6173 results
Nederlands tijdschrift voor geneeskunde,
Volume 145, Issue 25, 1 1 2001, Pages 1214-1218
[Treatment of intra-atrial reentry tachycardia by catheter ablation, using three-dimensional electro-anatomical map of the atrial activation pattern].
de Groot NM, Schalij MJ
A 30-year-old man, who had been treated surgically for tricuspid valve atresia as a boy, suffered from recurrent supraventricular tachycardias. These atrial reentry tachycardias are frequent post-operative complications in patients with congenital heart disease. The reentry circuit in these patients often circulates around areas of scar tissue or surgically created barriers such as incision scars and implanted synthetic material. A possible curative treatment of these arrhythmias is radiofrequen...
Abstract
Cited 29 times since 2001 (1.2 per year)
source: EuropePMC
Cardiovascular research,
Volume 50, Issue 3, 1 1 2001, Pages 516-524
Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice.
Palmen M, Daemen MJ, Bronsaer R, Dassen WR, Zandbergen HR, Kockx M, Smits JF, van der Zee R, Doevendans PA
Objective: To obtain more insight in the role of IGF-1 in cardiac remodeling and function after experimental myocardial infarction. We hypothesized that cardiac remodeling is altered in IGF-1 deficient mice, which may affect cardiac function. Methods: A myocardial infarction was induced by surgical coronary artery ligation in heterozygous IGF-1 deficient mice. One week after surgery, left ventricular function was analyzed, and parameters of cardiac remodeling were measured. Results: No significa...
Abstract
Cited 13 times since 2001 (0.5 per year)
source: EuropePMC
Early human development,
Volume 63, Issue 1, 1 1 2001, Pages 9-21
Endothelin-1 plasma concentration increases in the early phase of pulmonary hypertension development during respiratory distress syndrome: a study in newborn lambs.
de Vroomen M, Lopes Cardozo RH, Steendijk P, Frölich M, Baan J, van Bel F
Objective: Elevated plasma concentrations of endothelin-1 (ET-1) have been reported with pulmonary hypertension during respiratory distress syndrome (RDS). However, the exact role of ET-1 in the development of pulmonary hypertension during RDS is unclear. The relative time-course of changes in ET-1 concentrations and pulmonary artery pressure (P(ap)) during RDS may give insight in the role of ET-1. Methods: ET-1 and P(ap) changes were studied in an experimental model of RDS, induced by lung lava...
Abstract
Cited 49 times since 2001 (2 per year)
source: EuropePMC
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 19, Issue 5, 1 1 2001, Pages 667-670
Pulmonary valve insertion late after repair of Fallot's tetralogy.
Hazekamp MG, Kurvers MM, Schoof PH, Vliegen HW, Mulder BM, Roest AA, Ottenkamp J, Dion RA
Objectives: To analyze the results of pulmonary valve insertion late after initial repair of Fallot's tetralogy. Pulmonary insufficiency (PI) after correction of Fallot's tetralogy is usually well tolerated in the short term, but is associated with symptomatic right ventricular dilatation and an increased risk of ventricular arrhythmias over longer periods of time. Methods: From 1993 to July 2000, 51 patients were reoperated for PI at a mean age of 25.7+/-11.9 years. The mean age at in...
Abstract
Cited 20 times since 2001 (0.8 per year)
source: EuropePMC
RNA (New York, N.Y.),
Volume 7, Issue 5, 1 1 2001, Pages 741-752
Identification of a novel cis-acting RNA element involved in nuclear export of hY RNAs.
Rutjes SA, Lund E, van der Heijden A, Grimm C, van Venrooij WJ, Pruijn GJ
Ro RNPs are small cytoplasmic RNA-protein complexes of unknown function that have been found in all metazoan cells studied so far. In human cells, Ro RNPs consist of one of four small RNA molecules, termed hY RNAs and at least two well-characterized proteins, Ro60 and La. In previous Xenopus laevis oocyte microinjection studies, we showed that an intact Ro60 binding site (Stem-loop 1) is a prerequisite for efficient nuclear export of hY1 RNA, whereas an intact La-binding site promotes nuclear re...
Abstract
Cited 1 times since 2001 (0 per year)
source: EuropePMC
Circulation,
Volume 103, Issue 17, 1 1 2001, Pages E92-3
False aneurysms of an ascending-aorta-to-abdominal-aorta bypass for coarctation of the aorta.
Roest AA, Wasser MN, Versteegh MI, de Roos A, van Der Wall EE, Helbing WA, Vliegen HW
Abstract
Cited 35 times since 2001 (1.5 per year)
source: EuropePMC
Journal of molecular biology,
Volume 308, Issue 4, 1 1 2001, Pages 597-608
Mutational analysis of conserved sequence motifs in the budding yeast Cdc6 protein.
Schepers A, Diffley JF
The Cdc6 protein is required to load a complex of Mcm2-7 family members (the MCM complex) into prereplicative complexes at budding yeast origins of DNA replication. Cdc6p is a member of the AAA(+) superfamily of proteins, which includes the prokaryotic and eukaryotic clamp loading proteins. These proteins share a number of conserved regions of homology and a common three-dimensional architecture. Two of the conserved sequence motifs are the Walker A and B motifs that are involved in nucleotide m...
