mortality, and to examine whether these associations might be attributable to systemic inflammation and endothelial dysfunction. Methods and results: We studied 4084 older adults aged 70-82 years with k...
Abstract
Cited 119 times since 2012 (9.4 per year)
source: EuropePMC
Circulation,
Volume 127, Issue 3, 17 3 2012, Pages 322-330
Effect of valsartan on systemic right ventricular function: a double-blind, randomized, placebo-controlled pilot trial.
van der Bom T, Winter MM, Bouma BJ, Groenink M, Vliegen HW, Pieper PG, van Dijk AP, Sieswerda GT, Roos-Hesselink JW, Zwinderman AH, Mulder BJ
Background: The role of angiotensin II receptor blockers in patients with a systemic right ventricle has not been elucidated. Methods and results: We conducted a multicenter, double-blind, parallel, randomized controlled trial of angiotensin II receptor blocker valsartan 160 mg twice daily compared with placebo in patients with a systemic right ventricle caused by congenitally or surgically corrected transposition of the great arteries. The primary end point was change in right ventricular eject...
Abstract
Cited 46 times since 2012 (3.6 per year)
source: EuropePMC
Journal of dairy science,
Volume 96, Issue 2, 14 2 2012, Pages 1301-1311
Improving bovine udder health: a national mastitis control program in the Netherlands.
Lam TJ, van den Borne BH, Jansen J, Huijps K, van Veersen JC, van Schaik G, Hogeveen H
Because of increasing bulk milk somatic cell counts and continuous clinical mastitis problems in a substantial number of herds, a national mastitis control program was started in 2005 to improve udder health in the Netherlands. The program started with founding the Dutch Udder Health Centre (UGCN), which had the task to coordinate the program. The program consisted of 2 parts: a research part and a knowledge-transfer part, which were integrated as much as possible. The knowledge-transfer part co...
Abstract
Cited 8 times since 2012 (0.6 per year)
source: EuropePMC
European journal of radiology,
Volume 82, Issue 4, 14 2 2012, Pages 680-685
High field carotid vessel wall imaging: a study on reproducibility.
Kröner ES, Westenberg JJ, van der Geest RJ, Brouwer NJ, Doornbos J, Kooi ME, van der Wall EE, Lamb HJ, Siebelink HJ
Purpose: Currently, a multi-contrast protocol, including a combination of five MR-sequences is used as reference standard for morphologic imaging and quantitative measurements of the carotid artery vessel wall. The purpose of this study is to investigate the scan-rescan reproducibility together with intra- and inter-observer reproducibility of each of the five MR-sequences. Methods: Twenty healthy volunteers (55% male, mean age=26 years) underwent repeated MR-examinations (3T-Philips-MRI) of the...
Abstract
Cited 7 times since 2012 (0.6 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 93, Issue 3, 12 2 2012, Pages 233
Doubt about the feasibility of preemptive genotyping.
Koch BC, van Schaik RH, van Gelder T, Mathijssen RH, Rotterdam Clinical Pharmacology-Pharmacogenetics Group (RCPPG)
Abstract
Cited 4 times since 2012 (0.3 per year)
source: EuropePMC
Case reports in pediatrics,
Volume 2012, 12 2 2012, Pages 314256
Left pulmonary artery thrombosis in a neonate with left lung hypoplasia.
van Schendel MP, Visser DH, Rammeloo LA, Hazekamp MG, Hruda J
Thrombotic events in neonates may origin from fetal life. A 4-day-old newborn infant with a family history of heterozygous type 1 protein C deficiency was diagnosed with left lung hypoplasia and left pulmonary artery thrombosis. Its source was prenatally closed ductus arteriosus. Surgical removal of the thrombus was performed.
Abstract
Cited 5 times since 2012 (0.4 per year)
source: EuropePMC
Journal of pharmaceutical and biomedical analysis,
Volume 76, 10 2 2012, Pages 1-7
Analysis of submicron-sized niflumic acid crystals prepared by electrospray crystallization.
Ambrus R, Radacsi N, Szunyogh T, van der Heijden AE, Ter Horst JH, Szabó-Révész P
Interest in submicron-sized drug particles has emerged from both laboratory and industrial perspectives in the last decade. Production of crystals in the nano size scale offers a novel way to particles for drug formulation solving formulation problems of drugs with low solubility in class II of the Biopharmaceutical Classification System. In this work niflumic acid nanoparticles with a size range of 200-800nm were produced by the novel crystallization method, electrospray crystallization. Their...
