Research

Publications

Below you can find a list of our published research.

9618 results

Cited 81 times since 2012 (6.3 per year) source: EuropePMC

PLoS pathogens, Volume 8, Issue 9, 27 4 2012, Pages e1002889 Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years. Klarenbeek PL, Remmerswaal EB, ten Berge IJ, Doorenspleet ME, van Schaik BD, Esveldt RE, Koch SD, ten Brinke A, van Kampen AH, Bemelman FJ, Tak PP, Baas F, de Vries N, van Lier RA

CD8(+) T-cell responses against latent viruses can cover considerable portions of the CD8(+) T-cell compartment for many decades, yet their initiation and maintenance remains poorly characterized in humans. A key question is whether the clonal repertoire that is raised during the initial antiviral response can be maintained over these long periods. To investigate this we combined next-generation sequencing of the T-cell receptor repertoire with tetramer-sorting to identify, quantify and longitud... Abstract

Cited 8 times since 2012 (0.6 per year) source: EuropePMC

Medical devices (Auckland, N.Z.), Volume 5, 26 4 2012, Pages 81-88 Investigating the role of combined acoustic-visual feedback in one-dimensional synchronous brain computer interfaces, a preliminary study. Gargiulo GD, Mohamed A, McEwan AL, Bifulco P, Cesarelli M, Jin CT, Ruffo M, Tapson J, van Schaik A

Feedback plays an important role when learning to use a brain computer interface (BCI), particularly in the case of synchronous feedback that relies on the interaction subject. In this preliminary study, we investigate the role of combined auditory-visual feedback during synchronous μ rhythm-based BCI sessions to help the subject to remain focused on the selected imaginary task. This new combined feedback, now integrated within the general purpose BCI2000 software, has been tested on eight untra... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 2, 22 4 2012, Pages 453-461 Effect of dose reduction on image quality and diagnostic performance in coronary computed tomography angiography. van der Bijl N, Joemai RM, Mertens BJ, de Roos A, Veldkamp WJ, Bax JJ, Schuijf JD, Geleijns J, Kroft LJ

To evaluate the effect of radiation dose reduction on image quality and diagnostic accuracy of coronary computed tomography (CT) angiography. Coronary CT angiography studies of 40 patients with (n = 20) and without (n = 20) significant (≥50 %) stenosis were included (26 male, 14 female, 57 ± 11 years). In addition to the original clinical reconstruction (100 % dose), simulated images were created that correspond to 50, 25 and 12.5 % of the original dose. Image quality and diagnostic performance... Abstract

Cited 16 times since 2012 (1.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 29, Issue 3, 22 4 2012, Pages 633-641 Aortic stiffness is related to left ventricular diastolic function in patients with diabetes mellitus type 1: assessment with MRI and speckle tracking strain analysis. van Schinkel LD, Auger D, van Elderen SG, Ajmone Marsan N, Delgado V, Lamb HJ, Ng AC, Smit JW, Bax JJ, Westenberg JJ, de Roos A

Diabetes mellitus type 1 (DM1) is associated with aortic stiffening and left ventricular (LV) diastolic dysfunction, however the relationship between aortic stiffness and LV diastolic dysfunction in DM1 patients is still largely unknown. The purpose of this study was to evaluate whether an increased aortic stiffness, expressed by increased aortic pulse wave velocity (PWV), is associated with subclinical LV diastolic dysfunction and decreased left atrial (LA) compliance as assessed with speckle t... Abstract

Cited 18 times since 2012 (1.4 per year) source: EuropePMC

Pediatric cardiology, Volume 34, Issue 3, 22 4 2012, Pages 630-638 Tissue Doppler imaging detects impaired biventricular performance shortly after congenital heart defect surgery. Klitsie LM, Hazekamp MG, Roest AA, Van der Hulst AE, Gesink-van der Veer BJ, Kuipers IM, Blom NA, Ten Harkel AD

Cardiac surgery with cardiopulmonary bypass is associated with the development of a systemic inflammatory response, which can lead to myocardial damage. However, knowledge concerning the time course of ventricular performance deterioration and restoration after correction of a congenital heart defect (CHD) in pediatric patients is sparse. Therefore, the authors perioperatively quantified left ventricular (LV) and right ventricular (RV) performance using echocardiography. Their study included 141... Abstract