Abstract
Cited 90 times since 2001 (3.7 per year)
source: EuropePMC
Journal of virology,
Volume 75, Issue 7, 1 1 2001, Pages 3335-3342
Improved adenovirus vectors for infection of cardiovascular tissues.
Havenga MJ, Lemckert AA, Grimbergen JM, Vogels R, Huisman LG, Valerio D, Bout A, Quax PH
To identify improved adenovirus vectors for cardiovascular gene therapy, a library of adenovirus vectors based on adenovirus serotype 5 (Ad5) but carrying fiber molecules of other human serotypes, was generated. This library was tested for efficiency of infection of human primary vascular endothelial cells (ECs) and smooth muscle cells (SMCs). Based on luciferase, LacZ, or green fluorescent protein (GFP) marker gene expression, several fiber chimeric vectors were identified that displayed improv...
Abstract
Cited 18 times since 2001 (0.7 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 85, Issue 4, 1 1 2001, Pages 458-462
Increased risk for ischaemic events is related to combined RAS polymorphism.
van Geel PP, Pinto YM, Zwinderman AH, Henning RH, van Boven AJ, Jukema JW, Bruschke AV, Kastelein JJ, van Gilst WH
Objective: To determine whether the angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT(1)R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis. Design: Prospective defined substudy of the lipid lowering regression trial (REGRESS). Setting: University hospital. Patients: 885 male patients with stable coronary artery disease. Main outcome me...
Abstract
Cited 6 times since 2001 (0.2 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 71, Issue 4, 1 1 2001, Pages 1382-1383
Implantation of cardioverter device in young children: the perirenal approach.
Hazekamp MG, Blom NA, Schoof PH, Schalij MJ, Dion RA
Placement of Implantable cardioverter devices in young children is complicated because of the relatively large size and heavy weight of these devices. A technique is described where the device is implanted in the left perirenal space while an endovascular lead is used instead of an epicardial patch electrode.
Abstract
Cited 4 times since 2001 (0.2 per year)
source: EuropePMC
Thrombosis and haemostasis,
Volume 85, Issue 4, 1 1 2001, Pages 746-747
Factor VII polymorphisms and myocardial infarction: what is special in Italians? REGRESS study group. Regression Growth Evaluation Statin Study.
Nederhand RJ, de Maat MP, Jukema JW, Regression Growth Evaluation Statin Study group
Abstract
Cited 76 times since 2001 (3.2 per year)
source: EuropePMC
Circulation,
Volume 103, Issue 13, 1 1 2001, Pages 1778-1786
Acyl-CoA:cholesterol acyltransferase inhibitor avasimibe reduces atherosclerosis in addition to its cholesterol-lowering effect in ApoE*3-Leiden mice.
Delsing DJ, Offerman EH, van Duyvenvoorde W, van Der Boom H, de Wit EC, Gijbels MJ, van Der Laarse A, Jukema JW, Havekes LM, Princen HM
Background: The present study investigated whether the ACAT inhibitor avasimibe can reduce atherogenesis independently of its cholesterol-lowering effect in ApoE*3-Leiden mice. Methods and results: Two groups of 15 female ApoE*3-Leiden mice were put on a high-cholesterol (HC) diet; 1 group received 0.01% (wt/wt) avasimibe mixed into the diet. The HC diet resulted in a plasma cholesterol concentration of 18.7+/-2.6 mmol/L. Addition of avasimibe lowered plasma cholesterol by 56% to 8.1+/-1.2 mmol/...
Abstract
Cited 22 times since 2001 (0.9 per year)
source: EuropePMC
Gene therapy,
Volume 8, Issue 7, 1 1 2001, Pages 534-541
In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI.
Lamfers ML, Lardenoye JH, de Vries MR, Aalders MC, Engelse MA, Grimbergen JM, van Hinsbergh VW, Quax PH
Injury-induced neointimal development results from migration and proliferation of vascular smooth muscle cells (SMC). Cell migration requires controlled proteolytic degradation of extracellular matrix surrounding the cell. Plasmin is a major contributor to this process by degrading various matrix proteins directly, or indirectly by activating matrix metalloproteinases. This makes it an attractive target for inhibition by gene transfer. An adenoviral vector, Ad.ATF.BPTI, was constructed encoding...
Abstract
Cited 178 times since 2001 (7.4 per year)
source: EuropePMC
Circulation,
Volume 103, Issue 9, 1 1 2001, Pages 1198-1205
Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease.
Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HO, Roomp K, Jukema JW, van Wijland M, van Dam M, Hudson TJ, Brooks-Wilson A, Genest J, Kastelein JJ, Hayden MR
Background: Low plasma HDL cholesterol (HDL-C) is associated with an increased risk of coronary artery disease (CAD). We recently identified the ATP-binding cassette transporter 1 (ABCA1) as the major gene underlying the HDL deficiency associated with reduced cholesterol efflux. Mutations within the ABCA1 gene are associated with decreased HDL-C, increased triglycerides, and an increased risk of CAD. However, the extent to which common variation within this gene influences plasma lipid levels an...
