Research

Publications

Below you can find a list of our published research.

9618 results

Cited 14 times since 2004 (0.7 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 11, Issue 6, 1 1 2004, Pages 689-696 Added value of attenuation-corrected Tc-99m tetrofosmin SPECT for the detection of myocardial viability: comparison with FDG SPECT. Slart RH, Bax JJ, Sluiter WJ, van Veldhuisen DJ, Jager PL

Background: The aim of this study was to evaluate the value of attenuation correction of technetium 99m tetrofosmin single photon emission computed tomography (SPECT) imaging for the detection of myocardial viability. Methods and results: A head-to-head comparison between resting Tc-99m tetrofosmin SPECT and fluorine 18 fluorodeoxyglucose (FDG) SPECT was performed. Both the noncorrected and attenuation-corrected Tc-99m tetrofosmin SPECT images were compared with the FDG images that served as the... Abstract

Cited 5 times since 2004 (0.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 44, Issue 9, 1 1 2004, Pages 1877-1882 Functional significance of stenoses in coronary artery bypass grafts. Evaluation by single-photon emission computed tomography perfusion imaging, cardiovascular magnetic resonance, and angiography. Salm LP, Bax JJ, Vliegen HW, Langerak SE, Dibbets P, Jukema JW, Lamb HJ, Pauwels EK, de Roos A, van der Wall EE

Objectives: This study was designed to perform a head-to-head comparison between single-photon emission computed tomography (SPECT) and cardiovascular magnetic resonance (CMR) to evaluate hemodynamic significance of angiographic findings in bypass grafts. Background: The hemodynamic significance of a bypass graft stenosis may not always accurately be determined from the coronary angiogram. A variety of diagnostic tests (invasive or noninvasive) can further characterize the hemodynamic consequenc... Abstract

Cited 43 times since 2004 (2.1 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 89, Issue 11, 1 1 2004, Pages 5828-5836 Involvement of membrane-type matrix metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial cells: role of MT3-MMP. Plaisier M, Kapiteijn K, Koolwijk P, Fijten C, Hanemaaijer R, Grimbergen JM, Mulder-Stapel A, Quax PH, Helmerhorst FM, van Hinsbergh VW

In the endometrium, angiogenesis is a physiological process, whereas in most adult tissues neovascularization is initiated only during tissue repair or pathological conditions. Pericellular proteolysis plays an important role in angiogenesis being required for endothelial cell migration, invasion, and tube formation. We studied the expression of proteases by human endometrial microvascular endothelial cells (hEMVECs) and their involvement in the formation of capillary tubes and compared these re... Abstract

Cited 6 times since 2004 (0.3 per year) source: EuropePMC

Echocardiography (Mount Kisco, N.Y.), Volume 21, Issue 8, 1 1 2004, Pages 721-723 Transesophageal echocardiography-guided transvenous biopsy of an intracardiac tumor. Scholte AJ, Frissen PH, van der Wouw PA

Transesophageal echocardiography with simultaneous fluoroscopic guidance during a transvenous biopsy of an intracardiac tumor is a valuable technique. We present the case of a 67-year-old man with a metastasis in the right atrium from which histological examination of the tumor was indicated. The inaccessible location of the primary tumor in the liver and impaired hemostasis due to cirrhosis necessitated a transvenous biopsy of the metastasis. The procedure and the associated techniques are disc... Abstract

Cited 13 times since 2004 (0.6 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 11, Issue 6, 1 1 2004, Pages 704-709 Prognostic value of stress Tc-99m tetrofosmin SPECT in patients with previous myocardial infarction: impact of scintigraphic extent of coronary artery disease. Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Poldermans D

Background: Our objective was to assess the prognostic value of the scintigraphic extent of coronary artery disease on stress technetium 99m tetrofosmin single photon emission computed tomography in patients with previous myocardial infarction. Methods and results: We studied 383 patients (280 men and 103 women; mean age, 60 +/- 11 years) more than 3 months after an acute myocardial infarction by exercise bicycle or dobutamine (up to 40 mug . kg -1 . min -1 ) stress Tc-99m tetrofosmin myocardial... Abstract

Cited 53 times since 2004 (2.5 per year) source: EuropePMC

Circulation, Volume 110, Issue 19, 1 1 2004, Pages 3017-3022 Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Kies P, Wichter T, Schäfers M, Paul M, Schäfers KP, Eckardt L, Stegger L, Schulze-Bahr E, Rimoldi O, Breithardt G, Schober O, Camici PG

Background: Life-threatening ventricular tachyarrhythmias can occur in young patients without structural heart disease (idiopathic forms). In many patients, these are typically triggered by an increased sympathetic tone, eg, by physical or mental stress. In contrast, in Brugada syndrome, ventricular tachyarrhythmias more often occur during rest or sleep when the vagal tone is predominant. Furthermore, adrenergic agonists can reduce the level of ST-segment elevation, whereas it is increased by pa... Abstract

Tijdschrift voor diergeneeskunde, Volume 129, Issue 21, 1 1 2004, Pages 723-4; author reply 724 [Practice certification and recognition]. van Schaik AM

