Research

Publications

Below you can find a list of our published research.

8892 results

PLoS pathogens, Volume 21, Issue 9, 26 4 2025, Pages e1013535 Defined roles for the Staphylococcus aureus POT transporter DtpT in di/tripeptide uptake and glutathione utilisation inside human macrophages. Khan I, MacDonald SJ, Markússon S, Kies PJ, Kraemer-Zimpel C, Robson C, Parker JL, Newstead S, Boucher D, Hammer ND, Van Der Woude M, Thomas GH

Peptides available in biological niches inhabited by the human pathogen Staphylococcus aureus serve as a rich source of amino acids required for growth and successful host colonisation. Uptake of peptides by S. aureus involves at least two transport systems: the di/tripeptide permease DtpT and the oligopeptide ABC transporter Opp3. Here we study the individual and combined functions of DtpT and Opp3 in enabling utilisation of diverse di-/tripeptides via a high-throughput phenotypic screen. We re... Abstract

Arteriosclerosis, thrombosis, and vascular biology, 25 4 2025 Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Reijnders E, Bossuyt P, Jukema JW, Ruhaak LR, Romijn F, Szarek M, Trompet S, Bhatt D, Bittner V, Diaz R, Fazio S, Stevanovic I, Goodman S, Harrington R, White H, Steg PG, Schwartz G, Cobbaert C

Background: Residual cardiovascular risk remains, despite achieving low-density lipoprotein cholesterol targets with high-intensity statins. Traditional risk scores are suboptimal. This study evaluated the prognostic utility of a 9-plex apolipoprotein panel in recent patients with acute coronary syndrome on statins and its role in predicting treatment benefit by alirocumab, a PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor, enabling precision medicine. Methods: Baseline serum sam... Abstract

Allergy, 24 4 2025 Biologics to Treat Atopic Dermatitis: Effectiveness, Safety, and Future Directions. de Bruin-Weller MS, Boesjes CM, Achten RA, Beck LA, Irvine AD, Vestergaard C, de Graaf M, van Wijk F, Bakker DS, Weidinger S

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. The clinical presentation of AD is heterogeneous and is characterized by a relapsing and remitting course. Most patients suffer from mild AD while approximately 5% to 20% experience severe disease activity, which often requires systemic treatment. Before 2017, systemic treatment options were limited to broad immunosuppressants, which often had significant toxicity and limited effectiveness. Advances in... Abstract

Journal of vascular surgery, 24 4 2025, Pages S0741-5214(25)01771-9 Five-year outcomes of the ICEBERG study, an international, prospective, multicenter registry on the GORE® EXCLUDER® Iliac Branch Endoprosthesis for aorto-iliac aneurysms. van der Veen D, Holewijn S, Bellosta R, Attisani L, van Sterkenburg SMM, Heyligers JMM, Ficarelli I, Gómez Palonés FJ, Mangialardi N, Mosquera NJ, Holden A, Reijnen MMPJ, IceBERG Study collaboration

Objective: This study aims to provide insight in the long-term outcomes of patients treated with the Gore Excluder Iliac Branch Endoprosthesis (IBE) for aneurysms involving the common iliac artery. Both technical, clinical, and patient reported outcomes were evaluated. Methods: This is an investigator initiated, international, real world post-market, multicenter, prospective cohort study, enrolling patients with an indication for elective treatment of an (aorto)iliac aneurysm using the Gore Excl... Abstract

BMJ open, Volume 15, Issue 9, 23 4 2025, Pages e097306 Comparison of cardiovascular risk profiles of patients with type A aortic dissection and thoracic aortic aneurysm: a retrospective multicentre study. Tirpan AU, Dolmaci OB, Jansen EK, Twisk JWR, Klautz RJM, Grewal N

Objective: A thoracic aortic aneurysm (TAA) is often considered a precursor to an acute type A aortic dissection (ATAAD), a life-threatening condition requiring immediate surgical intervention. While both conditions share histopathological similarities, less is known about their overlap in clinical cardiovascular risk factors. This study aimed to map the cardiovascular disease burden in patients with ATAAD and compare it with patients with TAA. Design: A multicentre retrospective study. Setting:... Abstract

Clinical oral investigations, Volume 29, Issue 10, 20 3 2025, Pages 468 The effect of dry mouth on the pressure/pain sensitivity of the oral mucosa of patients using mandibular implant-supported overdenture prosthesis. Eraslan R, Kılıç D, Bayyıldız S, Yılmaz DD, Sert H

Abstract

The Journal of cardiovascular surgery, 19 3 2025 Contemporary randomized controlled trials in uncomplicated type B aortic dissection: a comparative methodological analysis. Rahman T, Bicknell CD, Mussa FF, Björkman P, SUNDAY Investigators, EARNEST Investigators

