Research

Publications

Below you can find a list of our published research.

7827 results

Cited 2 times since 2022 (0.8 per year) source: EuropePMC

Vascular biology (Bristol, England), Volume 4, Issue 1, 30 5 2022, Pages 40-49 No prominent role for complement C1-esterase inhibitor in Marfan syndrome mice. Hibender S, Li S, Postma AV, Hoogeland ME, Klaver D, Pouw RB, Niessen HW, Driessen AH, Koolbergen DR, de Vries CJ, Baars MJ, Houweling AC, Krijnen PA, de Waard V

Marfan syndrome (MFS) is a connective tissue disorder causing aortic aneurysm formation. Currently, only prophylactic aortic surgery and blood pressure-lowering drugs are available to reduce the risk of aortic rupture. Upon whole genome sequencing of a Marfan family, we identified a complement gene C1R variant (p.Ser152Leu), which is associated with severe aortic patients. Therefore, we assessed the role of complement activation in MFS aortic tissue. Expression of various complement genes and pr... Abstract

Cited 8 times since 2022 (3.1 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 9, Issue 3, 30 5 2022, Pages 345-355 Importance of Systematic Diagnostic Testing in Idiopathic Ventricular Fibrillation: Results From the Dutch iVF Registry. Groeneveld SA, Verheul LM, van der Ree MH, Mulder BA, Scholten MF, Alings M, van der Voort P, Bootsma M, Evertz R, Balt JC, Yap SC, Doevendans PAFM, Postema PG, Wilde AAM, Volders PGA, Hassink RJ

Background: Idiopathic ventricular fibrillation (iVF) is a diagnosis of exclusion. Systematic diagnostic testing is important to exclude alternative causes for VF. The early use of "high yield" testing, including cardiac magnetic resonance (CMR), exercise testing, and sodium channel blocker provocation, has been increasingly recognized. Objectives: The purpose of this study was to investigate the importance and consistency of systematic diagnostic testing in iVF. Methods: This study in... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

Animals : an open access journal from MDPI, Volume 12, Issue 23, 29 5 2022, Pages 3344 Coverage and Representativeness of Passive Surveillance Components for Cattle and Swine in The Netherlands. Vredenberg I, van Schaik G, van der Poel WHM, Stegeman A

Common aims of animal health surveillance systems are the timely detection of emerging diseases and health status monitoring. This study aimed to evaluate the coverage and representativeness of passive surveillance components for cattle and swine in the Netherlands from 2015-2019. The passive surveillance components consisted of a telephone helpdesk for veterinary advice and diagnostic and postmortem facilities. Spatial analysis showed heterogeneity (range in RR = 0.26-5.37) of participation acr... Abstract

Cited 5 times since 2022 (1.9 per year) source: EuropePMC

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, Volume 65, Issue 3, 29 5 2022, Pages 348-357 Excess Mortality for Abdominal Aortic Aneurysms and the Potential of Strict Implementation of Cardiovascular Risk Management: A Multifaceted Study Integrating Meta-Analysis, National Registry, and PHAST and TEDY Trial Data. Tomee SM, Bulder RMA, Meijer CA, van Berkum I, Hinnen JW, Schoones JW, Golledge J, Bastiaannet E, Matsumura JS, Hamming JF, Hultgren R, Lindeman JH

Objective: Previous studies imply a profound residual mortality risk following successful abdominal aorta aneurysm (AAA) repair. This excess mortality is generally attributed to increased cardiovascular risk. The aim of this study was (1) to quantify the excess residual mortality for patients with AAA, (2) to evaluate the cross sectional level of cardiovascular risk management, and (3) to estimate the potential of optimised cardiovascular risk management to reduce the excess mortality in these p... Abstract

Cited 27 times since 2022 (10.5 per year) source: EuropePMC

European journal of human genetics : EJHG, Volume 31, Issue 9, 28 4 2022, Pages 982-987 Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction between UGT1A1 and irinotecan. Hulshof EC, Deenen MJ, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Houwink EJF, Risselada A, Rongen GAPJM, van Schaik RHN, Touw DJ, van der Weide J, van Westrhenen R, Deneer VHM, Guchelaar HJ, Swen JJ

The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize pharmacotherapy. This guideline describes the starting dose optimization of the anti-cancer drug irinotecan to decrease the risk of severe toxicity, such as (febrile) neutropenia or diarrhoea. Uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1 encoded by the UGT1A1 gene) enzyme deficiency increases risk of irinotecan-induced toxicity. Ge... Abstract

