Research

Publications

Below you can find a list of our published research.

9618 results

Cited 1 times since 2001 (0 per year) source: EuropePMC

Circulation, Volume 103, Issue 17, 1 1 2001, Pages E92-3 False aneurysms of an ascending-aorta-to-abdominal-aorta bypass for coarctation of the aorta. Roest AA, Wasser MN, Versteegh MI, de Roos A, van Der Wall EE, Helbing WA, Vliegen HW

Abstract

Cited 36 times since 2001 (1.5 per year) source: EuropePMC

Journal of molecular biology, Volume 308, Issue 4, 1 1 2001, Pages 597-608 Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein. Schepers A, Diffley JF

The Cdc6 protein is required to load a complex of Mcm2-7 family members (the MCM complex) into prereplicative complexes at budding yeast origins of DNA replication. Cdc6p is a member of the AAA(+) superfamily of proteins, which includes the prokaryotic and eukaryotic clamp loading proteins. These proteins share a number of conserved regions of homology and a common three-dimensional architecture. Two of the conserved sequence motifs are the Walker A and B motifs that are involved in nucleotide m... Abstract

Cited 16 times since 2001 (0.7 per year) source: EuropePMC

Journal of vascular surgery, Volume 33, Issue 5, 1 1 2001, Pages 983-989 Nerve-preserving aortoiliac reconstruction surgery: anatomical study and surgical approach. van Schaik J, van Baalen JM, Visser MJ, DeRuiter MC

Objective: Dysfunctional ejaculation and, to a lesser extent, dysfunctional erection caused by disruption of efferent sympathetic pathways is a common complication after aortoiliac reconstruction surgery. The aim was to give an anatomic motivation for a nerve-preserving approach on the basis of right-sided unilateral disruption of lumbar splanchnic nerves. Methods: Anatomic and microscopic analysis of preaortic and para-aortic retroperitoneal regions in human cadavers was performed. Anatomic ana... Abstract

Cited 91 times since 2001 (3.7 per year) source: EuropePMC

Journal of virology, Volume 75, Issue 7, 1 1 2001, Pages 3335-3342 Improved adenovirus vectors for infection of cardiovascular tissues. Havenga MJ, Lemckert AA, Grimbergen JM, Vogels R, Huisman LG, Valerio D, Bout A, Quax PH

To identify improved adenovirus vectors for cardiovascular gene therapy, a library of adenovirus vectors based on adenovirus serotype 5 (Ad5) but carrying fiber molecules of other human serotypes, was generated. This library was tested for efficiency of infection of human primary vascular endothelial cells (ECs) and smooth muscle cells (SMCs). Based on luciferase, LacZ, or green fluorescent protein (GFP) marker gene expression, several fiber chimeric vectors were identified that displayed improv... Abstract

Cited 19 times since 2001 (0.8 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 85, Issue 4, 1 1 2001, Pages 458-462 Increased risk for ischaemic events is related to combined RAS polymorphism. van Geel PP, Pinto YM, Zwinderman AH, Henning RH, van Boven AJ, Jukema JW, Bruschke AV, Kastelein JJ, van Gilst WH

Objective: To determine whether the angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT(1)R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis. Design: Prospective defined substudy of the lipid lowering regression trial (REGRESS). Setting: University hospital. Patients: 885 male patients with stable coronary artery disease. Main outcome me... Abstract

Cited 6 times since 2001 (0.2 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 71, Issue 4, 1 1 2001, Pages 1382-1383 Implantation of cardioverter device in young children: the perirenal approach. Hazekamp MG, Blom NA, Schoof PH, Schalij MJ, Dion RA

Placement of Implantable cardioverter devices in young children is complicated because of the relatively large size and heavy weight of these devices. A technique is described where the device is implanted in the left perirenal space while an endovascular lead is used instead of an epicardial patch electrode. Abstract

Cited 4 times since 2001 (0.2 per year) source: EuropePMC

Thrombosis and haemostasis, Volume 85, Issue 4, 1 1 2001, Pages 746-747 Factor VII polymorphisms and myocardial infarction: what is special in Italians? REGRESS study group. Regression Growth Evaluation Statin Study. Nederhand RJ, de Maat MP, Jukema JW, Regression Growth Evaluation Statin Study group

Abstract

Cited 82 times since 2001 (3.4 per year) source: EuropePMC

Circulation, Volume 103, Issue 13, 1 1 2001, Pages 1778-1786 Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice. Delsing DJ, Offerman EH, van Duyvenvoorde W, van Der Boom H, de Wit EC, Gijbels MJ, van Der Laarse A, Jukema JW, Havekes LM, Princen HM

Background: The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden mice. Methods and results: Two groups of 15 female ApoE*3-Leiden mice were put on a high-cholesterol (HC) diet; 1 group received 0.01% (wt/wt) avasimibe mixed into the diet. The HC diet resulted in a plasma cholesterol concentration of 18.7+/-2.6 mmol/L. Addition of avasimibe lowered plasma cholesterol by 56% to 8.1+/-1.2 mmol/... Abstract

