Research

Publications

Below you can find a list of our published research.

6228 results

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

The American journal of cardiology, Volume 114, Issue 10, 27 4 2014, Pages 1490-1496 Determinants of right ventricular remodeling following ST-segment elevation myocardial infarction. Hoogslag GE, Haeck ML, Velders MA, Joyce E, Boden H, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

Right ventricular (RV) function after ST-segment elevation myocardial infarction (STEMI) has important prognostic implications. However, the changes in RV function over time after STEMI and the incidence of RV remodeling remain unknown. The present study evaluated changes in RV dimensions and function in contemporary patients with first STEMI and assessed the independent determinants of RV dysfunction at follow-up. Patients with first STEMI (n = 940, 60 ± 11 years, 77% men) treated with primary... Abstract

Cited 16 times since 2014 (1.5 per year) source: EuropePMC

The American journal of cardiology, Volume 114, Issue 10, 27 4 2014, Pages 1556-1561 Insights into new-onset rhythm conduction disorders detected by multi-detector row computed tomography after transcatheter aortic valve implantation. Katsanos S, van Rosendael P, Kamperidis V, van der Kley F, Joyce E, Debonnaire P, Karalis I, Bax JJ, Marsan NA, Delgado V

New-onset rhythm conduction disorders are frequent after transcatheter aortic valve implantation (TAVI). Multidetector row computed tomography may shed light on the pathophysiology of rhythm conduction disorders in patients who undergo TAVI with the Edwards SAPIEN valve. A total of 94 patients (mean age 81 ± 7 years, 48% men) treated with TAVI with the Edwards SAPIEN valve who underwent pre- and post-TAVI multidetector row computed tomography were included. Patients with preexisting right bundle... Abstract

Cited 22 times since 2014 (2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 46, Issue 5, 26 4 2014, Pages 831-839 Bicuspid aortic valve: phosphorylation of c-Kit and downstream targets are prognostic for future aortopathy. Grewal N, Gittenberger-de Groot AC, DeRuiter MC, Klautz RJ, Poelmann RE, Duim S, Lindeman JH, Koenraadt WM, Jongbloed MR, Mohamed SA, Sievers HH, Bogers AJ, Goumans MJ

Objectives: The clinical course of many patients with a bicuspid aortic valve (BAV) is complicated by ascending aortic dilatation. Currently, the indication for aortic surgery is solely based on the aortic diameter and subsequently only a small proportion of BAV patients undergoing valve surgery require concomitant ascending aortic replacement based on these recommendations. Unfortunately, a substantial number of BAV patients still develop aortic dilatation in the future and would potentially be... Abstract

Cited 61 times since 2014 (5.6 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 28, Issue 12, 25 4 2014, Pages 5361-5375 Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity. Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbée JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombès M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC

The endocannabinoid system is an important player in energy metabolism by regulating appetite, lipolysis, and energy expenditure. Chronic blockade of the cannabinoid 1 receptor (CB1R) leads to long-term maintenance of weight loss and reduction of dyslipidemia in experimental and human obesity. The molecular mechanism by which CB1R blockade reverses dyslipidemia in obesity has not yet been clarified. In this study, we showed that CB1R blockade with the systemic CB1R blocker rimonabant enhanced wh... Abstract

Cited 35 times since 2014 (3.2 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 7, Issue 5, 23 4 2014, Pages 889-897 Left-sided ablation of ventricular tachycardia in adults with repaired tetralogy of Fallot: a case series. Kapel GF, Reichlin T, Wijnmaalen AP, Tedrow UB, Piers SR, Schalij MJ, Hazekamp MG, Jongbloed MR, Stevenson WG, Zeppenfeld K

Background: Radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in repaired Tetralogy of Fallot focuses on isthmuses in the right ventricle but may be hampered by hypertrophied myocardium or prosthetic material. These patients may benefit from ablation at the left side of the ventricular septum. Methods and results: Records from 28 consecutive repaired Tetralogy of Fallot patients from 2 centers who underwent VT ablation were reviewed. Ablation targeted anatomic isthmuses con... Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

