9618 results
Cited 505 times since 2019 (85.7 per year)
source: EuropePMC
The Journal of general virology,
Volume 100, Issue 10, 1 1 2019, Pages 1393-1406
Updated classification of norovirus genogroups and genotypes.
Chhabra P, de Graaf M, Parra GI, Chan MC, Green K, Martella V, Wang Q, White PA, Katayama K, Vennema H, Koopmans MPG, Vinjé J
Noroviruses are genetically diverse RNA viruses associated with acute gastroenteritis in mammalian hosts. Phylogenetically, they can be segregated into different genogroups as well as P (polymerase)-groups and further into genotypes and P-types based on amino acid diversity of the complete VP1 gene and nucleotide diversity of the RNA-dependent RNA polymerase (RdRp) region of ORF1, respectively. In recent years, several new noroviruses have been reported that warrant an update of the existing cla...
Abstract
Cited 18 times since 2019 (3.1 per year)
source: EuropePMC
Molecular therapy. Nucleic acids,
Volume 18, 30 5 2019, Pages 638-649
Antisense Oligonucleotide Inhibition of MicroRNA-494 Halts Atherosclerotic Plaque Progression and Promotes Plaque Stabilization.
van Ingen E, Foks AC, Kröner MJ, Kuiper J, Quax PHA, Bot I, Nossent AY
We have previously shown that third-generation antisense (3GA) inhibition of 14q32 microRNA (miRNA)-494 reduced early development of atherosclerosis. However, patients at risk of atherosclerotic complications generally present with advanced and unstable lesions. Here, we administered 3GAs against 14q32 miRNA-494 (3GA-494), miRNA-329 (3GA-329), or a control (3GA-ctrl) to mice with advanced atherosclerosis. Atherosclerotic plaque formation in LDLr-/- mice was induced by a 10-week high-fat diet and...
Abstract
Cited 6 times since 2019 (1 per year)
source: EuropePMC
Nutrition, metabolism, and cardiovascular diseases : NMCD,
Volume 30, Issue 1, 30 5 2019, Pages 132-140
Moderate and heavy alcohol consumption are prospectively associated with decreased left ventricular ejection fraction: The Hoorn Study.
van Oort S, Beulens JW, van der Heijden AAWA, Elders PJM, Stehouwer CDA, van de Luitgaarden IAT, Schrieks IC, Grobbee DE, van Ballegooijen AJ
Background and aims: Data on the prospective relationship of alcohol consumption at more moderate levels with systolic and diastolic function are scarce. We aimed to examine the prospective association of alcohol consumption with echocardiographic measures of cardiac structure and function, in individuals with and without type 2 diabetes (T2DM). Methods and results: We included 778 participants from the Hoorn Study (aged 68.4 ± 7.2 years, 49% women), a population-based prospective cohort study,...
Abstract
Cited 17 times since 2019 (2.9 per year)
source: EuropePMC
RNA biology,
Volume 17, Issue 1, 27 4 2019, Pages 62-74
Neuronal-specific microexon splicing of <i>TAF1</i> mRNA is directly regulated by SRRM4/nSR100.
Capponi S, Stöffler N, Irimia M, Van Schaik FMA, Ondik MM, Biniossek ML, Lehmann L, Mitschke J, Vermunt MW, Creyghton MP, Graybiel AM, Reinheckel T, Schilling O, Blencowe BJ, Crittenden JR, Timmers HTM
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34' is included in the neuronal form of TAF1 mRNA, which encodes the largest subunit of the basal transcription factor TFIID. In this study, we investigate the tissue distribution of TAF1-34' mRNA and protein and the mechanism responsible for its neuronal-specific splicing...
Abstract
Cited 230 times since 2019 (39 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 74, Issue 24, 27 4 2019, Pages 2998-3008
Transcatheter Versus Medical Treatment of Patients With Symptomatic Severe Tricuspid Regurgitation.
