9618 results
Cited 96 times since 2012 (7.4 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 60, Issue 10, 15 3 2012, Pages 875-881
The controversies of statin therapy: weighing the evidence.
Jukema JW, Cannon CP, de Craen AJ, Westendorp RG, Trompet S
The debate whether statins, 3-hydroxymethyl-3-methylglutaryl coenzyme A reductase inhibitors, are safe to use has been raging since their introduction in 1987. Statins are generally well tolerated and are believed to have minimal adverse effects. However, individual, specific rare adverse events have been reported, such as elevations of liver enzymes, muscle aches, and very rarely, rhabdomyolysis. Discontinuation and/or reduction in the dose of the statin usually leads to resolution of these sid...
Abstract
Cited 13 times since 2012 (1 per year)
source: EuropePMC
The Journal of cell biology,
Volume 198, Issue 4, 13 2 2012, Pages 509-528
Open chromatin structures regulate the efficiencies of pre-RC formation and replication initiation in Epstein-Barr virus.
Papior P, Arteaga-Salas JM, Günther T, Grundhoff A, Schepers A
Whether or not metazoan replication initiates at random or specific but flexible sites is an unsolved question. The lack of sequence specificity in origin recognition complex (ORC) DNA binding complicates genome-scale chromatin immunoprecipitation (ChIP)-based studies. Epstein-Barr virus (EBV) persists as chromatinized minichromosomes that are replicated by the host replication machinery. We used EBV to investigate the link between zones of pre-replication complex (pre-RC) assembly, replication...
Abstract
Cited 631 times since 2012 (48.5 per year)
source: EuropePMC
Nature genetics,
Volume 44, Issue 9, 12 2 2012, Pages 991-1005
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ, Rehnberg E, Gustafsson S, Kanoni S, Rasmussen-Torvik LJ, Yengo L, Lecoeur C, Shungin D, Sanna S, Sidore C, Johnson PC, Jukema JW, Johnson T, Mahajan A, Verweij N, Thorleifsson G, Hottenga JJ, Shah S, Smith AV, Sennblad B, Gieger C, Salo P, Perola M, Timpson NJ, Evans DM, Pourcain BS, Wu Y, Andrews JS, Hui J, Bielak LF, Zhao W, Horikoshi M, Navarro P, Isaacs A, O'Connell JR, Stirrups K, Vitart V, Hayward C, Esko T, Mihailov E, Fraser RM, Fall T, Voight BF, Raychaudhuri S, Chen H, Lindgren CM, Morris AP, Rayner NW, Robertson N, Rybin D, Liu CT, Beckmann JS, Willems SM, Chines PS, Jackson AU, Kang HM, Stringham HM, Song K, Tanaka T, Peden JF, Goel A, Hicks AA, An P, Müller-Nurasyid M, Franco-Cereceda A, Folkersen L, Marullo L, Jansen H, Oldehinkel AJ, Bruinenberg M, Pankow JS, North KE, Forouhi NG, Loos RJ, Edkins S, Varga TV, Hallmans G, Oksa H, Antonella M, Nagaraja R, Trompet S, Ford I, Bakker SJ, Kong A, Kumari M, Gigante B
Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified furt...
Abstract
Cited 4 times since 2012 (0.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 167, Issue 6, 12 2 2012, Pages 2836-2840
Impaired cardiac reserve in asymptomatic patients with moderate pulmonary restenosis late after relief of severe pulmonary stenosis: evidence for diastolic dysfunction.
Romeih S, Blom NA, Van der Plas MN, Spijkerboer AM, Roest AA, Vliegen HW, Mulder BJ, Groenink M
Background: Patients with moderate pulmonary valve restenosis late after relief of severe pulmonary stenosis (PS) may show decreased exercise tolerance. To elucidate the mechanism of decreased exercise tolerance, we evaluated cardiac response to physical and pharmacological stress in these patients and compared results with those of patients with native moderate PS. Methods: Twenty asymptomatic patients with moderate PS were divided into 2 groups: Group I (late after relief of severe PS, n=9), a...
Abstract
Cited 11 times since 2012 (0.8 per year)
source: EuropePMC
Journal of neurology,
Volume 259, Issue 11, 10 2 2012, Pages 2393-2400
FabryScan: a screening tool for early detection of Fabry disease.
