Research

Publications

Below you can find a list of our published research.

9618 results

Cited 254 times since 2004 (11.9 per year) source: EuropePMC

Journal of cardiovascular electrophysiology, Volume 15, Issue 5, 1 1 2004, Pages 544-549 Relationship between QRS duration and left ventricular dyssynchrony in patients with end-stage heart failure. Bleeker GB, Schalij MJ, Molhoek SG, Verwey HF, Holman ER, Boersma E, Steendijk P, Van Der Wall EE, Bax JJ

Introduction: Patients with end-stage heart failure and a wide QRS complex are considered candidates for cardiac resynchronization therapy (CRT). However, 20% to 30% of patients do not respond to CRT. Lack of left ventricular dyssynchrony may explain the nonresponse. Accordingly, we evaluated the presence of left ventricular dyssynchrony using tissue Doppler imaging (TDI) in 90 consecutive patients with heart failure. Methods and results: Ninety patients with severe heart failure (left ventricul... Abstract

Cited 14 times since 2004 (0.7 per year) source: EuropePMC

Heart rhythm, Volume 1, Issue 1, 1 1 2004, Pages 51-57 Standardized screening and treatment of patients with life-threatening arrhythmias: the Leiden out-of-hospital cardiac arrest evaluation study. van der Burg AE, Bax JJ, Boersma E, van Erven L, Bootsma M, van der Wall EE, Schalij MJ

Objectives: The aim of this study was to evaluate the effect of a systematic screening/treatment protocol on outcome in patients after aborted sudden death. Background: Patients after aborted sudden death are at high risk for recurrent events. In this regard, systematic screening is mandatory to reveal the underlying etiology, to detect and subsequently treat reversible causes, and to establish patient-tailored antiarrhythmic treatment. Methods: A total of 417 consecutive patients after aborted... Abstract

Cited 10 times since 2004 (0.5 per year) source: EuropePMC

The American journal of cardiology, Volume 93, Issue 10, 1 1 2004, Pages 1298-1302 Anatomical observations of the pulmonary veins with intracardiac echocardiography and hemodynamic consequences of narrowing of pulmonary vein ostial diameters after radiofrequency catheter ablation of atrial fibrillation. Jongbloed MR, Bax JJ, Zeppenfeld K, van der Wall EE, Schalij MJ

Intracardiac echocardiography was used to explore pulmonary venous (PV) anatomy and to monitor PV stenosis in 31 patients referred for radiofrequency catheter ablation at PV ostia. Interindividual variations in PV anatomy and insertion in the left atrium were observed. Narrowing of PV ostia after radiofrequency catheter ablation did not produce significant hemodynamic changes. Abstract

Cited 111 times since 2004 (5.2 per year) source: EuropePMC

The Journal of experimental medicine, Volume 199, Issue 10, 1 1 2004, Pages 1409-1420 CD8 T cell recognition of endogenously expressed epstein-barr virus nuclear antigen 1. Lee SP, Brooks JM, Al-Jarrah H, Thomas WA, Haigh TA, Taylor GS, Humme S, Schepers A, Hammerschmidt W, Yates JL, Rickinson AB, Blake NW

The Epstein-Barr virus (EBV) nuclear antigen (EBNA)1 contains a glycine-alanine repeat (GAr) domain that appears to protect the antigen from proteasomal breakdown and, as measured in cytotoxicity assays, from major histocompatibility complex (MHC) class I-restricted presentation to CD8+ T cells. This led to the concept of EBNA1 as an immunologically silent protein that although unique in being expressed in all EBV malignancies, could not be exploited as a CD8 target. Here, using CD8+ T cell clon... Abstract

Cited 112 times since 2004 (5.3 per year) source: EuropePMC

European heart journal, Volume 25, Issue 10, 1 1 2004, Pages 815-836 Imaging techniques for the assessment of myocardial hibernation. Report of a Study Group of the European Society of Cardiology. Underwood SR, Bax JJ, vom Dahl J, Henein MY, Knuuti J, van Rossum AC, Schwarz ER, Vanoverschelde JL, van der Wall EE, Wijns W, Study Group of the European Society of Cardiology

