7995 results
Heliyon,
Volume 9, Issue 3, 9 2 2023, Pages e14411
Could deep brain stimulation be a possible solution for acquired hypothalamic obesity?
Dassen AR, van Schaik J, van den Munckhof P, Schuurman PR, Hoving EW, van Santen HM
Objective: Hypothalamic dysfunction may result in morbid obesity as a consequence of decreased energy expenditure, decreased feelings of satiety, and increased fat storage. In patients with hypothalamic dysfunction, neurobehavioral dysfunction is also often present. Currently, no effective treatment has been found for hypothalamic obesity (HO). We hypothesize that deep brain stimulation (DBS) may be an effective treatment for patients with hypothalamic dysfunction, aiming to treat HO as well as...
Abstract
Cited 2 times since 2023 (1 per year)
source: EuropePMC
Acta dermato-venereologica,
Volume 103, 8 2 2023, Pages adv00881
Economic and Humanistic Burden in Paediatric Patients with Atopic Dermatitis.
Achten R, Van der Rijst L, Piena M, Lamers H, De Beer F, De Bruin-Weller M, De Graaf M
Data concerning the economic and humanistic burden in patients with paediatric atopic dermatitis (AD) and their families are scarce. This retrospective study investigated these burdens in paediatric patients with AD using maintenance treatment with topical corticosteroids and/or conventional systemic immunosuppressants. Patient-reported outcomes regarding quality of life, AD severity, and parental work-related impairment were completed at inclusion. Data on healthcare resource utilization and me...
Abstract
CJC pediatric and congenital heart disease,
Volume 2, Issue 3, 8 2 2023, Pages 124-133
Anomalous Aortic Origin of the Right Coronary Artery: Invasive Haemodynamic Assessment in Adult Patients With High-Risk Anatomic Features.
Verheijen DBH, Egorova AD, Jongbloed MRM, van der Kley F, Koolbergen DR, Hazekamp MG, Lamb HJ, Jukema JW, Kiès P, Vliegen HW
Background: Anomalous aortic origin of a right coronary artery (AAORCA) with an interarterial course merits further evaluation; however, robust risk assessment strategies for myocardial ischemia and sudden cardiac death are currently lacking. The aim of this study is to explore the potential role of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and intravascular ultrasound (IVUS) in patients with AAORCA. Methods: Consecutive adult patients with AAORCA with an interarterial...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Cells,
Volume 12, Issue 6, 7 1 2023, Pages 830
Human β-Defensins in Diagnosis of Head and Neck Cancers.
Kompuinen J, Keskin M, Yilmaz D, Gürsoy M, Gürsoy UK
Head and neck cancers are malignant growths with high death rates, which makes the early diagnosis of the affected patients of utmost importance. Over 90% of oral cavity cancers come from squamous cells, and the tongue, oral cavity, and salivary glands are the most common locations for oral squamous cell carcinoma lesions. Human β-defensins (hBDs), which are mainly produced by epithelial cells, are cationic peptides with a wide antimicrobial spectrum. In addition to their role in antimicrobial d...
Abstract
Cited 3 times since 2023 (1.5 per year)
source: EuropePMC
BMJ open,
Volume 13, Issue 3, 7 1 2023, Pages e071304
EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing radical cystectomy: protocol of the ENHANCE multicentre randomised controlled trial.
Akdemir E, Sweegers MG, Vrieling A, Rundqvist H, Meijer RP, Leliveld-Kors AM, van der Heijden AG, Rutten VC, Koldewijn EL, Bos SD, Wijburg CJ, Marcelissen TAT, Bongers BC, Retèl VP, van Harten WH, May AM, Groen WG, Stuiver MM
Introduction: Radical cystectomy (RC) is the standard treatment for patients with non-metastatic muscle-invasive bladder cancer, as well as for patients with therapy refractory high-risk non-muscle invasive bladder cancer. However, 50-65% of patients undergoing RC experience perioperative complications. The risk, severity and impact of these complications is associated with a patient's preoperative cardiorespiratory fitness, nutritional and smoking status and presence of anxiety and depress...
Abstract
EBioMedicine,
Volume 90, 6 1 2023, Pages 104506
Peroxisome proliferator-activated receptor ɣ agonist mediated inhibition of heparanase expression reduces proteinuria.