Cited 34 times since 2012 (2.6 per year) source: EuropePMC

International journal of cardiology, Volume 167, Issue 6, 20 3 2012, Pages 2977-2982 MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome. Kröner ES, Scholte AJ, de Koning PJ, van den Boogaard PJ, Kroft LJ, van der Geest RJ, Hilhorst-Hofstee Y, Lamb HJ, Siebelink HM, Mulder BJ, Groenink M, Radonic T, van der Wall EE, de Roos A, Reiber JH, Westenberg JJ

Background: In patients with Marfan syndrome (MFS), increased aortic wall stiffening may lead to progressive aortic dilatation. Aortic Pulse Wave Velocity (PWV), a marker of wall stiffness can be assessed regionally, using in-plane multi-directional velocity-encoded MRI. This study examined the diagnostic accuracy of regional PWV for prediction of regional aortic luminal growth during 2-year follow-up in MFS patients. Methods: In twenty-one MFS patients (mean age 36 ± 15 years, 11 male) regional... Abstract

Cited 29 times since 2012 (2.2 per year) source: EuropePMC

Injury, Volume 43, Issue 12, 19 3 2012, Pages 1978-1984 Bias towards dementia: are hip fracture trials excluding too many patients? A systematic review. Hebert-Davies J, Laflamme GY, Rouleau D, HEALTH and FAITH investigators

Patients with hip fractures are older and often present many co-morbidities, including dementia. These patients cannot answer quality of life questionnaires and are generally excluded from trials. We hypothesized that a significant number of patients are being excluded from these studies and this may impact outcomes. This was a two part study; the first analyzing databases of two ongoing large-scale multi-centred hip fracture trials and the second being a systematic review. The FAITH and HEALTH... Abstract

Cited 190 times since 2012 (14.7 per year) source: EuropePMC

Circulation, Volume 126, Issue 17, 19 3 2012, Pages 2051-2064 Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Harada M, Luo X, Qi XY, Tadevosyan A, Maguy A, Ordog B, Ledoux J, Kato T, Naud P, Voigt N, Shi Y, Kamiya K, Murohara T, Kodama I, Tardif JC, Schotten U, Van Wagoner DR, Dobrev D, Nattel S

Background: Fibroblast proliferation and differentiation are central in atrial fibrillation (AF)-promoting remodeling. Here, we investigated fibroblast regulation by Ca(2+)-permeable transient receptor potential canonical-3 (TRPC3) channels. Methods and results: Freshly isolated rat cardiac fibroblasts abundantly expressed TRPC3 and had appreciable nonselective cation currents (I(NSC)) sensitive to a selective TPRC3 channel blocker, pyrazole-3 (3 μmol/L). Pyrazole-3 suppressed angiotensin II-ind... Abstract

Cited 3 times since 2012 (0.2 per year) source: EuropePMC

BMC veterinary research, Volume 8, 17 3 2012, Pages 164 Pregnancy detection and monitoring in cattle via combined foetus electrocardiogram and phonocardiogram signal processing. Gargiulo GD, Shephard RW, Tapson J, McEwan AL, Bifulco P, Cesarelli M, Jin C, Al-Ani A, Wang N, van Schaik A

Background: Pregnancy testing in cattle is commonly invasive requiring manual rectal palpation of the reproductive tract that presents risks to the operator and pregnancy. Alternative non-invasive tests have been developed but have not gained popularity due to poor specificity, sensitivity and the inconvenience of sample handling. Our aim is to present the pilot study and proof of concept of a new non invasive technique to sense the presence and age (limited to the closest trimester of pregnancy... Abstract

Cited 31 times since 2012 (2.4 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 94, Issue 6, 13 2 2012, Pages 2077-2082 Mild residual pulmonary stenosis in tetralogy of fallot reduces risk of pulmonary valve replacement. van der Hulst AE, Hylkema MG, Vliegen HW, Delgado V, Hazekamp MG, Rijlaarsdam ME, Holman ER, Blom NA, Roest AA

