9618 results
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Clinical epigenetics,
Volume 15, Issue 1, 6 1 2023, Pages 111
Epigenome-wide methylation analysis of colorectal carcinoma, adenoma and normal tissue reveals novel biomarkers addressing unmet clinical needs.
Janssens K, Neefs I, Ibrahim J, Schepers A, Pauwels P, Peeters M, Van Camp G, Op de Beeck K
Background: Biomarker discovery in colorectal cancer has mostly focused on methylation patterns in normal and colorectal tumor tissue, but adenomas remain understudied. Therefore, we performed the first epigenome-wide study to profile methylation of all three tissue types combined and to identify discriminatory biomarkers. Results: Public methylation array data (Illumina EPIC and 450K) were collected from a total of 1 892 colorectal samples. Pairwise differential methylation analyses between tis...
Abstract
BMC ophthalmology,
Volume 23, Issue 1, 6 1 2023, Pages 301
Correction: Effect of alirocumab on cataracts in patients with acute coronary syndromes.
Suc G, Schwartz GG, Goodman SG, Jukema JW, Manvelian G, Poulouin Y, Pordy R, Scemama M, Szarek M, Steg PG, ODYSSEY OUTCOMES Investigators
Abstract
Cited 34 times since 2023 (16 per year)
source: EuropePMC
The Journal of molecular diagnostics : JMD,
Volume 25, Issue 9, 6 1 2023, Pages 619-629
CYP3A4 and CYP3A5 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase.
Pratt VM, Cavallari LH, Fulmer ML, Gaedigk A, Hachad H, Ji Y, Kalman LV, Ly RC, Moyer AM, Scott SA, van Schaik RHN, Whirl-Carrillo M, Weck KE
The goals of the Association for Molecular Pathology Clinical Practice Committee's Pharmacogenomics (PGx) Working Group are to define the key attributes of pharmacogenetic alleles recommended for clinical testing and a minimum set of variants that should be included in clinical PGx genotyping assays. This document series provides recommendations for a minimum panel of variant alleles (tier 1) and an extended panel of variant alleles (tier 2) that will aid clinical laboratories when designin...
Abstract
Cited 7 times since 2023 (3.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 202, 5 1 2023, Pages 30-40
Prognostic Relevance of Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Reduced Ejection Fraction.
Chimed S, Stassen J, Galloo X, Meucci MC, Knuuti J, Delgado V, van der Bijl P, Ajmone Marsan N, Bax JJ
Patients with heart failure (HF) and reduced ejection fraction (HFrEF) are complex patients who often have a high prevalence of co-morbidities and risk factors. In the present study, we investigated the prognostic significance of left ventricular (LV) global longitudinal strain (GLS) along with important clinical and echocardiographic variables in patients with HFrEF. Patients who had a first echocardiographic diagnosis of LV systolic dysfunction, defined as LV ejection fraction ≤45%, were selec...
Abstract
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
Frontiers in molecular biosciences,
Volume 10, 5 1 2023, Pages 1223972
Glycosaminoglycans and fucoidan have a protective effect on experimental glomerulonephritis.
Buijsers B, Maciej-Hulme M, Jacobs M, Bebber MB, de Graaf M, Salmenov R, Parr N, Rabelink TJ, Nijenhuis T, van der Vlag J
Background: The glomerular endothelial glycocalyx is degraded during inflammation. The glycocalyx plays a pivotal role in endothelial function and is involved in many processes including binding of chemokines and cytokines, leukocyte trafficking, and preventing proteinuria. HS-based therapeutics are a promising novel class of anti-inflammatory drugs to restore a compromised endothelial glycocalyx under inflammatory conditions. Recently, we demonstrated that treatment with HS extracted from unsti...
Abstract
Cited 7 times since 2023 (3.3 per year)
source: EuropePMC
JAMA network open,
Volume 6, Issue 7, 3 1 2023, Pages e2323112
Clinical Characteristics and Outcomes of Patients With Cutibacterium acnes Endocarditis.