Cardiovascular and interventional radiology, Volume 38, Issue 3, 22 4 2014, Pages 600-605 Thromboembolic complications after Zenith® Low Profile Endovascular Graft for infrarenal abdominal aneurysms. Urlings TA, de Vries AC, de Mol van Otterloo JC, Eefting D, van der Linden E

Purpose: The purpose of this study was to objectify and evaluate risk factors for thromboembolic complications after treatment with a Zenith(®) Low Profile Endovascular Graft (Zenith LP). Results were compared with those in the recent literature on endovascular aortic repair (EVAR) and with the thromboembolic complications in the patient group treated with a Zenith Flex Endovascular Graft in our institute in the period before the use of the Zenith LP. Materials and methods: All consecutive patie... Abstract

Cited 29 times since 2014 (2.7 per year) source: EuropePMC

Journal of magnetic resonance imaging : JMRI, Volume 41, Issue 6, 20 3 2014, Pages 1512-1520 Characterization and improved quantification of left ventricular inflow using streamline visualization with 4DFlow MRI in healthy controls and patients after atrioventricular septal defect correction. Calkoen EE, Roest AA, Kroft LJ, van der Geest RJ, Jongbloed MR, van den Boogaard PJ, Blom NA, Hazekamp MG, de Roos A, Westenberg JJ

Purpose: To evaluate trans-left atrioventricular valve (LAVV) blood flow and optimize left ventricular inflow quantification in healthy controls and patients after atrioventricular septal defect (AVSD) correction. Materials and methods: Twenty-five patients after AVSD correction and 25 controls underwent 4DFlow MRI. Using streamline visualization in four- and two-chamber views, inflow direction at early and late filling was defined at the annulus level and at the peak inflow velocity (PIV) level... Abstract

Cited 56 times since 2014 (5.2 per year) source: EuropePMC

European heart journal, Volume 36, Issue 1, 20 3 2014, Pages 39-48 Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin. Kühnast S, van der Tuin SJ, van der Hoorn JW, van Klinken JB, Simic B, Pieterman E, Havekes LM, Landmesser U, Lüscher TF, Willems van Dijk K, Rensen PC, Jukema JW, Princen HM

Background: The residual risk that remains after statin treatment supports the addition of other LDL-C-lowering agents and has stimulated the search for secondary treatment targets. Epidemiological studies propose HDL-C as a possible candidate. Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from atheroprotective HDL to atherogenic (V)LDL. The CETP inhibitor anacetrapib decreases (V)LDL-C by ∼15-40% and increases HDL-C by ∼40-140% in clinical trials. We evaluated the effec... Abstract

Cited 133 times since 2014 (12.3 per year) source: EuropePMC

Journal of lipid research, Volume 55, Issue 10, 19 3 2014, Pages 2103-2112 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin. Kühnast S, van der Hoorn JW, Pieterman EJ, van den Hoek AM, Sasiela WJ, Gusarova V, Peyman A, Schäfer HL, Schwahn U, Jukema JW, Princen HM

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a potential novel strategy for treatment of CVD. Alirocumab is a fully human PCSK9 monoclonal antibody in phase 3 clinical development. We evaluated the antiatherogenic potential of alirocumab in APOE*3Leiden.CETP mice. Mice received a Western-type diet and were treated with alirocumab (3 or 10 mg/kg, weekly subcutaneous dosing) alone and in combination with atorvastatin (3.6 mg/kg/d) for 18 weeks. Alirocumab alone dose-dependen... Abstract

European heart journal. Cardiovascular Imaging, Volume 15, Issue 12, 19 3 2014, Pages 1428 Three-dimensional transoesophageal echocardiographic visualization of malignant anomalous left main coronary origin and course causing sudden cardiac death. Kamperidis V, Katsanos S, Bertels RA, Schalij MJ, Delgado V

Abstract

Cited 21 times since 2014 (1.9 per year) source: EuropePMC

European journal of heart failure, Volume 16, Issue 10, 19 3 2014, Pages 1104-1111 Super-responders to cardiac resynchronization therapy remain at risk for ventricular arrhythmias and benefit from defibrillator treatment. van der Heijden AC, Höke U, Thijssen J, Borleffs CJ, van Rees JB, van der Velde ET, Schalij MJ, van Erven L

