6125 results
Cited 83 times since 2001 (3.5 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 281, Issue 2, 1 1 2001, Pages H755-63
Hypertonic saline method accurately determines parallel conductance for dual-field conductance catheter.
Steendijk P, Staal E, Jukema JW, Baan J
Conversion of conductance catheter data to absolute ventricular volumes requires assessment of parallel conductance (G(P)). We determined the accuracy of GP obtained by the hypertonic saline method (G(P)saline) compared with angiographically derived GP (G(P)Angio) and quantified the variabilities of GP for the dual-field conductance catheter method in nine anesthetized sheep studied at baseline, treated with dobutamine, and subjected to volume loading and beta-blockade. G(P)saline and G(P)Angio...
Abstract
Cited 146 times since 2001 (6.2 per year)
source: EuropePMC
The EMBO journal,
Volume 20, Issue 16, 1 1 2001, Pages 4588-4602
Human origin recognition complex binds to the region of the latent origin of DNA replication of Epstein-Barr virus.
Schepers A, Ritzi M, Bousset K, Kremmer E, Yates JL, Harwood J, Diffley JF, Hammerschmidt W
Epstein-Barr virus (EBV) replicates in its latent phase once per cell cycle in proliferating B cells. The latent origin of DNA replication, oriP, supports replication and stable maintenance of the EBV genome. OriP comprises two essential elements: the dyad symmetry (DS) and the family of repeats (FR), both containing clusters of binding sites for the transactivator EBNA1. The DS element appears to be the functional replicator. It is not yet understood how oriP-dependent replication is integrated...
Abstract
Cited 1 times since 2001 (0 per year)
source: EuropePMC
Kidney international,
Volume 60, Issue 1, 1 1 2001, Pages 117-125
Adenovirus-mediated transfer of the 39 kD receptor-associated protein increases fibrinolytic capacity.
Goedde MF, Grimbergen JM, Toet KH, Sitter T, Quax PH, Kooistra T
Background: The mesothelium has an important role in maintaining an adequate fibrinolytic capacity in the peritoneal cavity and thus in preventing the formation of fibrinous peritoneal adhesions by secreting the fibrinolytic enzyme tissue-type plasminogen activator (t-PA). The fibrinolytic activity of human mesothelial cells (HMCs) is counteracted by rapid uptake of t-PA via the low-density lipoprotein receptor-related protein (LRP). The 39 kD receptor-associated protein (RAP) is an inhibitor of...
Abstract
Cited 3 times since 2001 (0.1 per year)
source: EuropePMC
Cardiovascular research,
Volume 51, Issue 1, 1 1 2001, Pages 122-130
Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency.
Trines SA, Slager CJ, Onderwater TA, Lamers JM, Verdouw PD, Krams R
Objective: We investigated whether an increased oxygen cost of contractility and/or a decreased myofibrillar efficiency contribute to oxygen wastage of stunned myocardium. Because Ca(2+)-sensitizers may increase myofibrillar Ca(2+)-sensitivity without increasing cross-bridge cycling, we also investigated whether EMD 60263 restores myofibrillar efficiency and/or the oxygen cost of contractility. Methods: Regional fiber stress and strain were calculated from mesomyocardially implanted ultrasound c...
Abstract
Journal of the American College of Cardiology,
Volume 38, Issue 1, 1 1 2001, Pages 286
Batista's operation: what have we learned?
Schreuder JJ, Steendijk P, Baan J, Alfieri O
Abstract
Cited 45 times since 2001 (1.9 per year)
source: EuropePMC
Pediatric cardiology,
Volume 22, Issue 4, 1 1 2001, Pages 321-326
Acute renal insufficiency and renal replacement therapy after pediatric cardiopulmonary bypass surgery.
Kist-van Holthe tot Echten JE, Goedvolk CA, Doornaar MB, van der Vorst MM, Bosman-Vermeeren JM, Brand R, van der Heijden AJ, Schoof PH, Hazekamp MG
The aim of the study was to investigate renal function and renal replacement therapy after cardiopulmonary bypass surgery in children. Patient characteristics (sex, age, diagnosis), operation type, and death were listed. The study was performed retrospectively using serum creatinine level before, and peak values after, cardiopulmonary bypass surgery for assessment of renal function. Of the children on renal replacement therapy, indication, efficacy, and complications were recorded. In a 5-year p...
Abstract
Cited 32 times since 2001 (1.3 per year)
source: EuropePMC
Acta physiologica Scandinavica,
Volume 172, Issue 2, 1 1 2001, Pages 97-106
Acute effects of pulmonary artery banding in sheep on right ventricle pressure-volume relations: relevance to the arterial switch operation.
Hon JK, Steendijk P, Khan H, Wong K, Yacoub M
The first stage of the two-stage arterial switch operation (ASO) for transposition of the great arteries (TGA) is associated with depressed ventricular function and an unstable immediate post-operative course. It is unclear if this is because of the acute increase in afterload of the thin-walled, low-pressure ventricle by pulmonary artery banding (PAB). To determine the acute effects of afterload increase on the contractile function of thin-walled ventricles, we studied the right ventricular pre...
