6196 results
Circulation,
Volume 151, Issue 14, 7 1 2025, Pages 1047-1050
Relation of Low-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Lipoprotein(a) Each to Future Cardiovascular Events and Death After Acute Coronary Syndrome on High-Intensity Statin Therapy: An Analysis of the Placebo Arm of ODYSSEY OUTCOMES.
Steg PG, Szarek M, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Schwartz GG, ODYSSEY OUTCOMES Investigators
Abstract
Journal of cardiovascular development and disease,
Volume 12, Issue 4, 7 1 2025, Pages 140
Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms.
Bacour N, Theijsse RT, Grewal S, Klautz RJM, Grewal N
(1) Background: Thoracic aortic aneurysms (TAAs) pose critical health risks and are often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasizing the importance of early detection and intervention. Despite established clinical risk factors for the early detection of TAAs, the influence of racial disparities on TAAs remains underexplored. This study aims to provide a comprehensive summary of existing...
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
3 1 2025
Infection risk in atopic dermatitis patients treated with biologics and JAK inhibitors: BioDay results.
van der Gang LF, Atash K, Zuithoff NPA, Haeck I, Boesjes CM, Bacoş-Cosma OI, Loman L, Kamsteeg M, Stadhouders-Keet S, Oosting AJ, van Lynden-van Nes AMT, Politiek K, Gostynksi A, Berntsen-Zandbergen L, Christoffers WA, Flinterman A, Touwslager WRH, Velstra B, Stewart SM, van Erp FC, de Graaf M, Schuttelaar MA, de Bruin-Weller MS
Background: Limited data exist on the comparative risk of infections during biologic and Janus kinase inhibitor (JAKi) treatment for atopic dermatitis (AD) in daily practice. Objective: To assess the differential infection risk of biologic and JAKi treatment in patients with moderate-to-severe AD in a real-world setting. Methods: This prospective, multicentre study evaluated treatment-emergent infections in patients (age ≥ 12 years) using biologics or JAKi from the BioDay registry from October 2...
Abstract
Atherosclerosis,
Volume 404, 3 1 2025, Pages 119184
Sex related coronary plaque progression patterns among patients with family history as the sole cardiovascular risk factor: A PARADIGM sub-study.
Conte E, Lee SE, Chang HJ, Hadamitzky M, Kim YJ, Pontone G, Budoff MJ, Gottlieb I, Lee BK, Chun EJ, Cademartiri F, Maffei E, Marques H, Di Lenarda F, Guarnieri G, Leipsic JA, Shin S, Choi JH, Mouaz AM, Chinnaiyan K, Pedro AG, Sung JM, Virmani R, Samady H, Lin FY, Stone PH, Narula J, Shaw L, Bax JJ, Andreini D
Background and aims: How sex may influence the prevalence and progression of coronary atherosclerosis in patients with positive family history for CAD is still unclear. Aim of the present study was to explore the role of family history of CAD in coronary atherosclerosis expression and progression in male and female subjects. Methods: A total of 2252 patients who underwent clinically indicated serial CCTAs at an interscan interval of more than 2 years were enrolled in the PARADIGM Study. For the...
Abstract
Cited 1 times since 2025 (11.5 per year)
source: EuropePMC
European heart journal,
2 1 2025, Pages ehaf133
Transcatheter vs. surgical aortic valve replacement in women: the RHEIA trial.
Tchetche D, Pibarot P, Bax JJ, Bonaros N, Windecker S, Dumonteil N, Nietlispach F, Messika-Zeitoun D, Pocock SJ, Berthoumieu P, Swaans MJ, Timmers L, Rudolph TK, Bleiziffer S, Leroux L, Modine T, van der Kley F, Auffret V, Tomasi J, Stastny L, Hengstenberg C, Andreas M, Leclercq F, Gandet T, Mascherbauer J, Trescher K, Prendergast B, Vasa-Nicotera M, Chieffo A, Mares J, Wesselink W, Rakova R, Kurucova J, Bramlage P, Eltchaninoff H
Background and aims: Although women with severe symptomatic aortic stenosis have more complications than men when undergoing surgical valve replacement, they are under-represented in clinical trials. The Randomized researcH in womEn all comers wIth Aortic stenosis (RHEIA) trial investigates the balance of benefits and risks of transcatheter aortic valve implantation (TAVI) vs. surgery in women. Methods: Women were randomized 1:1 to transfemoral TAVI with a balloon-expandable valve or surgery. Th...