Garsen M, Buijsers B, Sol M, Gockeln L, Sonneveld R, van Kuppevelt TH, de Graaf M, van den Born J, Kamps JAAM, van Raalte DH, van der Meer RW, Lamb HJ, Hillebrands JL, Rabelink TJ, Maciej-Hulme ML, Krenning G, Nijenhuis T, van der Vlag J
Background: Proteinuria is associated with many glomerular diseases and a risk factor for the progression to renal failure. We previously showed that heparanase (HPSE) is essential for the development of proteinuria, whereas peroxisome proliferator-activated receptor ɣ (PPARɣ) agonists can ameliorate proteinuria. Since a recent study showed that PPARɣ regulates HPSE expression in liver cancer cells, we hypothesized that PPARɣ agonists exert their reno-protective effect by inhibiting glomerular H...
Abstract
Annals of cardiothoracic surgery,
Volume 12, Issue 3, 6 1 2023, Pages 259-261
Patient selection for aortic valve-sparing operations.
Jahanyar J, de Kerchove L, Tsai PI, Mastrobuoni S, Arabkhani B, Aphram G, El Khoury G
Abstract
Multimedia manual of cardiothoracic surgery : MMCTS,
Volume 2023, 6 1 2023
Aortic root replacement with the stentless Freestyle bioprosthesis.
Velders BJJ, Arabkhani B, Schneider A, Vos RJ, Klautz RJM
In this video tutorial, the technical details for the implantation of the Freestyle stentless bioprosthesis are outlined based on the case of a 76-year-old male patient with symptomatic stenosis of a bicuspid aortic valve and aortic root dilatation.
Abstract
Cited 15 times since 2023 (7.6 per year)
source: EuropePMC
European heart journal,
5 1 2023, Pages ehad144
Transiently achieved very low LDL-cholesterol levels by statin and alirocumab after acute coronary syndrome are associated with cardiovascular risk reduction: the ODYSSEY OUTCOMES trial.
Schwartz GG, Szarek M, Bhatt DL, Bittner VA, Bujas-Bobanovic M, Diaz R, Fazio S, Fras Z, Goodman SG, Harrington RA, Jukema JW, Manvelian G, Pordy R, Ray KK, Scemama M, White HD, Steg PG, ODYSSEY OUTCOMES Investigators
Aims: Long-term, placebo-controlled cholesterol-lowering trials have demonstrated legacy effects (clinical benefits that persist or emerge after trial end). It is unknown whether legacy effects follow a short period of very low low-density lipoprotein cholesterol (LDL-C) levels achieved with statin plus PCSK9 inhibitor. Methods and results: In 18,924 patients post-acute coronary syndrome, the ODYSSEY OUTCOMES trial compared the PCSK9 inhibitor alirocumab with placebo, each added to high-intensit...
Abstract
Cited 169 times since 2023 (85 per year)
source: EuropePMC
The New England journal of medicine,
Volume 388, Issue 15, 4 1 2023, Pages 1353-1364
Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients.
Nissen SE, Lincoff AM, Brennan D, Ray KK, Mason D, Kastelein JJP, Thompson PD, Libby P, Cho L, Plutzky J, Bays HE, Moriarty PM, Menon V, Grobbee DE, Louie MJ, Chen CF, Li N, Bloedon L, Robinson P, Horner M, Sasiela WJ, McCluskey J, Davey D, Fajardo-Campos P, Petrovic P, Fedacko J, Zmuda W, Lukyanov Y, Nicholls SJ, CLEAR Outcomes Investigators
Background: Bempedoic acid, an ATP citrate lyase inhibitor, reduces low-density lipoprotein (LDL) cholesterol levels and is associated with a low incidence of muscle-related adverse events; its effects on cardiovascular outcomes remain uncertain. Methods: We conducted a double-blind, randomized, placebo-controlled trial involving patients who were unable or unwilling to take statins owing to unacceptable adverse effects ("statin-intolerant" patients) and had, or were at high risk for,...
Abstract
Cited 6 times since 2023 (3 per year)
source: EuropePMC
Frontiers in neurology,
Volume 14, 2 1 2023, Pages 1097422
Enhancing upper-limb neurorehabilitation in chronic stroke survivors using combined action observation and motor imagery therapy.
