Research

Publications

Below you can find a list of our published research.

9618 results

Cited 262 times since 2008 (15.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 52, Issue 17, 1 1 2008, Pages 1402-1409 Optimal left ventricular lead position predicts reverse remodeling and survival after cardiac resynchronization therapy. Ypenburg C, van Bommel RJ, Delgado V, Mollema SA, Bleeker GB, Boersma E, Schalij MJ, Bax JJ

Objectives: The aim of the current study was to evaluate echocardiographic parameters after 6 months of cardiac resynchronization therapy (CRT) as well as long-term outcome in patients with the left ventricular (LV) lead positioned at the site of latest activation (concordant LV lead position) as compared with that seen in patients with a discordant LV lead position. Background: A nonoptimal LV pacing lead position may be a potential cause for nonresponse to CRT. Methods: The site of latest mech... Abstract

Interactive cardiovascular and thoracic surgery, Volume 7, Issue 5, 1 1 2008, Pages 886 eComment: also in cardiac arrest it is important to think first. Versteegh MI, Braun J

Abstract

Cited 27 times since 2008 (1.6 per year) source: EuropePMC

The Veterinary record, Volume 163, Issue 15, 1 1 2008, Pages 441-444 Seroprevalence of bluetongue serotype 8 in cattle in the Netherlands in spring 2007, and its consequences. van Schaik G, Berends IM, van Langen H, Elbers AR, Vellema P

A cross-sectional study was carried out in spring 2007, at the end of the first bluetongue outbreak season, to determine the geographical spread of bluetongue virus serotype 8 (btv-8) infection in cattle in the Netherlands and the consequences for some production parameters. Blood samples from cattle submitted to the laboratory of the Dutch Animal Health Service for other voluntary and obligatory health programmes were tested serologically for btv-8. In total, 37,073 samples were tested and 659... Abstract

Cited 21 times since 2008 (1.2 per year) source: EuropePMC

Neurology, Volume 71, Issue 16, 1 1 2008, Pages 1254-1260 Motor axon loss is associated with hand dysfunction in Charcot-Marie-Tooth disease 1a. Videler AJ, van Dijk JP, Beelen A, de Visser M, Nollet F, van Schaik IN

Background: Charcot Marie Tooth type 1a (CMT1a) is a primarily demyelinating neuropathy, characterized by slowly progressive muscle weakness, atrophy, and sensory loss, and is most pronounced in both feet and hands. There is increasing evidence that muscle weakness is determined by motor axonal dysfunction. Objective: To investigate in patients with CMT1a whether motor axon loss, as estimated with motor unit number estimation (MUNE) and compound muscle action potential (CMAP), is related to hand... Abstract

Cited 23 times since 2008 (1.4 per year) source: EuropePMC

Acta anaesthesiologica Scandinavica, Volume 52, Issue 9, 1 1 2008, Pages 1194-1203 Establishment of a porcine right ventricular infarction model for cardioprotective actions of xenon and isoflurane. Hein M, Roehl AB, Baumert JH, Bantes B, Bleilevens C, Bernstein N, Steendijk P, Rossaint R

Background: Right ventricular (RV) function is an important determinant of post-operative outcome. Consequences of RV infarction might be limited by pre-conditioning with volatile anesthetic drugs. Therefore, we used a porcine model of RV ischemia and reperfusion (IR) injury to study the influence of isoflurane and xenon on the extent and degree of myocardial injury. Methods: IR injury was induced by a 90-min ligation of the distal right coronary artery and 120-min reperfusion in thiopental anes... Abstract

Cited 58 times since 2008 (3.4 per year) source: EuropePMC

Journal of electrocardiology, Volume 41, Issue 6, 25 4 2008, Pages 648-655 Normal limits of the spatial QRS-T angle and ventricular gradient in 12-lead electrocardiograms of young adults: dependence on sex and heart rate. Scherptong RW, Henkens IR, Man SC, Le Cessie S, Vliegen HW, Draisma HH, Maan AC, Schalij MJ, Swenne CA