Abstract
Journal of the American College of Cardiology,
Volume 85, Issue 14, 1 1 2025, Pages 1471-1484
Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis.
Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, Halley JD, Rocha S, Hoogeveen RC, Gudnason V, Bakker SJL, Wannamethee SG, Pareek M, Eggers KM, Jukema JW, Hankey GJ, deLemos JA, Ford I, Omland T, Lyngbakken MN, Psaty BM, deFilippi CR, Wood AM, Danesh J, Welsh P, Sattar N, Mills NL, Di Angelantonio E, CAPRICE Co-Investigators
Background: The extent to which high-sensitivity cardiac troponin can predict cardiovascular disease (CVD) is uncertain. Objectives: We aimed to quantify the potential advantage of adding information on cardiac troponins to conventional risk factors in the prevention of CVD. Methods: We meta-analyzed individual-participant data from 15 cohorts, comprising 62,150 participants without prior CVD. We calculated HRs, measures of risk discrimination, and reclassification after adding cardiac troponin...
Abstract
Diabetes care,
Volume 48, Issue 4, 1 1 2025, Pages 596-604
Risk of Incident Diabetes Related to Lipoprotein(a), LDL Cholesterol, and Their Changes With Alirocumab: Post Hoc Analyses of the ODYSSEY OUTCOMES Randomized Trial.
Schwartz GG, Szarek M, Jukema JW, Cobbaert CM, Reijnders E, Bittner VA, Schwertfeger M, Bhatt DL, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Steg PG
Objective: Previous genetic and clinical analyses have associated lower lipoprotein(a) and LDL cholesterol (LDL-C) with greater risk of new-onset type 2 diabetes (NOD). However, PCSK9 inhibitors such as alirocumab lower both lipoprotein(a) and LDL-C without effect on NOD. Research design and methods: In a post hoc analysis of the ODYSSEY OUTCOMES trial (NCT01663402), we examined the joint prediction of NOD by baseline lipoprotein(a), LDL-C, and insulin (or HOMA-insulin resistance [HOMA-IR]) and...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 5, 1 1 2025, Pages 918-927
The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting.
Myagmardorj R, Fortuni F, Généreux P, Nabeta T, Stassen J, Galloo X, Meucci MC, Butcher S, van der Kley F, Cohen DJ, Clavel MA, Pibarot P, Leon MB, Regeer MV, Delgado V, Ajmone Marsan N, Bax JJ
Aims: This study aims to assess the changes in cardiac damage stage in a real-world cohort of patients undergoing transcatheter aortic valve implantation (TAVI), and to investigate the prognostic value of cardiac damage stage evolution. Methods and results: Patients with severe aortic stenosis (AS) undergoing TAVI were retrospectively analysed. A five-stage system based on the presence and extent of cardiac damage assessed by echocardiography was applied before and 6 months after TAVI. Multivari...
Abstract
The Review of scientific instruments,
Volume 96, Issue 4, 1 1 2025, Pages 044504
Controlled partial gravity platform for milligravity in drop tower experiments.
Joeris K, Keulen M, Kollmer JE
We detail a platform for partial gravity environment and an experiment for simulated impacts on asteroid surfaces based on it. The partial gravity environment is created by a two stage approach: First, we place the experiment in the microgravity of a free-falling drop tower capsule in the ZARM (German acronym for Center of Applied Space Technology and Microgravity) Bremen drop tower. Second, we convert microgravity to partial gravity by steady acceleration of the experiment volume on a linear dr...
Abstract
Cited 2 times since 2025 (22.2 per year)
source: EuropePMC
Cardiovascular research,
Volume 121, Issue 1, 1 1 2025, Pages 143-156
miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues.
Senesi G, Lodrini AM, Mohammed S, Mosole S, Hjortnaes J, Veltrop RJA, Kubat B, Ceresa D, Bolis S, Raimondi A, Torre T, Malatesta P, Goumans MJ, Paneni F, Camici GG, Barile L, Balbi C, Vassalli G
Aims: Cardiac fibrosis in response to injury leads to myocardial stiffness and heart failure. At the cellular level, fibrosis is triggered by the conversion of cardiac fibroblasts (CF) into extracellular matrix-producing myofibroblasts. miR-24-3p regulates this process in animal models. Here, we investigated whether miR-24-3p plays similar roles in human models. Methods and results: Gain- and loss-of-function experiments were performed using human induced pluripotent stem cell-derived cardiomyoc...