Binks JA, Emerson JR, Scott MW, Wilson C, van Schaik P, Eaves DL
Introduction: For people who have had a stroke, recovering upper-limb function is a barrier to independence. When movement is difficult, mental practice can be used to complement physical therapy. In this within-participants study we investigated the effects of combined action observation and motor imagery (AO + MI) therapy on upper-limb recovery in chronic stroke survivors. Methods: A Graeco-Latin Square design was used to counterbalance four mental practice conditions (AO + MI, AO, MI, Control...
Abstract
Cited 4 times since 2023 (2 per year)
source: EuropePMC
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
Volume 49, Issue 5, 2 1 2023, Pages 990-995
A quantitative assessment of perfusion of the gastric conduit after oesophagectomy using near-infrared fluorescence with indocyanine green.
Galema HA, Faber RA, Tange FP, Hilling DE, van der Vorst JR, Upper-GI ICG quantification study group
Introduction: Anastomotic leakage is a severe complication after oesophageal resection with gastric conduit reconstruction. Poor perfusion of the gastric conduit plays an important role in the development of anastomotic leakage. Quantitative near-infrared (NIR) fluorescence angiography with indocyanine green (ICG-FA) is an objective technique that can be used for perfusion assessment. This study aims to assess perfusion patterns of the gastric conduit with quantitative ICG-FA. Methods: In this e...
Abstract
Cited 2 times since 2023 (1 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 31, Issue 5, 2 1 2023, Pages 181-184
NL-EVDR: Netherlands-ExtraVascular Device Registry.
Tjong FVY, Breeman KTN, Boersma LVA, Yap SC, van Erven L, van der Stoel MD, van Dijk VF, Maass AH, Knops RE, NL-EVDR Working Group and NHR Device Registration Committee
Cardiac implantable electronic device (CIED) therapy is an essential element in treating cardiac arrhythmias. Despite their benefits, conventional transvenous CIEDs are associated with a significant risk of mainly pocket- and lead-related complications. To overcome these complications, extravascular devices (EVDs), such as the subcutaneous implantable cardioverter-defibrillator and intracardiac leadless pacemaker, have been developed. In the near future, several other innovative EVDs will become...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Operative dentistry,
Volume 48, Issue 2, 1 1 2023, Pages 176-185
Effects of 16% Carbamide Peroxide on Optical Properties of Thermally Aged Monolithic CAD-CAM Glass Ceramics with Different Surface Treatments.
Murat S, Batak B, Yilmaz D, Öztürk C
This study aimed to investigate the effects of 16% carbamide peroxide (CP) on the relative translucency parameter (RTP) and color stability of thermally aged CAD-CAM glass-ceramics with glazing or polishing. Three different CAD-CAM blocks-feldspathic (VM), lithium disilicate (IPS), and zirconia-reinforced lithium silicate ceramic (VS)-were used in this study. The specimens were divided into two groups (n=10) according to surface treatments (glazing or polishing). Bleaching treatment with 16% CP...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 25, Issue 3, 1 1 2023, Pages 1194
Analysis of tricuspid regurgitation improvement following cardiac resynchronization therapy-Authors' reply.
Stassen J, Bax JJ
Abstract
Cited 5 times since 2023 (2.5 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 16, Issue 3, 1 1 2023, Pages 332-341
Prognostic Value of Preprocedural LV Global Longitudinal Strain for Post-TAVR-Related Morbidity and Mortality: A Meta-Analysis.
Stens NA, van Iersel O, Rooijakkers MJP, van Wely MH, Nijveldt R, Bakker EA, Rodwell L, Pedersen ALD, Poulsen SH, Kjønås D, Stassen J, Bax JJ, Tanner FC, Lerakis S, Shimoni S, Poulin F, Ferreira V, Reskovic Luksic V, van Royen N, Thijssen DHJ
Background: Left ventricular ejection fraction (LVEF) demonstrates limited prognostic value for post-transcatheter aortic valve replacement (TAVR) outcomes. Evidence regarding the potential role of left ventricular global longitudinal strain (LV-GLS) in this setting is inconsistent. Objectives: The aim of this systematic review and meta-analysis of aggregated data was to evaluate the prognostic value of preprocedural LV-GLS for post-TAVR-related morbidity and mortality. Methods: The authors sear...