Background: Current surgical strategies that aim at preventing pulmonary regurgitation in patients with corrected tetralogy of Fallot (cToF) may result in a certain grade of residual pulmonary stenosis (PS). The clinical implications of a postoperative residual PS in cToF patients remain unclear. Pulmonary valve replacement (PVR) is frequently needed during follow-up of cToF patients. The aim of the current study was to determine the role of residual PS in the need for PVR during follow-up in cT... Abstract

Cited 9 times since 2012 (0.7 per year) source: EuropePMC

Inflammation research : official journal of the European Histamine Research Society ... [et al.], Volume 62, Issue 1, 13 2 2012, Pages 53-59 Interleukin-9 release from human kidney grafts and its potential protective role in renal ischemia/reperfusion injury. Kortekaas KA, de Vries DK, Reinders ME, Lievers E, Ringers J, Lindeman JH, Schaapherder AF

Objective and design: The pathophysiology of ischemia/reperfusion (I/R) injury is dominated by an inflammatory response. In the identification of new therapeutic agents, the role of individual cytokines may be essential. Interleukin (IL)-9 is a pleiotropic cytokine recently identified to be involved in various immune responses. In this study, the role of IL-9 in renal I/R injury was assessed. Methods: We performed repeated direct measurements of arteriovenous IL-9 concentration differences over... Abstract

Cited 12 times since 2012 (0.9 per year) source: EuropePMC

Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 171-181 Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms. Askar SF, Bingen BO, Schalij MJ, Swildens J, Atsma DE, Schutte CI, de Vries AA, Zeppenfeld K, Ypey DL, Pijnappels DA

Aims: Cardiac hypertrophy and fibrosis are associated with potentially lethal arrhythmias. As these substrates often occur simultaneously in one patient, distinguishing between pro-arrhythmic mechanisms is difficult. This hampers understanding of underlying pro-arrhythmic mechanisms and optimal treatment. This study investigates and compares arrhythmogeneity and underlying pro-arrhythmic mechanisms of either cardiac hypertrophy or fibrosis in in vitro models. Methods and results: Fibrosis was mi... Abstract

Cited 18 times since 2012 (1.4 per year) source: EuropePMC

Cardiovascular research, Volume 97, Issue 1, 12 2 2012, Pages 161-170 Prolongation of minimal action potential duration in sustained fibrillation decreases complexity by transient destabilization. Bingen BO, Askar SF, Schalij MJ, Kazbanov IV, Ypey DL, Panfilov AV, Pijnappels DA

Aims: Sustained ventricular fibrillation (VF) is maintained by multiple stable rotors. Destabilization of sustained VF could be beneficial by affecting VF complexity (defined by the number of rotors). However, underlying mechanisms affecting VF stability are poorly understood. Therefore, the aim of this study was to correlate changes in arrhythmia complexity with changes in specific electrophysiological parameters, allowing a search for novel factors and underlying mechanisms affecting stability... Abstract

Cited 53 times since 2012 (4.1 per year) source: EuropePMC

Human molecular genetics, Volume 21, Issue 24, 8 2 2012, Pages 5329-5343 Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Chasman DI, Fuchsberger C, Pattaro C, Teumer A, Böger CA, Endlich K, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa MF, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson A, Tönjes A, Dehghan A, Lambert JC, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, WTCCC2, Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer HK, Nauck

In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that ar... Abstract

Cited 59 times since 2012 (4.6 per year) source: EuropePMC

PLoS pathogens, Volume 8, Issue 9, 6 1 2012, Pages e1002908 Real-time transcriptional profiling of cellular and viral gene expression during lytic cytomegalovirus infection. Marcinowski L, Lidschreiber M, Windhager L, Rieder M, Bosse JB, Rädle B, Bonfert T, Györy I, de Graaf M, Prazeres da Costa O, Rosenstiel P, Friedel CC, Zimmer R, Ruzsics Z, Dölken L

During viral infections cellular gene expression is subject to rapid alterations induced by both viral and antiviral mechanisms. In this study, we applied metabolic labeling of newly transcribed RNA with 4-thiouridine (4sU-tagging) to dissect the real-time kinetics of cellular and viral transcriptional activity during lytic murine cytomegalovirus (MCMV) infection. Microarray profiling on newly transcribed RNA obtained at different times during the first six hours of MCMV infection revealed discr... Abstract