The management of uncomplicated type B aortic dissection (uTBAD) remains a subject of ongoing debate. While best medical therapy (BMT) has been the conventional approach, thoracic endovascular aortic repair (TEVAR) has been proposed as an alternative due to its potential to promote aortic remodeling and reduce long-term complications. However, conflicting evidence regarding its survival benefits, procedural risks, and long-term durability has limited its widespread adoption. Three contemporary r... Abstract

Epidemiology and infection, Volume 153, 19 3 2025, Pages e115 Phylodynamic inference suggests introductions as main driver of Mpox Clade II outbreak in 2022 in Slovenia. Van der Roest B, Fischer EAJ, Klinkenberg D, Bootsma MCJ, Maticic M, Resman-Rus K, Korva M, Avsic-Zupanc T, Kretzschmar M

In 2022, an Mpox clade II outbreak affected many countries. To optimize control, knowledge on the number of new introductions (human cases infected from outside the study population) versus local transmission is important. We extracted sequences of all 48 Mpox cases in Slovenia in 2022 from the NCBI database, of which 42 passed quality control. We estimated the number of introductions using the phylodynamic model phybreak by integrating genomic and epidemiological data and inferred transmission... Abstract

Journal of neurological surgery. Part A, Central European neurosurgery, 19 3 2025 Duraplasty with Autologous Blood: A Cost-Effective and Efficient Alternative to Medical Products. Haciyakupoglu E, Yüvrük E, Yilmaz DM, Polat S, Haciyakupoglu S

Objective The aim of this experimental study was to investigate the effects of autologous plasma used as an alternative to duraplasty Materials and Methods We operated 21 patients and 8 New Zealand Rabbits and performed duraplasty with autologous blood. First heparin was added to autologous blood withdrawn from the patient/ rabbit, The sample was then centrifuged to obtain plasma. protamine sulfate was added to the plasma This mixture was then applied to the dural space and tumor cavity, resulti... Abstract

Scientific reports, Volume 15, Issue 1, 19 3 2025, Pages 32618 (Cardiac) complexity needs interaction. De Coster T

The heart exemplifies a complex system where electrical, mechanical, and biochemical processes interact dynamically. Understanding cardiac complexity requires exploring these interactions across multiple levels, from cellular dynamics to organ-wide behavior. This collection examines key interactions in cardiology, including excitation-contraction coupling, arrhythmia quantification, electromechanical modeling, and imaging advances. By integrating mathematical, computational, and clinical perspec... Abstract

NeuroImage. Clinical, Volume 48, 19 3 2025, Pages 103881 Brain age gap reduction following exercise mirrors clinical improvements in schizophrenia spectrum disorders. Yilmaz D, Papiol S, Keeser D, Cole JH, Malchow B, Walter H, Meyer-Lindenberg A, Hirjak D, Schmitt A, Falkai P, Maurus I, Roell L

Schizophrenia spectrum disorders (SSD) are associated with accelerated brain aging, reflected in an increased brain age gap. This gap serves as a biomarker, indicating poorer brain health, cognitive deficits, and greater severity in specific symptom domains. Exercise holds promise as an adjunct therapy to mitigate these deficits by potentially promoting brain recovery. However, the extent of overall improvements in brain health following exercise, along with their predictors and relationships to... Abstract

Applied and environmental microbiology, 19 3 2025, Pages e0082225 Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model. Leng J, Ferrandis-Vila M, Oldenkamp R, Mehat JW, Fivian-Hughes AS, Kumar Tiwari S, Van der Putten B, Trung Nguyen V, Bethe A, Clark J, Singh P, Semmler T, Schwarz S, Alvarez J, Hoa NT, Bootsma M, Menge C, Berens C, Schultsz C, Ritchie JM, La Ragione RM

The guts of animals and humans harbor diverse microbial communities that are regularly exposed to bacteria originating from food, water, and their surroundings. Species such as Escherichia coli are adept at colonizing multiple hosts, along with surviving in the environment. By encoding pathogenic traits and transmissible forms of antimicrobial resistance (AMR), E. coli can also pose a zoonotic risk. Our understanding of the factors that govern host residency is limited. Here, we used a chicken c... Abstract

American journal of clinical dermatology, 19 3 2025 Systemic Treatments in Moderate-to-Severe Atopic Dermatitis in Pediatric Patients up to 12 Years of Age: Real-World Treatment Outcomes from the PEDISTAD Registry. Paller AS, Marcoux D, Ramien M, Baselga E, Carvalho VO, Ardusso LRF, de Graaf M, Pasmans S, Toledo-Bahena M, Rubin C, Joyce JC, Lee LW, Gupta R, Adams B, Ardeleanu M, Zhang A

Background: Atopic dermatitis (AD), a chronic systemic disease, can cause intense skin itching and negatively impact sleep, mood, and quality of life (QoL) for patients and families. Methods: PEDISTAD is an ongoing, 10-year, observational registry describing disease characteristics, atopic comorbidities, and treatment patterns in pediatric patients (aged Abstract

