8088 results
Cited 11 times since 2021 (2.6 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 108, Issue 2, 8 2 2021, Pages 137-144
Prognostic implications of left atrial dilation in aortic regurgitation due to bicuspid aortic valve.
Butcher SC, Fortuni F, Kong W, Vollema EM, Prevedello F, Perry R, Ng ACT, Poh KK, Almeida AG, González-Gómez A, Shen M, Yeo TC, Shanks M, Popescu BA, Galian-Gay L, Fijalkowski M, Liang M, Tay E, Ajmone Marsan N, Selvanayagam JB, Pinto FJ, Zamorano J, Pibarot P, Evangelista A, Bax JJ, Delgado V
Objective: To investigate the prognostic value of left atrial volume index (LAVI) in patients with moderate to severe aortic regurgitation (AR) and bicuspid aortic valve (BAV). Methods: 554 individuals (45 (IQR 33-57) years, 80% male) with BAV and moderate or severe AR were selected from an international, multicentre registry. The association between LAVI and the combined endpoint of all-cause mortality or aortic valve surgery was investigated with Cox proportional hazard regression analyses. Re...
Abstract
Cited 9 times since 2021 (2.1 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 34, Issue 9, 8 2 2021, Pages 944-954
Ratio between Vena Contracta Width and Tricuspid Annular Diameter: Prognostic Value in Secondary Tricuspid Regurgitation.
Fortuni F, Dietz MF, Prihadi EA, van der Bijl P, De Ferrari GM, Bax JJ, Delgado V, Marsan NA
Background: Conventional approaches for the assessment of secondary tricuspid regurgitation (STR) severity do not correct for right heart dimensions. The authors hypothesized that STR severity can be proportional or disproportional to the dilation of the tricuspid annulus (TA) and investigated the prognostic impact of this novel definition. Methods: A total of 334 patients with moderate to severe STR and preserved left ventricular systolic function were included. The ratio between vena contracta...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Journal of the Royal Society, Interface,
Volume 18, Issue 177, 7 1 2021, Pages 20201027
Non-uniform mixing of hepatic venous flow and inferior vena cava flow in the Fontan conduit.
Rijnberg FM, van der Woude SFS, van Assen HC, Juffermans JF, Hazekamp MG, Jongbloed MRM, Kenjeres S, Lamb HJ, Westenberg JJM, Wentzel JJ, Roest AAW
Fontan patients require a balanced hepatic blood flow distribution (HFD) to prevent pulmonary arteriovenous malformations. Currently, HFD is quantified by tracking Fontan conduit flow, assuming hepatic venous (HV) flow to be uniformly distributed within the Fontan conduit. However, this assumption may be unvalid leading to inaccuracies in HFD quantification with potential clinical impact. The aim of this study was to (i) assess the mixing of HV flow and inferior vena caval (IVC) flow within the...
Abstract
Cited 3 times since 2021 (0.7 per year)
source: EuropePMC
Circulation. Genomic and precision medicine,
Volume 14, Issue 2, 2 1 2021, Pages e003219
Role of Adenylate Cyclase 9 in the Pharmacogenomic Response to Dalcetrapib: Clinical Paradigm and Molecular Mechanisms in Precision Cardiovascular Medicine.
Rhainds D, Packard CJ, Brodeur MR, Niesor EJ, Sacks FM, Jukema JW, Wright RS, Waters DD, Heinonen T, Black DM, Laghrissi-Thode F, Dubé MP, Pfeffer MA, Tardif JC
Following the neutral results of the dal-OUTCOMES trial, a genome-wide study identified the rs1967309 variant in the adenylate cyclase type 9 (ADCY9) gene on chromosome 16 as being associated with the risk of future cardiovascular events only in subjects taking dalcetrapib, a CETP (cholesterol ester transfer protein) modulator. Homozygotes for the minor A allele (AA) were protected from recurrent cardiovascular events when treated with dalcetrapib, while homozygotes for the major G allele (GG) h...
Abstract
Circulation. Cardiovascular imaging,
Volume 14, Issue 4, 2 1 2021, Pages e011688
Multimodality Evaluation of a Septal Cystic Cavity and Ventricular Septal Defect in the Setting of Neurocysticercosis and Endocarditis.