Heinen FJ, Arregle F, van den Brink FS, Ajmone Marsan N, Bernts L, Houthuizen P, Kamp O, Roescher N, Timmermans N, Verkaik N, Roos-Hesselink J, Post MC, Habib G, Tanis W
Importance: It is suggested that patients with Cutibacterium acnes endocarditis often present without fever or abnormal inflammatory markers. However, no study has yet confirmed this statement. Objective: To assess the clinical characteristics and outcomes of patients with C acnes endocarditis. Design, setting, and participants: A case series of 105 patients presenting to 7 hospitals in the Netherlands and France (4 university hospitals and 3 teaching hospitals) with definite endocarditis accord...
Abstract
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
Seminars in radiation oncology,
Volume 33, Issue 3, 1 1 2023, Pages 243-251
Machine Learning & Molecular Radiation Tumor Biomarkers.
Rydzewski NR, Helzer KT, Bootsma M, Shi Y, Bakhtiar H, Sjöström M, Zhao SG
Developing radiation tumor biomarkers that can guide personalized radiotherapy clinical decision making is a critical goal in the effort towards precision cancer medicine. High-throughput molecular assays paired with modern computational techniques have the potential to identify individual tumor-specific signatures and create tools that can help understand heterogenous patient outcomes in response to radiotherapy, allowing clinicians to fully benefit from the technological advances in molecular...
Abstract
Cited 4 times since 2023 (1.9 per year)
source: EuropePMC
The British journal of surgery,
Volume 110, Issue 8, 1 1 2023, Pages 991-992
Future surgeon: bridging the intergenerational gap.
Huizing F, Sier VQ, Tresfon JAS, van der Vorst JR, Liem RSL, Schmitz RF, Schepers A, Houwert RM, Vriens MR, Snijders HS, Blok JJ
Abstract
Mikrobiyoloji bulteni,
Volume 57, Issue 3, 1 1 2023, Pages 473-480
[An Infant with Zoonotic Pulmonary Tuberculosis due to Mycobacterium bovis].
Üstündağ G, Şahin A, Yazıcı YY, Kara Aksay A, Biçmen C, Belkaya S, Yılmaz D
Bovine tuberculosis might be seen in low-income countries, especially in children fed with raw milk. The most common transmission route is fecal-oral way, and it is most likely through unpasteurized dairy products. Although clinical and radiological findings are like non-zoonotic tuberculosis, treatment approaches may differ in individuals with zoonotic tuberculosis. Prevention of zoonotic diseases requires multidisciplinary approaches. These approaches include the development of veterinary and...
Abstract
Cited 2 times since 2023 (0.9 per year)
source: EuropePMC
Journal of oral & maxillofacial research,
Volume 14, Issue 3, 1 1 2023, Pages e4
Evaluation of Cortical Thicknesses and Bone Density Values of Mandibular Canal Borders and Coronal Site of Alveolar Crest.
Ataman-Duruel ET, Beycioğlu Z, Yılmaz D, Goyushov S, Çimen T, Duruel O, Yılmaz HG, Tözüm TF
Objectives: The objectives of this retrospective study are to measure the amount of the alveolar crest cortication and cortication around the mandibular canal, and to evaluate bone density values of alveolar crest, cortication around mandibular canal, and possible implant placement area for edentulous sites. Material and methods: Six hundred forty-two cone-beam computed tomography scans from 642 subjects were evaluated in four centers. Cortical thicknesses of alveolar crest and mandibular canal...
Abstract
Cited 16 times since 2023 (7.5 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 16, Issue 13, 1 1 2023, Pages 1612-1621
Evolution and Prognostic Impact of Right Ventricular-Pulmonary Artery Coupling After Transcatheter Aortic Valve Replacement.