Arning K, Naleschinski D, Maag R, Biegstraaten M, Kropp P, Lorenzen J, Hollak CE, van Schaik IN, Harten P, Zeuner RA, Binder A, Baron R
Fabry disease, an X-linked lipid storage disorder, is associated early morbidity and mortality. Since enzyme replacement therapy is available, accurate detection of unrecognized cases is important. Characteristic early symptoms are recurrent episodes of burning and lancinating pain in the distal extremities associated with small fiber neuropathy. The aim was to develop and validate an easy diagnostic questionnaire in combination with three simple bedside tests, the "FabryScan", for the...
Abstract
Cited 18 times since 2012 (1.4 per year)
source: Scopus
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 42, Issue 4, 10 2 2012, Pages e53-7
Primary closure using Redon drains vs vacuum-assisted closure in post-sternotomy mediastinitis.
Vos RJ, Yilmaz A, Sonker U, Kelder JC, Kloppenburg GT
Objectives: Vacuum-assisted closure (VAC) is a commonly used therapy for the treatment of post-sternotomy mediastinitis. Primary closure of the sternum with high vacuum suction using Redon drains is an alternative that may reduce hospital stay. The aim of this study was to describe for the first time, the results of VAC compared with Redon drainage. Methods: We performed a retrospective analysis of 132 patients undergoing VAC (n = 89) or primary closure of the sternum with Redon drains (n = 43)...
Abstract
Cited 4 times since 2012 (0.3 per year)
source: EuropePMC
International journal of cardiology,
Volume 167, Issue 6, 9 2 2012, Pages 2841-2845
Rates and determinants of progressive aortic valve dysfunction in aortic coarctation.
Luijendijk P, Stevens AW, de Bruin-Bon RH, Boekholdt SM, Vriend JW, Vliegen HW, Bouma BJ, Mulder BJ
Purpose: Aortic valve dysfunction is common in coarctation patients(CoA). Bicuspid aortic valve (BAV) in CoA is associated with aortic valve stenosis (AS), aortic valve regurgitation (AR), and ascending aortic dilatation. The aim of this study was to evaluate the progression of and predictors for aortic valve dysfunction in CoA. Methods: 96 CoA patients prospectively underwent echocardiography twice between 2001 and 2010. AS was defined as an aortic valve gradient ≥ 20 mmHg, AR as none/minor, or...
Abstract
Cited 148 times since 2012 (11.4 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 5, Issue 5, 8 2 2012, Pages 628-636
Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension.
Haeck ML, Scherptong RW, Marsan NA, Holman ER, Schalij MJ, Bax JJ, Vliegen HW, Delgado V
Background: Right ventricular (RV) function is an important prognostic marker in patients with pulmonary hypertension. The present evaluation assessed the prognostic value of RV longitudinal peak systolic strain (LPSS) in patients with pulmonary hypertension. Methods and results: A total of 150 patients with pulmonary hypertension of different etiologies (mean age, 59±15 years; 37.3% male) were evaluated. RV fractional area change and tricuspid annular plane systolic excursion index were evaluat...
Abstract
Cited 54 times since 2012 (4.1 per year)
source: EuropePMC
PLoS medicine,
Volume 9, Issue 8, 7 1 2012, Pages e1001281
Feasibility, yield, and cost of active tuberculosis case finding linked to a mobile HIV service in Cape Town, South Africa: a cross-sectional study.
Kranzer K, Lawn SD, Meyer-Rath G, Vassall A, Raditlhalo E, Govindasamy D, van Schaik N, Wood R, Bekker LG
Background: The World Health Organization is currently developing guidelines on screening for tuberculosis disease to inform national screening strategies. This process is complicated by significant gaps in knowledge regarding mass screening. This study aimed to assess feasibility, uptake, yield, treatment outcomes, and costs of adding an active tuberculosis case-finding program to an existing mobile HIV testing service. Methods and findings: The study was conducted at a mobile HIV testing servi...
Abstract
Cited 13 times since 2012 (1 per year)
source: EuropePMC
PloS one,
Volume 7, Issue 8, 3 1 2012, Pages e42401
Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study.
Verschuren JJ, Trompet S, Postmus I, Sampietro ML, Heijmans BT, Houwing-Duistermaat JJ, Slagboom PE, Jukema JW
Background: Coronary restenosis after percutaneous coronary intervention still remains a significant problem, despite all medical advances. Unraveling the mechanisms leading to restenosis development remains challenging. Many studies have identified genetic markers associated with restenosis, but consistent replication of the reported markers is scarce. The aim of the current study was to analyze the joined effect of previously in literature reported candidate genes for restenosis in the GENetic...