Cited 22 times since 2001 (0.9 per year) source: EuropePMC

Gene therapy, Volume 8, Issue 7, 1 1 2001, Pages 534-541 In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI. Lamfers ML, Lardenoye JH, de Vries MR, Aalders MC, Engelse MA, Grimbergen JM, van Hinsbergh VW, Quax PH

Injury-induced neointimal development results from migration and proliferation of vascular smooth muscle cells (SMC). Cell migration requires controlled proteolytic degradation of extracellular matrix surrounding the cell. Plasmin is a major contributor to this process by degrading various matrix proteins directly, or indirectly by activating matrix metalloproteinases. This makes it an attractive target for inhibition by gene transfer. An adenoviral vector, Ad.ATF.BPTI, was constructed encoding... Abstract

Cited 9 times since 2001 (0.4 per year) source: EuropePMC

The veterinary quarterly, Volume 23, Issue 2, 1 1 2001, Pages 71-76 Risk factors for introduction of BHV1 into BHV1-free Dutch dairy farms: a case-control study. van Schaik G, Schukken YH, Nielen M, Dijkhuizen AA, Benedictus G

In May 1998, a compulsory eradication programme for BHV1 started in the Netherlands. In December 1999 approximately 24% of Dutch dairy farms were certified BHV1-free (Animal Health Service (AHS)). Ninety-three certified BHV1-free dairy farms participated in a cohort study that investigated the probability of introduction of infectious diseases. The probability of introduction of BHV1 was determined from March 1997 until April 1999. Ninety of these farms remained BHV1-free and could be used as co... Abstract

Cited 183 times since 2001 (7.5 per year) source: EuropePMC

Circulation, Volume 103, Issue 9, 1 1 2001, Pages 1198-1205 Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HO, Roomp K, Jukema JW, van Wijland M, van Dam M, Hudson TJ, Brooks-Wilson A, Genest J, Kastelein JJ, Hayden MR

Background: Low plasma HDL cholesterol (HDL-C) is associated with an increased risk of coronary artery disease (CAD). We recently identified the ATP-binding cassette transporter 1 (ABCA1) as the major gene underlying the HDL deficiency associated with reduced cholesterol efflux. Mutations within the ABCA1 gene are associated with decreased HDL-C, increased triglycerides, and an increased risk of CAD. However, the extent to which common variation within this gene influences plasma lipid levels an... Abstract

Cited 18 times since 2001 (0.7 per year) source: EuropePMC

The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), Volume 45, Issue 1, 1 1 2001, Pages 108-114 Perfusion and functional abnormalities outside the septal region in patients with left bundle branch block assessed with gated SPECT. Bavelaar-Croon CD, Wahba FF, Van Hecke MV, Atsma DE, Stokkel MP, Pauwels EK, Van der Wall EE

Background: The presence of a left bundle branch block (LBBB) pattern on the electrocardiogram may frequently lead to perfusion defects in the septum not necessarily due to ischemic heart disease, but probably due to abnormal septal wall motion. The introduction of gated single photon emission computed tomography (SPECT) allows the evaluation of myocardial perfusion and function in one study. Accordingly, we analysed perfusion and function and the relation between perfusion and regional function... Abstract

Cited 14 times since 2001 (0.6 per year) source: EuropePMC

Analytical biochemistry, Volume 290, Issue 2, 1 1 2001, Pages 283-291 Simultaneous detection of NOS-3 protein expression and nitric oxide production using a flow cytometer. Havenga MJ, van Dam B, Groot BS, Grimbergen JM, Valerio D, Bout A, Quax PH

Nitric oxide (NO) is involved in the regulation of SMC proliferation during intimal hyperplasia as has been shown by the inhibitory effect on intimal hyperplasia of adenovirus-mediated ceNOS overexpression in injured arteries in pig. Good assays to quantify the NO-producing enzymes, i.e., NO synthases (NOS), are essential to analyze the mechanism of action of NO in this process. We have developed novel flow cytometric assays for the simultaneous detection of NOS-3 protein, using NOS-3 specific a... Abstract

Cited 15 times since 2001 (0.6 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 71, Issue 2, 1 1 2001, Pages 601-7; discussion 607-8 Outcome and follow-up of aortic valve replacement with the freestyle stentless bioprosthesis. Kappetein AP, Braun J, Baur LH, Prat A, Peels K, Hazekamp MG, Schoof PH, Huysmans HA

Background: The aim of this study was to determine the morbidity, mortality, and hemodynamics after implantation of the Freestyle stentless bioprosthesis in the aortic position. Methods: A total of 280 patients were operated on from June 1993 to July 1999 as part of a multicenter investigation. Factors influencing hospital mortality and long-term survival were assessed by logistic regression and Cox proportional hazards analysis. Patients were evaluated postoperatively at discharge, at 3 to 6 mo... Abstract