Aims: Mortality and ventricular arrhythmias are reduced in patients responding to cardiac resynchronization therapy (CRT). This response is accompanied by improvement in LVEF, and some patients even outgrow original eligibility criteria for implantable cardioverter-defibrillator (ICD) implantation. It is however unclear if these patients still benefit from ICD treatment. The current study aimed to evaluate if the incidence of ICD therapy is related to the extent of CRT response. Methods and resu... Abstract

Cited 20 times since 2014 (1.8 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 98, Issue 5, 19 3 2014, Pages 1680-1686 More than 25 years of experience in managing pulmonary atresia with intact ventricular septum. Schneider AW, Blom NA, Bruggemans EF, Hazekamp MG

Background: Management of pulmonary atresia with intact ventricular septum (PAIVS) is challenging and depends on the individual patient's morphologic characteristics. We evaluated outcomes of 25 years of experience in morphologically driven management of PAIVS. Methods: Between January 1985 and December 2011, 60 patients were treated for PAIVS. Patients were retrospectively categorized into mild (n=27), moderate (n=18), and severe (n=15) right ventricular (RV) hypoplasia subgroups based on... Abstract

Cited 20 times since 2014 (1.8 per year) source: EuropePMC

International journal of cardiology, Volume 176, Issue 3, 17 3 2014, Pages 776-781 Increased carotid intima-media thickness predicts cardiovascular events in aortic coarctation. Luijendijk P, Lu H, Heynneman FB, Huijgen R, de Groot EE, Vriend JW, Vliegen HW, Groenink M, Bouma BJ, Mulder BJ

Background: Adult post-coarctectomy patients (CoA) demonstrate increased cardiovascular morbidity and mortality. The carotid intima-media thickness (CIMT), a marker for atherosclerosis, is increased in CoA. The aim was to evaluate the predictive value of CIMT for cardiovascular events. Methods and results: Consecutive CoA patients were prospectively studied during 10.1±0.7 years follow-up. At baseline and follow-up echocardiography, MRI imaging and CIMT imaging were performed, while cardiovascul... Abstract

Cited 4 times since 2014 (0.4 per year) source: Scopus

The international journal of cardiovascular imaging, Volume 31, Issue 1, 17 3 2014, Pages 37-43 Pericardial effusion following transcatheter aortic valve implantation: echocardiography and multi-detector row computed tomography evaluation. Katsanos S, van Rosendael P, Kamperidis V, van der Kley F, Regeer M, Al-Amri I, Karalis I, Palmen M, de Weger A, Marsan NA, Bax JJ, Delgado V

Although pericardial effusion (PE) early after transcatheter aortic valve implantation (TAVI) has been reported in few registries, late PE at follow-up remains unexplored. Particularly, after transapical TAVI, diagnosis of PE with transthoracic echocardiography (TTE) may be challenging. The present evaluation assessed the incidence of PE early after TAVI and at 1 month follow-up using TTE and multi-detector computed tomography (MDCT). The agreement between TTE and MDCT to diagnose the presence a... Abstract

Cited 34 times since 2014 (3.1 per year) source: EuropePMC

Journal of cellular and molecular medicine, Volume 18, Issue 10, 15 3 2014, Pages 2020-2030 Complement factor C5a induces atherosclerotic plaque disruptions. Wezel A, de Vries MR, Lagraauw HM, Foks AC, Kuiper J, Quax PH, Bot I

Complement factor C5a and its receptor C5aR are expressed in vulnerable atherosclerotic plaques; however, a causal relation between C5a and plaque rupture has not been established yet. Accelerated atherosclerosis was induced by placing vein grafts in male apoE(-/-) mice. After 24 days, when advanced plaques had developed, C5a or PBS was applied locally at the lesion site in a pluronic gel. Three days later mice were killed to examine the acute effect of C5a on late stage atherosclerosis. A signi... Abstract