Cited 2 times since 2022 (0.8 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 31, Issue 5, 28 4 2022, Pages 177-180 Career perspectives for young cardiologists in the Netherlands: a steady increase in temporary positions. Vorselaars VMM, Minneboo M, Meijers WC, van der Heijden AC, Haroun D, Baggen VJM, Berger WR, van Hout GPJ

In the Netherlands, concerns have been raised regarding the high unemployment rates and the lack of permanent positions for young medical specialists. In the current study, we present data on contemporary early career perspectives in the field of cardiology. We conducted a survey among 304 young cardiologists who completed their training between 2015 and 2020; the response rate was 91%. Our analysis revealed a low unemployment rate (0.3%). One, 3 and 5 years after registration, 81%, 41% and 18%... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 28 4 2022, Pages 1-4 Career perspectives for young cardiologists in the Netherlands: a steady increase in temporary positions. Vorselaars VMM, Minneboo M, Meijers WC, van der Heijden AC, Haroun D, Baggen VJM, Berger WR, van Hout GPJ

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

Herz, Volume 48, Issue 1, 28 4 2022, Pages 3-14 [The new ESC guidelines on the management of ventricular tachyarrhythmias : Implications for daily practice]. Könemann H, Frommeyer G, Zeppenfeld K, Eckardt L

The recently published guidelines of the European Society of Cardiology (ESC) on the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death is an update of the 2015 guideline. For the first time a new section is dedicated to public basic life support. In the acute treatment of ventricular arrhythmias electrical cardioversion is upgraded, and there is a new focus on the management of electrical storm. Recommendations for the comprehensive diagnostic evaluat... Abstract

Cited 4 times since 2022 (1.5 per year) source: EuropePMC

Biomedicines, Volume 10, Issue 12, 28 4 2022, Pages 3056 NLRP3-Inflammasome Inhibition with IZD334 Does Not Reduce Cardiac Damage in a Pig Model of Myocardial Infarction. Silvis MJM, Demkes EJ, Timmers L, Arslan F, de Jager SCA, Sluijter JPG, Mosterd A, de Kleijn DPV, Bosch L, van Hout GPJ

NLRP3-inflammasome-mediated signaling is thought to significantly contribute to the extent of myocardial damage after myocardial infarction (MI). The purpose of this study was to investigate the effects of the NLRP3-inflammasome inhibitor IZD334 on cardiac damage in a pig model of myocardial infarction. Prior to in vivo testing, in vitro, porcine peripheral blood mononuclear cells and whole blood were treated with increasing dosages of IZD334, a novel NLRP3-inflammasome inhibitor, and were stimu... Abstract

Cited 10 times since 2022 (3.9 per year) source: EuropePMC

Acta dermato-venereologica, Volume 102, 24 4 2022, Pages adv00820 Daily Practice Experience of Baricitinib Treatment for Patients with Difficult-to-Treat Atopic Dermatitis: Results from the BioDay Registry. Boesjes CM, Kamphuis E, Zuithoff NPA, Bakker DS, Loman L, Spekhorst LS, Haeck I, Kamsteeg M, Van Lynden-van Nes AMT, Garritsen FM, Politiek K, Oldhoff M, De Graaf M, Schuttelaar MLA, De Bruin-Weller MS

Clinical trials have shown that baricitinib, an oral selective Janus kinase 1/2 inhibitor, is effective for the treatment of moderate-to-severe atopic dermatitis. However, daily practice data are limited. Therefore, this multicentre prospective study evaluated the effectiveness and safety of 16-weeks' treatment with baricitinib in adult patients with moderate-to-severe atopic dermatitis in daily practice. A total of 51 patients from the BioDay registry treated with baricitinib were included... Abstract

Cited 3 times since 2022 (1.2 per year) source: EuropePMC

International journal of cardiology, Volume 373, 23 4 2022, Pages 101-106 Incremental value of left ventricular global longitudinal strain in moderate aortic stenosis and reduced left ventricular ejection fraction. Stassen J, Singh GK, Pio SM, Chimed S, Butcher SC, Hirasawa K, Marsan NA, Bax JJ

