9618 results
Cited 18 times since 2012 (1.4 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 11, 12 2 2012, Pages e48385
Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index.
van Lierop MJ, Alkema W, Laskewitz AJ, Dijkema R, van der Maaden HM, Smit MJ, Plate R, Conti PG, Jans CG, Timmers CM, van Boeckel CA, Lusher SJ, McGuire R, van Schaik RC, de Vlieg J, Smeets RL, Hofstra CL, Boots AM, van Duin M, Ingelse BA, Schoonen WG, Grefhorst A, van Dijk TH, Kuipers F, Dokter WH
Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-steroidal Glucocorticoid Receptor (GR)-selective compound (Org 214007-0) with a binding affinity to GR similar to that of prednisolone. Structural modelling of the GR-Org 214007-0 binding site shows dist...
Abstract
Cited 11 times since 2012 (0.9 per year)
source: EuropePMC
European journal of heart failure,
Volume 15, Issue 4, 9 2 2012, Pages 400-407
Heart failure determines the myocardial inflammatory response to injury.
Kortekaas KA, Lindeman JH, Versteegh MI, van Beelen E, Kleemann R, Klautz RJ
Aims: Systemic complications after cardiac surgery are common in heart failure patients. However, the pathophysiological mechanisms, such as a different local inflammatory response of failing hearts, remain in question. This study examines whether failing hearts respond differently to cardioplegic arrest and reperfusion compared with non-failing hearts (controls). Methods and results: The inflammatory response was evaluated in samples collected simultaneously from the radial artery and coronary...
Abstract
Cited 40 times since 2012 (3.1 per year)
source: EuropePMC
Diabetes care,
Volume 36, Issue 2, 8 2 2012, Pages 457-462
Right ventricular involvement in diabetic cardiomyopathy.
Widya RL, van der Meer RW, Smit JW, Rijzewijk LJ, Diamant M, Bax JJ, de Roos A, Lamb HJ
Objective: To compare magnetic resonance imaging-derived right ventricular (RV) dimensions and function between men with type 2 diabetes and healthy subjects, and to relate these parameters to left ventricular (LV) dimensions and function. Research design and methods: RV and LV volumes and functions were assessed in 78 men with uncomplicated type 2 diabetes and 28 healthy men within the same range of age using magnetic resonance imaging. Steady-state free precession sequences were used to assess...
Abstract
Cited 10 times since 2012 (0.8 per year)
source: EuropePMC
Current biology : CB,
Volume 22, Issue 23, 8 2 2012, Pages 2231-2235
Sumatran orangutans differ in their cultural knowledge but not in their cognitive abilities.
Gruber T, Singleton I, van Schaik C
Animal cultures are controversial because the method used to isolate culture in animals aims at excluding genetic and environmental influences rather than demonstrating social learning. Here, we analyzed these factors in parallel in captivity to determine their influences on tool use. We exposed Sumatran orangutan (Pongo abelii) orphans from tool-using and non-tool-using regions (western swamps and eastern Langkat, respectively) that differed in both genetic and cultural backgrounds to a raking...
Abstract
Cited 40 times since 2012 (3.1 per year)
source: EuropePMC
Journal of human evolution,
Volume 63, Issue 6, 8 2 2012, Pages 843-850
How to explain the unusually late age at skill competence among humans.
Schuppli C, Isler K, van Schaik CP
Humans stand out among primates and other mammals in reaching adult-level foraging skills very late in development, well after the onset of reproduction. The aim of this paper is to place this unusual human skill development into a broader comparative context. Among birds and mammals in general, duration of immaturity, indexed by age at first reproduction (AFR), and adult brain size have undergone correlated evolution. This pattern is consistent with two causal processes: AFR is either limited b...
Abstract
Cited 32 times since 2012 (2.5 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 11, 7 1 2012, Pages e49142
Understanding the impacts of land-use policies on a threatened species: is there a future for the Bornean orang-utan?