Schuuring MJ, van der Bom T, Konings TC, Götte MJW, Koolbergen DR, Boekholdt SM, de Winter RJ
Abstract
Cited 95 times since 2021 (22.5 per year)
source: EuropePMC
Therapeutic drug monitoring,
Volume 43, Issue 2, 1 1 2021, Pages 150-200
Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.
Bergan S, Brunet M, Hesselink DA, Johnson-Davis KL, Kunicki PK, Lemaitre F, Marquet P, Molinaro M, Noceti O, Pattanaik S, Pawinski T, Seger C, Shipkova M, Swen JJ, van Gelder T, Venkataramanan R, Wieland E, Woillard JB, Zwart TC, Barten MJ, Budde K, Dieterlen MT, Elens L, Haufroid V, Masuda S, Millan O, Mizuno T, Moes DJAR, Oellerich M, Picard N, Salzmann L, Tönshoff B, van Schaik RHN, Vethe NT, Vinks AA, Wallemacq P, Åsberg A, Langman LJ
Abstract: When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy, fixed doses were recommended by the manufacturer. Awareness of the potential for a more personalized dosing has led to development of methods to estimate MPA area under the curve based on the measurement of drug concentrations in only a few samples. This approach is feasible in the clinical routine and has proven successful in terms of correlation with outcome. However, the search for superior correlate...
Abstract
Cited 26 times since 2021 (6.1 per year)
source: EuropePMC
Rheumatology (Oxford, England),
Volume 60, Issue 4, 1 1 2021, Pages 1784-1792
Intravenous immunoglobulins as first-line treatment in idiopathic inflammatory myopathies: a pilot study.
Lim J, Eftimov F, Verhamme C, Brusse E, Hoogendijk JE, Saris CGJ, Raaphorst J, De Haan RJ, van Schaik IN, Aronica E, de Visser M, van der Kooi AJ
Objectives: We explored efficacy and safety of IVIg as first-line treatment in patients with an idiopathic inflammatory myopathy. Methods: In this investigator-initiated phase 2 open-label study, we included 20 adults with a newly diagnosed, biopsy-proven idiopathic inflammatory myopathy, and a disease duration of less than 9 months. Patients with IBM and prior use of immunosuppressants were excluded. The standard treatment regimen consisted of IVIg (Privigen) monotherapy for 9 weeks: a loading...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Academic medicine : journal of the Association of American Medical Colleges,
Volume 96, Issue 4, 1 1 2021, Pages 495-500
Accessible and Adaptable Faculty Development to Support Curriculum Reform in Medical Education.
van Schaik SM
Contemporary curricular reform in medical education focuses on areas that current physician-educators were likely not exposed to during medical school, such as interprofessional teamwork; informatics; health care systems improvement; and diversity, equity, and inclusion. Thus, faculty may not be ready to support the planned curricular reform without adequate faculty development to acquire the necessary knowledge and skills. In an era with increasing demands on faculty, new approaches that are fl...
Abstract
Cited 24 times since 2021 (5.7 per year)
source: EuropePMC
The Journal of antimicrobial chemotherapy,
Volume 76, Issue 5, 1 1 2021, Pages 1130-1134
Transferable Acinetobacter baumannii plasmid pDETAB2 encodes OXA-58 and NDM-1 and represents a new class of antibiotic resistance plasmids.
Liu H, Moran RA, Chen Y, Doughty EL, Hua X, Jiang Y, Xu Q, Zhang L, Blair JMA, McNally A, van Schaik W, Yu Y
Objectives: To characterize a blaOXA-58- and blaNDM-1-containing MDR plasmid from a rare Acinetobacter baumannii lineage and compare it with related plasmids to explore the distribution and evolution of a new plasmid group. Methods: A. baumannii DETAB-P2 was isolated from a rectal swab of an intensive care patient. Antibiotic susceptibility was determined using broth microdilution. DETAB-P2 was mated with A. baumannii ATCC 17978 and putative transconjugants were characterized by S1/PFGE and Sout...