Background: Moderate aortic stenosis (AS) often coexists with left ventricular (LV) systolic dysfunction and may affect survival through afterload mismatch. Because outcomes are ultimately driven by the condition of the LV, accurate assessment of LV performance is crucial to improve risk stratification. This study investigated the prognostic value of LV global longitudinal strain (GLS) in patients with moderate AS and reduced LV systolic dysfunction. Methods: Patients with moderate AS (aortic va... Abstract

Cited 10 times since 2022 (3.9 per year) source: EuropePMC

European journal of heart failure, Volume 25, Issue 2, 23 4 2022, Pages 213-222 Sequencing and titrating approach of therapy in heart failure with reduced ejection fraction following the 2021 European Society of Cardiology guidelines: an international cardiology survey. Fauvel C, Bonnet G, Mullens W, Giraldo CIS, Mežnar AZ, Barasa A, Tokmakova M, Shchendrygina A, Costa FM, Mapelli M, Zemrak F, Tops LF, Jakus N, Sultan A, Bahouth F, Hadjseyd CE, Salvat M, Anselmino M, Messroghli D, Weberndörfer V, Giverts I, Bochaton T, Courand PY, Berthelot E, Legallois D, Beauvais F, Bauer F, Lamblin N, Damy T, Girerd N, Sebbag L, Pezel T, Cohen-Solal A, Rosano G, Roubille F, Mewton N

Aims: In symptomatic patients with heart failure and reduced ejection fraction (HFrEF), recent international guidelines recommend initiating four major therapeutic classes rather than sequential initiation. It remains unclear how this change in guidelines is perceived by practicing cardiologists versus heart failure (HF) specialists. Methods and results: An independent academic web-based survey was designed by a group of HF specialists and posted by email and through various social networks to a... Abstract

Cited 31 times since 2022 (11.9 per year) source: EuropePMC

Nature cancer, Volume 3, Issue 11, 22 4 2022, Pages 1284-1299 cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis. Wang L, Jin H, Jochems F, Wang S, Lieftink C, Martinez IM, De Conti G, Edwards F, de Oliveira RL, Schepers A, Zhou Y, Zheng J, Wu W, Zheng X, Yuan S, Ling J, Jastrzebski K, Santos Dias MD, Song JY, Celie PNH, Yagita H, Yao M, Zhou W, Beijersbergen RL, Qin W, Bernards R

Senolytics, drugs that kill senescent cells, have been proposed to improve the response to pro-senescence cancer therapies; however, this remains challenging due to a lack of broadly acting senolytic drugs. Using CRISPR/Cas9-based genetic screens in different senescent cancer cell models, we identify loss of the death receptor inhibitor cFLIP as a common vulnerability of senescent cancer cells. Senescent cells are primed for apoptotic death by NF-κB-mediated upregulation of death receptor 5 (DR5... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

European journal of trauma and emergency surgery : official publication of the European Trauma Society, Volume 49, Issue 2, 22 4 2022, Pages 825-835 The effect of age on resilience of health-related quality of life among polytrauma patients: a cross-sectional multicenter study. de Vries R, Reininga I, de Graaf M, Banierink H, Bosma E, Munzebrock A, Heineman E, Moumni ME, Wendt K

Purpose: The aim of this study was to determine the impact of age on patient-reported health-related quality of life (HRQoL) and the capacity to show resilience-i.e., the ability to adapt to stressful adverse events-after sustaining a polytrauma. Methods: A cross-sectional multicenter cohort was conducted between 2013 and 2016 that included surviving polytrauma patients (ISS ≥ 16). HRQoL was obtained by the Short Musculoskeletal Function assessment and EuroQol (SMFA and EQ-5D-5L). The effect of... Abstract

Cited 9 times since 2022 (3.5 per year) source: EuropePMC

Journal of clinical medicine, Volume 11, Issue 22, 19 3 2022, Pages 6843 Anemia and Iron Deficiency in Outpatients with Inflammatory Bowel Disease: Ubiquitous Yet Suboptimally Managed. Loveikyte R, Boer M, van der Meulen CN, Ter Steege RWF, Tack G, Kuyvenhoven J, Jharap B, Vu MK, Vogelaar L, West RL, van der Marel S, Römkens TEH, Mujagic Z, Hoentjen F, van Bodegraven AA, van Schaik FDM, de Vries AC, Dijkstra G, van der Meulen-de Jong AE, Dutch Initiative on Crohn and Colitis (ICC)

