9020 results
Cited 90 times since 2011 (6.3 per year)
source: EuropePMC
Gut,
Volume 61, Issue 2, 20 3 2011, Pages 235-240
Thiopurines prevent advanced colorectal neoplasia in patients with inflammatory bowel disease.
van Schaik FD, van Oijen MG, Smeets HM, van der Heijden GJ, Siersema PD, Oldenburg B
Background and aims: Previous studies have suggested a chemopreventive effect of 5-aminosalicylic acid (5-ASA) therapy in patients with inflammatory bowel disease (IBD). This effect has not been reported in IBD patients using thiopurines. We investigated the association between thiopurine or 5-ASA use and the risk of advanced neoplasia (AN), including high-grade dysplasia and colorectal cancer, in a large cohort of patients with IBD in the Netherlands. Methods: PALGA, the nationwide network and...
Abstract
The international journal of cardiovascular imaging,
Volume 28, Issue 3, 19 3 2011, Pages 563-565
Does heart rate influence CMR image quality of the coronary vessel wall?
van der Wall EE, Kröner EJ, Siebelink HM, Scholte AJ, Schalij MJ
Abstract
Cited 10 times since 2011 (0.7 per year)
source: EuropePMC
PloS one,
Volume 6, Issue 5, 16 3 2011, Pages e18609
The dyad symmetry element of Epstein-Barr virus is a dominant but dispensable replication origin.
Ott E, Norio P, Ritzi M, Schildkraut C, Schepers A
OriP, the latent origin of Epstein-Barr virus (EBV), consists of two essential elements: the dyad symmetry (DS) and the family of repeats (FR). The function of these elements has been predominantly analyzed in plasmids transfected into transformed cells. Here, we examined the molecular functions of DS in its native genomic context and at an ectopic position in the mini-EBV episome. Mini-EBV plasmids contain 41% of the EBV genome including all information required for the proliferation of human B...
Abstract
Cited 13 times since 2011 (0.9 per year)
source: EuropePMC
Drug discovery today,
Volume 16, Issue 13-14, 13 2 2011, Pages 555-568
A molecular informatics view on best practice in multi-parameter compound optimization.
Lusher SJ, McGuire R, Azevedo R, Boiten JW, van Schaik RC, de Vlieg J
The difference between biologically active molecules and drugs is that the latter balance an array of related and unrelated properties required for administration to patients. Inevitability, during optimization, some of these multiple factors will conflict. Although informatics has a crucial role in addressing the challenges of modern compound optimization, it is arguably still undervalued and underutilized. We present here some of the basic requirements of multi-parameter drug design, the cruci...
Abstract
Cited 5 times since 2011 (0.4 per year)
source: EuropePMC
Current medical research and opinion,
Volume 27, Issue 7, 12 2 2011, Pages 1347-1357
How to reduce the incidence of contrast induced acute kidney injury after cardiac invasive procedures, a review and practical recommendations.
de Bie MK, van Rees JB, Herzog CA, Rabelink TJ, Schalij MJ, Jukema JW
Background: Contrast induced acute kidney injury is an important complication after cardiac (invasive) procedures and is associated with substantial morbidity and mortality. The aim of the current article is to provide a comprehensive overview of the current knowledge regarding contrast induced acute kidney injury. Methods: Current literature was reviewed and relevant articles were selected. Articles were identified through MEDLINE and Pubmed selecting articles, limited between 1980 and 2010. Re...
Abstract
Cited 78 times since 2011 (5.5 per year)
source: EuropePMC
Cytometry. Part B, Clinical cytometry,
Volume 80, Issue 5, 12 2 2011, Pages 271-281
Flow cytometric characterization of cerebrospinal fluid cells.
de Graaf MT, de Jongste AH, Kraan J, Boonstra JG, Sillevis Smitt PA, Gratama JW
Flow cytometry facilitates the detection of a large spectrum of cellular characteristics on a per cell basis, determination of absolute cell numbers and detection of rare events with high sensitivity and specificity. White blood cell (WBC) counts in cerebrospinal fluid (CSF) are important for the diagnosis of many neurological disorders. WBC counting and differential can be performed by microscopy, hematology analyzers, or flow cytometry. Flow cytometry of CSF is increasingly being considered as...