Abstract
Cited 39 times since 2021 (9.2 per year)
source: EuropePMC
Human molecular genetics,
Volume 30, Issue 5, 1 1 2021, Pages 393-409
Genome-wide association study of circulating interleukin 6 levels identifies novel loci.
Ahluwalia TS, Prins BP, Abdollahi M, Armstrong NJ, Aslibekyan S, Bain L, Jefferis B, Baumert J, Beekman M, Ben-Shlomo Y, Bis JC, Mitchell BD, de Geus E, Delgado GE, Marek D, Eriksson J, Kajantie E, Kanoni S, Kemp JP, Lu C, Marioni RE, McLachlan S, Milaneschi Y, Nolte IM, Petrelis AM, Porcu E, Sabater-Lleal M, Naderi E, Seppälä I, Shah T, Singhal G, Standl M, Teumer A, Thalamuthu A, Thiering E, Trompet S, Ballantyne CM, Benjamin EJ, Casas JP, Toben C, Dedoussis G, Deelen J, Durda P, Engmann J, Feitosa MF, Grallert H, Hammarstedt A, Harris SE, Homuth G, Hottenga JJ, Jalkanen S, Jamshidi Y, Jawahar MC, Jess T, Kivimaki M, Kleber ME, Lahti J, Liu Y, Marques-Vidal P, Mellström D, Mooijaart SP, Müller-Nurasyid M, Penninx B, Revez JA, Rossing P, Räikkönen K, Sattar N, Scharnagl H, Sennblad B, Silveira A, Pourcain BS, Timpson NJ, Trollor J, CHARGE Inflammation Working Group, van Dongen J, Van Heemst D, Visvikis-Siest S, Vollenweider P, Völker U, Waldenberger M, Willemsen G, Zabaneh D, Morris RW, Arnett DK, Baune BT,
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inv...
Abstract
Cited 16 times since 2021 (3.8 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 32, Issue 4, 1 1 2021, Pages 506-514
Evolution from mitral annular dysfunction to severe mitral regurgitation in Barlow's disease.
Hiemstra YL, Tomsic A, Gripari P, van Wijngaarden AL, van der Pas SL, Palmen M, Klautz RJM, Pepi M, Bax JJ, Delgado V, Marsan NA
Objectives: Barlow's disease (BD) is characterized by thick, redundant mitral valve (MV) leaflets, which can lead to prolapse and significant mitral regurgitation (MR). MV annular abnormalities are also commonly observed and increasingly recognized as possible primary pathology, with leaflet thickening being secondary to increased stress on the MV apparatus. To provide more insights into this hypothesis, the evolution of MV abnormalities over time in patients with BD was assessed. Methods:...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 5, 1 1 2021, Pages 516-517
Prognostic significance of left ventricular diastolic dysfunction and filling pressures based on current guideline recommendations.
Ng ACT, Narula J, Bax JJ
Abstract
Cited 1 times since 2021 (0.2 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 14, Issue 4, 1 1 2021, Pages 880-881
The Authors Reply.
Namazi F, Delgado V, Bax JJ
Abstract
Cited 23 times since 2021 (5.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 5, 1 1 2021, Pages 471-479
The structural heart disease interventional imager rationale, skills and training: a position paper of the European Association of Cardiovascular Imaging.
Agricola E, Ancona F, Brochet E, Donal E, Dweck M, Faletra F, Lancellotti P, Mahmoud-Elsayed H, Marsan NA, Maurovich-Hovart P, Monaghan M, Ribeiro J, Sade LE, Swaans M, Von Bardeleben RS, Wunderlich N, Zamorano JL, Popescu BA, Cosyns B, Edvardsen T, Reviewers: This document was reviewed by members of the 2018-2020 EACVI Scientific Documents Committee
Percutaneous therapeutic options for an increasing variety of structural heart diseases (SHD) have grown dramatically. Within this context of continuous expansion of devices and procedures, there has been increased demand for physicians with specific knowledge, skills, and advanced training in multimodality cardiac imaging. As a consequence, a new subspecialty of 'Interventional Imaging' for SHD interventions and a new dedicated professional figure, the 'Interventional Imager'...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 5, 1 1 2021, Pages 589-596
Assessment of left atrial electro-mechanical delay to predict atrial fibrillation in hypertrophic cardiomyopathy.
