Research

Publications

Below you can find a list of our published research.

6730 results

Cited 3 times since 2024 (3.9 per year) source: EuropePMC

Blood, Volume 144, Issue 21, 1 1 2024, Pages 2248-2265 Whole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles. Huffman JE, Nicholas J, Hahn J, Heath AS, Raffield LM, Yanek LR, Brody JA, Thibord F, Almasy L, Bartz TM, Bielak LF, Bowler RP, Carrasquilla GD, Chasman DI, Chen MH, Emmert DB, Ghanbari M, Haessler J, Hottenga JJ, Kleber ME, Le NQ, Lee J, Lewis JP, Li-Gao R, Luan J, Malmberg A, Mangino M, Marioni RE, Martinez-Perez A, Pankratz N, Polasek O, Richmond A, Rodriguez BAT, Rotter JI, Steri M, Suchon P, Trompet S, Weiss S, Zare M, Auer P, Cho MH, Christofidou P, Davies G, de Geus E, Deleuze JF, Delgado GE, Ekunwe L, Faraday N, Gögele M, Greinacher A, Gao H, Howard T, Joshi PK, Kilpeläinen TO, Lahti J, Linneberg A, Naitza S, Noordam R, Paüls-Vergés F, Rich SS, Rosendaal FR, Rudan I, Ryan KA, Souto JC, van Rooij FJA, Wang H, Zhao W, Becker LC, Beswick A, Brown MR, Cade BE, Campbell H, Cho K, Crapo JD, Curran JE, de Maat MPM, Doyle M, Elliott P, Floyd JS, Fuchsberger C, Grarup N, Guo X, Harris SE, Hou L, Kolcic I, Kooperberg C, Menni C, Nauck M, O'Connell JR, Orrù V, Psaty BM, Räikkönen K, Smith JA, Soria JM, Stott DJ,

Abstract: Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared with array-based genotyping, whole-genome sequencing (WGS) data provide better coverage of the genome and better representation of non-European variants. To better understand the genetic landscape regulating plasma fibrinogen levels, we meta-analy... Abstract

Cited 1 times since 2024 (1.3 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 25, Issue 12, 1 1 2024, Pages 1638-1648 Prognostic implications and alterations in left atrial deformation following transcatheter aortic valve implantation. Butcher SC, Hirasawa K, Meucci MC, Stassen J, Kuneman JH, Pereira AR, van der Kley F, de Weger A, van Rosendael PJ, Marsan NA, Playford D, Delgado V, Bax JJ

Aims: To evaluate the prognostic implications of the left atrial reservoir strain-defined diastolic dysfunction (LARS-DD) grade in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) and to determine whether post-TAVI LARS was more closely associated with new-onset atrial fibrillation than pre-TAVI LARS. Methods and results: Pre-TAVI LARS-DD was evaluated by speckle-tracking echocardiography and was assigned as Grade 0 to 1 (LARS ≥24%), Grade 2 (LAR... Abstract

Cited 1 times since 2024 (1.3 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 66, Issue 6, 1 1 2024, Pages ezae440 The effect of virtual reality on postoperative anxiety and pain in patients following cardiac surgery: a randomized controlled trial. El Mathari S, Shehadeh S, Zwaan WP, Boulidam N, Kuitert L, Twisk JWR, Klautz RJM, de Lind van Wijngaarden R, Veen K, Kluin J

Objectives: The VRECOVERY investigated the impact of virtual reality (VR) distraction therapy on postoperative pain, anxiety and quality of recovery in patients undergoing coronary artery bypass grafting surgery. Methods: A single-centre randomized controlled trial was conducted involving 192 participants, allocated to either the intervention or control group. Participants in the intervention group received VR distraction therapy on postoperative days 1, 2 and 3, while the control group received... Abstract

Microorganisms, Volume 12, Issue 11, 31 5 2024, Pages 2216 Evaluation of the Antimicrobial Effects of Olive Mill Wastewater Extract Against Food Spoiling/Poisoning, Fish-Pathogenic and Non-Pathogenic Microorganisms. Yılmaz DK, Kesbiç FI, Çelik EŞ, Odabaşı DA, Yilmaz S, Abdel-Latif HMR

Although antibiotics are the main therapy for bacterial infections, the reports showed that the overuse (or misuse) of antibiotics will results in several problems such as the development of antibiotic-resistant strains, persistence of drug residues, and numerous environmental concerns. Therefore, finding antibiotic alternatives is considered of vital importance. Investigation of the antimicrobial properties of several plant substances and extracts is of great value to replace antibiotics. With... Abstract

Journal of cell science, Volume 137, Issue 20, 31 5 2024, Pages jcs262041 Cell-cell junctions in focus - imaging junctional architectures and dynamics at high resolution. Janssen V, Huveneers S