This report of an ESC Study Group reviews current knowledge on myocardial hibernation and relevant imaging techniques, and provides an algorithm for investigation and management when a patient presents with ischaemic left ventricular dysfunction. It covers the definitions of myocardial viability, stunning and hibernation, it reviews the morphological findings in hibernation and it describes relevant clinical settings. The imaging and other techniques that are reviewed are electrocardiography, po... Abstract

Cited 228 times since 2004 (10.7 per year) source: EuropePMC

General hospital psychiatry, Volume 26, Issue 3, 1 1 2004, Pages 184-189 Patients' preferences in the treatment of depressive disorder in primary care. van Schaik DJ, Klijn AF, van Hout HP, van Marwijk HW, Beekman AT, de Haan M, van Dyck R

Patients' preferences in the treatment of depression are important in clinical practice and in research. Antidepressant medication is often prescribed, but adherence is low. This may be caused by patients preferring psychotherapy, which is often not available in primary care. In randomized clinical trials, patients' preferences may affect the external validity. The aim of this article is to study patients' preferences regarding psychotherapy and antidepressant medication and the i... Abstract

Cited 18 times since 2004 (0.8 per year) source: EuropePMC

Primates; journal of primatology, Volume 45, Issue 3, 20 3 2004, Pages 177-182 Determinants of orangutan density in the dryland forests of the Leuser Ecosystem. Wich S, Buij R, van Schaik C

Orangutans are the only great ape in Asia. Since orangutan densities vary between habitat types within regions and within similar habitat types among regions, it is important to determine areas with high densities for their protection. In this paper we show that orangutan density in old-growth dryland forests in the Leuser Ecosystem, Sumatra is significantly related to the density of large strangling figs and topsoil pH. In addition, large fig density depends on topsoil pH. Provided that orangut... Abstract

Cited 39 times since 2004 (1.8 per year) source: EuropePMC

Basic research in cardiology, Volume 99, Issue 5, 16 3 2004, Pages 351-359 Left ventricular pressure-volume measurements in mice: comparison of closed-chest versus open-chest approach. Lips DJ, van der Nagel T, Steendijk P, Palmen M, Janssen BJ, van Dantzig JM, de Windt LJ, Doevendans PA

Objective: We investigated whether in vivo closed-chest left ventricular pressure-volume measurements would yield similar values for LV hemodynamics compared with open-chest PV measurements under several anesthetics. Methods: The right common carotid of C57Bl/6 mice was cannulated with a combined pressure-conductance catheter and inserted retrogradely into the left ventricle in the closed-chest model. The open-chest model consisted of an abdominal approach involving the opening of the thoracic c... Abstract

Cited 313 times since 2004 (14.6 per year) source: EuropePMC

Annals of the rheumatic diseases, Volume 63, Issue 4, 1 1 2004, Pages 373-381 Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Vossenaar ER, Radstake TR, van der Heijden A, van Mansum MA, Dieteren C, de Rooij DJ, Barrera P, Zendman AJ, van Venrooij WJ

Background: Antibodies directed to proteins containing the non-standard amino acid citrulline, are extremely specific for rheumatoid arthritis (RA). Peptidylcitrulline can be generated by post-translational conversion of arginine residues. This process, citrullination, is catalysed by a group of calcium dependent peptidylarginine deiminase (PAD) enzymes. Objective: To investigate the expression and activity of four isotypes of PAD in peripheral blood and synovial fluid cells of patients with RA.... Abstract

Cited 70 times since 2004 (3.3 per year) source: EuropePMC

The American journal of cardiology, Volume 93, Issue 7, 1 1 2004, Pages 860-863 Comparison of benefits from cardiac resynchronization therapy in patients with ischemic cardiomyopathy versus idiopathic dilated cardiomyopathy. Molhoek SG, Bax JJ, van Erven L, Bootsma M, Boersma E, Steendijk P, van der Wall EE, Schalij MJ