Abstract
Cited 18 times since 2001 (0.7 per year)
source: EuropePMC
The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR),
Volume 45, Issue 1, 1 1 2001, Pages 108-114
Perfusion and functional abnormalities outside the septal region in patients with left bundle branch block assessed with gated SPECT.
Bavelaar-Croon CD, Wahba FF, Van Hecke MV, Atsma DE, Stokkel MP, Pauwels EK, Van der Wall EE
Background: The presence of a left bundle branch block (LBBB) pattern on the electrocardiogram may frequently lead to perfusion defects in the septum not necessarily due to ischemic heart disease, but probably due to abnormal septal wall motion. The introduction of gated single photon emission computed tomography (SPECT) allows the evaluation of myocardial perfusion and function in one study. Accordingly, we analysed perfusion and function and the relation between perfusion and regional function...
Abstract
Cited 13 times since 2001 (0.5 per year)
source: EuropePMC
Analytical biochemistry,
Volume 290, Issue 2, 1 1 2001, Pages 283-291
Simultaneous detection of NOS-3 protein expression and nitric oxide production using a flow cytometer.
Havenga MJ, van Dam B, Groot BS, Grimbergen JM, Valerio D, Bout A, Quax PH
Nitric oxide (NO) is involved in the regulation of SMC proliferation during intimal hyperplasia as has been shown by the inhibitory effect on intimal hyperplasia of adenovirus-mediated ceNOS overexpression in injured arteries in pig. Good assays to quantify the NO-producing enzymes, i.e., NO synthases (NOS), are essential to analyze the mechanism of action of NO in this process. We have developed novel flow cytometric assays for the simultaneous detection of NOS-3 protein, using NOS-3 specific a...
Abstract
Cited 15 times since 2001 (0.6 per year)
source: EuropePMC
The Annals of thoracic surgery,
Volume 71, Issue 2, 1 1 2001, Pages 601-7; discussion 607-8
Outcome and follow-up of aortic valve replacement with the freestyle stentless bioprosthesis.
Kappetein AP, Braun J, Baur LH, Prat A, Peels K, Hazekamp MG, Schoof PH, Huysmans HA
Background: The aim of this study was to determine the morbidity, mortality, and hemodynamics after implantation of the Freestyle stentless bioprosthesis in the aortic position. Methods: A total of 280 patients were operated on from June 1993 to July 1999 as part of a multicenter investigation. Factors influencing hospital mortality and long-term survival were assessed by logistic regression and Cox proportional hazards analysis. Patients were evaluated postoperatively at discharge, at 3 to 6 mo...
Abstract
Cited 41 times since 2001 (1.7 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 21, Issue 2, 1 1 2001, Pages 118-122
Quality of life in patients with intermittent claudication using the World Health Organisation (WHO) questionnaire.
Breek JC, Hamming JF, De Vries J, Aquarius AE, van Berge Henegouwen DP
Objective: to assess quality of life (QOL) in patients with intermittent claudication. Design: a prospective, open study. Material and method: one hundred and fifty-one consecutive claudicants (100 men, 51 women), and 161 healthy controls (70 men and 91 women) completed an adapted version of the World Health Organisation Quality of Life Assessment Instrument-100. Results: patients scored significantly worse on the domains Physical health and Level of independence, as well as on the facets Pain a...
Abstract
Cited 24 times since 2001 (1 per year)
source: EuropePMC
Pflugers Archiv : European journal of physiology,
Volume 441, Issue 5, 1 1 2001, Pages 717-724
Within-subject electrocardiographic differences at equal heart rates: role of the autonomic nervous system.
Frederiks J, Swenne CA, Kors JA, van Herpen G, Maan AC, Levert JV, Schalij MJ, Bruschke AV
Various combinations of sympathetic and vagal tone can yield the same heart rate, while ventricular electrophysiology differs. To demonstrate this in humans, we studied healthy volunteers in the sitting position with horizontal legs. First, heart rate was increased by lowering the legs to 60 degrees and back. Thereafter, heart rate was increased by handgrip. In each subject, a leg-lowering angle was selected at which heart rate matched best with heart rate in the third handgrip minute. Thirteen...
Abstract
Cited 26 times since 2001 (1.1 per year)
source: EuropePMC
Radiology,
Volume 218, Issue 2, 1 1 2001, Pages 540-547
Improved MR flow mapping in coronary artery bypass grafts during adenosine-induced stress.
Langerak SE, Kunz P, Vliegen HW, Lamb HJ, Jukema JW, van Der Wall EE, de Roos A
Purpose: To validate a recently developed fast high-temporal-resolution magnetic resonance (MR) flow sequence and use it to assess coronary artery bypass graft function during pharmacologic stress. Materials and methods: Aortic and internal mammary artery flow was measured in 11 healthy volunteers by using conventional cine gradient-echo imaging as a reference standard method and turbo-field echo-planar imaging (TFEPI). By using TFEPI, breath-hold flow mapping with a spatial and temporal resolut...
Abstract
