Research

Publications

Below you can find a list of our published research.

8892 results

Cited 18 times since 2012 (1.3 per year) source: EuropePMC

Geriatrics & gerontology international, Volume 13, Issue 1, 11 2 2012, Pages 190-197 Do clinical characteristics and outcome in nonagenarians with a hip fracture differ from younger patients? Vochteloo AJ, Borger van der Burg BL, Tuinebreijer WE, de Vries MR, Niggebrugge AH, Bloem RM, Maier AB, Nelissen RG, Pilot P

Aim: To compare clinical characteristics and outcome of nonagenarian hip fracture patients with younger patients aged 65-89 years. Methods: This was a cohort follow-up study of admissions for a hip fracture between 2005-2010 (mean follow up of 3.5 years) in two teaching hospitals in The Netherlands; 230 nonagenarians and 1014 patients aged 65-89 years were included. Clinical characteristics, adverse events, mobility and mortality were compared. Results: Nonagenarians were more likely to be femal... Abstract

Cited 50 times since 2012 (3.7 per year) source: EuropePMC

European heart journal, Volume 33, Issue 24, 5 1 2012, Pages 3034-3045 From abstract to impact in cardiovascular research: factors predicting publication and citation. Winnik S, Raptis DA, Walker JH, Hasun M, Speer T, Clavien PA, Komajda M, Bax JJ, Tendera M, Fox K, Van de Werf F, Mundow C, Lüscher TF, Ruschitzka F, Matter CM

Aims: Through a 4-year follow-up of the abstracts submitted to the European Society of Cardiology Congress in 2006, we aimed at identifying factors predicting high-quality research, appraising the quality of the peer review and editorial processes, and thereby revealing potential ways to improve future research, peer review, and editorial work. METHODS AND RESULTS All abstracts submitted in 2006 were assessed for acceptance, presentation format, and average reviewer rating. Accepted and rejected... Abstract

Cited 30 times since 2012 (2.2 per year) source: EuropePMC

Differentiation; research in biological diversity, Volume 84, Issue 1, 3 1 2012, Pages 131-148 Normal and abnormal development of the cardiac conduction system; implications for conduction and rhythm disorders in the child and adult. Jongbloed MR, Vicente Steijn R, Hahurij ND, Kelder TP, Schalij MJ, Gittenberger-de Groot AC, Blom NA

The cardiac conduction system is a specialized network that initiates and closely coordinates the heart beat. Cardiac conduction system development is intricately related to the development and maturation of the embryonic heart towards its four-chambered form, as is indicated by the fact that disturbed development of cardiac structures is often accompanied by a disturbed formation of the CCS. Electrophysiological studies have shown that selected conduction disturbances and cardiac arrhythmias do... Abstract

Cited 19 times since 2012 (1.4 per year) source: EuropePMC

Stem cells (Dayton, Ohio), Volume 30, Issue 6, 1 1 2012, Pages 1236-1245 Gap junctional coupling with cardiomyocytes is necessary but not sufficient for cardiomyogenic differentiation of cocultured human mesenchymal stem cells. Ramkisoensing AA, Pijnappels DA, Swildens J, Goumans MJ, Fibbe WE, Schalij MJ, de Vries AA, Atsma DE

Gap junctional coupling is important for functional integration of transplanted cells with host myocardium. However, the role of gap junctions in cardiomyogenic differentiation of transplanted cells has not been directly investigated. The objective of this work is to study the role of connexin43 (Cx43) in cardiomyogenic differentiation of human mesenchymal stem cells (hMSCs). Knockdown of Cx43 gene expression (Cx43↓) was established in naturally Cx43-rich fetal amniotic membrane (AM) hMSCs, whil... Abstract

