Research

Publications

Below you can find a list of our published research.

9618 results

Cited 35 times since 2001 (1.4 per year) source: EuropePMC

Circulation, Volume 103, Issue 4, 1 1 2001, Pages 562-569 Adenoviral expression of a urokinase receptor-targeted protease inhibitor inhibits neointima formation in murine and human blood vessels. Quax PH, Lamfers ML, Lardenoye JH, Grimbergen JM, de Vries MR, Slomp J, de Ruiter MC, Kockx MM, Verheijen JH, van Hinsbergh VW

Background: Smooth muscle cell migration, in addition to proliferation, contributes to a large extent to the neointima formed in humans after balloon angioplasty or bypass surgery. Plasminogen activator/plasmin-mediated proteolysis is an important mediator of this smooth muscle cell migration. Here, we report the construction of a novel hybrid protein designed to inhibit the activity of cell surface-bound plasmin, which cannot be inhibited by its natural inhibitors, such as alpha(2)-antiplasmin.... Abstract

Cited 6 times since 2001 (0.2 per year) source: EuropePMC

Early human development, Volume 60, Issue 3, 1 1 2001, Pages 159-170 Inhibition of nitric oxide synthesis following severe hypoxia-ischemia restores autoregulation of cerebral blood flow in newborn lambs. Dorrepaal CA, Steendijk P, Baan J, van Bel F

Birth asphyxia impairs the autoregulatory ability of the cerebral blood flow. Inappropriate synthesis of vasodilatory nitric oxide may be important in this respect. We investigated if nitric oxide synthesis inhibition by N(omega)-nitro-L-arginine (NLA) could restore cerebral autoregulation after severe hypoxia-ischemia (HI). HI was induced in 15 newborn lambs. Cerebral blood flow (carotid artery blood flow [ml/min]: Qcar) and mean aortic blood pressure [mmHg]: MABP) were measured over a 30 min p... Abstract

Cited 25 times since 2001 (1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 8, Issue 1, 1 1 2001, Pages 10-18 Comparison of left ventricular function at rest and post-stress in patients with myocardial infarction: Evaluation with gated SPECT. Bavelaar-Croon CD, America YG, Atsma DE, Dibbets-Schneider P, Zwinderman AH, Stokkel MP, Pauwels EK, van der Wall EE

Background: Quantitative electrocardiogram-gated single photon emission computed tomography (SPECT) myocardial imaging (QGS) is a means of providing functional information about the left ventricle and myocardial perfusion. However, the functional information derived 30 minutes post-stress may be different from the left ventricular (LV) function determined at rest. This study determined whether LV function post-stress would be different from LV function at rest in patients with an earlier myocard... Abstract

Cited 9 times since 2001 (0.4 per year) source: EuropePMC

Nuclear medicine communications, Volume 22, Issue 1, 1 1 2001, Pages 45-55 The additive value of gated SPET myocardial perfusion imaging in patients with known and suspected coronary artery disease. Bavelaar-Croon CD, Atsma DE, van der Wall EE, Dibbets-Schneider P, Zwinderman AH, Pauwels EK

In myocardial perfusion scintigraphy, the clinical significance of fixed defects presents some difficulty. In this study, we evaluated whether additional information on left ventricular function assessed by quantitative gated single-photon emission computed tomography (gated SPET) would increase the diagnostic yield of the study in such patients. We studied 55 patients with a previous myocardial infarction and 20 patients without a previous myocardial infarction using gated SPET 99Tc(m)-tetrofos... Abstract

Cited 20 times since 2001 (0.8 per year) source: EuropePMC

Journal of biomechanics, Volume 34, Issue 1, 1 1 2001, Pages 41-50 Predicting systolic and diastolic aortic blood pressure and stroke volume in the intact sheep. Segers P, Steendijk P, Stergiopulos N, Westerhof N

