9618 results
Cited 20 times since 2022 (6.9 per year)
source: EuropePMC
Molecular therapy. Nucleic acids,
Volume 30, 17 3 2022, Pages 162-172
C/D box snoRNA SNORD113-6 guides 2'-O-methylation and protects against site-specific fragmentation of tRNA<sup>Leu</sup>(TAA) in vascular remodeling.
van Ingen E, Engbers PAM, Woudenberg T, van der Bent ML, Mei H, Wojta J, Quax PHA, Nossent AY
C/D box small nucleolar RNAs (snoRNAs) of the DLK1-DIO3 locus are associated with vascular remodeling and cardiovascular disease. None of these snoRNAs has any known targets yet except for one, AF357425/SNORD113-6. We previously showed that this snoRNA targets mRNAs of the integrin signaling pathway and affects arterial fibroblast function. Here, we aimed to identify whether AF357425/SNORD113-6 can also target small RNAs. We overexpressed or inhibited AF357425 in murine fibroblasts and performed...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
Journal of diabetes and its complications,
Volume 36, Issue 12, 15 3 2022, Pages 108309
Extent of subclinical atherosclerosis on coronary computed tomography and impact of statins in patients with diabetes without known coronary artery disease: Results from CONFIRM registry.
Shaikh K, Ahmed A, Gransar H, Lee J, Leipsic J, Nakanishi R, Alla V, Bax JJ, Chow BJW, Berman DS, Maffei E, Lin FY, Ahmad A, DeLago A, Pontone G, Feuchtner G, Marques H, Min JK, Hausleiter J, Hadamitzky M, Kaufmann PA, de Araújo Gonçalves P, Cury RC, Kim YJ, Chang HJ, Rubinshtein R, Villines TC, Lu Y, Shaw LJ, Acenbach S, Al Mallah MH, Andreini D, Cademartiri F, Callister TQ, Budoff MJ
Background: Absence of subclinical atherosclerosis is considered safe to defer statin therapy in general population. However, impact of statins on atherosclerotic cardiovascular disease in patients with diabetes stratified by coronary artery calcium (CAC) scores and extent of non-obstructive CAD on coronary computed tomography angiography (CCTA) has not been evaluated. Methods: CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multi-center Registry) study enroll...
Abstract
Cited 6 times since 2022 (2.1 per year)
source: EuropePMC
The American journal of cardiology,
Volume 183, 14 2 2022, Pages 33-39
Effect of Bi-Atrial Size and Function in Patients With Paroxysmal or Permanent Atrial Fibrillation.
Bax M, Ajmone Marsan N, Delgado V, Bax JJ, van der Bijl P
Atrial fibrillation (AF) remains the most common arrhythmia in clinical practice. The choice between a rate-control and rhythm-control strategy depends on various factors, including the anatomical and functional substrate. This study investigates the anatomical and functional characteristics of both atria in patients with AF and explores the potential therapeutic implications. From an ongoing registry of patients with paroxysmal or permanent AF, those who underwent cardiac computed tomography (C...
Abstract
Cited 5 times since 2022 (1.7 per year)
source: EuropePMC
PNAS nexus,
Volume 1, Issue 4, 14 2 2022, Pages pgac168
Problem-solving in groups of common marmosets (<i>Callithrix jacchus</i>): more than the sum of its parts.
Sehner S, Willems EP, Vinicus L, Migliano AB, van Schaik CP, Burkart JM
Human hypercooperativity and the emergence of division of labor enables us to solve problems not only effectively within a group but also collectively. Collective problem-solving occurs when groups perform better than the additive performance of separate individuals. Currently, it is unknown whether this is unique to humans. To investigate the evolutionary origin of collective problem-solving and potential precursors, we propose a continuum of group effects on problem-solving, from simple to com...
Abstract
Cited 5 times since 2022 (1.7 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 36, Issue 2, 13 2 2022, Pages 252-254
Left Ventricular Myocardial Work to Differentiate Cardiac Amyloidosis From Hypertrophic Cardiomyopathy.
Stassen J, Tjahjadi C, Adam R, Debonnaire P, Claeys M, Popescu BA, Jurcut R, Delgado V, Bax JJ, Marsan NA
Abstract
Cited 6 times since 2022 (2 per year)
source: EuropePMC
International journal of cardiology,
Volume 371, 13 2 2022, Pages 153-159
Common genetic variants improve risk stratification after the atrial switch operation for transposition of the great arteries.