Cited 343 times since 2012 (25.6 per year) source: EuropePMC

JAMA, Volume 307, Issue 23, 1 1 2012, Pages 2499-2506 Lipid-related markers and cardiovascular disease prediction. Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Pennells L, Kaptoge S, Caslake M, Thompson A, Butterworth AS, Sarwar N, Wormser D, Saleheen D, Ballantyne CM, Psaty BM, Sundström J, Ridker PM, Nagel D, Gillum RF, Ford I, Ducimetiere P, Kiechl S, Koenig W, Dullaart RP, Assmann G, D'Agostino RB, Dagenais GR, Cooper JA, Kromhout D, Onat A, Tipping RW, Gómez-de-la-Cámara A, Rosengren A, Sutherland SE, Gallacher J, Fowkes FG, Casiglia E, Hofman A, Salomaa V, Barrett-Connor E, Clarke R, Brunner E, Jukema JW, Simons LA, Sandhu M, Wareham NJ, Khaw KT, Kauhanen J, Salonen JT, Howard WJ, Nordestgaard BG, Wood AM, Thompson SG, Boekholdt SM, Sattar N, Packard C, Gudnason V, Danesh J

Context: The value of assessing various emerging lipid-related markers for prediction of first cardiovascular events is debated. Objective: To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction. Design, setting, and participants: Individual records were available for 165,544 participant... Abstract

Cited 23 times since 2012 (1.7 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 6, 1 1 2012, Pages 254-259 Acute myocardial infarction system of care in the third world. Dharma S, Juzar DA, Firdaus I, Soerianata S, Wardeh AJ, Jukema JW

Background: We studied the characteristics of ST-elevation myocardial infarction (STEMI) patients from a local acute coronary syndrome (ACS) registry in order to find and build an appropriate acute myocardial infarction (AMI) system of care in Jakarta, Indonesia. Methods: Data were collected from the Jakarta Acute Coronary Syndrome (JAC) registry 2008-2009, which contained 2103 ACS patients, including 654 acute STEMI patients admitted to the National Cardiovascular Center Harapan Kita, Jakarta,... Abstract

Cited 36 times since 2012 (2.7 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 98, Issue 11, 1 1 2012, Pages 872-877 Clinical prediction model for death prior to appropriate therapy in primary prevention implantable cardioverter defibrillator patients with ischaemic heart disease: the FADES risk score. van Rees JB, Borleffs CJ, van Welsenes GH, van der Velde ET, Bax JJ, van Erven L, Putter H, van der Bom JG, Schalij MJ

Objectives: To construct a risk score out of baseline variables to estimate the risk of death without prior implantable cardioverter defibrillator (ICD) in primary prevention ICD patients with ischaemic heart disease. Design: Retrospective cohort study. Setting: Tertiary care facility in The Netherlands. Patients: All patients with ischaemic heart disease who received an ICD for primary prevention of sudden cardiac death at the Leiden University Medical Center, Leiden, The Netherlands in the per... Abstract

Cited 44 times since 2012 (3.3 per year) source: EuropePMC

Vaccine, Volume 30, Issue 29, 1 1 2012, Pages 4369-4376 A review of influenza haemagglutinin receptor binding as it relates to pandemic properties. Wilks S, de Graaf M, Smith DJ, Burke DF

Haemagglutinin is a determinant of many viral properties, and successful adaptation to a human-like form is thought to be an important step toward pandemic influenza emergence. The availability of structurally distinct sialic acid linked receptors in the sites of human and avian influenza infection are generally held to account for the differences observed, but the relevance of other selection pressures has not been elucidated. There is evidence for genetic and structural constraints of haemaggl... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Vascular, Volume 20, Issue 4, 1 1 2012, Pages 203-209 Influence of aneurysm wall stiffness and the presence of intraluminal thrombus on the wall movement of an aneurysm - an in vitro study. Bosman WM, Hinnen JW, Kopp WH, van der Steenhoven TJ, Kaptein BL, Koning OH, Hamming JF

The purpose of this in vitro study was to investigate the influence of aneurysm wall stiffness and of the presence of intraluminal thrombus (ILT) on aneurysm wall movement. Three latex aneurysms were used with different wall stiffness. The aneurysms, equipped with 20 tantalum markers, were attached to an in vitro circulation model. Fluoroscopic roentgenographic stereo photogrammetric analysis was used to measure marker movement during six cardiac cycles at three different systemic pressures. To... Abstract