We developed a mathematical model describing the interaction between the heart and the arterial system. The model was constructed and tested on basis of invasive hemodynamic data in six sheep. Data from a first group of three animals (49 cardiac cycles) were used to assess a template time-varying elastance curve for the left ventricle, while the baseline steady-state data of a second group of three animals were used to assess reference cardiac and arterial parameters in sheep. The model is fully... Abstract

Cited 16 times since 2001 (0.6 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 280, Issue 1, 1 1 2001, Pages H392-400 Enhanced systolic function of the right ventricle during respiratory distress syndrome in newborn lambs. De Vroomen M, Steendijk P, Lopes Cardozo RH, Brouwers HH, Van Bel F, Baan J

Respiratory distress syndrome (RDS) causes pulmonary hypertension. It is often suggested that this increased afterload for the right ventricle (RV) might lead to cardiac dysfunction. To examine this, we studied biventricular function in an experimental model. RDS was induced by lung lavages in seven newborn lambs. Five additional lambs served as controls. Cardiac function was quantified by indexes derived from end-systolic pressure-volume relations obtained by pressure-conductance catheters. Aft... Abstract

Cited 52 times since 2001 (2.1 per year) source: EuropePMC

Genomics, Volume 71, Issue 2, 1 1 2001, Pages 214-221 The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32. Spieker N, van Sluis P, Beitsma M, Boon K, van Schaik BD, van Kampen AH, Caron H, Versteeg R

Neuroblastoma is an embryonal tumor originating from neural crest-derived cells. Here we present the serendipitous cloning of amplified sequences of chromosome 2p15 in neuroblastoma cell line IMR32. The amplified region was analyzed for oncogene activation using a SAGE (serial analysis of gene expression) library of IMR32. SAGE permits a quantitative analysis of all transcripts of a tissue or cell line. The expression of genes and ESTs mapping within a 30-cR region covering the amplicon was comp... Abstract

Cited 8 times since 2000 (0.3 per year) source: EuropePMC

Cardiovascular research, Volume 48, Issue 3, 1 1 2000, Pages 455-463 A new approach to determine parallel conductance for left ventricular volume measurements. Kornet L, Schreuder JJ, van der Velde ET, Baan J, Jansen JR

Objectives: To determine absolute ventricular volume with the conductance catheter technique, the electrical conductance of tissues and fluids (parallel conductance) around the ventricle should be determined precisely. Methods: A new objective method to estimate parallel conductance based on analysis of the dilution curve of hypertonic saline was investigated. The parallel conductances obtained with the new method (G(a)(p)) were compared to those obtained with the conventional method (G(l)(p)).... Abstract

Cited 19 times since 2000 (0.8 per year) source: EuropePMC

International journal of cardiac imaging, Volume 16, Issue 6, 1 1 2000, Pages 447-453 Good correlation between gated single photon emission computed myocardial tomography and contrast ventriculography in the assessment of global and regional left ventricular function. Atsma DE, Bavelaar-Croon CD, Germano G, Dibbets-Schneider P, van Eck-Smit BL, Pauwels EK, van der Wall EE

Purpose: The purpose of this study was to determine the reliability of the measured left ventricular ejection fraction (LVEF) and wall motion analysis by the recently introduced quantitative electrocardiographically (ECG)-gated myocardial perfusion single-photon emission computed myocardial tomography technique (gated SPECT) (QGS). Materials and methods: We compared technetium-99 m tetrofosmin gated SPECT imaging and contrast ventriculography in the assessment of global and regional left ventric... Abstract

Cited 107 times since 2000 (4.3 per year) source: EuropePMC

The American journal of cardiology, Volume 86, Issue 12, 1 1 2000, Pages 1299-1305 Comparison of gated single-photon emission computed tomography with magnetic resonance imaging for evaluation of left ventricular function in ischemic cardiomyopathy. Bax JJ, Lamb H, Dibbets P, Pelikan H, Boersma E, Viergever EP, Germano G, Vliegen HW, de Roos A, Pauwels EK, Van der Wall EE