Studies utilizing electron microscopy and live fluorescence microscopy have significantly enhanced our understanding of the molecular mechanisms that regulate junctional dynamics during homeostasis, development and disease. To fully grasp the enormous complexity of cell-cell adhesions, it is crucial to study the nanoscale architectures of tight junctions, adherens junctions and desmosomes. It is important to integrate these junctional architectures with the membrane morphology and cellular topog... Abstract

Cited 3 times since 2024 (3.9 per year) source: EuropePMC

Journal of clinical medicine, Volume 13, Issue 21, 31 5 2024, Pages 6567 Evaluating Virtual Reality Patient Education in Cardiac Surgery: Impact on Preoperative Anxiety and Postoperative Patient Satisfaction. El Mathari S, Kuitert L, Boulidam N, Shehadeh S, Klautz RJM, de Lind van Wijngaarden R, Kluin J

Background/Objectives: Preoperative anxiety in cardiac surgery patients can adversely affect mental well-being and postoperative outcomes. Virtual reality (VR) patient education has been proposed as a novel method to enhance patient education and potentially reduce preoperative anxiety. The VR Patient Journey Trial aimed to evaluate the impact of VR patient education on preoperative anxiety and patient satisfaction compared to traditional education methods. Methods: This randomized controlled tr... Abstract

Cited 3 times since 2024 (3.8 per year) source: EuropePMC

JACC. Basic to translational science, Volume 10, Issue 3, 30 5 2024, Pages 383-395 EPA Induces an Anti-Inflammatory Transcriptome in T Cells, Implicating a Triglyceride-Independent Pathway in Cardiovascular Risk Reduction. Reilly NA, Dekkers KF, Molenaar J, Arumugam S, Kuipers TB, Ariyurek Y, Hoeksema MA, Jukema JW, Heijmans BT

Twice-daily intake of purified eicosapentaenoic acid (EPA) reduces atherosclerotic cardiovascular disease risk in patients with high triglycerides, but its exact mechanism remains unclear. We exposed non-activated CD4+ T cells to 100μM EPA, oleic acid, palmitic acid, or control, and conducted RNA and ATAC-sequencing after 48 hours. EPA exposure downregulated immune response-related genes like HLA-DRA, CD69, and IL2RA, and upregulated oxidative stress prevention genes like NQO1. Transcription fac... Abstract

Scientific reports, Volume 14, Issue 1, 29 5 2024, Pages 26018 Accessible viral metagenomics for public health and clinical domains with Jovian. Schmitz D, Zwagemaker F, Nooij S, Janssens TKS, Cremer J, Verhagen R, Vennema H, Kroneman A, Koopmans MPG, Laros JFJ, de Graaf M

The integration of next-generation sequencing into clinical diagnostics and surveillance initiatives is impeded by the lack of data analysis pipelines that align with privacy legislation and laboratory certification protocols. To address these challenges, we developed Jovian, an open-source, virus-focused, metagenomic analysis workflow for Illumina data. Jovian generates scaffolds enriched with pertinent annotations, including taxonomic classification, combined with metrics needed for quality as... Abstract

Cited 14 times since 2024 (17.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 85, Issue 9, 28 4 2024, Pages 878-890 Transcatheter Aortic Valve Replacement in Patients With Systolic Heart Failure and Moderate Aortic Stenosis: TAVR UNLOAD. Van Mieghem NM, Elmariah S, Spitzer E, Pibarot P, Nazif TM, Bax JJ, Hahn RT, Popma A, Ben-Yehuda O, Kallel F, Redfors B, Chuang ML, Alu MC, Lindeboom W, Kolte D, Zahr FE, Kodali SK, Strote JA, Hermanides RS, Cohen DJ, Tijssen JGP, Leon MB

Background: Neurohormonal modulation and afterload reduction are key for treatment of heart failure with reduced ejection fraction (HFrEF). In HFrEF patients with concomitant moderate aortic stenosis (AS), treatment with transcatheter aortic valve replacement (TAVR) may be complementary to guideline-directed medical therapy (GDMT). Objectives: This study sought to determine whether TAVR for moderate AS provides clinical benefit in patients with HFrEF on top of GDMT. Methods: We performed an inve... Abstract

Translational lung cancer research, Volume 13, Issue 10, 28 4 2024, Pages 2813-2827 What do we know about the role of neoadjuvant targeted therapy in early-stage EGFR-mutant and ALK-fused non-small cell lung cancer?-a narrative review of the current literature. Kemper M, Elges S, Kies P, Wiebe K, Lenz G, Bleckmann A, Evers G

Background and objective: The standard first-line treatment for patients with advanced non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) fusions is targeted therapy using tyrosine kinase inhibitors (TKIs). However, data are still lacking on the use of TKIs as a neoadjuvant or induction approach. Therefore, this narrative review aims to summarize the current knowledge on resectable EGFR-mutant and ALK-fused NSCLC re... Abstract