Background: Iron deficiency (ID) and anemia in patients with Inflammatory Bowel Disease (IBD) are associated with a reduced quality of life. We assessed the prevalence of ID and anemia in Dutch outpatients with IBD and compared routine ID(A) management among medical professionals to the European Crohn’s and Colitis Organisation (ECCO) treatment guidelines. Methods: Between January and November 2021, consecutive adult outpatients with IBD were included in this study across 16 Dutch hospitals. Cli... Abstract

Cited 7 times since 2022 (2.7 per year) source: EuropePMC

Communications medicine, Volume 2, Issue 1, 19 3 2022, Pages 146 The importance of sustained compliance with physical distancing during COVID-19 vaccination rollout. Teslya A, Rozhnova G, Pham TM, van Wees DA, Nunner H, Godijk NG, Bootsma M, Kretzschmar ME

Background: Increasing vaccination coverage against SARS-CoV-2 enabled relaxation of lockdowns in many countries in Europe. As the vaccination rollouts progressed, the public health authorities were seeking recommendations on the continuation of physical distancing measures during ongoing vaccination rollouts. Compliance with these measures was declining while more transmissible virus variants have emerged. Methods: We used a SARS-CoV-2 transmission model to investigate the feedback between comp... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, Volume 63, 18 3 2022, Pages 107498 Can transforming growth factor beta and downstream signalers distinguish bicuspid aortic valve patients susceptible for future aortic complications? Grewal N, Klautz R, Poelmann RE

Patients with a bicuspid aortic valve have an extreme high risk to develop a thoracic aortic aneurysm and dissection (TAAD). TAADs form a leading cause of death worldwide, with the majority of deaths being preventable if individuals at risk are identified and properly managed. Risk stratification for TAADs in bicuspidy is so far solely based on the aortic diameter. Exclusive use of aortic wall dimension, as in the current guidelines, is however not sufficient in selecting patients vulnerable for... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

Clinical nutrition (Edinburgh, Scotland), Volume 42, Issue 1, 17 3 2022, Pages 18-21 An omission in guidelines. Cardiovascular disease prevention should also focus on dietary policies for healthcare facilities. de Frel DL, Assendelft WJJ, Hondmann S, Janssen VR, Molema JJW, Trines SA, de Vries IAC, Schalij MJ, Atsma DE

Suboptimal diet is a major modifiable risk factor in cardiovascular disease. Governments, individuals, educational institutes, healthcare facilities and the industry all share the responsibility to improve dietary habits. Healthcare facilities in particular present a unique opportunity to convey the importance of healthy nutrition to patients, visitors and staff. Guidelines on cardiovascular disease do include policy suggestions for population-based approaches to diet in a broad list of settings... Abstract

Cited 1 times since 2022 (0.4 per year) source: EuropePMC

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 101, Issue 1, 16 3 2022, Pages 97-101 Bail out lithotripsy to treat delayed valve-in-valve TAVR-related coronary obstruction. Bingen BO, Al Amri I, Montero-Cabezas JM, van der Kley F

Coronary access difficulty and stent compression by the juxtaposed aortic valve leaflet hamper percutaneous management of delayed coronary artery obstruction (CAO) after valve-in-valve (Edwards Sapien 3 in St. Jude Trifecta) transcatheter aortic valve replacement (TAVR). Here, we present a case of delayed post-TAVR CAO treated with intravascular lithotripsy and multistenting to overcome stent compression by the adjacent calcified leaflet. Abstract

Cited 3 times since 2022 (1.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 30, Issue 1, 15 3 2022, Pages 178-188 Incorporating coronary artery calcium scoring in the prediction of obstructive coronary artery disease with myocardial ischemia: a study with sequential use of coronary computed tomography angiography and positron emission tomography imaging. van den Hoogen IJ, Wang X, Butcher SC, Maaniitty T, Schultz J, van Rosendael AR, Saraste A, Knuuti J, Bax JJ

Background: Additional strategies are needed to refine the referral for diagnostic testing of symptomatic patients with suspected coronary artery disease (CAD). We aimed to compare various models to predict hemodynamically obstructive CAD. Methods and results: Symptomatic patients with suspected CAD who underwent coronary artery calcium scoring (CACS) and sequential coronary computed tomography angiography (CCTA) and [15O]H2O positron emission tomography (PET) myocardial perfusion imaging were a... Abstract