Research

Publications

Below you can find a list of our published research.

7401 results

Cited 19 times since 2020 (3.9 per year) source: EuropePMC

Journal of the American Heart Association, Volume 9, Issue 23, 16 3 2020, Pages e017094 Extreme Diversity of the Human Vascular Mesenchymal Cell Landscape. Bruijn LE, van den Akker BEWM, van Rhijn CM, Hamming JF, Lindeman JHN

Background Human mesenchymal cells are culprit factors in vascular (patho)physiology and are hallmarked by phenotypic and functional heterogeneity. At present, they are subdivided by classic umbrella terms, such as "fibroblasts," "myofibroblasts," "smooth muscle cells," "fibrocytes," "mesangial cells," and "pericytes." However, a discriminative marker-based subclassification has to date not been established. Methods and Results As a fir... Abstract

Cited 174 times since 2020 (35.8 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 18, Issue 4, 13 2 2020, Pages 291-304 Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging. Ng ACT, Delgado V, Borlaug BA, Bax JJ

Diabesity is a term used to describe the combined adverse health effects of obesity and diabetes mellitus. The worldwide dual epidemic of obesity and type 2 diabetes is an important public health issue. Projections estimate a sixfold increase in the number of adults with obesity in 40 years and an increase in the number of individuals with diabetes to 642 million by 2040. Increased adiposity is the strongest risk factor for developing diabetes. Early detection of the effects of diabesity on the... Abstract

Cited 4 times since 2020 (0.8 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 44, Issue 1, 12 2 2020, Pages 120-128 Mechanical extraction of cardiac implantable electronic devices leads with long dwell time: Efficacy and safety of the step up approach. Lensvelt LMH, Egorova AD, Schalij MJ, Yilmaz D, Kennergren C, Bootsma M, van Erven L

The aim of this study was to evaluate the efficacy and safety of the stepwise mechanical transvenous lead extraction approach in a patient population with chronically implanted transvenous leads with a long dwell time. From January 2014 till December 2018, all lead extractions with lead dwell time ≥5 years performed at our tertiary centre were retrospectively analysed. A total of 173 leads, from 78 patients (median age 68 years; 81% male) with a median dwell time of 9 years (interquartile range... Abstract

Cited 10 times since 2020 (2.1 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 164, Issue 3, 12 2 2020, Pages 822-829.e6 Why the categorization of indexed effective orifice area is not justified for the classification of prosthesis-patient mismatch. Vriesendorp MD, Deeb GM, Reardon MJ, Kiaii B, Bapat V, Labrousse L, Rao V, Sabik JF, Gearhart E, Klautz RJM

Objectives: Although the impact of prosthesis-patient mismatch (PPM) on survival has been widely studied, there has been little debate about whether the current definition of PPM truly reflects hemodynamic obstruction. This study aimed to validate the categorization of indexed effective orifice area (EOAi) for the classification of PPM. Methods: In total, 2171 patients who underwent aortic valve replacement with a surgical stented bioprosthesis in 5 trials (CoreValve US High-Risk, SURTAVI [Surgi... Abstract

Trends in cardiovascular medicine, Volume 31, Issue 8, 11 2 2020, Pages 495-496 Editorial commentary: Future of transcatheter mitral valve interventions for secondary mitral regurgitation. Vo NM, Bax JJ, Delgado V

Abstract

Cited 9 times since 2020 (1.9 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 48, Issue 5, 11 2 2020, Pages 1434-1444 Global and segmental absolute stress myocardial blood flow in prediction of cardiac events: [15O] water positron emission tomography study. Harjulahti E, Maaniitty T, Nammas W, Stenström I, Biancari F, Bax JJ, Knuuti J, Saraste A

Purpose: We evaluated the value of reduced global and segmental absolute stress myocardial blood flow (sMBF) quantified by [15O] water positron emission tomography (PET) for predicting cardiac events in patients with suspected obstructive coronary artery disease (CAD). Methods: Global and segmental sMBF during adenosine stress were retrospectively quantified in 530 symptomatic patients who underwent [15O] water PET for evaluation of coronary stenosis detected by coronary computed tomography angi... Abstract

Cited 9 times since 2020 (1.9 per year) source: EuropePMC

Scientific reports, Volume 10, Issue 1, 11 2 2020, Pages 19596 Increased Ca2+ content of the sarcoplasmic reticulum provides arrhythmogenic trigger source in swimming-induced rat athlete's heart model. Gazdag P, Oravecz K, Acsai K, Demeter-Haludka V, Ördög B, Szlovák J, Kohajda Z, Polyák A, Barta BA, Oláh A, Radovits T, Merkely B, Papp JG, Baczkó I, Varró A, Nagy N, Prorok J

Sudden cardiac death among top athletes is very rare, however, it is 2-4 times more frequent than in the age-matched control population. In the present study, the electrophysiological consequences of long-term exercise training were investigated on Ca2+ homeostasis and ventricular repolarization, together with the underlying alterations of ion channel expression, in a rat athlete's heart model. 12-week swimming exercise-trained and control Wistar rats were used. Electrophysiological data we... Abstract