Abstract
Cited 11 times since 2011 (0.8 per year)
source: EuropePMC
Journal of clinical pharmacology,
Volume 52, Issue 5, 12 2 2011, Pages 704-716
Integration of pharmacogenetics and pharmacogenomics in drug development: implications for regulatory and medical decision making in pediatric diseases.
Piana C, Surh L, Furst-Recktenwald S, Iolascon A, Jacqz-Aigrain EM, Jonker I, Russo R, van Schaik RH, Wessels J, Della Pasqua OE
This article aims to provide an overview of the current situation regarding pharmacogenetic and pharmacogenomic (PG) studies in pediatrics, with a special focus on the role of PG data in the regulatory decision-making process. Despite the gap in pharmacogenetic research due to the lack of translational studies in adults and children, several technologies exist in drug development and biomarkers validation, which could supply valuable information concerning labeling and dosing recommendations. If...
Abstract
Cited 3 times since 2011 (0.2 per year)
source: EuropePMC
The Cochrane database of systematic reviews,
Issue 5, 11 2 2011, Pages CD008128
Treatment of valvular heart disease during pregnancy for improving maternal and neonatal outcome.
Henriquez DD, Roos-Hesselink JW, Schalij MJ, Klautz RJ, Helmerhorst FM, de Groot CJ
Background: Valvular heart disease constitutes the majority of all causes of heart disease in pregnancy. In the presence of valvular heart disease, the necessary haemodynamic changes of pregnancy might cause heart failure, leading to severe maternal and fetal morbidity and even mortality. Treatment of valvular heart disease is indicated when patients experience a deterioration of symptoms and in case of a severe valvular lesion. Whether medical therapy or interventional therapy is the optimal tr...
Abstract
Cited 11 times since 2011 (0.8 per year)
source: EuropePMC
Circulation. Arrhythmia and electrophysiology,
Volume 4, Issue 4, 11 2 2011, Pages 486-493
ECG identification of scar-related ventricular tachycardia with a left bundle-branch block configuration.
Wijnmaalen AP, Stevenson WG, Schalij MJ, Field ME, Stephenson K, Tedrow UB, Koplan BA, Putter H, Epstein LM, Zeppenfeld K
Background: A left bundle-branch block (LBBB)-like pattern with a dominant S-wave in V(1) is common in idiopathic ventricular arrhythmias (VA). Discrimination between idiopathic and scar-related LBBB pattern VA has important clinical implications. We hypothesized that the VA QRS morphology is influenced by the presence of ventricular scar, allowing ECG discrimination of VA arising from structurally normal versus scarred myocardium. Methods and results: Twelve-lead ECGs of 297 LBBB pattern monomo...
Abstract
Cited 18 times since 2011 (1.3 per year)
source: EuropePMC
American heart journal,
Volume 161, Issue 6, 11 2 2011, Pages 1060-1066
Site of latest activation in patients eligible for cardiac resynchronization therapy: patterns of dyssynchrony among different QRS configurations and impact of heart failure etiology.
van Bommel RJ, Ypenburg C, Mollema SA, Borleffs CJ, Delgado V, Bertini M, Marsan NA, van der Wall EE, Schalij MJ, Bax JJ
Introduction: Cardiac resynchronization therapy (CRT) has emerged as a treatment option for patients with end-stage heart failure and a QRS duration ≥120 ms. Nonetheless, many patients with a prolonged QRS do not demonstrate left ventricular (LV) mechanical dyssynchrony, and discrepancies between electrical and mechanical dyssynchrony have been observed. In addition, several studies demonstrated that superior benefits after CRT could be achieved when the LV pacing lead was positioned at the most...