Cited 4 times since 2012 (0.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 6, 1 1 2012, Pages 251 Durrer prizes 2011. van der Wall EE, Schalij MJ

Abstract

Cited 27 times since 2012 (2 per year) source: EuropePMC

PloS one, Volume 7, Issue 5, 30 5 2012, Pages e38240 Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy. Shiffman D, Trompet S, Louie JZ, Rowland CM, Catanese JJ, Iakoubova OA, Kirchgessner TG, Westendorp RG, de Craen AJ, Slagboom PE, Buckley BM, Stott DJ, Sattar N, Devlin JJ, Packard CJ, Ford I, Sacks FM, Jukema JW

Statin therapy reduces the risk of coronary heart disease (CHD), however, the person-to-person variability in response to statin therapy is not well understood. We have investigated the effect of genetic variation on the reduction of CHD events by pravastatin. First, we conducted a genome-wide association study of 682 CHD cases from the Cholesterol and Recurrent Events (CARE) trial and 383 CHD cases from the West of Scotland Coronary Prevention Study (WOSCOPS), two randomized, placebo-controlled... Abstract

Cited 4 times since 2012 (0.3 per year) source: EuropePMC

BMJ case reports, Volume 2012, 30 5 2012, Pages bcr0120125602 A rare case of portal vein gas: accidental hydrogen peroxide ingestion. Zengin S, Al B, Genç S, Yarbil P, Yilmaz DA, Gulsen MT

Hydrogen peroxide (H(2)O(2)) is a colourless and odourless liquid with oxidant characteristics used for various purposes. Whereas in lower concentrations (3%), H(2)O(2) is used as a disinfectant in home cleaning products and wound care, in higher concentrations (35%) it is used in textile and paper industry as a bleaching agent and is diluted for use in lightening hair dyes. Like other caustic substances, direct injuries may develop if H(2)O(2) is swallowed and systemic air embolisms may occur d... Abstract

Cited 25 times since 2012 (1.9 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 43, Issue 3, 30 5 2012, Pages 505-11; discussion 511-2 Transapical aortic valve implantation: mid-term outcome from the SOURCE registry. Wendler O, Walther T, Schroefel H, Lange R, Treede H, Fusari M, Rubino P, Thomas M, SOURCE investigators

Objectives: Transapical (TA) aortic valve implantation using the Edwards SAPIEN bioprosthesis was commercially introduced in Europe in January 2008. Limited data on the mid-term results are available. Methods: Using data from the SOURCE-Registry (largest consecutive cohort treated using Edwards SAPIEN bioprosthesis in Europe), we report on the mid-term results (≥30 days-2 years) of TA patients. Results: Between November 2007 and December 2009, a total of 1387 patients from 38 European centres un... Abstract

Cited 6 times since 2012 (0.4 per year) source: EuropePMC

International wound journal, Volume 10, Issue 3, 28 4 2012, Pages 348-350 Acute mediastinal bleeding during vacuum-assisted closure. Vos RJ, Yilmaz A, Sonker U, Kloppenburg GT

Vacuum-assisted closure is commonly used to treat post-sternotomy mediastinitis. Several studies show improved outcome using vacuum-assisted therapy; however, risks using negative pressure should not be underestimated. We describe two cases of acute mediastinal bleeding during vacuum treatment for post-sternotomy mediastinitis and discuss preventative measurements. Abstract

Cited 22 times since 2012 (1.6 per year) source: EuropePMC

Resuscitation, Volume 83, Issue 12, 24 4 2012, Pages 1503-1510 Left ventricular diastolic dysfunction during acute myocardial infarction: effect of mild hypothermia. Schwarzl M, Huber S, Maechler H, Steendijk P, Seiler S, Truschnig-Wilders M, Nestelberger T, Pieske BM, Post H