Cited 28 times since 2020 (5.8 per year) source: EuropePMC

Cell reports. Medicine, Volume 1, Issue 9, 10 2 2020, Pages 100146 Hydroxychloroquine Inhibits the Trained Innate Immune Response to Interferons. Rother N, Yanginlar C, Lindeboom RGH, Bekkering S, van Leent MMT, Buijsers B, Jonkman I, de Graaf M, Baltissen M, Lamers LA, Riksen NP, Fayad ZA, Mulder WJM, Hilbrands LB, Joosten LAB, Netea MG, Vermeulen M, van der Vlag J, Duivenvoorden R

Hydroxychloroquine is being investigated for a potential prophylactic effect in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but its mechanism of action is poorly understood. Circulating leukocytes from the blood of coronavirus disease 2019 (COVID-19) patients show increased responses to Toll-like receptor ligands, suggestive of trained immunity. By analyzing interferon responses of peripheral blood mononuclear cells from healthy donors conditioned with heat-killed Can... Abstract

Cited 20 times since 2020 (4.1 per year) source: Scopus

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 34, Issue 3, 9 2 2020, Pages 257-266 Left Ventricular Myocardial Work in Patients with Severe Aortic Stenosis. Fortuni F, Butcher SC, van der Kley F, Lustosa RP, Karalis I, de Weger A, Priori SG, van der Bijl P, Bax JJ, Delgado V, Ajmone Marsan N

Background: Left ventricular myocardial work (LVMW) is a novel method to assess left ventricular (LV) function using pressure-strain loops that takes into consideration LV afterload. The estimation of LV afterload in patients with severe aortic stenosis (AS) may be challenging, and no study so far has investigated LVMW in this setting. The aim of this study was to develop a method to calculate LVMW in patients with severe AS and to analyze its relationship with heart failure symptoms. Methods: I... Abstract

Cited 120 times since 2020 (24.6 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 15, Issue 2, 9 2 2020, Pages 93-109 Society of Cardiovascular Computed Tomography / North American Society of Cardiovascular Imaging - Expert Consensus Document on Coronary CT Imaging of Atherosclerotic Plaque. Shaw LJ, Blankstein R, Bax JJ, Ferencik M, Bittencourt MS, Min JK, Berman DS, Leipsic J, Villines TC, Dey D, Al'Aref S, Williams MC, Lin F, Baskaran L, Litt H, Litmanovich D, Cury R, Gianni U, van den Hoogen I, R van Rosendael A, Budoff M, Chang HJ, E Hecht H, Feuchtner G, Ahmadi A, Ghoshajra BB, Newby D, Chandrashekhar YS, Narula J

Coronary computed tomographic angiography (CCTA) provides a wealth of clinically meaningful information beyond anatomic stenosis alone, including the presence or absence of nonobstructive atherosclerosis and high-risk plaque features as precursors for incident coronary events. There is, however, no uniform agreement on how to identify and quantify these features or their use in evidence-based clinical decision-making. This statement from the Society of Cardiovascular Computed Tomography and Nort... Abstract

Cited 17 times since 2020 (3.5 per year) source: EuropePMC

Scientific reports, Volume 10, Issue 1, 5 1 2020, Pages 19111 An individual participant data analysis of prospective cohort studies on the association between subclinical thyroid dysfunction and depressive symptoms. Wildisen L, Del Giovane C, Moutzouri E, Beglinger S, Syrogiannouli L, Collet TH, Cappola AR, Åsvold BO, Bakker SJL, Yeap BB, Almeida OP, Ceresini G, Dullaart RPF, Ferrucci L, Grabe H, Jukema JW, Nauck M, Trompet S, Völzke H, Westendorp R, Gussekloo J, Klöppel S, Aujesky D, Bauer D, Peeters R, Feller M, Rodondi N

In subclinical hypothyroidism, the presence of depressive symptoms is often a reason for starting levothyroxine treatment. However, data are conflicting on the association between subclinical thyroid dysfunction and depressive symptoms. We aimed to examine the association between subclinical thyroid dysfunction and depressive symptoms in all prospective cohorts with relevant data available. We performed a systematic review of the literature from Medline, Embase, Cumulative Index to Nursing and A... Abstract

Cited 8 times since 2020 (1.6 per year) source: EuropePMC

Cells, Volume 9, Issue 11, 4 1 2020, Pages E2412 Cardiac and Vascular α1-Adrenoceptors in Congestive Heart Failure: A Systematic Review. Kaykı-Mutlu G, Papazisi O, Palmen M, Danser AHJ, Michel MC, Arioglu-Inan E

As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limit... Abstract

Cited 13 times since 2020 (2.7 per year) source: EuropePMC

Journal of the American Heart Association, Volume 9, Issue 22, 4 1 2020, Pages e016391 Periprocedural Hydrogen Sulfide Therapy Improves Vascular Remodeling and Attenuates Vein Graft Disease. Kip P, Tao M, Trocha KM, MacArthur MR, Peters HAB, Mitchell SJ, Mann CG, Sluiter TJ, Jung J, Patterson S, Quax PHA, de Vries MR, Mitchell JR, Keith Ozaki C