Abstract

Cited 2 times since 2004 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 12, Issue 11, 1 1 2004, Pages 491-496 Enhancing reverse cholesterol transport/raising HDL cholesterol: new options for prevention and treatment of cardiovascular disease. Jukema JW, Lenselink M, de Grooth GJ, Boekholdt SM, Liem AH, Kuivenhoven JA, Kastelein JJ

High-density lipoprotein cholesterol (HDL-c) plays a crucial role in the concept of reverse cholesterol transport and has many other beneficial properties which may interfere with atherogenesis and plaque rupture. Low HDL-c levels are currently considered to be an important risk factor for the development of cardiovascular disease. However until recently no effective and safe treatment for powerfully increasing HDL-c selectively was available. This short overview describes possible new therapeut... Abstract

Cited 31 times since 2004 (1.5 per year) source: EuropePMC

Journal of molecular biology, Volume 344, Issue 2, 1 1 2004, Pages 513-526 Solution structure of the ubiquitin-conjugating enzyme UbcH5B. Houben K, Dominguez C, van Schaik FM, Timmers HT, Bonvin AM, Boelens R

The ubiquitination pathway is the main pathway for protein degradation in eukaryotic cells. The attachment of ubiquitin to a substrate protein is catalyzed by three types of enzymes, namely a ubiquitin activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin ligase (E3). Here, the structure of the human ubiquitin-conjugating enzyme (E2) UbcH5B has been solved by a combination of homology modeling, NMR relaxation data and automated NOE assignments. Comparison to E2 structures... Abstract

Cited 10 times since 2004 (0.5 per year) source: EuropePMC

Pediatric blood & cancer, Volume 43, Issue 6, 1 1 2004, Pages 659-667 Health status of young children during therapy for advanced neuroblastoma. Nathan PC, Furlong W, De Pauw S, Horsman J, Van Schaik C, Rolland M, Weitzman S, Feeny D, Barr RD

Background: The purpose of this study was to describe the health status experienced by young children during various phases of therapy for advanced neuroblastoma. Methods: Nineteen patients aged 2.00-4.99 years at the time of diagnosis of neuroblastoma (stages 3 or 4) who received active therapy between 1996 and 2000 were enrolled on the study. Their parents provided proxy assessments of their health status at a maximum of 10 assessment points during therapy using the Comprehensive Health Status... Abstract

Cited 98 times since 2004 (4.7 per year) source: EuropePMC

Journal of the National Cancer Institute, Volume 96, Issue 21, 1 1 2004, Pages 1585-1592 Prediction of irinotecan pharmacokinetics by use of cytochrome P450 3A4 phenotyping probes. Mathijssen RH, de Jong FA, van Schaik RH, Lepper ER, Friberg LE, Rietveld T, de Bruijn P, Graveland WJ, Figg WD, Verweij J, Sparreboom A

Background: Irinotecan is a topoisomerase I inhibitor that has been approved for use as a first- and second-line treatment for colorectal cancer. The response to irinotecan is variable, possibly because of interindividual variation in the expression of the enzymes that metabolize irinotecan, including cytochrome P450 3A4 (CYP3A4) and uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1). We prospectively explored the relationships between CYP3A phenotype, as assessed by erythromycin metabolis... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 12, Issue Suppl 2, 1 1 2004, Pages 9-10 Hot line III: Inflammation in coronary disease: Munich, 30 August 2004. van Huysduynen BH, Jukema JW

Abstract

Cited 107 times since 2004 (5.1 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 15, Issue 11, 1 1 2004, Pages 1258-1262 Incidence and risk factors of early venous thrombosis associated with permanent pacemaker leads. van Rooden CJ, Molhoek SG, Rosendaal FR, Schalij MJ, Meinders AE, Huisman MV

Introduction: Pacemaker lead implantation can cause thrombosis, which can be associated with serious local morbidity and complicated by pulmonary embolism. Few reliable estimates of the incidence of thrombosis have been reported. The contribution of established risk factors to venous thrombosis in patients with implanted pacemaker leads is unknown. Methods and results: One hundred forty-five consecutive patients n = 145) underwent routine clinical and Doppler ultrasound evaluation for thrombosis... Abstract

Cited 31 times since 2004 (1.5 per year) source: EuropePMC

European urology, Volume 46, Issue 5, 1 1 2004, Pages 670-674 The effect of hyperthermia on mitomycin-C induced cytotoxicity in four human bladder cancer cell lines. van der Heijden AG, Jansen CF, Verhaegh G, O'donnell MA, Schalken JA, Witjes JA

Introduction: Hyperthermia and mitomycin-C (MMC) have given very encouraging results in several clinical studies for the treatment of superficial transitional cell carcinoma of the bladder. However, a synergistic effect of hyperthermia and MMC on the decrease of cell proliferation has never been demonstrated accurately in vitro. We investigated the effect of MMC versus MMC combined with hyperthermia on the cytotoxicity in four human bladder cancer cell lines. Material and methods: The RT112, RT4... Abstract