Taramasso M, Benfari G, van der Bijl P, Alessandrini H, Attinger-Toller A, Biasco L, Lurz P, Braun D, Brochet E, Connelly KA, de Bruijn S, Denti P, Deuschl F, Estevez-Loureiro R, Fam N, Frerker C, Gavazzoni M, Hausleiter J, Ho E, Juliard JM, Kaple R, Besler C, Kodali S, Kreidel F, Kuck KH, Latib A, Lauten A, Monivas V, Mehr M, Muntané-Carol G, Nazif T, Nickening G, Pedrazzini G, Philippon F, Pozzoli A, Praz F, Puri R, Rodés-Cabau J, Schäfer U, Schofer J, Sievert H, Tang GHL, Thiele H, Topilsky Y, Rommel KP, Delgado V, Vahanian A, Von Bardeleben RS, Webb JG, Weber M, Windecker S, Winkel M, Zuber M, Leon MB, Hahn RT, Bax JJ, Enriquez-Sarano M, Maisano F
Background: Tricuspid regurgitation is associated with increased rates of heart failure (HF) and mortality. Transcatheter tricuspid valve interventions (TTVI) are promising, but the clinical benefit is unknown. Objectives: The purpose of this study was to investigate the potential benefit of TTVI over medical therapy in a propensity score matched population. Methods: The TriValve (Transcatheter Tricuspid Valve Therapies) registry collected 472 patients from 22 European and North American centers...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
Psychotherapy and psychosomatics,
Volume 89, Issue 1, 25 4 2019, Pages 54-55
Long-Term Outcome of Treatment for Persistent Depressive Disorder: A Naturalistic Follow-Up Study.
Emmelkamp J, Kooistra L, Van Oppen P, Van Schaik D, Hoogendoorn A, Dekker J, Beekman A, McCullough J, Wiersma J
Abstract
Cited 10 times since 2019 (1.7 per year)
source: EuropePMC
European journal of neurology,
Volume 27, Issue 1, 23 4 2019, Pages 196-203
Patient-reported outcomes with subcutaneous immunoglobulin in chronic inflammatory demyelinating polyneuropathy: the PATH study.
Hartung HP, Mallick R, Bril V, Lewis RA, Sobue G, Lawo JP, Mielke O, Durn BL, Cornblath DR, Merkies ISJ, van Schaik IN, PATH study group
Background and purpose: Chronic inflammatory demyelinating polyneuropathy (CIDP) causes weakness which adversely impacts function and quality of life (QOL). CIDP often requires long-term management with intravenous or subcutaneous immunoglobulin. The Polyneuropathy and Treatment with Hizentra® (PATH) study showed that subcutaneous immunoglobulin (SCIG) was efficacious in CIDP maintenance. Here, patient-reported outcomes in patients on SCIG are assessed. Methods: Subjects stabilized on intravenou...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
Biomarkers in medicine,
Volume 13, Issue 13, 23 4 2019, Pages 1081-1091
Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study.
van Paassen J, van Dissel JT, Hiemstra PS, Zwaginga JJ, Cobbaert CM, Juffermans NP, de Wilde RB, Stijnen T, de Jonge E, Klautz RJ, Arbous MS
Aim: Biomarkers of acute respiratory distress syndrome (ARDS) after cardiac-surgery may help risk-stratification and management. Preoperative single-value proADM increases predictive capacity of scoring-system EuroSCORE. To include the impact of surgery, we aim to assess the predictive value of the perioperative proADM-change on development of ARDS in 40 cardiac-surgery patients. Materials & methods: ProADM was measured in nine sequential blood samples. The Berlin definition of ARDS was used...
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
Clinical kidney journal,
Volume 13, Issue 6, 23 4 2019, Pages 1077-1082
Mortality after amputation in dialysis patients is high but not modified by diabetes status.
Schroijen MA, van Diepen M, Hamming JF, Dekker FW, Dekkers OM
Background: Survival among dialysis patients with diabetes mellitus (DM) is inferior to survival of non-diabetic dialysis patients, probably due to the higher prevalence of diabetes-related comorbid conditions. One could hypothesize that these comorbid conditions also contribute to a decreased survival after amputation in diabetic patients compared with non-diabetic patients on dialysis. Methods: Data were collected from the Netherlands Cooperative Study on the Adequacy of Dialysis, a multicentr...
Abstract
Cited 9 times since 2019 (1.5 per year)
source: EuropePMC
Diabetes,
Volume 68, Issue 12, 19 3 2019, Pages 2327-2336
Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study.
Li-Gao R, Carlotti F, de Mutsert R, van Hylckama Vlieg A, de Koning EJP, Jukema JW, Rosendaal FR, Willems van Dijk K, Mook-Kanamori DO
Early-phase insulin secretion is a determinant of postprandial glucose homeostasis. In this study, we aimed to identify novel genetic variants associated with the early-phase insulin response to a liquid mixed meal by a genome-wide association study using a discovery and replication design embedded in the Netherlands Epidemiology of Obesity (NEO) study. The early-phase insulin response was defined as the difference between the natural logarithm-transformed insulin concentrations of the postprand...