Abstract
Cited 2 times since 2023 (1 per year)
source: EuropePMC
Human molecular genetics,
Volume 32, Issue 7, 1 1 2023, Pages 1072-1082
Reclassification of a likely pathogenic Dutch founder variant in KCNH2; implications of reduced penetrance.
Copier JS, Bootsma M, Ng CA, Wilde AAM, Bertels RA, Bikker H, Christiaans I, van der Crabben SN, Hol JA, Koopmann TT, Knijnenburg J, Lommerse AAJ, van der Smagt JJ, Bezzina CR, Vandenberg JI, Verkerk AO, Barge-Schaapveld DQCM, Lodder EM
Background: Variants in KCNH2, encoding the human ether a-go-go (hERG) channel that is responsible for the rapid component of the cardiac delayed rectifier K+ current (IKr), are causal to long QT syndrome type 2 (LQTS2). We identified eight index patients with a new variant of unknown significance (VUS), KCNH2:c.2717C > T:p.(Ser906Leu). We aimed to elucidate the biophysiological effect of this variant, to enable reclassification and consequent clinical decision-making. Methods: A genotype-phe...
Abstract
Cited 5 times since 2023 (2.5 per year)
source: EuropePMC
Bioconjugate chemistry,
Volume 34, Issue 3, 1 1 2023, Pages 538-548
Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology.
de Bever L, Popal S, van Schaik J, Rubahamya B, van Delft FL, Thurber GM, van Berkel SS
GlycoConnect technology can be readily adapted to provide different drug-to-antibody ratios (DARs) and is currently also evaluated in various clinical programs, including ADCT-601 (DAR2), MRG004a (DAR4), and XMT-1660 (DAR6). While antibody-drug conjugates (ADCs) typically feature a DAR2-8, it has become clear that ADCs with ultrapotent payloads (e.g., PBD dimers and calicheamicin) can only be administered to patients at low doses (
Abstract
Cited 10 times since 2023 (5 per year)
source: EuropePMC
Journal of Crohn's & colitis,
Volume 17, Issue 2, 1 1 2023, Pages 221-230
Prophylactic Medication for the Prevention of Endoscopic Recurrence in Crohn's Disease: a Prospective Study Based on Clinical Risk Stratification.
Arkenbosch JHC, Beelen EMJ, Dijkstra G, Romberg-Camps M, Duijvestein M, Hoentjen F, van der Marel S, Maljaars PWJ, Jansen S, de Boer NKH, West RL, Horjus CS, Stassen LPS, van Schaik FDM, van Ruler O, Jharap BJH, Visschedijk M, Janssen A, Erler NS, Doukas M, Ooms AHAG, Kats-Ugurlu G, van der Woude CJ, de Vries AC
Background: To prevent recurrence after ileocolonic resection [ICR] in Crohn's disease [CD], postoperative prophylaxis based on risk stratification is recommended in international guidelines. This study aimed to evaluate postoperative CD recurrence after implementation of a clinical management algorithm and to determine the predictive value of clinical and histological risk factors [RFs]. Methods: In this multicentre, prospective cohort study, CD patients [≥16 years] scheduled for ICR were...
Abstract
Cited 5 times since 2023 (2.5 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 24, Issue 4, 1 1 2023, Pages 542-551
Comparative analysis of right ventricular strain in Fabry cardiomyopathy and sarcomeric hypertrophic cardiomyopathy.
Meucci MC, Lillo R, Lombardo A, Lanza GA, Bootsma M, Butcher SC, Massetti M, Manna R, Bax JJ, Crea F, Ajmone Marsan N, Graziani F
Aims: To perform a comparative analysis of right ventricle (RV) myocardial mechanics, assessed by 2D speckle-tracking echocardiography (2D-STE), between patients with Fabry disease and patients with sarcomeric disease. Methods and results: Patients with Fabry cardiomyopathy (FC) (n = 28) were compared with patients with sarcomeric hypertrophic cardiomyopathy (HCM), matched for degree of left ventricle hypertrophy (LVH) and demographic characteristics (n = 112). In addition, patients with Fabry d...
Abstract