Woudstra OI, Skoric-Milosavljevic D, Mulder BJM, Meijboom FJ, Post MC, Jongbloed MRM, van Dijk APJ, van Melle JP, Konings TC, Postma AV, Bezzina CR, Bouma BJ, Tanck MWT
Background: Clinical factors are used to estimate late complication risk in adults after atrial switch operation (AtrSO) for transposition of the great arteries (TGA), but heterogeneity in clinical course remains. We studied whether common genetic variants are associated with outcome and add value to a clinical risk score in TGA-AtrSO patients. Methods and results: This multicenter study followed 133 TGA-AtrSO patients (aged 28 [IQR 24-35] years) for 13 (IQR 9-16) years and examined the associat...
Abstract
Cited 15 times since 2022 (5.1 per year)
source: EuropePMC
Oral oncology,
Volume 134, 12 2 2022, Pages 106099
Comparison of narrow band and fluorescence molecular imaging to improve intraoperative tumour margin assessment in oral cancer surgery.
de Wit JG, van Schaik JE, Voskuil FJ, Vonk J, de Visscher SAHJ, Schepman KP, van der Laan BFAM, Doff JJ, van der Vegt B, Plaat BEC, Witjes MJH
Objective: New techniques have emerged to aid in preventing inadequate margins in oral squamous cell carcinoma (OSCC) surgery, but studies comparing different techniques are lacking. Here, we compared narrow band imaging (NBI) with fluorescence molecular imaging (FMI), to study which intraoperative technique best assesses the mucosal tumour margins. Materials and methods: NBI was performed in vivo and borders were marked with three sutures. For FMI, patients received 75 mg of unlabelled cetuxima...
Abstract
Cited 3 times since 2022 (1 per year)
source: EuropePMC
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery,
Volume 64, Issue 6, 8 2 2022, Pages 602-608
Cost of Follow Up After Endovascular Abdominal Aortic Aneurysm Repair in Patients With an Initial Post-Operative Computed Tomography Angiogram Without Abnormalities.
Geraedts ACM, van Dieren S, Mulay S, Vahl AC, Koelemay MJW, Balm R, ODYSSEUS Study Group
Objective: The Observing a Decade of Yearly Standardised Surveillance in EVAR patients with Ultrasound or CT Scan (ODYSSEUS) study was conducted to assess differences in outcomes of patients with continued or discontinued yearly follow up after endovascular abdominal aortic aneurysm repair (EVAR). Earlier results of this study showed that discontinued follow up was not associated with poor outcomes. Therefore, an incremental cost analysis and budget impact analysis of de-implementation of yearly...
Abstract
Cited 2 times since 2022 (0.7 per year)
source: EuropePMC
The American journal of cardiology,
Volume 182, 6 1 2022, Pages 69-76
Impact of Left Ventricular Global Longitudinal Strain on Outcomes After Transcatheter Edge-to-Edge Repair in Secondary Mitral Regurgitation.
Yoon SH, Makar M, Kar S, Koseki K, Oakley L, Sekhon N, Patel D, Chakravarty T, Nakamura M, Hamilton M, Patel JK, Singh S, Sabah S, Siegel RJ, Bax JJ, Makkar RR
Assessment of left ventricular (LV) systolic function is essential in patient selection for transcatheter edge-to-edge repair (TEER) in secondary mitral regurgitation (MR). Although LV ejection fraction (EF) is mostly used for assessing LV function, it represents the change of LV chamber size, but not myocardial contractility. LV global longitudinal strain (GLS) provides an alternative to assess LV systolic function in patients with secondary MR. This study included 380 patients with secondary M...
Abstract
Cited 7 times since 2022 (2.4 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 31, Issue 3, 6 1 2022, Pages 89-99
Implantable defibrillator therapy and mortality in patients with non-ischaemic dilated cardiomyopathy : An updated meta-analysis and effect on Dutch clinical practice by the Task Force of the Dutch Society of Cardiology.