Abstract
Circulation. Cardiovascular imaging,
31 5 2025
AI-Quantitative CT Coronary Plaque Features Associate with a Higher Relative Risk in Women: CONFIRM2-Registry.
Feuchtner GM, Lacaita PG, Bax JJ, Rodriguez F, Nakanishi R, Pontone G, Mushtaq S, Buechel RR, Gräni C, Patel AR, Singulane CC, Choi AD, Al-Mallah M, Andreini D, Karlsberg RP, Cho GW, Rochitte CE, Alasnag M, Hamdan A, Cademartiri F, Maffei E, Marques H, Gonçalves Pereira PM, Gupta H, Hadamitzky M, Khalique O, Kalra D, Mills JD, Nurmohamed NS, Knaapen P, Budoff M, Shaikh K, Martin E, German DM, Ferencik M, Oehler AC, Deaño R, Nagpal P, van Assen M, De Cecco CN, Foldyna B, Brendel JM, Cheng VY, Branch K, Bittencourt M, Bhatti S, Polsani Md V, Wesbey G, Cardoso R, Blankstein R, Delago A, Pursnani A, Alsaid A, Bloom S, Kamperidis V, Barbieri F, Aquino M, Danad I, van Rosendael A
Background: Coronary plaque features are imaging biomarkers of cardiovascular risk, but less is known about sex-specific patterns in their prognostic value. This study aimed to define sex differences in the coronary atherosclerotic phenotypes assessed by artificial intelligence-based quantitative coronary computed tomography (AI-QCT) and the associated risk of major adverse cardiovascular events (MACE). Methods: Global multicenter registry (CONFIRM2) including symptomatic patients with suspicion...
Abstract
JACC. Cardiovascular imaging,
29 5 2025, Pages S1936-878X(25)00138-X
The Last Decade in Tricuspid Regurgitation: How Imaging Shaped a Field.
Hahn RT, Badano L, Praz F, Muraru D, Agricola E, Ajmone Marsan N, Bartkowiak J, Delgado V, Dreyfus J, Hausleiter J, Lurz P, Maisano F, Margonato D, Messika-Zeitoun D, Enriquez-Sarano M, Cavalcante JL
The tricuspid valve has become a major focus of novel structural heart interventions, with the Conformité Européenne approval of 5 devices in Europe and the U.S. Food and Drug Administration approval of 2 devices in the United States. Multiple meta-analyses and large population-based registries have shown that although significant tricuspid regurgitation (TR) often accompanies left heart or pulmonary vascular diseases, it is associated with an increased risk of mortality and a reduced quality of...
Abstract
Journal of cardiothoracic and vascular anesthesia,
29 5 2025, Pages S1053-0770(25)00272-1
Anesthesia Management for the Personalized External Aortic Root Support (PEARS) Procedure: A Single-Center Experience.
Pandey AK, Kougioumtzoglou AM, Lam BCY, Kho E, Eberl S, Dilai J, Koolbergen DR, Hermanns H
Objective: To delineate anesthesia management during the personalized external aortic root support (PEARS) procedure, with a focus on the use of multimodal monitoring and deliberate profound hypotension. Design: A single-center retrospective cohort study. Setting: Tertiary academic hospital. Participants: Patients undergoing the PEARS procedure due to aortic aneurysm. Interventions: None. Methods: Patient characteristics and anesthesia management are described, with particular emphasis on multim...
Abstract
The international journal of cardiovascular imaging,
29 5 2025
Prognostic impact of left ventricular myocardial work in patients undergoing surgery for primary mitral regurgitation.
Nabeta T, Peters F, Wu HW, Chua AP, Palmen M, Tomšič A, Marsan NA, Bax JJ, van der Bijl P
Purpose: Echocardiography-based, left ventricular myocardial work (LVMW) can assess LV function by incorporating LV afterload. This study aims to evaluate the prognostic value of LVMW indices in patients with primary mitral regurgitation (MR) undergoing mitral valve surgery. Methods and results: A total of 306 patients (mean age 63 ± 12 years, 68% male) with severe, primary MR who underwent surgery, were included. All patients underwent transthoracic echocardiography and LVMW indices were assess...