Meucci MC, Malara S, Butcher SC, Hirasawa K, van der Kley F, Lombardo A, Aurigemma C, Romagnoli E, Trani C, Massetti M, Burzotta F, Bax JJ, Crea F, Ajmone Marsan N, Graziani F
Background: There is limited evidence regarding the association between right ventricular-to-pulmonary artery (RV-PA) coupling and outcomes after transcatheter aortic valve replacement (TAVR). Objectives: This study aimed to explore the evolution of RV-PA coupling in patients with severe aortic stenosis undergoing TAVR and its prognostic impact. Methods: A total of 900 patients who underwent TAVR in 2 tertiary centers and with echocardiographic analysis performed within 3 months before and after...
Abstract
Cited 13 times since 2023 (6.1 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 16, Issue 13, 1 1 2023, Pages 1682-1687
TAVR in Bicuspid Aortic Stenosis: Current Evidence and Proposal for a Randomized Controlled Trial Design.
Nuyens P, De Backer O, Sathananthan J, Højsgaard Jørgensen T, Treede H, Leipsic JA, Bax JJ, Webb JG, Mehran R, Chen M, Reardon M, Leon MB, Søndergaard L
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Nigerian journal of clinical practice,
Volume 26, Issue 7, 1 1 2023, Pages 992-997
Characteristics of maxillary sinus ostia and their correlation with anatomic variations of the osteomeatal complex: Indications for sinus floor elevation.
Eberlikose H, Yilmaz D, Gulen O
Background: Knowledge of the anatomy and variations of the maxillary sinus is essential for reducing oral surgery complications, such as sinus floor elevation, and increasing surgery success. The CBCT images of 385 patients were examined. Materials and methods: The prevalence, localization, and height of PMO (Primer Maxillary Ostium) and AMO (Accessory Maxillary Ostium) were evaluated with respect to sex, dentition, dental treatment, Schneiderian membrane (SM) thickness, concha bullosa, Haller C...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
European heart journal. Acute cardiovascular care,
Volume 12, Issue 7, 1 1 2023, Pages 451-461
Serially measured high-sensitivity cardiac troponin T, N-terminal-pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and growth differentiation factor 15 for risk assessment after acute coronary syndrome: the BIOMArCS cohort.
Gürgöze MT, Akkerhuis KM, Oemrawsingh RM, Umans VAWM, Kietselaer B, Schotborgh CE, Ronner E, Lenderink T, Aksoy I, van der Harst P, Asselbergs FW, Maas AC, Oude Ophuis AJ, Krenning B, de Winter RJ, The SHK, Wardeh AJ, Hermans WRM, Cramer GE, van Gorp I, de Rijke YB, van Schaik RHN, Boersma E
Aims: Evidence regarding the role of serial measurements of biomarkers for risk assessment in post-acute coronary syndrome (ACS) patients is limited. The aim was to explore the prognostic value of four, serially measured biomarkers in a large, real-world cohort of post-ACS patients. Methods and results: BIOMArCS is a prospective, multi-centre, observational study in 844 post-ACS patients in whom 12 218 blood samples (median 17 per patient) were obtained during 1-year follow-up. The longitudinal...
Abstract
Cited 4 times since 2023 (1.9 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 62, Issue 7, 1 1 2023, Pages 2585-2593
B-cell receptor profiling before and after IVIG monotherapy in newly diagnosed idiopathic inflammatory myopathies.
Anang DC, Walter HAW, Lim J, Niewold I, van der Weele L, Aronica E, Eftimov F, Raaphorst J, van Schaik BDC, van Kampen AHC, van der Kooi AJ, de Vries N
Objective: To unravel B-cell receptor (BcR) characteristics in muscle tissues and peripheral blood and gain more insight into BcR repertoire changes in peripheral blood in idiopathic inflammatory myopathies (IIMs), and study how this correlates to the clinical response to IVIG. Methods: Nineteen treatment-naive patients with newly diagnosed IIM were prospectively treated with IVIG monotherapy. RNA-based BcR repertoire sequencing was performed in muscle biopsies collected before, and in periphera...