Background: Mild hypothermia (MH) decreases infarct size and mortality in experimental reperfused myocardial infarction, but may potentiate ischaemia-induced left ventricular (LV) diastolic dysfunction. Methods: In anaesthetized pigs (70 ± 2 kg), polystyrol microspheres (45 μm) were infused repeatedly into the left circumflex artery until cardiac power output decreased >40%. Then, pigs were assigned to normothermia (NT, 38.0°C, n=8) or MH (33.0°C, n=8, intravascular cooling) and followed for... Abstract

Cited 30 times since 2012 (2.2 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 32, Issue 8, 24 4 2012, Pages e72-80 Blocking toll-like receptors 7 and 9 reduces postinterventional remodeling via reduced macrophage activation, foam cell formation, and migration. Karper JC, Ewing MM, Habets KL, de Vries MR, Peters EA, van Oeveren-Rietdijk AM, de Boer HC, Hamming JF, Kuiper J, Kandimalla ER, La Monica N, Jukema JW, Quax PH

Objective: The role of toll-like receptors (TLRs) in vascular remodeling is well established. However, the involvement of the endosomal TLRs is unknown. Here, we study the effect of combined blocking of TLR7 and TLR9 on postinterventional remodeling and accelerated atherosclerosis. Methods and results: In hypercholesterolemic apolipoprotein E*3-Leiden mice, femoral artery cuff placement led to strong increase of TLR7 and TLR9 presence demonstrated by immunohistochemistry. Blocking TLR7/9 with a... Abstract

Cited 26 times since 2012 (1.9 per year) source: EuropePMC

Diabetes & vascular disease research, Volume 10, Issue 2, 23 4 2012, Pages 123-134 Non-invasive assessment of microcirculation by sidestream dark field imaging as a marker of coronary artery disease in diabetes. Djaberi R, Schuijf JD, de Koning EJ, Wijewickrama DC, Pereira AM, Smit JW, Kroft LJ, Roos Ad, Bax JJ, Rabelink TJ, Jukema JW

Purpose: In diabetes, generalised microvascular disease and coronary artery disease (CAD) are likely to occur in parallel. We used a sidestream dark field (SDF) handheld imaging device to determine the relation between the labial microcirculation parameters and CAD in asymptomatic patients with diabetes. Methods: SDF imaging was validated for assessment of labial capillary density and tortuosity. Thereafter, mean labial capillary density and tortuosity were evaluated and compared in non-diabetic... Abstract

Cited 32 times since 2012 (2.4 per year) source: EuropePMC

Molecular genetics and metabolism, Volume 107, Issue 1-2, 22 4 2012, Pages 213-221 Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis. Hu J, Lu JY, Wong AM, Hynan LS, Birnbaum SG, Yilmaz DS, Streit BM, Lenartowicz EM, Thompson TC, Cooper JD, Hofmann SL

PPT1-related neuronal ceroid lipofuscinosis (NCL) is a lysosomal storage disorder caused by deficiency in a soluble lysosomal enzyme, palmitoyl-protein thioesterase-1 (PPT1). Enzyme replacement therapy (ERT) has not been previously examined in a preclinical animal model. Homozygous PPT1 knockout mice reproduce the known features of the disease, developing signs of motor dysfunction at 5 months of age and death by around 8 months. In the current study, PPT1 knockout mice were treated with purifie... Abstract

Cited 17 times since 2012 (1.3 per year) source: EuropePMC

Bulletin of mathematical biology, Volume 74, Issue 8, 19 3 2012, Pages 1691-1705 Modeling non-inherited antibiotic resistance. Bootsma MC, van der Horst MA, Guryeva T, ter Kuile BH, Diekmann O

A mathematical model is presented for the increase and decrease of non-inherited antibiotic resistance levels in bacteria. The model is applied to experimental data on E. coli exposed to amoxicillin or tetracyclin in different concentrations. The parameters of the model are estimated using a Monte Carlo Markov Chain method. The model accurately describes build-up and decline of antibiotic resistance caused by physiological adaptations as long as no genetic changes have occurred. The main conclus... Abstract

European heart journal, Volume 33, Issue 22, 18 3 2012, Pages 2882 Completely occluded aorta associated with coronary heart disease. Montero Cabezas JM, Jurado Roman A, Alonso AR

Abstract