Abstract
Clinical case reports,
Volume 13, Issue 4, 28 4 2025, Pages e70282
A <i>PDLIM7</i> Variant in Familial Mitral Valve Prolapse: A Case Series.
van Wijngaarden AL, Koopmann TT, Ruivenkamp CAL, Wu HW, Ajmone Marsan N, Barge-Schaapveld DQCM
In the presented case of familial mitral valve prolapse, whole exome sequencing was used to reveal a missense variant in the PDLIM7 gene. This gene is considered a possible novel candidate gene for familial MVP based on PDLIM7 knock-out mice and zebrafish showing mitral valve abnormalities.
Abstract
European heart journal. Quality of care & clinical outcomes,
28 4 2025, Pages qcae106
Key priorities for the implementation of the 2023 ESC Guidelines for the management of endocarditis in low-resource settings.
Borger MA, de Waha S, Marsan NA, Zühlke L, Mestres CA, Fosbol E, Bonaros N, Pizzi MN, Brida M, Sionis A, Delgado V, Members of the Task Force for the 2023 ESC Guidelines for the management of endocarditis
European Society of Cardiology (ESC) Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinician...
Abstract
American heart journal plus : cardiology research and practice,
Volume 53, 26 4 2025, Pages 100534
The clinical impact of prophylactic concomitant left atrial appendage occlusion during cardiac surgery: A systematic review and meta-analysis.
Zhao C, Girdauskas E, Schoones JW, Klautz RJM, Palmen M, Tomšič A
Background: Recently, concomitant left atrial appendage occlusion (LAAO) has emerged as prophylactic treatment option for preventing thromboembolic events in patients undergoing cardiac surgery with no known history of atrial fibrillation. The efficacy of prophylactic LAAO remains unknown. Methods: PubMed, Embase, Web of Science, Emcare, and the Cochrane Library were searched for studies on prophylactic LAAO in patients undergoing cardiac surgery. The primary endpoints were postoperative thrombo...
Abstract
European heart journal. Cardiovascular Imaging,
25 4 2025, Pages jeaf093
CCTA-Derived Coronary Plaque Burden Offers Enhanced Prognostic Value Over CAC Scoring In Suspected CAD Patients.
Dahdal J, Jukema RA, Maaniitty T, Nurmohamed NS, Raijmakers PG, Hoek R, Driessen RS, Twisk JWR, Bär S, Planken RN, van Royen N, Nijveldt R, Bax JJ, Saraste A, van Rosendael AR, Knaapen P, Knuuti J, Danad I
Aim: To assess the prognostic utility of coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA) - derived quantitative plaque metrics for predicting adverse cardiovascular outcomes. Methods and results: The study enrolled 2,404 patients with suspected CAD but without prior history of CAD. All participants underwent CAC scoring and CCTA, with plaque metrics quantified using an artificial intelligence (AI)-based tool (Cleerly, Inc). Percent atheroma volume (PAV)...
Abstract
ESC heart failure,
23 4 2025
Prognostic implications of functional tricuspid regurgitation in asymptomatic degenerative mitral regurgitation.
Tribouilloy C, Bohbot Y, Essayagh B, Benfari G, Bax JJ, Le Tourneau T, Topilsky Y, Antoine C, Rusinaru D, Grigioni F, Ajmone Marsan N, van Wijngaarden A, Hochstadt A, Roussel JC, Thapa P, Hector M, Enriquez-Sarano M
Aims: Functional tricuspid regurgitation (FTR) associated with degenerative mitral regurgitation (DMR) accentuates the severity of heart failure and is a marker of poor prognosis. Little is known about FTR associated with asymptomatic DMR. Methods and results: The study included 1249 asymptomatic patients with moderate or severe DMR from the Mitral Regurgitation International Database-Quantitative (MIDA-Q) registry (mean age 64 ± 15 years, 25% female). Despite the asymptomatic status, absent/tri...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 7, 21 3 2025, Pages e037531
Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts.
Garoffolo G, Sluiter TJ, Thomas A, Piacentini L, Ruiter MS, Schiavo A, Salvi M, Saccu C, Zoli S, Chiesa M, Yokoyama T, Agrifoglio M, Soncini M, Fiore GB, Martelli F, Condorelli G, Madeddu P, Molinari F, Morbiducci U, Quax PHA, Spinetti G, de Vries MR, Pesce M
Background: Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth muscle cells in the intima layer, leading to progressive bypass stenosis. We previously showed that cyclic strain deriving from exposure to coronary flow induces the expression of the matricellular protein thrombospondin-1 in the human SV, promoting activation...
Abstract