Bladder cancer (Amsterdam, Netherlands), Volume 10, Issue 3, 23 4 2024, Pages 215-220 Lifestyle Advice to Patients with Bladder Cancer: A National Survey of Dutch Urologists. Beeren I, Koops C, van der Heijden AG, Aben KKH, Kiemeney LALM, Witjes JA, Vrieling A

Background: Not much is known about the extent to which urologists discuss lifestyle with patients with bladder cancer (BC), despite patients considering urologists as an important source of information and motivation. Objective: To determine how often lifestyle is asked about, advised on, and referred for by Dutch urologists to patients with BC, as well as to evaluate urologists' perceptions and barriers. Methods: An anonymous online survey was sent to Dutch urologists. The survey included... Abstract

Cited 4 times since 2024 (5 per year) source: EuropePMC

GeroScience, Volume 47, Issue 2, 22 4 2024, Pages 2035-2045 Increased 1H-NMR metabolomics-based health score associates with declined cognitive performance and functional independence in older adults at risk of cardiovascular disease. Zonneveld MH, Al Kuhaili N, Mooijaart SP, Slagboom PE, Jukema JW, Noordam R, Trompet S

The 1-HMR metabolomics-based MetaboHealth score, comprised of 14 serum metabolic markers, associates with disease-specific mortality, but it is unclear whether the score also reflects cognitive changes and functional impairment. We aimed to assess the associations between the MetaboHealth score with cognitive function and functional decline in older adults at increased cardiovascular risk. A total of 5292 older adults free of dementia at baseline with mean age 75.3 years (SD = 3.4) from the Pros... Abstract

British journal of pharmacology, 17 3 2024 Site-specific m6A-miR-494-3p, not unmethylated miR-494-3p, compromises blood brain barrier by targeting tight junction protein 1 in intracranial atherosclerosis. Woudenberg T, van der Bent ML, Kremer V, Waas ISE, Daemen MJAP, Boon RA, Quax PHA, Nossent AY

Background and purpose: Intracranial atherosclerosis is one of the most common causes of ischaemic stroke. However, there is a substantial knowledge gap on the development of intracranial atherosclerosis. Intracranial arteries are characterized by an upregulation of tight junctions between endothelial cells, which control endothelial permeability. We investigated the role of N6-methyladenosine (m6A), a common RNA modification, on endothelial integrity, focusing on the pro-atherogenic microRNA mi... Abstract

Nature communications, Volume 15, Issue 1, 17 3 2024, Pages 8953 Author Correction: Time-series sewage metagenomics distinguishes seasonal, human-derived and environmental microbial communities potentially allowing source-attributed surveillance. Becsei Á, Fuschi A, Otani S, Kant R, Weinstein I, Alba P, Stéger J, Visontai D, Brinch C, de Graaf M, Schapendonk CME, Battisti A, De Cesare A, Oliveri C, Troja F, Sironen T, Vapalahti O, Pasquali F, Bányai K, Makó M, Pollner P, Merlotti A, Koopmans M, Csabai I, Remondini D, Aarestrup FM, Munk P

Abstract

Cureus, Volume 16, Issue 10, 15 3 2024, Pages e71545 Should Gallbladder Pathologies Be Investigated in Patients With Colon Polyps? Turhan N, Ertorul D, Duran C, Kılıç MG, Kuzan TY, Yaşar S, Yılmaz D, Zarbaliyev E

Background Data regarding the frequency of development of gallbladder pathologies in patients with colon polyps are quite limited and heterogeneous. Hence, this study aimed to investigate whether colon polyps cause an increased risk of developing gallbladder pathologies and the necessity of ultrasonographic screening. Methodology This retrospective, cross-sectional study was conducted among adult patients who underwent a colonoscopy and hepatobiliary ultrasound as part of their health check-up f... Abstract

The Journal of antibiotics, Volume 78, Issue 1, 15 3 2024, Pages 54-63 Exploration of vanoxerine analogues as antibacterial agents. Kingdon ADH, Adcock HV, Kasimati EM, Craven P, van Schaik W, Cox LR, Besra GS

Mycobacterium tuberculosis is a bacterial pathogen, responsible for approximately 1.3 million deaths in 2022 through tuberculosis infections. The complex treatment regimen required to treat tuberculosis and growing rates of drug resistance, necessitates the development of new anti-mycobacterial agents. One approach is to repurpose drugs from other clinical applications. Vanoxerine (GBR 12909) was previously shown to have anti-mycobacterial activity, through dissipating the membrane electric pote... Abstract