Wich SA, Gaveau D, Abram N, Ancrenaz M, Baccini A, Brend S, Curran L, Delgado RA, Erman A, Fredriksson GM, Goossens B, Husson SJ, Lackman I, Marshall AJ, Naomi A, Molidena E, Nardiyono, Nurcahyo A, Odom K, Panda A, Purnomo, Rafiastanto A, Ratnasari D, Santana AH, Sapari I, van Schaik CP, Sihite J, Spehar S, Santoso E, Suyoko A, Tiju A, Usher G, Atmoko SS, Willems EP, Meijaard E
The geographic distribution of Bornean orang-utans and its overlap with existing land-use categories (protected areas, logging and plantation concessions) is a necessary foundation to prioritize conservation planning. Based on an extensive orang-utan survey dataset and a number of environmental variables, we modelled an orang-utan distribution map. The modelled orang-utan distribution map covers 155,106 km(2) (21% of Borneo's landmass) and reveals four distinct distribution areas. The most...
Abstract
Cited 1296 times since 2012 (101.3 per year)
source: EuropePMC
The New England journal of medicine,
Volume 367, Issue 22, 5 1 2012, Pages 2089-2099
Effects of dalcetrapib in patients with a recent acute coronary syndrome.
Schwartz GG, Olsson AG, Abt M, Ballantyne CM, Barter PJ, Brumm J, Chaitman BR, Holme IM, Kallend D, Leiter LA, Leitersdorf E, McMurray JJ, Mundl H, Nicholls SJ, Shah PK, Tardif JC, Wright RS, dal-OUTCOMES Investigators
Background: In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events. However, whether raising HDL cholesterol levels therapeutically reduces cardiovascular risk remains uncertain. Inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels and might therefore improve cardiovascular outcomes. Methods: We randomly assigned 15,871 patients who had had a recent acute coron...
Abstract
Cited 1 times since 2012 (0.1 per year)
source: EuropePMC
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery,
Volume 41, Issue 3, 3 1 2012, Pages 242-244
Nasal folliculosebaceous hamartoma with vascular-mesenchymal overgrowth in an infant.
Selçuk ÖT, Osma U, Süren D, Eyigör H, Yılmaz D, Sezer C
The nasal hamartoma is a rare non-neoplastic malformation or inborn error of tissue development, characterized by a mix of several tissue types. Folliculosebaceous cystic hamartoma is a distinct type of cutaneous hamartoma. We present a 3-month-old male infant who had nasal obstruction and who had a diagnosis of nasal folliculosebaceous cystic hamartoma after surgery.
Abstract
Cited 55 times since 2012 (4.3 per year)
source: EuropePMC
Journal of hepato-biliary-pancreatic sciences,
Volume 19, Issue 6, 1 1 2012, Pages 626-637
Image-guided hepatopancreatobiliary surgery using near-infrared fluorescent light.
Verbeek FP, van der Vorst JR, Schaafsma BE, Hutteman M, Bonsing BA, van Leeuwen FW, Frangioni JV, van de Velde CJ, Swijnenburg RJ, Vahrmeijer AL
Background: Improved imaging methods and surgical techniques have created a new era in hepatopancreatobiliary (HPB) surgery. Despite these developments, visual inspection, palpation, and intraoperative ultrasound remain the most utilized tools during surgery today. This is problematic, though, especially in laparoscopic HPB surgery, where palpation is not possible. Optical imaging using near-infrared (NIR) fluorescence can be used for the real-time assessment of both anatomy (e.g., sensitive det...
Abstract
Cited 4 times since 2012 (0.3 per year)
source: EuropePMC
Planta medica,
Volume 78, Issue 18, 31 5 2012, Pages 1918-1926
Antibiofilm activity of Dendrophthoe falcata against different bacterial pathogens.
Karthikeyan A, Rameshkumar R, Sivakumar N, Al Amri IS, Karutha Pandian S, Ramesh M
Dendrophthoe falcata is a hemiparasitic plant commonly used for ailments such as ulcers, asthma, impotence, paralysis, skin diseases, menstrual troubles, pulmonary tuberculosis, and wounds. In this context, the validations of the traditional claim that the leaf extract of D. falcata possesses antibiofilm and anti-quorum sensing activity against different bacterial pathogens were assessed. The bacterial biofilms were quantified by crystal violet staining. Among the 17 bacterial pathogens screened...