Abstract
Cited 13 times since 2001 (0.5 per year)
source: EuropePMC
European journal of heart failure,
Volume 3, Issue 3, 1 1 2001, Pages 331-333
Carvedilol increases plasma vascular endothelial growth factor (VEGF) in patients with chronic heart failure.
de Boer RA, Siebelink HJ, Tio RA, Boomsma F, van Veldhuisen DJ
Abstract
Cited 21 times since 2001 (0.9 per year)
source: EuropePMC
The Biochemical journal,
Volume 356, Issue Pt 3, 1 1 2001, Pages 907-910
Cloning and characterization of human liver cytosolic beta-glycosidase.
de Graaf M, van Veen IC, van der Meulen-Muileman IH, Gerritsen WR, Pinedo HM, Haisma HJ
Cytosolic beta-glucosidase (EC 3.2.1.21) from mammalian liver is a member of the family 1 glycoside hydrolases and is known for its ability to hydrolyse a range of beta-D-glycosides, including beta-D-glucoside and beta-D-galactoside. We therefore refer to this enzyme as cytosolic beta-glycosidase. We cloned the cDNA encoding the human cytosolic beta-glycosidase by performing PCR on cDNA prepared from total human liver RNA. Specific primers were based on human expressed sequence tags found in the...
Abstract
Cited 30 times since 2001 (1.3 per year)
source: EuropePMC
Radiology,
Volume 219, Issue 3, 1 1 2001, Pages 637-643
Aortic valve replacement in patients with aortic valve stenosis improves myocardial metabolism and diastolic function.
Beyerbacht HP, Lamb HJ, van Der Laarse A, Vliegen HW, Leujes F, Hazekamp MG, de Roos A, van Der Wall EE
Purpose: To evaluate whether functional and metabolic changes recover after aortic valve replacement (AVR). Materials and methods: Eighteen men with aortic valve stenosis (mean pressure gradient +/- SD, 79.9 mm Hg +/- 15.1) underwent magnetic resonance (MR) imaging and phosphorus 31 MR spectroscopy. In nine patients who underwent AVR, MR imaging and spectroscopy were repeated 40 weeks +/- 12 after AVR. Ten age-matched healthy men were control subjects. Results: Before AVR, the myocardial phospho...
Abstract
Cited 19 times since 2001 (0.8 per year)
source: EuropePMC
Virology,
Volume 284, Issue 2, 1 1 2001, Pages 259-276
Recombinant equine arteritis virus as an expression vector.
de Vries AA, Glaser AL, Raamsman MJ, Rottier PJ
Equine arteritis virus (EAV) is the prototypic member of the family Arteriviridae, which together with the Corona- and Toroviridae constitutes the order Nidovirales. A common trait of these positive-stranded RNA viruses is the 3'-coterminal nested set of six to eight leader-containing subgenomic mRNAs which are generated by a discontinuous transcription mechanism and from which the viral open reading frames downstream of the polymerase gene are expressed. In this study, we investigated whet...
Abstract
Cited 7 times since 2001 (0.3 per year)
source: EuropePMC
The British journal of surgery,
Volume 88, Issue 6, 1 1 2001, Pages 884-886
Totally extraperitoneal endoscopic repair of recurrent inguinal hernia.
van der Hem JA, Hamming JF, Meeuwis JD, Oostvogel HJ
Background: Conventional repair of recurrent inguinal hernia is associated with a re-recurrence rate as high as 35 per cent. Endoscopic mesh repair has promising results regarding both recurrence and complication rates. Methods: In a retrospective review, the results of endoscopic totally extraperitoneal repair were evaluated in 104 patients with 108 recurrent hernias. Follow-up was at least 1 year. Type of recurrence, time of occurrence after previous repair, duration of surgery, complications,...
Abstract
Nederlands tijdschrift voor geneeskunde,
Volume 145, Issue 25, 1 1 2001, Pages 1214-1218
[Treatment of intra-atrial reentry tachycardia by catheter ablation, using three-dimensional electro-anatomical map of the atrial activation pattern].
de Groot NM, Schalij MJ
A 30-year-old man, who had been treated surgically for tricuspid valve atresia as a boy, suffered from recurrent supraventricular tachycardias. These atrial reentry tachycardias are frequent post-operative complications in patients with congenital heart disease. The reentry circuit in these patients often circulates around areas of scar tissue or surgically created barriers such as incision scars and implanted synthetic material. A possible curative treatment of these arrhythmias is radiofrequen...
Abstract
Cited 27 times since 2001 (1.1 per year)
source: EuropePMC
Cardiovascular research,
Volume 50, Issue 3, 1 1 2001, Pages 516-524
Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice.