Abstract
Cited 114 times since 2011 (8 per year)
source: EuropePMC
Water research,
Volume 45, Issue 14, 10 2 2011, Pages 4081-4091
Detection of the human specific Bacteroides genetic marker provides evidence of widespread sewage contamination of stormwater in the urban environment.
Sauer EP, Vandewalle JL, Bootsma MJ, McLellan SL
Human sewage contamination of surface waters is a major human health concern. We found urban stormwater systems that collect and convey runoff from impervious surfaces act as a conduit for sewage originating from breeches in sanitary sewer infrastructure. A total of 828 samples at 45 stormwater outfalls were collected over a four-year period and assessed by culture based methods, PCR, and quantitative PCR (qPCR) to test for traditional and alternative indicators of fecal pollution. All outfalls...
Abstract
Cited 34 times since 2011 (2.4 per year)
source: EuropePMC
The American journal of cardiology,
Volume 108, Issue 3, 6 1 2011, Pages 435-439
Usefulness of exercise-induced hypertension as predictor of chronic hypertension in adults after operative therapy for aortic isthmic coarctation in childhood.
Luijendijk P, Bouma BJ, Vriend JW, Vliegen HW, Groenink M, Mulder BJ
Chronic hypertension is a major concern in adults who have undergone resection of coarctation of the aorta (CoA) in childhood. In otherwise healthy subjects, exercise-induced hypertension is prognostic for chronic hypertension; however, the prognostic value in patients with CoA remains unknown. The aim of the present study was to evaluate the predictive value of exercise-induced hypertension for chronic hypertension in these patients. In the present prospective follow-up study, 74 patients with...
Abstract
Cited 18 times since 2011 (1.3 per year)
source: EuropePMC
Congenital heart disease,
Volume 6, Issue 3, 5 1 2011, Pages 219-227
The perspective of patients with congenital heart disease: does health care meet their needs?
Schoormans D, Sprangers MA, Pieper PG, van Melle JP, van Dijk AP, Sieswerda GT, Hulsbergen-Zwarts MS, Plokker TH, Brunninkhuis LG, Vliegen HW, Mulder BJ
Objective: A first step in the delivery of tailored care is answering the following question: does health care meet the needs of patients? Therefore patients' perspective on health care use and their needs was examined. The design used was cross-sectional questionnaire study. Patients: A total of 1109 adult congenital heart defect (CHD) patients attending one of eight Dutch hospitals were randomly selected from a national database (10% of all registered patients). Main outcome measures: Pat...
Abstract
Cited 1 times since 2011 (0.1 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 18, Issue 3, 1 1 2011, Pages 393-395
Cardiac risk assessment in asymptomatic diabetes: combining [corrected] different imaging modalities and surrogate markers?
Scholte AJ
Abstract
Cited 12 times since 2011 (0.8 per year)
source: EuropePMC
Mycoses,
Volume 54, Issue 3, 1 1 2011, Pages 234-242
A rescue therapy with a combination of caspofungin and liposomal amphotericin B or voriconazole in children with haematological malignancy and refractory invasive fungal infections.
Yilmaz D, Balkan C, Ay Y, Akin M, Karapinar B, Kavakli K
Combination treatment of paediatric invasive fungal infections (IFIs) has rarely been reported. A total of 17 children with 19 IFI episodes were enrolled in the study. The median age of the patients was 5.3 (range 0.5-17) years. IFI was classified as proven in 4, probable in 12 and possible in 3 episodes. These patients received empiric antifungal treatment, which consisted of liposomal amphotericin B (LAmB) monotherapy for a median duration of 12 days (range 3-69 days). All patients were refrac...
Abstract
Cited 25 times since 2011 (1.8 per year)
source: EuropePMC
The Journal of the Acoustical Society of America,
Volume 129, Issue 5, 1 1 2011, Pages EL210-15
Localization in speech mixtures by listeners with hearing loss.