Abstract
Cited 21 times since 2012 (1.6 per year)
source: EuropePMC
Medical teacher,
Volume 35, Issue 2, 26 4 2012, Pages 139-144
Promoting self-directed learning through portfolios in undergraduate medical education: the mentors' perspective.
van Schaik S, Plant J, O'Sullivan P
Background: Medical students need to acquire self-directed learning (SDL) skills for effective lifelong learning. Portfolios allow learners to reflect on their progress, diagnose learning needs and create learning plans, all elements of SDL. While mentorship is deemed to be essential for successful portfolio use, it is not known what constitutes effective mentorship in this process. In-depth understanding of the SDL construct seems a prerequisite. Aims: The aim of this study was to examine how p...
Abstract
Cited 1 times since 2012 (0.1 per year)
source: EuropePMC
European biophysics journal : EBJ,
Volume 42, Issue 4, 23 4 2012, Pages 241-255
Depolarization-induced automaticity in rat ventricular cardiomyocytes is based on the gating properties of L-type calcium and slow Kv channels.
Ypey DL, van Meerwijk WP, Umar S, Pijnappels DA, Schalij MJ, van der Laarse A
Depolarization-induced automaticity (DIA) of cardiomyocytes is the property of those cells to generate pacemaker cell-like spontaneous electrical activity when subjected to a depolarizing current. This property provides a candidate mechanism for generation of pathogenic ectopy in cardiac tissue. The purpose of this study was to determine the biophysical mechanism of DIA in terms of the ion conductance properties of the cardiomyocyte membrane. First, we determined, by use of the conventional whol...
Abstract
Cited 6 times since 2012 (0.5 per year)
source: EuropePMC
Journal of plastic, reconstructive & aesthetic surgery : JPRAS,
Volume 66, Issue 1, 23 4 2012, Pages e26-8
Associated anomalies and diagnostic approach in lumbosacral and perineal haemangiomas: case report and review of the literature.
de Graaf M, Pasmans SG, van Drooge AM, Nievelstein RA, Gooskens RH, Raphael MF, Breugem CC
Abstract
Cited 31 times since 2012 (2.4 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 5, Issue 6, 22 4 2012, Pages 1059-1063
Prevalence and presentation of externalized conductors and electrical abnormalities in Riata defibrillator leads after fluoroscopic screening: report from the Netherlands Heart Rhythm Association Device Advisory Committee.
Theuns DA, Elvan A, de Voogt W, de Cock CC, van Erven L, Meine M
Background: The Riata family of implantable cardioverter-defibrillator (ICD) leads is prone to a specific insulation abrasion characterized by externalization of conductor cables. The objective of this study was to determine the prevalence of externalized conductors and electrical abnormalities in Riata ICD leads by fluoroscopic screening and standard ICD interrogation. Methods and results: All ICD implantation centers were contacted by the Netherlands Heart Rhythm Association Device Advisory Co...
Abstract
Cited 6 times since 2012 (0.5 per year)
source: EuropePMC
Case reports in urology,
Volume 2012, 16 3 2012, Pages 193787
Synchronous penile metastasis from a high-grade adenocarcinoma of the prostate.
Dijkstra S, van der Heijden AG, Schaafsma HE, Mulders PF
Metastasis to the glans penis is a rare phenomenon and usually occurs in a late stage of disease. A 68-year-old man was referred to our clinic because of two indurated lesions of the glans penis and minor lower urinary tract symptoms. Digital rectal examination revealed a hard nodular prostate, and serum prostate-specific antigen (sPSA) level was 13.3 ng/mL. Biopsies of the penile lesions and transrectal ultrasound-guided prostate biopsies were taken. Immunohistochemical staining of formalin-fix...
Abstract
Cited 32 times since 2012 (2.5 per year)
source: EuropePMC
The Journal of heredity,
Volume 104, Issue 1, 16 3 2012, Pages 2-13
Marked population structure and recent migration in the critically endangered Sumatran orangutan (Pongo abelii).