Abstract
Cited 5 times since 2019 (0.8 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 12, Issue 11 Pt 1, 18 3 2019, Pages 2266-2267
Absolute Stress Myocardial Blood Flow After Coronary CT Angiography Guides Referral to Invasive Angiography.
Stenström I, Maaniitty T, Uusitalo V, Ukkonen H, Kajander S, Mäki M, Nammas W, Bax JJ, Knuuti J, Saraste A
Abstract
Cited 4 times since 2019 (0.7 per year)
source: EuropePMC
Journal of biological research (Thessalonike, Greece),
Volume 26, 18 3 2019, Pages 8
<i>T</i>-<i>Box20</i> inhibits osteogenic differentiation in adipose-derived human mesenchymal stem cells: the role of <i>T</i>-<i>Box20</i> on osteogenesis.
Mollazadeh S, Fazly Bazzaz BS, Neshati V, de Vries AAF, Naderi-Meshkin H, Mojarad M, Neshati Z, Kerachian MA
Background: Skeletal development and its cellular function are regulated by various transcription factors. The T-box (Tbx) family of transcription factors have critical roles in cellular differentiation as well as heart and limbs organogenesis. These factors possess activator and/or repressor domains to modify the expression of target genes. Despite the obvious effects of Tbx20 on heart development, its impact on bone development is still unknown. Methods: To investigate the consequence by force...
Abstract
Cited 3 times since 2019 (0.5 per year)
source: EuropePMC
Pediatric allergy, immunology, and pulmonology,
Volume 32, Issue 3, 17 3 2019, Pages 121-127
Levels of Soluble Urokinase Plasminogen Activator Receptor in Pediatric Lower Respiratory Tract Infections.
Çitlenbik H, Ulusoy E, Er A, Çağlar A, Akgül F, Küme T, Yılmaz D, Duman M
Background: Lower respiratory tract infections (LTRIs) are the most common cause of pediatric emergency department visits and are associated with significant morbidity and mortality. The aim of this study was to evaluate the soluble urokinase plasminogen activator receptor (suPAR) levels in pediatric patients with LRTIs and to investigate the correlation of suPAR with disease severity. Methods: This is a prospective case-control study of children with LTRIs. Demographic data, diagnoses, vital si...
Abstract
Cited 5 times since 2019 (0.8 per year)
source: EuropePMC
Circulation. Cardiovascular imaging,
Volume 12, Issue 9, 17 3 2019, Pages e008737
Point of Care Clinical Risk Score to Improve the Negative Diagnostic Utility of an Agatston Score of Zero: Averting the Need for Coronary Computed Tomography Angiography.
Alshahrani AM, Mahmood H, Wells GA, Hossain A, Rybicki FJ, Achenbach S, Al-Mallah MH, Andreini D, Bax JJ, Berman DS, Budoff MJ, Cademartiri F, Callister TQ, Chang HJ, Chinnaiyan K, Cury RC, DeLago A, Feuchtner G, Hadamitzky M, Hausleiter J, Kaufmann PA, Kim YJ, Leipsic JA, Maffei E, Marques H, Pontone G, Raff G, Rubinshtein R, Shaw LJ, Villines TC, Lin FY, Min JK, Chow BJ
Background: Coronary artery calcification is a marker of underlying atherosclerotic vascular disease. The absence of coronary artery calcification is associated with a low prevalence of obstructive coronary artery disease (CAD), but it cannot be ruled out completely. We sought to develop a clinical tool that can be added to Agatston score of zero to rule out obstructive CAD with high accuracy. Methods: We developed a clinical score retrospectively from a cohort of 4903 consecutive patients with...
Abstract
Cited 1 times since 2019 (0.2 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 28, Issue 4, 16 3 2019, Pages 1707-1714
Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain.
El Mahdiui M, Smit JM, van Rosendael AR, Jukema JW, Bax JJ, Scholte AJHA
Background: Coronary artery calcium (CAC) score has shown to provide incremental prognostic information when added to the Framingham risk score. Although the relation between CAC and myocardial ischemia has been evaluated, there has been little evaluation of the relationship between CAC score and inducible myocardial ischemia on computed tomography myocardial perfusion (CTP). Methods and results: Patients who were referred with stable chest pain from the outpatient clinic and who underwent non-c...
Abstract
Cited 21 times since 2019 (3.5 per year)
source: EuropePMC
European journal of heart failure,
Volume 21, Issue 11, 16 3 2019, Pages 1426-1433
Safety and efficacy of the partial adenosine A1 receptor agonist neladenoson bialanate in patients with chronic heart failure with reduced ejection fraction: a phase IIb, randomized, double-blind, placebo-controlled trial.