Background Failure rates after revascularization surgery remain high, both in vein grafts (VG) and arterial interventions. One promising approach to improve outcomes is endogenous upregulation of the gaseous transmitter-molecule hydrogen sulfide, via short-term dietary restriction. However, strict patient compliance stands as a potential translational barrier in the vascular surgery patient population. Here we present a new therapeutic approach, via a locally applicable gel containing the hydrog... Abstract

Cited 2 times since 2020 (0.4 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 28, Issue 12, 3 1 2020, Pages 625-627 Dutch cardiology residents and the COVID-19 pandemic: Every little thing counts in a crisis. Berger WR, Baggen V, Vorselaars VMM, van der Heijden AC, van Hout GPJ, Kapel GFL, Woudstra P, Junior Board (Juniorkamer) of the Netherlands Society of Cardiology (NVVC)

The COVID-19 pandemic has overwhelmed healthcare systems worldwide, and a large part of regular cardiology care came to a quick halt. A Dutch nationwide survey showed that 41% of cardiology residents suspended their training and worked at COVID-19 cohort units for up to 3 months. With tremendous flexibility, on-call schedules were altered and additional training was provided in order for residents to be directly available where needed most. These unprecedented times have taught them important le... Abstract

Cited 1 times since 2020 (0.2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 58, Issue 5, 1 1 2020, Pages 1105 What we see depends on what we look for. Tomšič A, Klautz RJM

Abstract

Cited 3 times since 2020 (0.6 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 22, Issue 11, 1 1 2020, Pages 1680-1687 Arrhythmia exacerbation after post-infarction ventricular tachycardia ablation: prevalence and prognostic significance. Siontis KC, Kim HM, Vergara P, Peretto G, Do DH, de Riva M, Lam A, Qian P, Yokokawa M, Jongnarangsin K, Latchamsetty R, Jais P, Sacher F, Tedrow U, Shivkumar K, Zeppenfeld K, Della Bella P, Stevenson WG, Morady F, Bogun FM

Aims: Catheter ablation is an effective treatment for post-infarction ventricular tachycardia (VT). However, some patients may experience a worsened arrhythmia phenotype after ablation. We aimed to determine the prevalence and prognostic impact of arrhythmia exacerbation (AE) after post-infarction VT ablation. Methods and results: A total of 1187 consecutive patients (93% men, median age 68 years, median ejection fraction 30%) who underwent post-infarction VT ablation at six centres were include... Abstract

Cited 22 times since 2020 (4.5 per year) source: EuropePMC

Arrhythmia & electrophysiology review, Volume 9, Issue 3, 1 1 2020, Pages 128-135 Impact of Micro-, Mini- and Multi-Electrode Mapping on Ventricular Substrate Characterisation. Berte B, Zeppenfeld K, Tung R

Accurate substrate characterisation may improve the evolving understanding and treatment of cardiac arrhythmias. During substrate-based ablation techniques, wide practice variations exist with mapping via dedicated multi-electrode catheter or conventional ablation catheters. Recently, newer ablation catheter technology with embedded mapping electrodes have been introduced. This article focuses on the general misconceptions of voltage mapping and more specific differences in unipolar and bipolar... Abstract

Cited 14 times since 2020 (2.9 per year) source: EuropePMC

Annals of surgery, Volume 272, Issue 5, 1 1 2020, Pages 678-683 Taking Morbidity and Mortality Conferences to a Next Level: The Resilience Engineering Concept. Verhagen MJ, de Vos MS, Hamming JF

Objective: To explore possibilities to improve morbidity and mortality conferences using advancing insights in safety science. Summary background data: Mortality and Morbidity conferences (M&M) are the golden practice for case-based learning. While learning from complications is useful, M&M does not meet expectations for system-wide improvement. Resilience engineering principles may be used to improve M&M. Methods: After a review of the shortcomings of traditional M&M, resilience... Abstract

Cited 23 times since 2020 (4.7 per year) source: EuropePMC

Annals of surgery, Volume 272, Issue 5, 1 1 2020, Pages 773-778 Long-term Prognosis After Elective Abdominal Aortic Aneurysm Repair is Poor in Women and Men: The Challenges Remain. Bulder RMA, Talvitie M, Bastiaannet E, Hamming JF, Hultgren R, Lindeman JHN

Objective: To evaluate the impact of changes in elective Abdominal Aortic Aneurysm (AAA) management on life-expectancy of AAA patients. Background: Over the past decades AAA repair underwent substantial changes, that is, the introduction of EVAR and implementation of intensified cardiovascular risk management. The question rises to what extent these changes improved longevity of AAA patients. Methods: National evaluation including all 12.907 (82.7% male) patients who underwent elective AAA repai... Abstract

European heart journal, Volume 41, Issue 43, 1 1 2020, Pages 4213 Anomalous origin of the left coronary artery from the pulmonary artery in a 72-year-old patient. Kuneman JH, Fortuni F, van Dijkman PRM, Bax JJ

Abstract