Theuns DA, Verstraelen TE, van der Lingen ACJ, Delnoy PP, Allaart CP, van Erven L, Maass AH, Vernooy K, Wilde AAM, Boersma E, Meeder JG
Background: Primary prophylactic implantable cardioverter-defibrillators (ICDs) in patients with non-ischaemic cardiomyopathy (NICMP) remains controversial. This study sought to assess the benefit of ICD therapy with or without cardiac resynchronisation therapy (CRT) in patients with NICMP. In addition, data were compared with real-world clinical data to perform a risk/benefit analysis. Methods: Relevant randomised clinical trials (RCTs) published in meta-analyses since DANISH, and in PubMed, EM...
Abstract
Cited 9 times since 2022 (3.1 per year)
source: EuropePMC
PloS one,
Volume 17, Issue 9, 6 1 2022, Pages e0273182
Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.
Pogacar Z, Johnson JL, Krenning L, De Conti G, Jochems F, Lieftink C, Velds A, Wardak L, Groot K, Schepers A, Wang L, Song JY, van de Ven M, van Tellingen O, Medema RH, Beijersbergen RL, Bernards R, Leite de Oliveira R
Inducing senescence in cancer cells is emerging as a new therapeutic strategy. In order to find ways to enhance senescence induction by palbociclib, a CDK4/6 inhibitor approved for treatment of metastatic breast cancer, we performed functional genetic screens in palbociclib-resistant cells. Using this approach, we found that loss of CDK2 results in strong senescence induction in palbociclib-treated cells. Treatment with the CDK2 inhibitor indisulam, which phenocopies genetic CDK2 inactivation, l...
Abstract
Cited 9 times since 2022 (3 per year)
source: EuropePMC
Surgery,
Volume 172, Issue 5, 3 1 2022, Pages 1358-1363
The big five: Studying the surgical personality.
Sier VQ, Schmitz RF, Putter H, Schepers A, van der Vorst JR
Background: The challenging nature of performing surgery on a personal and professional level demands specific characteristics. Personality traits play an important role in the nature and behavior of humans, which are studied using the five-factor model. Therefore, we investigated the personality of 3 surgical generations. Methods: Three distinct surgical populations were approached. The Dutch Big Five Inventory-2 was sent out online to 126 surgical residents (response: n = 69) and 104 surgeons...
Abstract
Cited 13 times since 2022 (4.4 per year)
source: EuropePMC
European journal of human genetics : EJHG,
Volume 32, Issue 2, 2 1 2022, Pages 155-162
Dutch pharmacogenetics working group guideline for the gene-drug interaction of ABCG2, HLA-B and Allopurinol, and MTHFR, folic acid and methotrexate.
van der Pol KH, Nijenhuis M, Soree B, de Boer-Veger NJ, Buunk AM, Guchelaar HJ, Risselada A, van Schaik RHN, Swen JJ, Touw D, van der Weide J, van Westrhenen R, Deneer VHM, Houwink EJF, Rongen GA
The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based pharmacogenetics guidelines to optimize pharmacotherapy. This guideline describes the gene-drug interaction of ABCG2 with allopurinol, HLA-B with allopurinol, MTHFR with folic acid, and MTHFR with methotrexate, relevant for the treatment of gout, cancer, and rheumatoid arthritis. A systematic review was performed based on which pharmacotherapeutic recommendations were developed. All...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 10, 1 1 2022, Pages 1336-1344
Measurement of compensatory arterial remodelling over time with serial coronary computed tomography angiography and 3D metrics.
van den Hoogen IJ, van Rosendael AR, Lin FY, Gianni U, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Hyun Choi J, Conte E, Marques H, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Leipsic J, Maffei E, Pontone G, Shin S, Kim YJ, Lee BK, Chun EJ, Sung JM, Lee SE, Berman DS, Virmani R, Samady H, Stone PH, Narula J, Chang HJ, Min JK, Shaw LJ, Bax JJ
Aims: The magnitude of alterations in which coronary arteries remodel and narrow over time is not well understood. We aimed to examine changes in coronary arterial remodelling and luminal narrowing by three-dimensional (3D) metrics from serial coronary computed tomography angiography (CCTA). Methods and results: From a multicentre registry of patients with suspected coronary artery disease who underwent clinically indicated serial CCTA (median interscan interval = 3.3 years), we quantitatively m...