Abstract
Cited 32 times since 2012 (2.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 14, Issue 8, 7 1 2012, Pages 774-781
Impact of clinical and echocardiographic response to cardiac resynchronization therapy on long-term survival.
Bertini M, Höke U, van Bommel RJ, Ng AC, Shanks M, Nucifora G, Auger D, Borleffs CJ, van Rijnsoever EP, van Erven L, Schalij MJ, Marsan NA, Bax JJ, Delgado V
Background: Clinical or echocardiographic mid-term responses to cardiac resynchronization therapy (CRT) may have a different influence on a long-term prognosis of heart failure patients treated with CRT. The aim of the evaluation was to establish which definition of response to CRT, clinical or echocardiographic, best predicts long-term prognosis. Methods and results: A total of 679 heart failure patients treated with CRT were included. All the patients underwent a complete history and physical...
Abstract
Cited 59 times since 2012 (4.6 per year)
source: EuropePMC
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 19, Issue 3, 6 1 2012, Pages 743-751
A phase II study of sorafenib in patients with platinum-pretreated, advanced (Stage IIIb or IV) non-small cell lung cancer with a KRAS mutation.
Dingemans AM, Mellema WW, Groen HJ, van Wijk A, Burgers SA, Kunst PW, Thunnissen E, Heideman DA, Smit EF
Purpose: Sorafenib inhibits the Ras/Raf pathway, which is overactive in cancer patients with a KRAS mutation. We hypothesized that patients with non-small cell lung cancer (NSCLC) with KRAS mutation will benefit from treatment with sorafenib. Experimental design: In this phase II study, patients with KRAS-mutated, stage IIIb or IV NSCLC that progressed after at least one platinum-containing regimen were treated with sorafenib. Treatment consisted of sorafenib 400 mg twice daily until disease pro...
Abstract
Cited 18 times since 2012 (1.4 per year)
source: EuropePMC
The Journal of hand surgery, European volume,
Volume 38, Issue 6, 6 1 2012, Pages 634-639
The long-term follow-up of treatment with corticosteroid injections in patients with carpal tunnel syndrome. When are multiple injections indicated?
Berger M, Vermeulen M, Koelman JH, van Schaik IN, Roos YB
The objective of this prospective study was to investigate the long-term effect of one or more local corticosteroid injections in patients with carpal tunnel syndrome and whether a good response can be predicted. Follow-up visits took place at 3 weeks, 6 months, and 1 year after the first corticosteroid injection. Thirty of the 120 patients (25%) had a good outcome with a single injection, 11 additional patients (9%) needed a second injection, and five patients (4%) needed a third injection to r...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 14, Issue 5, 5 1 2012, Pages 507
Rapid aortic aneurysm formation in Marfan patient with dissection of the entire aorta.
Scholte AJ, Hilhorst-Hofstee Y, Versteegh MI, Kroft LJ
Abstract
Cited 16 times since 2012 (1.3 per year)
source: EuropePMC
Diabetes care,
Volume 36, Issue 4, 5 1 2012, Pages 985-991
Influence of diabetes on left ventricular systolic and diastolic function and on long-term outcome after cardiac resynchronization therapy.
Höke U, Thijssen J, van Bommel RJ, van Erven L, van der Velde ET, Holman ER, Schalij MJ, Bax JJ, Delgado V, Marsan NA
Objective: The influence of diabetes on cardiac resynchronization therapy (CRT) remains unclear. The aims of the current study were to 1) assess the changes in left ventricular (LV) systolic and diastolic function and 2) evaluate long-term prognosis in CRT recipients with diabetes. Research design and methods: A total of 710 CRT recipients (171 with diabetes) were included from an ongoing registry. Echocardiographic evaluation, including LV systolic and diastolic function assessment, was perform...
Abstract
Cited 18 times since 2012 (1.4 per year)
source: EuropePMC
Anatomical record (Hoboken, N.J. : 2007),
Volume 296, Issue 2, 4 1 2012, Pages 192-197
Steep increase in myonuclear domain size during infancy.
Delhaas T, Van der Meer SF, Schaart G, Degens H, Drost MR
We investigated whether myonuclear number increases in proportion to the increase in fiber size during maturational growth of skeletal muscle. Thoraco-abdominal muscle tissue was obtained from twenty 6-day to 15-year-old boys and girls during cardiothoracic surgery. Cross-sections were stained by anti-laminin for the basal lamina and by DAPI to identify nuclei. Basal lamina was traced on digital images to measure the fiber cross-sectional area (FCSA). Nuclei located within the basal lamina were...
Abstract