Cardiac resynchronization therapy (CRT) is a recently introduced therapeutic option for patients with severe heart failure and intraventricular conduction disturbances. However, it is estimated that 20% to 30% of patients may not respond to CRT. Patients with ischemic cardiomyopathy (IC) may respond less favorably to CRT compared with patients with idiopathic dilated cardiomyopathy (IDC). Accordingly, the beneficial effects of CRT were evaluated in 2 subsets of patients (IC and IDC). Seventy-fou... Abstract

Cited 5 times since 2004 (0.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 20, Issue 2, 1 1 2004, Pages 113-116 Thrombus in the left atrial appendage detected by intracardiac echocardiography. Jongbloed MR, Bax JJ, van der Wall EE, Schalij MJ

Radiofrequency catheter ablation (RFCA) at the ostium of the pulmonary veins can potentially cure atrial fibrillation. Left-sided ablation procedures may carry a risk of thrombo-embolic events. Emboli from intracardiac thrombus originate from the left atrial appendage (LAA) in a substantial number of patients. The presence of spontaneous echo contrast in the left atrium (LA) and LAA peak emptying flow < or = 20 cm/s are also significantly related to thrombo-embolic events. Evaluation of the a... Abstract

Cited 15 times since 2004 (0.7 per year) source: EuropePMC

Critical care medicine, Volume 32, Issue 4, 1 1 2004, Pages 1087-1089 Right ventricular function and failure: methods, models, and mechanisms. Steendijk P

Abstract

Cited 6 times since 2004 (0.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 12, Issue 4, 1 1 2004, Pages 157-164 Recommendations and cardiological evaluation of athletes with arrhythmias: Part 1. Hoogsteen J, Bennekers JH, van der Wall EE, van Hemel NM, Wilde AA, Crijns HJ, Gorgels AP, Smeets JL, Hauer RN, Jordaens JL, Schalij MJ

Besides the consensus meeting in Amersfoort in 1988 and the Bethesda conference in 1994 recommendations are not available in the Netherlands for screening and evaluation of athletes with cardiac arrhythmias. Guidelines for competitive athletes with cardiac arrhythmias in the United States and Italy were published in 2000. In 1998 Estes et al. published the most important opinions on sudden cardiac death, screening and evaluation of athletes and arrhythmias. This study addresses the physiological... Abstract

Cited 2 times since 2004 (0.1 per year) source: EuropePMC

Physiological measurement, Volume 25, Issue 2, 1 1 2004, Pages 565-576 Assessment of parallel conductance for the trans-cardiac conductance method: can we use the hypertonic saline method with pulmonary artery injections? Staal EM, Baan J, Jukema JW, van der Wall EE, Steendijk P

The trans-cardiac conductance (TCC) method provides on-line left ventricular (LV) volume signals by determining the electrical conductance of blood in the LV using central venous and epithoracic electrodes. Conductive structures outside the LV cause a 'parallel conductance' offset term (Vp) that is determined by bolus injections of hypertonic saline in the pulmonary artery (Vp(saline)). Analysis of the increased conductance signal during passage of the bolus through the LV yields Vp(sa... Abstract

Cited 9 times since 2004 (0.4 per year) source: EuropePMC

Allergy, Volume 59, Issue 4, 1 1 2004, Pages 457-460 Sensory testing of recipes masking peanut or hazelnut for double-blind placebo-controlled food challenges. Ronteltap A, van Schaik J, Wensing M, Rynja FJ, Knulst AC, de Vries JH

Background: In a double-blind placebo-controlled food challenge (DBPCFC), it is necessary that recipes comprising the allergen cannot be distinguished from placebo. Aims of the study: We investigated whether the method of paired comparisons, a sensory difference test, could be used to test the suitability of recipes for a DBPCFC. Methods: We used two recipes, each with three concentrations of peanut or hazelnut flour. The recipe for peanut consisted of mashed potatoes with 2.7, 8.9, or 26.8 mg o... Abstract