To perform a head-to-head comparison between magnetic resonance imaging (MRI) and gated single-photon emission computed tomography (SPECT) for the evaluation of left ventricular (LV) function (LV ejection fraction [LVEF], LV volumes, and regional wall motion) in patients with ischemic cardiomyopathy, we studied 22 patients with chronic coronary artery disease and LV dysfunction. Multislice, multiphase echoplanar MRI was performed with Philips Gyroscan ACS-NT15. Image analysis was performed using... Abstract

Cited 40 times since 2000 (1.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 36, Issue 7, 1 1 2000, Pages 2104-2114 Acute and short-term effects of partial left ventriculectomy in dilated cardiomyopathy: assessment by pressure-volume loops. Schreuder JJ, Steendijk P, van der Veen FH, Alfieri O, van der Nagel T, Lorusso R, van Dantzig JM, Prenger KB, Baan J, Wellens HJ, Batista RJ

Objectives: The aim of this study was to evaluate the short-term effects of partial left ventriculectomy (PLV) on left ventricular (LV) pressure-volume (P-V) loops, wall stress, and the synchrony of LV segmental volume motions in patients with dilated cardiomyopathy. Background: Surgical LV volume reduction is under investigation as an alternative for, or bridge to, heart transplantation for patients with end-stage dilated cardiomyopathy. Methods: We measured P-V loops in eight patients with dil... Abstract

Journal of endourology, Volume 14, Issue 9, 1 1 2000, Pages 739-742 Antegrade ureteral stent placement: positioning without use of a retraction string. van Schaik JP, de Lange EE, van Waes PF

Purpose: To evaluate a simple method of antegrade ureteral stent insertion allowing optimal positioning of the stent without the use of a retraction string. Patients and methods: Seventeen stents were placed in sixteen patients with ureteral obstruction. Materials included a long vascular introducer sheath and radiopaque markers on the tips of both the sheath and the pusher catheter. For optimal positioning of the proximal pigtail in the renal pelvis, the distal end of the sheath was used to hol... Abstract

Cited 33 times since 2000 (1.3 per year) source: EuropePMC

Clinical chemistry, Volume 46, Issue 11, 1 1 2000, Pages 1834-1836 CYP3A4-V polymorphism detection by PCR-restriction fragment length polymorphism analysis and its allelic frequency among 199 Dutch Caucasians. van Schaik RH, de Wildt SN, van Iperen NM, Uitterlinden AG, van den Anker JN, Lindemans J

Abstract

Cited 41 times since 2000 (1.7 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 11, Issue 11, 1 1 2000, Pages 1183-1192 Three-dimensional catheter positioning during radiofrequency ablation in patients: first application of a real-time position management system. de Groot NM, Bootsma M, van der Velde ET, Schalij MJ

Introduction: Precise localization of target sites for radiofrequency catheter ablation (RFCA) of arrhythmias is hampered by the relative inaccuracy of X-ray localization procedures. This study evaluated the efficacy of a three-dimensional (3D) real-time position management system in guiding RFCA procedures in patients. Methods and results: Patients (n = 30, age 59+/-20 years) referred for ablation of either atrial flutter (n = 10), ventricular tachycardia (n = 15), or accessory pathways (n = 5)... Abstract

Cited 21 times since 2000 (0.8 per year) source: EuropePMC

The British journal of radiology, Volume 73, Issue 875, 1 1 2000, Pages 1185-1191 Ultrasonographic features of nephrocalcinosis in preterm neonates. Schell-Feith EA, Holscher HC, Zonderland HM, Kist-Van Holthe JE, Conneman N, van Zwieten PH, Brand R, van der Heijden AJ