Cited 140 times since 2014 (12.9 per year) source: EuropePMC

Circulation, Volume 130, Issue 15, 14 2 2014, Pages 1225-1235 Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation. Sinner MF, Tucker NR, Lunetta KL, Ozaki K, Smith JG, Trompet S, Bis JC, Lin H, Chung MK, Nielsen JB, Lubitz SA, Krijthe BP, Magnani JW, Ye J, Gollob MH, Tsunoda T, Müller-Nurasyid M, Lichtner P, Peters A, Dolmatova E, Kubo M, Smith JD, Psaty BM, Smith NL, Jukema JW, Chasman DI, Albert CM, Ebana Y, Furukawa T, Macfarlane PW, Harris TB, Darbar D, Dörr M, Holst AG, Svendsen JH, Hofman A, Uitterlinden AG, Gudnason V, Isobe M, Malik R, Dichgans M, Rosand J, Van Wagoner DR, METASTROKE Consortium, AFGen Consortium, Benjamin EJ, Milan DJ, Melander O, Heckbert SR, Ford I, Liu Y, Barnard J, Olesen MS, Stricker BH, Tanaka T, Kääb S, Ellinor PT

Background: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. Methods and results: To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative trait loci) mapping, and functional validation. F... Abstract

Cited 7 times since 2014 (0.6 per year) source: EuropePMC

PloS one, Volume 9, Issue 8, 14 2 2014, Pages e105019 Increased platelet reactivity is associated with circulating platelet-monocyte complexes and macrophages in human atherosclerotic plaques. Rutten B, Tersteeg C, Vrijenhoek JE, van Holten TC, Elsenberg EH, Mak-Nienhuis EM, de Borst GJ, Jukema JW, Pijls NH, Waltenberger J, van Zonneveld AJ, Moll FL, McClellan E, Stubbs A, Pasterkamp G, Hoefer I, de Groot PG, Roest M

Objective: Platelet reactivity, platelet binding to monocytes and monocyte infiltration play a detrimental role in atherosclerotic plaque progression. We investigated whether platelet reactivity was associated with levels of circulating platelet-monocyte complexes (PMCs) and macrophages in human atherosclerotic carotid plaques. Methods: Platelet reactivity was determined by measuring platelet P-selectin expression after platelet stimulation with increasing concentrations of adenosine diphosphate... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 21, Issue 6, 12 2 2014, Pages 1072-1074 The potential role of gated myocardial perfusion SPECT imaging in patient selection for cardiac resynchronization therapy. Marsan NA, Bax JJ

Abstract

Cited 34 times since 2014 (3.1 per year) source: EuropePMC

Journal of surgical oncology, Volume 110, Issue 7, 11 2 2014, Pages 845-850 Optimization of sentinel lymph node mapping in bladder cancer using near-infrared fluorescence imaging. Schaafsma BE, Verbeek FP, Elzevier HW, Tummers QR, van der Vorst JR, Frangioni JV, van de Velde CJ, Pelger RC, Vahrmeijer AL

Background and objectives: Unlike other cancers, the Sentinel Lymph Node (SLN) procedure in bladder cancer requires special attention to the injection technique. The aim of this study was to assess feasibility and to optimize tracer injection technique for SLN mapping in bladder cancer patients using NIR fluorescence imaging. Methods: Twenty patients with invasive bladder cancer scheduled for radical cystectomy were prospectively enrolled. Indocyanine green (ICG) bound to human serum albumin (co... Abstract

Cited 59 times since 2014 (5.4 per year) source: EuropePMC

International journal of cancer, Volume 136, Issue 6, 8 2 2014, Pages 1434-1444 Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation. Groenendijk FH, Mellema WW, van der Burg E, Schut E, Hauptmann M, Horlings HM, Willems SM, van den Heuvel MM, Jonkers J, Smit EF, Bernards R

The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases, the molecular target responsible for the clinical effect is unknown. Furthermore, enhancing the effectiveness of sorafenib using combination strategies is a major clinical challenge. Here, we identify sorafenib as an activator of AMP-activated protein kinase (AMPK), in a manner that involves either upstream LKB1 or CAMKK2. We further show in a phase II clinical trial in... Abstract