Nater A, Arora N, Greminger MP, van Schaik CP, Singleton I, Wich SA, Fredriksson G, Perwitasari-Farajallah D, Pamungkas J, Krützen M
A multitude of factors influence how natural populations are genetically structured, including dispersal barriers, inhomogeneous habitats, and social organization. Such population subdivision is of special concern in endangered species, as it may lead to reduced adaptive potential and inbreeding in local subpopulations, thus increasing the risk of future extinctions. With only 6600 animals left in the wild, Sumatran orangutans (Pongo abelii) are among the most endangered, but also most enigmatic...
Abstract
Cited 19 times since 2012 (1.5 per year)
source: EuropePMC
American heart journal,
Volume 164, Issue 5, 16 3 2012, Pages 771-778
Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparison.
Rodrigo SF, van Ramshorst J, Beeres SL, Al Younis I, Dibbets-Schneider P, de Roos A, Fibbe WE, Zwaginga JJ, Schalij MJ, Bax JJ, Atsma DE
Background: We recently demonstrated in a randomized, double-blind, placebo-controlled trial that intramyocardial bone marrow cell (BMC) injection is associated with improvements in myocardial perfusion and anginal symptoms in chronic myocardial ischemia patients. In the present study the results of the crossover phase of this trial, in which patients previously treated with placebo received autologous BMC injections are reported. This allows a unique intra-patient comparison on the effect of BM...
Abstract
Cited 3 times since 2012 (0.2 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 10, 16 3 2012, Pages e46356
Fractional flow reserve is not associated with inflammatory markers in patients with stable coronary artery disease.
Sels JW, Elsenberg EH, Hoefer IE, van Zonneveld AJ, Kuiper J, Jukema JW, Pijls NH, Pasterkamp G
Background: Atherosclerosis is an inflammatory condition and increased blood levels of inflammatory biomarkers have been observed in acute coronary syndromes. In addition, high expression of inflammatory markers is associated with worse prognosis of coronary artery disease. The presence and extent of inducible ischemia in patients with stable angina has previously been shown to have strong prognostic value. We hypothesized that evidence of inducible myocardial ischemia by local lesions, as measu...
Abstract
Cited 40 times since 2012 (3.1 per year)
source: EuropePMC
Cardiovascular research,
Volume 97, Issue 2, 14 2 2012, Pages 311-320
Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease.
de Vries MR, Wezel A, Schepers A, van Santbrink PJ, Woodruff TM, Niessen HW, Hamming JF, Kuiper J, Bot I, Quax PH
Aims: Failure of vein graft conduits due to vein graft thickening, accelerated atherosclerosis, and subsequent plaque rupture is applicable to 50% of all vein grafts within 10 years. New potential therapeutic targets to treat vein graft disease may be found in components of the innate immune system, such as mast cells and complement factors, which are known to be involved in atherosclerosis and plaque destabilization. Interestingly, mast cells can be activated by complement factor C5a and, there...
Abstract
Cited 59 times since 2012 (4.6 per year)
source: EuropePMC
Heart rhythm,
Volume 10, Issue 2, 13 2 2012, Pages 158-164
Electrophysiological characteristics of ventricular tachyarrhythmias in cardiac sarcoidosis versus arrhythmogenic right ventricular cardiomyopathy.
Dechering DG, Kochhäuser S, Wasmer K, Zellerhoff S, Pott C, Köbe J, Spieker T, Piers SR, Bittner A, Mönnig G, Breithardt G, Wichter T, Zeppenfeld K, Eckardt L
Background: Recent evidence suggests that cardiac sarcoidosis (CS) and arrhythmogenic right ventricular cardiomyopathy (ARVC) can manifest very similarly. Objective: To investigate whether there are significant demographic and electrophysiological differences between patients with CS and ARVC. Methods: We prospectively compared patients with proven CS or ARVC who underwent radiofrequency catheter ablation of ventricular tachycardias by using 3-dimensional electroanatomical mapping. Furthermore,...
Abstract