Nephrocalcinosis (NC) in preterm neonates has been reported frequently and small studies suggest an unfavourable effect on renal function. Data on ultrasonic features are limited and the reproducibility of ultrasonography (US) in detecting NC in preterm neonates is unknown. In this study, interobserver and intraobserver agreement of US was determined through videotape recordings of US examinations of preterm neonates. Furthermore, a prospective US study was performed in 215 preterm neonates (ges... Abstract

Cited 2 times since 2000 (0.1 per year) source: EuropePMC

Health & social work, Volume 25, Issue 4, 1 1 2000, Pages 276-279 Suggestions to social workers for surviving in managed care. Schneider AW, Hyer K, Luptak M

Abstract

Cited 104 times since 2000 (4.2 per year) source: EuropePMC

Radiology, Volume 217, Issue 2, 1 1 2000, Pages 572-575 Left ventricular function: correlation of quantitative gated SPECT and MR imaging over a wide range of values. Bavelaar-Croon CD, Kayser HW, van der Wall EE, de Roos A, Dibbets-Schneider P, Pauwels EK, Germano G, Atsma DE

In 21 patients, the authors compared results with quantitative gated single photon emission computed tomography (SPECT) to results with magnetic resonance imaging in the assessment of left ventricular (LV) end-diastolic volume (LVEDV), end-systolic volume (LVESV), and ejection fraction (LVEF). Between the two methods, correlations were good for LVEF (r = 0.85), LVEDV (r = 0.94), and LVESV (r = 0.95). Quantitative gated SPECT can help determine LVEF, LVEDV, and LVESV. Abstract

Cited 31 times since 2000 (1.2 per year) source: EuropePMC

Circulation, Volume 102, Issue 21, 1 1 2000, Pages 2650-2658 Anisotropic reentry in a perfused 2-dimensional layer of rabbit ventricular myocardium. Schalij MJ, Boersma L, Huijberts M, Allessie MA

Background: Anisotropy creates nonuniformity in electrical propagation and may contribute to the occurrence of unidirectional conduction block and reentry. We describe the characteristics of reentrant tachycardia in a 2D layer of anisotropic ventricular myocardium. Methods and results: A Langendorff-perfused epicardial sheet (1.0+/-0.4 mm, n=35) was created by freezing the intramural layers of the rabbit left ventricle. Epicardial activation maps were constructed by use of different high-resolut... Abstract

Cited 31 times since 2000 (1.2 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 23, Issue 11 Pt 1, 1 1 2000, Pages 1638-1644 Reduction of radiation exposure in the cardiac electrophysiology laboratory. Wittkampf FH, Wever EF, Vos K, Geleijns J, Schalij MJ, van der Tol J, Robles de Medina EO

The purpose of this study was to determine the effects of various protective measures on patient and operator radiation dose levels in catheter ablation procedures. Catheter ablation procedures are associated with significant radiation levels. The patient's skin and operator radiation levels were measured (1) at baseline, (2) after primary beam filtration by 0.3-mm copper sheet and 2-mm aluminium plate and implementation of the LocaLisa system, and (3) after reduction of the left anterior o... Abstract

Cited 43 times since 2000 (1.7 per year) source: EuropePMC

Journal of hypertension, Volume 18, Issue 11, 1 1 2000, Pages 1635-1644 The importance of high-frequency paced breathing in spectral baroreflex sensitivity assessment. Frederiks J, Swenne CA, TenVoorde BJ, Honzíková N, Levert JV, Maan AC, Schalij MJ, Bruschke AV

Objective: Computation of the low-frequency (LF) blood pressure variability (BPV) to heart rate variability (HRV) transfer-index is a common method to assess baroreflex sensitivity (BRS), tacitly assuming that all LF-HRV is caused by baroreflex feedback of LF-BPV. However, respiration may also cause HRV by mechanisms not involving the baroreflex. Application of narrow-band (controlled) high-frequency breathing would keep such non-baroreflex-mediated HRV best out of the LF band. Spontaneous breat... Abstract