Voors AA, Bax JJ, Hernandez AF, Wirtz AB, Pap AF, Ferreira AC, Senni M, van der Laan M, Butler J, PANTHEON Investigators
Aims: Neladenoson bialanate is a partial adenosine A1 receptor agonist with demonstrated beneficial effects on cardiac function in animal models. We aimed to assess the dose-response effect of neladenoson bialanate on cardiac structure and function, clinical outcome, and safety in patients with heart failure (HF) with reduced ejection fraction (HFrEF). Methods and results: PANTHEON was a dose-finding, phase IIb, randomized, double-blind, placebo-controlled trial conducted in 92 centres in 11 cou...
Abstract
Cited 12 times since 2019 (2 per year)
source: EuropePMC
Journal of patient experience,
Volume 7, Issue 4, 12 2 2019, Pages 600-606
Measurement of Perceived Physician Empathy in Orthopedic Patients.
Keulen MHF, Teunis T, Kortlever JTP, Vagner GA, Ring D, Reichel LM
Background: Empathy is a key component of a therapeutic relationship. Perceived empathy and compassion are associated with patient satisfaction, reduced symptoms, and adherence to treatment. Objective: To assess the advantages and disadvantages of the validated Jefferson Scale of Patient's Perception of Physician Empathy (JSPPPE) and the Consultation and Relational Empathy (CARE) tools. Methods: Eighty-four patients completed the JSPPPE and the CARE measure. With Pearson's correlation...
Abstract
Cited 280 times since 2019 (47.1 per year)
source: EuropePMC
Circulation,
Volume 140, Issue 14, 12 2 2019, Pages 1156-1169
Contemporary Presentation and Management of Valvular Heart Disease: The EURObservational Research Programme Valvular Heart Disease II Survey.
Iung B, Delgado V, Rosenhek R, Price S, Prendergast B, Wendler O, De Bonis M, Tribouilloy C, Evangelista A, Bogachev-Prokophiev A, Apor A, Ince H, Laroche C, Popescu BA, Piérard L, Haude M, Hindricks G, Ruschitzka F, Windecker S, Bax JJ, Maggioni A, Vahanian A, EORP VHD II Investigators
Background: Valvular heart disease (VHD) is an important cause of mortality and morbidity and has been subject to important changes in management. The VHD II survey was designed by the EURObservational Research Programme of the European Society of Cardiology to analyze actual management of VHD and to compare practice with guidelines. Methods: Patients with severe native VHD or previous valvular intervention were enrolled prospectively across 28 countries over a 3-month period in 2017. Indication...
Abstract
Cited 70 times since 2019 (11.8 per year)
source: EuropePMC
Microbial genomics,
Volume 5, Issue 9, 11 2 2019
Loss of microbial diversity and pathogen domination of the gut microbiota in critically ill patients.
Ravi A, Halstead FD, Bamford A, Casey A, Thomson NM, van Schaik W, Snelson C, Goulden R, Foster-Nyarko E, Savva GM, Whitehouse T, Pallen MJ, Oppenheim BA
Among long-stay critically ill patients in the adult intensive care unit (ICU), there are often marked changes in the complexity of the gut microbiota. However, it remains unclear whether such patients might benefit from enhanced surveillance or from interventions targeting the gut microbiota or the pathogens therein. We therefore undertook a prospective observational study of 24 ICU patients, in which serial faecal samples were subjected to shotgun metagenomic sequencing, phylogenetic profiling...
Abstract
Cited 5 times since 2019 (0.8 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 160, Issue 2, 9 2 2019, Pages 371-381.e4
Safety, efficacy, and hemodynamic performance of a stented bovine pericardial aortic valve bioprosthesis: Two-year analysis.
Dagenais F, Moront MG, Brown WM, Reardon MJ, Chu MWA, Gearhart E, Klautz RJM
Objectives: The study objectives were to evaluate the safety, efficacy, and hemodynamic performance of a novel stented bovine pericardial aortic valve bioprosthesis 2 years after implantation. Methods: The PERIcardial SurGical AOrtic Valve ReplacemeNT Pivotal Trial enrolled patients with symptomatic moderate/severe aortic stenosis or regurgitation at centers in Canada, Europe, and the United States. We report the outcomes and hemodynamic performance in patients with up to 2 years of follow-up. R...
Abstract