Cited 43 times since 2001 (1.8 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 21, Issue 2, 1 1 2001, Pages 118-122 Quality of life in patients with intermittent claudication using the World Health Organisation (WHO) questionnaire. Breek JC, Hamming JF, De Vries J, Aquarius AE, van Berge Henegouwen DP

Objective: to assess quality of life (QOL) in patients with intermittent claudication. Design: a prospective, open study. Material and method: one hundred and fifty-one consecutive claudicants (100 men, 51 women), and 161 healthy controls (70 men and 91 women) completed an adapted version of the World Health Organisation Quality of Life Assessment Instrument-100. Results: patients scored significantly worse on the domains Physical health and Level of independence, as well as on the facets Pain a... Abstract

Cited 24 times since 2001 (1 per year) source: EuropePMC

Pflugers Archiv : European journal of physiology, Volume 441, Issue 5, 1 1 2001, Pages 717-724 Within-subject electrocardiographic differences at equal heart rates: role of the autonomic nervous system. Frederiks J, Swenne CA, Kors JA, van Herpen G, Maan AC, Levert JV, Schalij MJ, Bruschke AV

Various combinations of sympathetic and vagal tone can yield the same heart rate, while ventricular electrophysiology differs. To demonstrate this in humans, we studied healthy volunteers in the sitting position with horizontal legs. First, heart rate was increased by lowering the legs to 60 degrees and back. Thereafter, heart rate was increased by handgrip. In each subject, a leg-lowering angle was selected at which heart rate matched best with heart rate in the third handgrip minute. Thirteen... Abstract

Cited 26 times since 2001 (1.1 per year) source: EuropePMC

Radiology, Volume 218, Issue 2, 1 1 2001, Pages 540-547 Improved MR flow mapping in coronary artery bypass grafts during adenosine-induced stress. Langerak SE, Kunz P, Vliegen HW, Lamb HJ, Jukema JW, van Der Wall EE, de Roos A

Purpose: To validate a recently developed fast high-temporal-resolution magnetic resonance (MR) flow sequence and use it to assess coronary artery bypass graft function during pharmacologic stress. Materials and methods: Aortic and internal mammary artery flow was measured in 11 healthy volunteers by using conventional cine gradient-echo imaging as a reference standard method and turbo-field echo-planar imaging (TFEPI). By using TFEPI, breath-hold flow mapping with a spatial and temporal resolut... Abstract

Cited 492 times since 2001 (20 per year) source: EuropePMC

Science (New York, N.Y.), Volume 291, Issue 5507, 1 1 2001, Pages 1289-1292 The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Caron H, van Schaik B, van der Mee M, Baas F, Riggins G, van Sluis P, Hermus MC, van Asperen R, Boon K, Voûte PA, Heisterkamp S, van Kampen A, Versteeg R

The chromosomal position of human genes is rapidly being established. We integrated these mapping data with genome-wide messenger RNA expression profiles as provided by SAGE (serial analysis of gene expression). Over 2.45 million SAGE transcript tags, including 160,000 tags of neuroblastomas, are presently known for 12 tissue types. We developed algorithms to assign these tags to UniGene clusters and their chromosomal position. The resulting Human Transcriptome Map generates gene expression prof... Abstract

Cited 38 times since 2001 (1.5 per year) source: EuropePMC

European journal of immunology, Volume 31, Issue 1, 1 1 2001, Pages 146-155 Long lasting p53-specific T cell memory responses in the absence of anti-p53 antibodies in patients with resected primary colorectal cancer. van der Burg SH, de Cock K, Menon AG, Franken KL, Palmen M, Redeker A, Drijfhout J, Kuppen PJ, van de Velde C, Erdile L, Tollenaar RA, Melief CJ, Offringa R

Colorectal carcinoma is commonly associated with mutation and overexpression of p53, making this antigen a potential target for immune intervention. We analyzed humoral and proliferative immunity against p53 in the blood of patients with resected primary colorectal cancer. The majority of these patients displayed anti-p53 T helper (Th) immunity in the absence of measurable p53 specific antibody levels. The Th responses were long-lasting since they could be detected up to several years after rese... Abstract

Cited 1 times since 2001 (0 per year) source: EuropePMC

Clinical laboratory, Volume 47, Issue 11-12, 1 1 2001, Pages 549-554 Detection limit, cut-off and specificity of an improved rapid assay for cardiac troponin T. Baum H, Bertsch T, Bohner J, von Pap KW, Hoff T, Wilke B, Katz N, Luthe H, Luz H, Nagel D, Niederhauser C, van Schaik RH, Aschenneller C, Schul I, Zerback R

The performance of an improved version of the troponin T rapid test TROPT Sensitive was investigated in a multicentre evaluation at twelve centres. The detection limit and the cut-off were determined in a method comparison with Elecsys Troponin T using a total of 365 samples from patients with suspected acute coronary syndromes and 91 samples from healthy blood donors or non-cardiological patients. The analytical specificity was determined by measuring 1271 blood samples from blood donors withou... Abstract