Cited 1709 times since 2012 (131.9 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 60, Issue 16, 5 1 2012, Pages 1581-1598 Third universal definition of myocardial infarction. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, Joint ESC/ACCF/AHA/WHF Task Force for Universal Definition of Myocardial Infarction, Authors/Task Force Members Chairpersons, Thygesen K, Alpert JS, White HD, Biomarker Subcommittee, Jaffe AS, Katus HA, Apple FS, Lindahl B, Morrow DA, ECG Subcommittee, Chaitman BR, Clemmensen PM, Johanson P, Hod H, Imaging Subcommittee, Underwood R, Bax JJ, Bonow JJ, Pinto F, Gibbons RJ, Classification Subcommittee, Fox KA, Atar D, Newby LK, Galvani M, Hamm CW, Intervention Subcommittee, Uretsky BF, Steg PG, Wijns W, Bassand JP, Menasche P, Ravkilde J, Trials & Registries Subcommittee, Ohman EM, Antman EM, Wallentin LC, Armstrong PW, Simoons ML, Trials & Registries Subcommittee, Januzzi JL, Nieminen MS, Gheorghiade M, Filippatos G, Trials & Registries Subcommittee, Luepker RV, Fortmann SP, Rosamond WD, Levy D, Wood D, Trials & Registries Subcommittee, Smith SC, Hu D, Lopez-Sendon JL, Robertson RM, Weaver D, Tendera M, Bove AA, Parkhomenko AN, Vasilieva EJ, Me

Abstract

Cited 26 times since 2012 (2 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 21, Issue 4, 5 1 2012, Pages 469-470 High prevalence of occult paragangliomas in asymptomatic carriers of SDHD and SDHB gene mutations. Heesterman BL, Bayley JP, Tops CM, Hes FJ, van Brussel BT, Corssmit EP, Hamming JF, van der Mey AG, Jansen JC

Hereditary paraganglioma is a benign tumor syndrome with an age-dependent penetrance. Carriers of germline mutations in the SDHB or SDHD genes may develop parasympathetic paragangliomas in the head and neck region or sympathetic catecholamine-secreting abdominal and thoracic paragangliomas (pheochromocytomas). In this study, we aimed to establish paraganglioma risk in 101 asymptomatic germline mutation carriers and evaluate the results of our surveillance regimen. Asymptomatic carriers of an SDH... Abstract

Cited 431 times since 2012 (33.2 per year) source: EuropePMC

European journal of epidemiology, Volume 27, Issue 9, 1 1 2012, Pages 739-756 The Generation R Study: design and cohort update 2012. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, van der Lugt A, Mackenbach JP, Moll HA, Raat H, Rivadeneira F, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A

The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. The study focuses on six areas of research: (1) maternal health; (2) growth and physical development; (3) behavioural and cognitive development; (4) respiratory health and allergies; (5) diseases in... Abstract

Cited 25 times since 2012 (1.9 per year) source: EuropePMC

Rhinology, Volume 50, Issue 3, 1 1 2012, Pages 255-261 Quality of life in extended endonasal approaches for skull base tumours. Georgalas C, Badloe R, van Furth W, Reinartz S, Fokkens WJ

Objective: To assess the quality of life (QOL) impact of extended endonasal approaches and nasoseptal flap reconstruction for benign skull base tumours Methods: A random sample of 110 patients undergoing either limited endonasal transphenoidal hypophysectomy or extended endonasal approaches (trans-cribriform, trans-sellar, trans-tuberculum, trans-pterygoid) for the removal of benign skull base tumours were asked to complete Rhinosinusitis Outcome Measure (RSOM-31) questionnaire. Results: A total... Abstract

Cited 2 times since 2012 (0.2 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 8 Suppl Q, 1 1 2012, Pages Q21-30 Imaging and quantification of aortic regurgitation after TAVI. Ewe SH, Delgado V, Bax JJ

During the last decade, transcatheter aortic valve implantation (TAVI) techniques have evolved rapidly providing several systems that conform to a broad spectrum of aortic valve annulus sizes, developing new delivery systems that provide an alternative to patients with difficult vascular access and permitting more controlled and accurate prosthesis deployment that result in improved procedural outcomes. However, residual aortic regurgitation (AR) (paravalvular or transvalvular) remains a recurre... Abstract