Tjahjadi C, Hiemstra YL, van der Bijl P, Pio SM, Bootsma M, Ajmone Marsan N, Delgado V, Bax JJ
Aims: Atrial fibrillation (AF) is frequently observed in hypertrophic cardiomyopathy (HCM) and is associated with poor clinical outcome. Total atrial conduction time, estimated by tissue Doppler imaging (TDI), the so-called PA-TDI duration, reflects the left atrial (LA) structural and electrical remodelling. The aim of this study was to evaluate the association between PA-TDI and new-onset AF in patients with HCM. Methods and results: From a large cohort of patients with HCM, 208 patients (64% m...
Abstract
Cited 12 times since 2021 (2.8 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 22, Issue 5, 1 1 2021, Pages 480-490
The role of myocardial innervation imaging in different clinical scenarios: an expert document of the European Association of Cardiovascular Imaging and Cardiovascular Committee of the European Association of Nuclear Medicine.
Gimelli A, Liga R, Agostini D, Bengel FM, Ernst S, Hyafil F, Saraste A, Scholte AJHA, Verberne HJ, Verschure DO, Slart RHJA
Cardiac sympathetic activity plays a key role in supporting cardiac function in both health and disease conditions, and nuclear cardiac imaging has always represented the only way for the non-invasive evaluation of the functional integrity of cardiac sympathetic terminals, mainly through the use of radiopharmaceuticals that are analogues of norepinephrine and, in particular, with the use of 123I-mIBG imaging. This technique demonstrates the presence of cardiac sympathetic dysfunction in differen...
Abstract
Cited 4 times since 2021 (0.9 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 59, Issue 4, 1 1 2021, Pages 814-822
Wall shear stress in the thoracic aorta at rest and with dobutamine stress after arterial switch operation.
van der Palen RLF, Juffermans JF, Kroft LJM, Hazekamp MG, Lamb HJ, Blom NA, Roest AAW, Westenberg JJM
Objectives: Progressive root dilatation is an important complication in patients with transposition of the great arteries (TGA) after arterial switch operation (ASO) that may be caused by altered flow dynamics. Aortic wall shear stress (WSS) distribution at rest and under dobutamine stress (DS) conditions using 4D flow magnetic resonance imaging were investigated in relation to thoracic aorta geometry. Methods: 4D flow magnetic resonance imaging was performed in 16 adolescent TGA patients after...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 59, Issue 4, 1 1 2021, Pages 830-831
We can, but should we?
Hazekamp MG, Sojak V
Abstract
Cited 13 times since 2021 (3.1 per year)
source: EuropePMC
Journal of patient safety,
Volume 17, Issue 3, 1 1 2021, Pages 157-165
Preoperative Anticoagulation Management in Everyday Clinical Practice: An International Comparative Analysis of Work-as-Done Using the Functional Resonance Analysis Method.
Damen NL, de Vos MS, Moesker MJ, Braithwaite J, de Lind van Wijngaarden RAF, Kaplan J, Hamming JF, Clay-Williams R
Objectives: Preoperative anticoagulation management (PAM) is a complex, multidisciplinary process important to patient safety. The Functional Resonance Analysis Method (FRAM) is a novel method to study how complex processes usually go right at the frontline (labeled Safety-II) and how this relates to predefined procedures. This study aimed to assess PAM in everyday practice and explore the usability and utility of FRAM. Methods: The study was conducted at an Australian and European Cardiothoraci...
Abstract
Cited 8 times since 2021 (1.9 per year)
source: EuropePMC
Journal of patient safety,
Volume 17, Issue 3, 1 1 2021, Pages 231-238
Learning From Morbidity and Mortality Conferences: Focus and Sustainability of Lessons for Patient Care.
de Vos MS, Hamming JF, Marang-van de Mheen PJ
Objective: It remains unclear to what extent the morbidity and mortality conference (M&M) meets the objective of improving quality and safety of patient care. It has been suggested that M&M may be too focused on individual performance, hampering system-level improvement. The aim of this study was to assess focus and sustainability of lessons for patient care that were derived from M&M. Methods: This is an observational study of routinely collected data on evaluated complications and...
Abstract