Abstract
Cited 13 times since 2023 (6.1 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 24, Issue 8, 1 1 2023, Pages e119-e197
Three-dimensional transoesophageal echocardiography: how to use and when to use-a clinical consensus statement from the European Association of Cardiovascular Imaging of the European Society of Cardiology.
Faletra FF, Agricola E, Flachskampf FA, Hahn R, Pepi M, Ajmone Marsan N, Wunderlich N, Elif Sade L, Donal E, Zamorano JL, Cosyns B, Vannan M, Edvardsen T, Berrebi A, Popescu BA, Lancellotti P, Lang R, Bäck M, Bertrand PB, Dweck M, Keenan N, Stankovic I
Three-dimensional transoesophageal echocardiography (3D TOE) has been rapidly developed in the last 15 years. Currently, 3D TOE is particularly useful as an additional imaging modality for the cardiac echocardiographers in the echo-lab, for cardiac interventionalists as a tool to guide complex catheter-based procedures cardiac, for surgeons to plan surgical strategies, and for cardiac anaesthesiologists and/or cardiologists, to assess intra-operative results. The authors of this document believe...
Abstract
The British journal of dermatology,
Volume 189, Issue 1, 1 1 2023, Pages 129-147
Investigator Global Assessment for impetiginization in atopic dermatitis: development and initial reliability testing.
Ragamin A, Tupker RA, de Graaf M, Rustemeyer T, Pasmans SGMA, Schappin R, Schuttelaar MLA
Abstract
International journal of cardiology. Congenital heart disease,
Volume 13, 30 5 2023, Pages 100465
An unusual case of unilateral vascular hypoplasia in an adult patient - late diagnosis of PHACE syndrome.
Regeer MV, Stöger JL, Bökenkamp R, Lakeman IMM, Hazekamp MG, Kiѐs P, Egorova AD, Jongbloed MRM
A case of unilateral vascular hypoplasia is presented. A female patient was born with a complex aortic arch anatomy - a double aortic arch with an interrupted left arch. Surgical correction was performed at the age of 3 months. The patient was also noted to have had an ipsilateral large infantile haemangioma. These findings raised the suspicion of the diagnosis of PHACE syndrome. PHACE syndrome is an acronym for Posterior fossa abnormalities, Haemangioma, Arterial anomalies, Cardiac anomalies an...
Abstract
Cited 5 times since 2023 (2.3 per year)
source: EuropePMC
Stem cell reports,
Volume 18, Issue 7, 29 5 2023, Pages 1421-1435
Single-cell analysis of human fetal epicardium reveals its cellular composition and identifies CRIP1 as a modulator of EMT.
Streef TJ, Groeneveld EJ, van Herwaarden T, Hjortnaes J, Goumans MJ, Smits AM
The epicardium plays an essential role in cardiogenesis by providing cardiac cell types and paracrine cues to the developing myocardium. The human adult epicardium is quiescent, but recapitulation of developmental features may contribute to adult cardiac repair. The cell fate of epicardial cells is proposed to be determined by the developmental persistence of specific subpopulations. Reports on this epicardial heterogeneity have been inconsistent, and data regarding the human developing epicardi...
Abstract
Cited 3 times since 2023 (1.4 per year)
source: EuropePMC
Journal of the mechanical behavior of biomedical materials,
Volume 144, 28 4 2023, Pages 105980
Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform.
Bracco Gartner TCL, Wang Y, Leiteris L, van Adrichem I, Marsman J, Goumans MJ, Bouten CVC, Sluijter JPG, den Toonder JMJ, Suyker WJL, Hjortnaes J
In cardiac fibrosis, in response to stress or injury, cardiac fibroblasts deposit excessive amounts of collagens which contribute to the development of heart failure. The biochemical stimuli in this process have been extensively studied, but the influence of cyclic deformation on the fibrogenic behavior of cardiac fibroblasts in the ever-beating heart is not fully understood. In fact, most investigated mechanotransduction pathways in cardiac fibroblasts seem to ultimately have profibrotic effect...
Abstract