Placenta, Volume 158, 15 3 2024, Pages 105-112 First-trimester maternal tryptophan metabolites, utero-placental (vascular)development and hypertensive disorders of pregnancy: The Rotterdam periconceptional cohort. van Zundert SKM, Broekhuizen M, Mirzaian M, van Rossem L, Danser AHJ, Willemsen SP, Griffioen PH, Koning AHJ, Mulders AGMGJ, van Schaik RHN, Steegers-Theunissen RPM

Background: Hypertensive disorders of pregnancy (HDP) are a significant cause of maternal and perinatal mortality and morbidity. Knowledge on the placenta-related pathophysiology of HDP is increasing. Since maternal tryptophan metabolites are involved in placentation, we investigated associations between first-trimester tryptophan metabolites and utero-placental (vascular) development, and the occurrence of HDP. Methods: 911 women were included from a prospective tertiary hospital cohort. Serum... Abstract

Cited 1 times since 2024 (1.2 per year) source: EuropePMC

JACC. Advances, Volume 3, Issue 11, 14 2 2024, Pages 101327 30 Years' Experience in Percutaneous Pulmonary Artery Interventions in Transposition of the Great Arteries. Joosen RS, van der Palen RLF, Udink Ten Cate FEA, Voskuil M, Krings GJ, Bökenkamp R, Molenschot MC, Hahurij ND, Dickinson MG, Hazekamp MG, Schoof PH, Slieker MG, Straver B, Blom NA, Breur JMPJ

Background: Pulmonary artery (PA) stenosis is common after arterial switch operation (ASO) for transposition of the great arteries (TGA). Differences between balloon angioplasty (BA) and stents on right ventricular (RV) and PA pressures are not well studied. Objectives: The purpose of this study was to analyze percutaneous PA interventions' frequency after ASO, complications, and the effects of BA and stents on RV and PA pressures. Methods: All TGA patients with ASO between 1977 and 2022 in... Abstract

Cited 3 times since 2024 (3.6 per year) source: EuropePMC

European journal of clinical investigation, Volume 54, Issue 12, 13 2 2024, Pages e14317 Cardiac troponin elevation and mortality in takotsubo syndrome: New insights from the international takotsubo registry. Stähli BE, Schindler M, Schweiger V, Cammann VL, Szawan KA, Niederseer D, Würdinger M, Schönberger A, Schönberger M, Koleva I, Mercier JC, Petkova V, Mayer S, Citro R, Vecchione C, Bossone E, Gili S, Neuhaus M, Franke J, Meder B, Jaguszewski M, Noutsias M, Knorr M, Jansen T, D'Ascenzo F, Dichtl W, von Lewinski D, Burgdorf C, Kherad B, Tschöpe C, Sarcon A, Shinbane J, Rajan L, Michels G, Pfister R, Cuneo A, Jacobshagen C, Karakas M, Koenig W, Pott A, Meyer P, Roffi M, Banning A, Wolfrum M, Cuculi F, Kobza R, Fischer TA, Vasankari T, Airaksinen KEJ, Napp LC, Dworakowski R, MacCarthy P, Kaiser C, Osswald S, Galiuto L, Chan C, Bridgman P, Beug D, Delmas C, Lairez O, Gilyarova E, Shilova A, Gilyarov M, El-Battrawy I, Akin I, Poledniková K, Toušek P, Winchester DE, Massoomi M, Galuszka J, Ukena C, Poglajen G, Carrilho-Ferreira P, Hauck C, Paolini C, Bilato C, Kobayashi Y, Kato K, Ishibashi I, Himi T, Din J, Al-Shammari A, Prasad A, Rihal CS, Liu K, Schulze PC, Bianco M, Jörg L, Rickli H, Pestana G, Nguyen TH, Böhm

Background: The clinical relevance of cardiac troponin (cTn) elevation in takotsubo syndrome (TTS) remains uncertain. The present study sought to investigate the role of cardiac troponin (cTn) elevations in mortality prediction of patients with Takotsubo syndrome (TTS). Methods: Patients enrolled in the International Takotsubo (InterTAK) Registry from January 2011 to February 2020 with available data on peak cTn levels were included in the analysis. Peak cTn levels during the index hospitalizati... Abstract

Cited 3 times since 2024 (3.6 per year) source: EuropePMC

Advances in simulation (London, England), Volume 9, Issue 1, 12 2 2024, Pages 43 Changing the conversation: impact of guidelines designed to optimize interprofessional facilitation of simulation-based team training. Ju M, Bochatay N, Werne A, Essakow J, Tsang L, Nottingham M, Franzon D, Lyndon A, van Schaik S

Background: Interprofessional simulation-based team training (ISBTT) is commonly used to optimize interprofessional teamwork in healthcare. The literature documents the benefits of ISBTT, yet effective interprofessional collaboration continues to be challenged by complex hierarchies and power dynamics. Explicitly addressing these issues during ISBTT may help participants acquire skills to navigate such challenges, but guidelines on how to do this are limited. Methods: We applied an educational d... Abstract