Background and purpose: Normal limits of the spatial QRS-T angle and spatial ventricular gradient (SVG) are only available from Frank vectorcardiograms (VCGs) of male subjects. We determined normal limits for these variables derived from standard 12-lead electrocardiograms (ECGs) of 660 male and female students aged 18 to 29 years. Methods: A computer algorithm was used that constructed approximated VCG leads by inverse Dower matrix transformation of the 12-lead ECG and subsequently calculated t... Abstract

Cited 1 times since 2008 (0.1 per year) source: EuropePMC

Intensive care medicine, Volume 35, Issue 2, 24 4 2008, Pages 386-387 Time dependent decrease in blood glucose levels after sampling potentially affects intensive insulin therapy in the intensive care unit. Posthouwer D, de Graaf MJ, Frederiks M, Remijn JA, Rommes JH, Schultz MJ, Spronk PE

Abstract

Cited 72 times since 2008 (4.3 per year) source: EuropePMC

Archives of disease in childhood. Fetal and neonatal edition, Volume 94, Issue 3, 19 3 2008, Pages F196-200 Intelligence of very preterm or very low birthweight infants in young adulthood. Weisglas-Kuperus N, Hille ET, Duivenvoorden HJ, Finken MJ, Wit JM, van Buuren S, van Goudoever JB, Verloove-Vanhorick SP, Dutch POPS-19 Collaborative Study Group

Objective: To examine the effect of intrauterine and neonatal growth, prematurity and personal and environmental risk factors on intelligence in adulthood in survivors of the early neonatal intensive care era. Methods: A large geographically based cohort comprised 94% of all babies born alive in the Netherlands in 1983 with a gestational age below 32 weeks and/or a birth weight >1500 g (POPS study). Intelligence was assessed in 596 participants at 19 years of age. Intrauterine and neonatal gr... Abstract

Cited 5 times since 2008 (0.3 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 25, Issue 2, 18 3 2008, Pages 183-185 Classical methods to measure aortic valve area in the era of new invasive therapies: still accurate enough? Delgado V, Bax JJ

Abstract

Cited 15 times since 2008 (0.9 per year) source: EuropePMC

Stem cells (Dayton, Ohio), Volume 26, Issue 12, 18 3 2008, Pages 3210-3217 Phenotypic and functional reversal within the early human hematopoietic compartment. Knaän-Shanzer S, van der Velde-van Dijke I, van de Watering MJ, de Leeuw PJ, Valerio D, van Bekkum DW, de Vries AA

The fate of phenotypically defined human hematopoietic stem cells (hHSCs) in culture and the link between their surface marker expression profile and function are still controversial. We studied these aspects of hHSC biology by relating the expression of the early lineage markers (ELM) CD33, CD38, and CD71 on the surface of human umbilical cord blood (UCB) CD34(+) cells to their long-term nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse repopulation activity (LT-SRA). In uncult... Abstract

Cited 8 times since 2008 (0.5 per year) source: EuropePMC

Journal of applied physiology (Bethesda, Md. : 1985), Volume 105, Issue 6, 18 3 2008, Pages 1725-1732 Enhanced airway dilation by positive-pressure inflation of the lungs compared with active deep inspiration in patients with asthma. Slats AM, Janssen K, de Jeu RC, van der Plas DT, Schot R, van den Aardweg JG, Sterk PJ

Deep inspiration temporarily reduces induced airways obstruction in healthy subjects. This bronchodilatory effect of deep inspiration is impaired in asthma. Passive machine-assisted lung inflation may augment bronchodilation compared with an active deep inspiration in patients with asthma by either opening closed airways or by reducing fluid flux across the airway wall during deep inspiration, and thereby increasing the tethering forces on the airway wall. We recruited 24 patients with asthma [1... Abstract