Cited 12 times since 2004 (0.6 per year) source: EuropePMC

Journal of applied physiology (Bethesda, Md. : 1985), Volume 98, Issue 3, 29 5 2004, Pages 1044-1049 Is carbon monoxide-mediated cyclic guanosine monophosphate production responsible for low blood pressure in neonatal respiratory distress syndrome? van Bel F, Latour V, Vreman HJ, Wong RJ, Stevenson DK, Steendijk P, Egberts J, Krediet TG

Infant respiratory distress syndrome (RDS) involves inflammatory processes, causing an increased expression of inducible heme oxygenase with subsequent production of carbon monoxide (CO). We hypothesized that increased production of CO during RDS might be responsible for increased plasma levels of vasodilatory cGMP and, consequently, low blood pressure observed in infants with RDS. Fifty-two infants (no-RDS, n = 21; RDS, n = 31), consecutively admitted to the neonatal intensive care unit (NICU)... Abstract

Cited 32 times since 2004 (1.5 per year) source: EuropePMC

British journal of anaesthesia, Volume 94, Issue 2, 29 5 2004, Pages 181-185 Gut permeability in paediatric cardiac surgery. Malagon I, Onkenhout W, Klok G, van der Poel PF, Bovill JG, Hazekamp MG

Background: Intestinal mucosal ischaemia can occur in infants and children during and after cardiac surgery. Severe decreases in mucosal perfusion may cause complications such as necrotizing enterocolitis and postoperative mortality. We investigated gut permeability in paediatric patients undergoing cardiac surgery using the dual sugar permeability test and absorption of two other saccharides. Methods: Thirty-four patients undergoing palliative or corrective surgical procedures with and without... Abstract

Cited 9 times since 2004 (0.4 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 32, Issue 3, 12 2 2004, Pages 314-321 Incidence of stunned, hibernating and scarred myocardium in ischaemic cardiomyopathy. Hernandez-Pampaloni M, Bax JJ, Morita K, Dutka DP, Camici PG

Purpose: Different criteria to identify residual viability in chronically dysfunctioning myocardium in patients with coronary artery disease (CAD) can be derived by the combined assessment of myocardial blood flow (MBF) and glucose utilisation (MRG) using positron emission tomography (PET). The aim of this study was to evaluate, in a large number of patients, the prevalence of these different patterns by purely quantitative means. Methods: One hundred and sixteen consecutive patients with ischae... Abstract

Cited 48 times since 2004 (2.3 per year) source: EuropePMC

Circulation, Volume 110, Issue 16, 11 2 2004, Pages 2395-2400 Left ventricular pacing minimizes diastolic ventricular interaction, allowing improved preload-dependent systolic performance. Bleasdale RA, Turner MS, Mumford CE, Steendijk P, Paul V, Tyberg JV, Morris-Thurgood JA, Frenneaux MP

Background: Left ventricular (LV) pacing improves hemodynamics in patients with heart failure. We hypothesized that at least part of this benefit occurs by minimization of external constraint to LV filling from ventricular interaction. Methods and results: We present median values (interquartile ranges) for 13 heart failure patients with LV pacing systems implanted for New York Heart Association class III/IV limitation. We used the conductance catheter method to measure LV pressure and volume si... Abstract

Cited 50 times since 2004 (2.4 per year) source: EuropePMC

Circulation, Volume 110, Issue 16, 11 2 2004, Pages 2383-2388 Opposite patterns of left ventricular remodeling after coronary revascularization in patients with ischemic cardiomyopathy: role of myocardial viability. Rizzello V, Poldermans D, Boersma E, Biagini E, Schinkel AF, Krenning B, Elhendy A, Vourvouri EC, Sozzi FB, Maat A, Crea F, Roelandt JR, Bax JJ

Background: In patients with ischemic cardiomyopathy, left ventricular (LV) remodeling is an important prognostic indicator. The precise relation between viable myocardium, revascularization, and ongoing or reversed remodeling is unknown and was evaluated in the present study. Methods and results: A total of 100 patients with ischemic cardiomyopathy underwent dobutamine stress echocardiography to assess myocardial viability and LV geometry (volumes and shape). At a mean of 10.2 months and 4.5 ye... Abstract

Cited 8 times since 2004 (0.4 per year) source: EuropePMC

Alcohol and alcoholism (Oxford, Oxfordshire), Volume 39, Issue 6, 11 2 2004, Pages 499-502 Oral chronic ethanol administration to rodents by agar gel diet. Bykov I, Palmén M, Piirainen L, Lindros KO

Background: Chronic ethanol administration to rodents requires specially designed equipment and is labor intensive. Here we report a new procedure. Method: A commercial liquid diet preparation was made into a gel by addition of 0.5% agar. The gel, containing 5.3% ethanol, was offered in Falcon tubes equipped with a feeding opening. Results: The gel consumption by C57/Bl mice resulted in high blood ethanol levels (average 43 mM). After 6 weeks, marked liver steatosis and significantly increased s... Abstract