Abstract
Cited 26 times since 2022 (8.8 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
Volume 15, Issue 17, 1 1 2022, Pages 1711-1722
Outcomes After Transcatheter Edge-to-Edge Mitral Valve Repair According to Mitral Regurgitation Etiology and Cardiac Remodeling.
Yoon SH, Makar M, Kar S, Chakravarty T, Oakley L, Sekhon N, Koseki K, Nakamura M, Hamilton M, Patel JK, Singh S, Skaf S, Siegel RJ, Bax JJ, Makkar RR
Background: Transcatheter edge-to-edge repair (TEER) has been increasingly used for selected patients with mitral regurgitation (MR), but limited data are available regarding clinical outcomes in patients with varied etiology and mechanism of MR. Objectives: The aim of this study was to evaluate the outcomes of TEER according to etiology and left ventricular (LV) and left atrial remodeling. Methods: Consecutive patients who underwent TEER between 2007 and 2020 were included in the analysis. Amon...
Abstract
Cited 14 times since 2022 (4.7 per year)
source: EuropePMC
Trends in biotechnology,
Volume 41, Issue 2, 1 1 2022, Pages 184-196
Killing two birds with one stone: chemical and biological upcycling of polyethylene terephthalate plastics into food.
Schaerer LG, Wu R, Putman LI, Pearce JM, Lu T, Shonnard DR, Ong RG, Techtmann SM
Most polyethylene terephthalate (PET) plastic waste is landfilled or pollutes the environment. Additionally, global food production must increase to support the growing population. This article explores the feasibility of using microorganisms in an industrial system that upcycles PET into edible microbial protein powder to solve both problems simultaneously. Many microorganisms can utilize plastics as feedstock, and the resultant microbial biomass contains fats, nutrients, and proteins similar t...
Abstract
Cited 1 times since 2022 (0.3 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 23, Issue 10, 1 1 2022, Pages 1302-1303
Echocardiography to identify cardiac amyloidosis in patients with calcific aortic stenosis.
van der Bijl P, Stassen J, Bax JJ
Abstract
Cited 6 times since 2022 (2 per year)
source: EuropePMC
Interactive cardiovascular and thoracic surgery,
Volume 35, Issue 4, 1 1 2022, Pages ivac108
Robotic coronary revascularization in Europe, state of art and future of EACTS-endorsed Robotic Cardiothoracic Surgery Taskforce.
Pettinari M, Gianoli M, Palmen M, Cerny S, Onan B, Singh S, Segers P, Bolcal C, Alhan C, Navarra E, De Praetere H, Vojacek J, Cebotaru T, Modi P, Doguet F, Franke U, Ouda A, Melly L, Malapert G, Labrousse L, Agnino A, Philipsen T, Jansens JL, Folliguet T, Pereda D, Musumeci F, Suwalski P, Cathenis K, Van Praet F, Bonatti J, Oosterlinck W, European Robotic CardioThoracic Surgeons (ERCTS)
Abstract
Cited 18 times since 2022 (6.1 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 24, Issue 8, 1 1 2022, Pages 1291-1299
Tricuspid regurgitation after cardiac resynchronization therapy: evolution and prognostic significance.
Stassen J, Galloo X, Hirasawa K, Marsan NA, van der Bijl P, Delgado V, Bax JJ
Aims: Tricuspid regurgitation (TR) is common in patients with heart failure (HF) and is associated with worse outcome. This study investigated the effect of cardiac resynchronization therapy (CRT) on TR severity and long-term outcome. Methods and results: Tricuspid regurgitation severity was assessed at baseline and 6 months after CRT implantation, using a multiparametric approach. Patients were divided into four groups: (i) no or mild TR without progression; (ii) no or mild TR with progression...
Abstract
Cited 17 times since 2022 (5.7 per year)
source: EuropePMC
Genome biology,
Volume 23, Issue 1, 1 1 2022, Pages 185
CTCF and cohesin promote focal detachment of DNA from the nuclear lamina.
van Schaik T, Liu NQ, Manzo SG, Peric-Hupkes D, de Wit E, van Steensel B
Background: Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs. Because the insulator protein CTCF is enriched at LAD borders, it was postulated that CTCF binding could position some LAD boundaries, possibly through its function in stalling cohesin and hence preventing cohesin invading into the LAD. To test this, we mapped genome-nuclear lamina interactions in mo...
Abstract