Best V, Carlile S, Kopco N, van Schaik A
The ability of listeners with bilateral sensorineural hearing loss to localize a speech source in a multitalker mixture was measured. Five simultaneous words spoken by different talkers were presented over loudspeakers in a small room, and listeners localized one target word. Errors were significantly larger in this group compared to a control group with normal hearing. Localization of the target presented alone was not different between groups. The results suggest that hearing loss does not imp...
Abstract
Cited 50 times since 2011 (3.5 per year)
source: EuropePMC
Journal of neuropathology and experimental neurology,
Volume 70, Issue 5, 1 1 2011, Pages 386-398
Myelin and axon pathology in a long-term study of PMP22-overexpressing mice.
Verhamme C, King RH, ten Asbroek AL, Muddle JR, Nourallah M, Wolterman R, Baas F, van Schaik IN
We analyzed clinical and pathological disease in 2 peripheral myelin protein-22 (PMP22) overexpressing mouse models for 1.5 years. C22 mice have 7 and C3-PMP mice have 3 to 4 copies of the human PMP22 gene. C3-PMP mice showed no overt clinical signs at 3 weeks and developed mild neuromuscular impairment; C22 mice showed signs at 3 weeks that progressed to severe impairment. Adult C3-PMP mice had very similar, stable, low nerve conduction velocities similar to adults with human Charcot-Marie-Toot...
Abstract
Cited 45 times since 2011 (3.2 per year)
source: EuropePMC
Arthritis and rheumatism,
Volume 63, Issue 5, 1 1 2011, Pages 1265-1273
Identification of CXCL13 as a marker for rheumatoid arthritis outcome using an in silico model of the rheumatic joint.
Meeuwisse CM, van der Linden MP, Rullmann TA, Allaart CF, Nelissen R, Huizinga TW, Garritsen A, Toes RE, van Schaik R, van der Helm-van Mil AH
Objective: Rheumatoid arthritis (RA) is characterized by inflammation and joint destruction, with the degree of damage varying greatly among patients. Prediction of disease severity using known clinical and serologic risk factors is inaccurate. This study was undertaken to identify new serologic markers for RA severity using an in silico model of the rheumatic joint. Methods: An in silico model of a prototypical rheumatic joint was used to predict candidate markers associated with erosiveness. T...
Abstract
Cited 6 times since 2011 (0.4 per year)
source: EuropePMC
Pharmacogenomics,
Volume 12, Issue 5, 1 1 2011, Pages 597-610
Pharmacogenomics and personalized medicine in clinical practice.
Manolopoulos VG, Dechairo B, Huriez A, Kühn A, Llerena A, Llerena A, van Schaik RH, Yeo KT, Ragia G, Siest G
The Santorini Conference on prospective biology, genomics and pharmacogenomics occurs every 2 years. On 30 September to 2nd October 2010, the fifth meeting in this series took place in Santorini, Greece. This conference has established a tradition of organizing a workshop each time to address the most recent developments and key issues in pharmacogenomics. This year, the workshop was chaired by Bryan Dechairo and Alain Huriez, and was titled 'Pharmacogenomics and personalized medicine in cl...
Abstract
Cited 12 times since 2011 (0.8 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 13 Suppl 2, 1 1 2011, Pages ii32-8
Cardiac resynchronization therapy: a cost or an investment?
Boriani G, Mantovani LG, Biffi M, Schalij MJ, Martignani C, Leclercq C, Bax JJ, Auricchio A
Cost-effectiveness estimates can help optimize use of available financial resources and this is especially relevant for implementation of cardiac resynchronization therapy (CRT), given the high upfront costs and the timescale of expected benefits. All available cost-effectiveness estimates for devices with (CRT-P) or without (CRT-D) a defibrillator are based on results of randomized trials of selected patients, with a relatively brief follow-up. Extrapolation suggests that the cost effectiveness...
Abstract