Cited 37 times since 2008 (2.2 per year) source: EuropePMC

Pediatric nephrology (Berlin, Germany), Volume 25, Issue 2, 17 3 2008, Pages 221-230 Nephrocalcinosis in preterm neonates. Schell-Feith EA, Kist-van Holthe JE, van der Heijden AJ

The prevalence of nephrocalcinosis (NC) in preterm neonates in recent reports is 7-41%. The wide range in prevalence is a consequence of different study populations and ultrasound equipment and criteria, in addition to a moderate interobserver variation. NC in preterm neonates has a multifactorial aetiology, consisting of low gestational age and birth weight, often in combination with severe respiratory disease, and occurs as a result of an imbalance between stone-promoting and stone-inhibiting... Abstract

Cited 9 times since 2008 (0.5 per year) source: EuropePMC

European journal of endocrinology, Volume 159, Issue 6, 11 2 2008, Pages 705-712 Cardiac manifestations of GH deficiency after treatment for acromegaly: a comparison to patients with biochemical remission and controls. van der Klaauw AA, Bax JJ, Bleeker GB, Holman ER, Delgado V, Smit JW, Romijn JA, Pereira AM

Objective: Both GH excess and GH deficiency (GHD) lead to specific cardiac pathology. The aim of this study was to evaluate cardiac morphology and function in patients with GHD after treatment for acromegaly. Design: Cross-sectional study. Patients and methods: Cardiac parameters were studied by conventional two-dimensional echocardiography and tissue Doppler imaging in 53 patients with acromegaly (16 patients with GHD, 20 patients with biochemical remission, and 17 patients with active disease)... Abstract

Cited 92 times since 2008 (5.4 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 85, Issue 1, 10 2 2008, Pages 45-50 Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users. Bijl MJ, Visser LE, van Schaik RH, Kors JA, Witteman JC, Hofman A, Vulto AG, van Gelder T, Stricker BH

Several beta-blockers are metabolized by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). CYP2D6*4 is the main polymorphism leading to decreased enzyme activity. The clinical significance of impaired elimination of beta-blockers is controversial, and most studies suffer from inclusion of small numbers of poor metabolizers (PMs) of CYP2D6. In this study, the association between CYP2D6*4 and blood pressure or heart rate was examined in 1,533 users of beta-blockers in the Rotterdam Study, a pop... Abstract

Cited 39 times since 2008 (2.3 per year) source: EuropePMC

European journal of internal medicine, Volume 20, Issue 3, 7 1 2008, Pages 253-260 The role of inflammation on atherosclerosis, intermediate and clinical cardiovascular endpoints in type 2 diabetes mellitus. Ray A, Huisman MV, Tamsma JT, Research and Writing-group, van Asten J, Bingen BO, Broeders EA, Hoogeveen ES, van Hout F, Kwee VA, Laman B, Malgo F, Mohammadi M, Nijenhuis M, Rijkée M, van Tellingen MM, Tromp M, Tummers Q, de Vries L

Background: Type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular morbidity and mortality. Sub-clinical systemic inflammation is often present in T2DM patients. Systemic inflammation has also been implicated in the pathophysiology of atherosclerosis. This review investigates the direct evidence present in literature for the effect of inflammation on atherosclerosis, specifically in the setting of T2DM. Special emphasis is given to the pathogenesis of atherosclerosis as well... Abstract

Cited 29 times since 2008 (1.7 per year) source: EuropePMC

The American journal of cardiology, Volume 102, Issue 10, 6 1 2008, Pages 1366-1372 Comparison between tissue Doppler imaging and velocity-encoded magnetic resonance imaging for measurement of myocardial velocities, assessment of left ventricular dyssynchrony, and estimation of left ventricular filling pressures in patients with ischemic cardiomyopathy. Marsan NA, Westenberg JJ, Tops LF, Ypenburg C, Holman ER, Reiber JH, de Roos A, van der Wall EE, Schalij MJ, Roelandt JR, Bax JJ