Abstract
Cited 50 times since 2012 (3.8 per year)
source: EuropePMC
PLoS pathogens,
Volume 8, Issue 8, 2 1 2012, Pages e1002834
AsrR is an oxidative stress sensing regulator modulating Enterococcus faecium opportunistic traits, antimicrobial resistance, and pathogenicity.
Lebreton F, van Schaik W, Sanguinetti M, Posteraro B, Torelli R, Le Bras F, Verneuil N, Zhang X, Giard JC, Dhalluin A, Willems RJ, Leclercq R, Cattoir V
Oxidative stress serves as an important host/environmental signal that triggers a wide range of responses in microorganisms. Here, we identified an oxidative stress sensor and response regulator in the important multidrug-resistant nosocomial pathogen Enterococcus faecium belonging to the MarR family and called AsrR (antibiotic and stress response regulator). The AsrR regulator used cysteine oxidation to sense the hydrogen peroxide which results in its dissociation to promoter DNA. Transcriptome...
Abstract
Cited 14 times since 2012 (1.1 per year)
source: EuropePMC
Optics express,
Volume 20, Issue 18, 1 1 2012, Pages 20635-20646
Asymmetric light propagation in chirped photonic crystal waveguides.
Kurt H, Yilmaz D, Akosman AE, Ozbay E
We report numerical and experimental investigations of asymmetric light propagation in a newly designed photonic structure that is formed by creating a chirped photonic crystal (PC) waveguide. The use of a non-symmetric distribution of unit cells of PC ensures the obtaining of asymmetric light propagation. Properly designing the spatial modulation of a PC waveguide inherently modifies the band structure. That in turn induces asymmetry for the light's followed path. The investigation of the...
Abstract
Cited 793 times since 2012 (60.8 per year)
source: EuropePMC
Science (New York, N.Y.),
Volume 337, Issue 6095, 1 1 2012, Pages 730-735
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.
Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H
The concept that tumors are maintained by dedicated stem cells, the so-called cancer stem cell hypothesis, has attracted great interest but remains controversial. Studying mouse models, we provide direct, functional evidence for the presence of stem cell activity within primary intestinal adenomas, a precursor to intestinal cancer. By "lineage retracing" using the multicolor Cre-reporter R26R-Confetti, we demonstrate that the crypt stem cell marker Lgr5 (leucine-rich repeat-containing...
Abstract
Cited 73 times since 2012 (5.6 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 98, Issue 16, 1 1 2012, Pages 1229-1236
Intraoperative 2D and 3D transoesophageal echocardiographic predictors of aortic regurgitation after transcatheter aortic valve implantation.
Gripari P, Ewe SH, Fusini L, Muratori M, Ng AC, Cefalù C, Delgado V, Schalij MJ, Bax JJ, Marsan NA, Tamborini G, Pepi M
Background: Post-procedural aortic regurgitation (AR) has been described in a large number of patients receiving transcatheter aortic valve implantation (TAVI). Objective: The aim of this study was to examine the intraoperative 2-dimensional (2D) and 3-dimensional (3D) echocardiographic features of the aortic valve associated with significant post-procedural paravalvular AR. Methods: A total of 135 patients (81±7 years) with severe symptomatic aortic stenosis, who underwent TAVI, were imaged wit...
Abstract
Cited 47 times since 2012 (3.6 per year)
source: EuropePMC
The Journal of rheumatology,
Volume 39, Issue 10, 1 1 2012, Pages 2032-2040
ABCB1 and ABCC3 gene polymorphisms are associated with first-year response to methotrexate in juvenile idiopathic arthritis.
de Rotte MC, Bulatovic M, Heijstek MW, Jansen G, Heil SG, van Schaik RH, Wulffraat NM, de Jonge R
Objective: Although methotrexate (MTX) is the most widely prescribed drug in juvenile idiopathic arthritis (JIA), 30% of patients fail to respond to it. To individualize treatment strategies, the genetic determinants of response to MTX should be identified. Methods: A cohort of 287 patients with JIA treated with MTX was studied longitudinally over the first year of treatment. MTX response was defined as the American College of Rheumatology pediatric 70 criteria (ACRped70). We genotyped 21 single...
Abstract
Cited 22 times since 2012 (1.7 per year)
source: EuropePMC
Journal of acquired immune deficiency syndromes (1999),
Volume 60, Issue 4, 1 1 2012, Pages 400-404
Mid-dosing interval efavirenz plasma concentrations in HIV-1-infected children in Rwanda: treatment efficacy, tolerability, adherence, and the influence of CYP2B6 polymorphisms.