Palmen M, Daemen MJ, Bronsaer R, Dassen WR, Zandbergen HR, Kockx M, Smits JF, van der Zee R, Doevendans PA
Objective: To obtain more insight in the role of IGF-1 in cardiac remodeling and function after experimental myocardial infarction. We hypothesized that cardiac remodeling is altered in IGF-1 deficient mice, which may affect cardiac function. Methods: A myocardial infarction was induced by surgical coronary artery ligation in heterozygous IGF-1 deficient mice. One week after surgery, left ventricular function was analyzed, and parameters of cardiac remodeling were measured. Results: No significa...
Abstract
Cited 13 times since 2001 (0.5 per year)
source: EuropePMC
Early human development,
Volume 63, Issue 1, 1 1 2001, Pages 9-21
Endothelin-1 plasma concentration increases in the early phase of pulmonary hypertension development during respiratory distress syndrome: a study in newborn lambs.
de Vroomen M, Lopes Cardozo RH, Steendijk P, Frölich M, Baan J, van Bel F
Objective: Elevated plasma concentrations of endothelin-1 (ET-1) have been reported with pulmonary hypertension during respiratory distress syndrome (RDS). However, the exact role of ET-1 in the development of pulmonary hypertension during RDS is unclear. The relative time-course of changes in ET-1 concentrations and pulmonary artery pressure (P(ap)) during RDS may give insight in the role of ET-1. Methods: ET-1 and P(ap) changes were studied in an experimental model of RDS, induced by lung lava...
Abstract
Cited 46 times since 2001 (1.9 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 19, Issue 5, 1 1 2001, Pages 667-670
Pulmonary valve insertion late after repair of Fallot's tetralogy.
Hazekamp MG, Kurvers MM, Schoof PH, Vliegen HW, Mulder BM, Roest AA, Ottenkamp J, Dion RA
Objectives: To analyze the results of pulmonary valve insertion late after initial repair of Fallot's tetralogy. Pulmonary insufficiency (PI) after correction of Fallot's tetralogy is usually well tolerated in the short term, but is associated with symptomatic right ventricular dilatation and an increased risk of ventricular arrhythmias over longer periods of time. Methods: From 1993 to July 2000, 51 patients were reoperated for PI at a mean age of 25.7+/-11.9 years. The mean age at in...
Abstract
Cited 18 times since 2001 (0.8 per year)
source: EuropePMC
RNA (New York, N.Y.),
Volume 7, Issue 5, 1 1 2001, Pages 741-752
Identification of a novel cis-acting RNA element involved in nuclear export of hY RNAs.
Rutjes SA, Lund E, van der Heijden A, Grimm C, van Venrooij WJ, Pruijn GJ
Ro RNPs are small cytoplasmic RNA-protein complexes of unknown function that have been found in all metazoan cells studied so far. In human cells, Ro RNPs consist of one of four small RNA molecules, termed hY RNAs and at least two well-characterized proteins, Ro60 and La. In previous Xenopus laevis oocyte microinjection studies, we showed that an intact Ro60 binding site (Stem-loop 1) is a prerequisite for efficient nuclear export of hY1 RNA, whereas an intact La-binding site promotes nuclear re...
Abstract
Cited 1 times since 2001 (0 per year)
source: EuropePMC
Circulation,
Volume 103, Issue 17, 1 1 2001, Pages E92-3
False aneurysms of an ascending-aorta-to-abdominal-aorta bypass for coarctation of the aorta.
Roest AA, Wasser MN, Versteegh MI, de Roos A, van Der Wall EE, Helbing WA, Vliegen HW
Abstract
Cited 34 times since 2001 (1.4 per year)
source: EuropePMC
Journal of molecular biology,
Volume 308, Issue 4, 1 1 2001, Pages 597-608
Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein.
Schepers A, Diffley JF
The Cdc6 protein is required to load a complex of Mcm2-7 family members (the MCM complex) into prereplicative complexes at budding yeast origins of DNA replication. Cdc6p is a member of the AAA(+) superfamily of proteins, which includes the prokaryotic and eukaryotic clamp loading proteins. These proteins share a number of conserved regions of homology and a common three-dimensional architecture. Two of the conserved sequence motifs are the Walker A and B motifs that are involved in nucleotide m...
Abstract
Cited 86 times since 2001 (3.6 per year)
source: EuropePMC
Journal of virology,
Volume 75, Issue 7, 1 1 2001, Pages 3335-3342
Improved adenovirus vectors for infection of cardiovascular tissues.
Havenga MJ, Lemckert AA, Grimbergen JM, Vogels R, Huisman LG, Valerio D, Bout A, Quax PH
To identify improved adenovirus vectors for cardiovascular gene therapy, a library of adenovirus vectors based on adenovirus serotype 5 (Ad5) but carrying fiber molecules of other human serotypes, was generated. This library was tested for efficiency of infection of human primary vascular endothelial cells (ECs) and smooth muscle cells (SMCs). Based on luciferase, LacZ, or green fluorescent protein (GFP) marker gene expression, several fiber chimeric vectors were identified that displayed improv...
Abstract