Velocity-encoded magnetic resonance imaging (VE-MRI), commonly used to perform flow measurements, can be applied for myocardial velocity analysis, similar to tissue Doppler imaging (TDI). In this study, a comparison between VE-MRI and TDI was performed for the assessment of left ventricular dyssynchrony and left ventricular filling pressures. Ten healthy volunteers and 22 patients with heart failure secondary to ischemic cardiomyopathy underwent both VE-MRI and TDI. Longitudinal myocardial peak... Abstract

Cited 2 times since 2008 (0.1 per year) source: EuropePMC

Journal of internal medicine, Volume 264, Issue 6, 6 1 2008, Pages 571-585 Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes. Ye D, Kraaijeveld AO, Grauss RW, Willems SM, van Vark-van der Zee LC, de Jager SC, Jauhiainen M, Kuivenhoven JA, Dallinga-Thie GM, Atsma DE, Hogendoorn PC, Biessen EA, Van Berkel TJ, Jukema JW, van Eck M

Objective: Cholesterol ester transfer protein (CETP) plays an important role in HDL cholesterol metabolism. Leucocytes, including monocyte-derived macrophages in the arterial wall synthesize and secrete CETP, but its role in atherosclerosis is unclear. The aim of the current study was to investigate the effect of acute coronary syndromes (ACS) on leucocyte CETP expression. Research design: Peripheral blood mononuclear cells (PBMCs) were freshly isolated from hospitalized ACS patients displaying... Abstract

Cited 14 times since 2008 (0.8 per year) source: EuropePMC

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 35, Issue 5, 4 1 2008, Pages 492-496 Micro-metastases in stages I and II colon cancer are a predictor of the development of distant metastases and worse disease-free survival. van Schaik PM, Hermans E, van der Linden JC, Pruijt JR, Ernst MF, Bosscha K

Approximately 30% of the patients with Dukes A/B colon carcinoma will develop loco-regional recurrence or distant metastases. The aim of this study was to evaluate if patients with micro-metastases are at higher risk for developing distant metastases and therefore a worse disease-free survival and overall survival. In the period January 2000-January 2002, 137 patients underwent curative surgery for colon cancer. When patients had a Dukes A/B colon carcinoma, additional staining and sectioning on... Abstract

Cited 76 times since 2008 (4.5 per year) source: EuropePMC

Animal cognition, Volume 12, Issue 2, 3 1 2008, Pages 209-216 Skill mastery inhibits adoption of observed alternative solutions among chimpanzees (Pan troglodytes). Hrubesch C, Preuschoft S, van Schaik C

Geographic variation in socially transmitted skills and signals, similar to human culture, has been well documented for great apes. The rules governing the adoption of novel behaviours, however, are still largely unknown. We conducted an innovation-and-transmission experiment with two groups of chimpanzees living at hopE Primate Sanctuary Gänserndorf, Austria, presenting a board on which food had to be manoeuvred around obstacles to be acquired. Most chimpanzees used sticks to acquire the food,... Abstract

Cited 20 times since 2008 (1.2 per year) source: EuropePMC

European journal of heart failure, Volume 10, Issue 9, 2 1 2008, Pages 878-883 Myocardial collagen metabolism in failing hearts before and during cardiac resynchronization therapy. Umar S, Bax JJ, Klok M, van Bommel RJ, Hessel MH, den Adel B, Bleeker GB, Henneman MM, Atsma DE, van der Wall EE, Schalij MJ, van der Laarse A

Background: In patients with heart failure cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling. Aim: To evaluate whether myocardial collagen metabolism in patients with heart failure is implicated in adverse ventricular remodelling and response to CRT. Methods: Collagen synthesis and degradation were assessed from the concentrations of aminoterminal propeptides of type I and type III collagen (PINP and PIIINP) and carboxyterminal telopeptide of type I collagen (ICTP)... Abstract