Mutwa PR, Fillekes Q, Malgaz M, Tuyishimire D, Kraats Rv, Boer KR, Burger DM, van Schaik RH, Muganga N, Geelen SP
This study evaluated mid-dosing interval efavirenz plasma concentrations and the influence of CYP2B6 polymorphisms in relation to efficacy, tolerability, and adherence in 97 Rwandan HIV-infected children (3-16 years). Plasma drug concentrations and CYP2B6 polymorphisms were determined. Ten children were excluded for nonadherence. Large intersubject variability in efavirenz plasma concentrations was found. Of the 87 remaining, efavirenz concentrations were therapeutic, supratherapeutic, and subth...
Abstract
Cited 21 times since 2012 (1.6 per year)
source: EuropePMC
Journal of cellular and molecular medicine,
Volume 16, Issue 8, 1 1 2012, Pages 1866-1877
Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors.
Wierda RJ, Kuipers HF, van Eggermond MC, Benard A, van Leeuwen JC, Carluccio S, Geutskens SB, Jukema JW, Marquez VE, Quax PH, van den Elsen PJ
Previously, we have shown that CCR5 transcription is regulated by CREB-1. However, the ubiquitous pattern of CREB-1 expression suggests the involvement of an additional level of transcriptional control in the cell type-specific expression of CCR5. In this study, we show that epigenetic changes (i.e. DNA methylation and histone modifications) within the context of the CCR5 P1 promoter region correlate with transcript levels of CCR5 in healthy and in malignant CD4(+) T lymphocytes as well as in C...
Abstract
Cited 1924 times since 2012 (147.4 per year)
source: EuropePMC
European journal of heart failure,
Volume 14, Issue 8, 1 1 2012, Pages 803-869
ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC.
McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, Falk V, Filippatos G, Fonseca C, Gomez-Sanchez MA, Jaarsma T, Køber L, Lip GY, Maggioni AP, Parkhomenko A, Pieske BM, Popescu BA, Rønnevik PK, Rutten FH, Schwitter J, Seferovic P, Stepinska J, Trindade PT, Voors AA, Zannad F, Zeiher A, Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology, Bax JJ, Baumgartner H, Ceconi C, Dean V, Deaton C, Fagard R, Funck-Brentano C, Hasdai D, Hoes A, Kirchhof P, Knuuti J, Kolh P, McDonagh T, Moulin C, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Torbicki A, Vahanian A, Windecker S, McDonagh T, Sechtem U, Bonet LA, Avraamides P, Ben Lamin HA, Brignole M, Coca A, Cowburn P, Dargie H, Elliott P, Flachskampf FA, Guida GF, Hardman S, Iung B, Merkely B, Mueller C, Nanas JN, Nielsen OW, Orn S, Parissis JT, Ponikowski P, ESC Committee for Practice Guidelines
Abstract
Cited 2 times since 2012 (0.2 per year)
source: EuropePMC
The Eurasian journal of medicine,
Volume 44, Issue 2, 1 1 2012, Pages 94-98
Obesity and its diagnostic methods in Turkish children.
Yilmaz D, Inan G, Karakas S, Buyukozturk-Karul A, Sonmez F
Objective: The application of body mass index (BMI) for obesity classification in all population studies has been questioned by the scientific community. It has been found that the bioelectrical impedance analysis (BIA) is an accurate method for screening obesity. This study was conducted to evaluate the accuracies of BMI, skinfold thickness (SFT), leptin and BIA measurements in obesity classification and to find correlations between BIA and the other indicators for obesity. Materials and method...
Abstract
Cited 17 times since 2012 (1.3 per year)
source: EuropePMC
American heart journal,
Volume 164, Issue 2, 1 1 2012, Pages 146-152
The rationale and design of the Shockless IMPLant Evaluation (SIMPLE) trial: a randomized, controlled trial of defibrillation testing at the time of defibrillator implantation.
Healey JS, Hohnloser SH, Glikson M, Neuzner J, Viñolas X, Mabo P, Kautzner J, O'Hara G, Van Erven L, Gadler F, Appl U, Connolly SJ
Defibrillation testing (DT) has been an integral part of defibrillator (implantable cardioverter defibrillator [ICD]) implantation; however, there is little evidence that it improves outcomes. Surveys show a trend toward ICD implantation without DT, which now exceeds 30% to 60% in some regions. Because there is no evidence to support dramatic shift in practice, a randomized trial is urgently needed. The SIMPLE trial will determine if ICD implantation without any DT is noninferior to implantation...
Abstract