Cited 19 times since 2004 (0.9 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 26, Issue 2, 1 1 2004, Pages 236-240 Implications of cytochrome P450 genetic polymorphisms on the toxicity of antitumor agents. van Schaik RH

In the treatment of cancer, a narrow therapeutic window generally exists between toxicity and suboptimal therapy. In addition, interindividual variation in drug metabolism seriously complicates therapy. Genetic polymorphisms in phase 1 and phase 2 enzymes are present in the population and may explain part of the observed interindividual variation in drug pharmacokinetics. For the cytochrome P450 superfamily, information on variant alleles encoding enzymes with decreased activity is rapidly on th... Abstract

Cited 97 times since 2004 (4.5 per year) source: EuropePMC

Structure (London, England : 1993), Volume 12, Issue 4, 1 1 2004, Pages 633-644 Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R

The protein CNOT4 possesses an N-terminal RING finger domain that acts as an E3 ubiquitin ligase and specifically interacts with UbcH5B, a ubiquitin-conjugating enzyme. The structure of the CNOT4 RING domain has been solved and the amino acids important for the binding to UbcH5B have been mapped. Here, the residues of UbcH5B important for the binding to CNOT4 RING domain were identified by NMR chemical shift perturbation experiments, and these data were used to generate structural models of the... Abstract

Cited 16 times since 2004 (0.7 per year) source: EuropePMC

Journal of vascular surgery, Volume 39, Issue 4, 1 1 2004, Pages 850-858 Ingrowth of aorta wall into stent grafts impregnated with basic fibroblast growth factor: a porcine in vivo study of blood vessel prosthesis healing. van der Bas JM, Quax PH, van den Berg AC, Visser MJ, van der Linden E, van Bockel JH

Objective: Endovascular aneurysm repair is an alternative treatment of abdominal aortic aneurysm. The procedure is less invasive, and morbidity and most probably mortality are reduced. However, some problems, such as endoleakage, are yet to be resolved. Endoleakage can occur after graft migration, as a result of insufficient fixation of the stent graft. One cause is deficient healing between the aortic neck and the stent graft. We hypothesize that better healing, achieved by induction of vascula... Abstract

Cited 19 times since 2004 (0.9 per year) source: EuropePMC

Virology, Volume 321, Issue 2, 1 1 2004, Pages 287-296 Stable transduction of large DNA by high-capacity adeno-associated virus/adenovirus hybrid vectors. Gonçalves MA, van der Velde I, Knaän-Shanzer S, Valerio D, de Vries AA

Viral vectors with high cloning capacity and host chromosomal integration ability are in demand for the efficient and permanent genetic modification of target cells with large DNA molecules. We have generated a hybrid gene transfer vehicle consisting of recombinant adeno-associated virus (AAV) replicative intermediates packaged in adenovirus (Ad) capsids. This arrangement allows cell cycle-independent nuclear delivery of recombinant AAV genomes with lengths considerably above the maximum size (i... Abstract

Cited 76 times since 2004 (3.5 per year) source: EuropePMC

Urology, Volume 63, Issue 3, 1 1 2004, Pages 466-471 Combined local bladder hyperthermia and intravesical chemotherapy for the treatment of high-grade superficial bladder cancer. Gofrit ON, Shapiro A, Pode D, Sidi A, Nativ O, Leib Z, Witjes JA, van der Heijden AG, Naspro R, Colombo R

Objectives: To evaluate the effectiveness of combined local bladder hyperthermia and intravesical chemotherapy for the treatment of patients with high-grade (G3) superficial bladder cancer. Methods: Patients with G3 bladder tumors (Stage Ta or T1) were treated with combined intravesical chemotherapy with mitomycin-C and local radiofrequency hyperthermia of the bladder wall. The patients were treated with either a prophylactic protocol (40 mg mitomycin-C) after complete transurethral resection of... Abstract