Microbiology spectrum, Volume 13, Issue 10, 18 3 2025, Pages e0176225 Activity of HOCl-generating e-bandage with clinically available hydrogels against Staphylococcus aureus and Acinetobacter baumannii biofilms. Dagsuyu E, Kies P, Karau MJ, Patel R, Beyenal H

Biofilms hinder wound infection healing, making wound infections a healthcare challenge for which innovative treatments are needed. A 1.77 cm2 electrochemical bandage (e-bandage), which generates the biocide hypochlorous acid (HOCl), has shown promising anti-biofilm activity in vitro, ex vivo, and in vivo. The e-bandage is a three-electrode system operationalized by a hydrogel. In addition to providing a conductive electrolyte for the electrodes, the hydrogel provides a protective barrier for th... Abstract

Signal transduction and targeted therapy, Volume 10, Issue 1, 18 3 2025, Pages 311 Reversion of aortic valve cells calcification by activation of Notch signalling via histone acetylation induction. Garoffolo G, Ferrari S, De Martino S, Pizzo E, Candino V, Curini L, Macrì F, Kruithof BPT, Mongelli A, Grillo M, Fanotti N, Fejzaj P, Casaburo M, Alanazi A, Marsan NA, Khaliel F, Alsulbud A, Agrifoglio M, Colombo GI, Chiesa M, Farsetti A, Gaetano C, Raucci A, Pesce M

Calcification of the aortic valve is a prevalent cardiovascular pathology in the aging population. Traditionally linked to inflammation, lipid accumulation, and risk conditions, this disease remains poorly understood, and effective treatments to halt its progression are not yet available. We hypothesized that calcification of the human valve interstitial cells (VICs) is associated with cellular senescence and alterations in the epigenetic setup, like in arteries. To verify this hypothesis, we ex... Abstract

Annals of vascular surgery, Volume 122, 17 3 2025, Pages 774-779 Diagnostic Accuracy of Elastic Deformation for Detecting High Aneurysm Sac Pressure After Endovascular Aneurysm Repair. van Rijn K, van Genderen OS, Putter H, Eiberg JP, van Wissen RC, Hamming JF, van Schaik J, van der Vorst JR

Objectives: Elastic deformation (ED) is a novel noninvasive follow-up modality after endovascular aortic repair (EVAR). ED is defined as the percentage of diameter change of the aneurysm sac after application of a controlled ultrasound transducer pressure. It is hypothesized that low aneurysm sac deformation indicates high sac pressure. The current study aims to determine the ideal cutoff value of ED and analyze the corresponding diagnostic accuracy. Methods: A prospective cohort study was perfo... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, 17 3 2025 Radiofrequency ablation of supraventricular tachyarrhythmias in newborns and infants: why, when, and how? Palma A, Bertels RA, de Riva M, Zeppenfeld K, Blom NA

Supraventricular tachyarrhythmias (SVTs) in newborns and infants ( Abstract

Transfusion, 17 3 2025 Storage duration of platelet concentrates and clinical outcomes in cardiac surgery patients. van Hout FMA, Caram-Deelder C, Pors A, Middelburg RA, Klautz RJM, Rosseel PMJ, Helmerhorst HJF, van de Watering LMG, Kerkhoffs JL, Palmen M, van der Bom JG

Background: The changes in platelet structure and function arising from its collection and storage are collectively called "platelet storage lesion." In patients this might potentially be associated with impaired hemostasis and adverse events. We performed a hypothesis-generating retrospective study in cardiac surgery patients transfused with platelets in two hospitals between 2005 and 2017. Study design and methods: We explored whether longer storage duration of platelets is associate... Abstract

Innovations (Philadelphia, Pa.), 16 3 2025, Pages 15569845251367418 Application of Augmented Reality in Robot-Assisted Mitral Valve Repair Surgery: A Feasibility Study. Peek JJ, Hildebrandt K, Zhang X, Kharbanda RK, Oudeman MAP, Klautz RJM, Palmen M, Mahtab EAF

Objective: In mitral valve surgery, it is important to be aware of adjacent intraoperatively invisible anatomy, to avoid complications and enhance safety. In this feasibility study, we aimed to develop semi-automated intraoperative 3-dimensional (3D) augmented reality (3D-AR) overlays for robotic mitral valve repair. Methods: In 5 patients undergoing robot-assisted mitral valve repair, a 3D point cloud was generated, using intraoperatively recorded images from both eyes of the stereoscopic da Vi... Abstract

Frontiers in sports and active living, Volume 7, 15 3 2025, Pages 1642180 Platform power, athlete branding, generative AI, and the future of sport governance-a systematic review. Westerbeek H, van Schaik T

This systematic review examines how elite athletes are leveraging digital platforms, generative artificial intelligence (AI), and blockchain to build autonomous brands, bypass traditional sport gatekeepers, and develop athlete-owned business models. Drawing on 47 peer-reviewed studies (2016-2025), we synthesise evidence across five domains: athlete branding and self-production, disintermediation, platform-enabled empowerment, AI-driven content innovation, and emerging commercial structures. The... Abstract