Research

Publications

Below you can find a list of our published research.

6177 results

Cited 27 times since 2005 (1.4 per year) source: EuropePMC

Heart rhythm, Volume 2, Issue 12, 1 1 2005, Pages 1286-1293 Dispersion of repolarization in cardiac resynchronization therapy. van Huysduynen BH, Swenne CA, Bax JJ, Bleeker GB, Draisma HH, van Erven L, Molhoek SG, van de Vooren H, van der Wall EE, Schalij MJ

Background: Proarrhythmic effects of cardiac resynchronization therapy (CRT) as a result of increased transmural dispersion of repolarization (TDR) induced by left ventricular (LV) epicardial pacing in a subset of vulnerable patients have been reported. The possibility of identifying these patients by ECG repolarization indices has been suggested. Objectives: The purpose of this study was to test whether repolarization indices on the ECG can be used to measure dispersion of repolarization during... Abstract

Cited 7 times since 2005 (0.4 per year) source: EuropePMC

The American journal of medicine, Volume 118, Issue 12, 1 1 2005, Pages 1381-1386 Pacemaker stress echocardiography predicts cardiac events in patients with permanent pacemaker. Biagini E, Schinkel AF, Elhendy A, Bax JJ, Rizzello V, van Domburg RT, Krenning BJ, Schouten O, Branzi A, Rocchi G, Simoons ML, Poldermans D

Purpose: Noninvasive pacemaker stress echocardiography is a newly introduced method for the diagnosis of coronary artery disease in patients with a permanent pacemaker. The prognostic value of pacemaker stress echocardiography has not been studied. Subjects and methods: We studied 136 patients (mean age 64+/-12 years) with a permanent pacemaker who underwent pacemaker stress echocardiography for evaluation of coronary artery disease. All patients underwent pacemaker stress echocardiography by ex... Abstract

Cited 14 times since 2005 (0.7 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 46, Issue 12, 1 1 2005, Pages 2003-2008 Risk stratification of patients with angina pectoris by stress 99mTc-tetrofosmin myocardial perfusion imaging. Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Huurman A, Feringa HH, Poldermans D

Unlabelled: Angina pectoris is a major symptom associated with myocardial ischemia. The aim of this study was to find whether stress myocardial perfusion imaging can independently predict mortality in patients with angina. Methods: We studied 455 patients with stable angina pectoris by exercise or dobutamine stress (99m)Tc-tetrofosmin myocardial perfusion tomographic imaging. An abnormal finding was defined as a reversible or fixed perfusion abnormality. The endpoint during follow-up was death f... Abstract

Cited 24 times since 2005 (1.2 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 28, Issue 12, 1 1 2005, Pages 1271-1275 Does a gender difference in response to cardiac resynchronization therapy exist? Bleeker GB, Schalij MJ, Boersma E, Steendijk P, van der Wall EE, Bax JJ

Background: Cardiac resynchronization therapy (CRT) has a beneficial effect on clinical symptoms, exercise capacity, and systolic left ventricular (LV) performance in patients with heart failure. The aim of the current study was to evaluate whether a gender difference exists in response to CRT. Methods: Consecutive patients with end-stage heart failure (New York Heart Association, NYHA, class III-IV), LV ejection fraction (LVEF) < or =35%, QRS duration >120 ms, and left bundle branch block... Abstract

Cited 123 times since 2005 (6.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 12, 1 1 2005, Pages 2168-2182 Cardiac resynchronization therapy: Part 2--issues during and after device implantation and unresolved questions. Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JW, Garrigue S, Gorcsan J, Hayes DL, Kass DA, Knuuti J, Leclercq C, Linde C, Mark DB, Monaghan MJ, Nihoyannopoulos P, Schalij MJ, Stellbrink C, Yu CM

Encouraged by the clinical success of cardiac resynchronization therapy (CRT), the implantation rate has increased exponentially, although several limitations and unresolved issues of CRT have been identified. This review concerns issues that are encountered during implantation of CRT devices, including the role of electroanatomical mapping, whether CRT implantation should be accompanied by simultaneous atrioventricular nodal ablation in patients with atrial fibrillation, procedural complication... Abstract

Cited 72 times since 2005 (3.7 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 12, 1 1 2005, Pages 2264-2269 Left ventricular dyssynchrony predicts right ventricular remodeling after cardiac resynchronization therapy. Bleeker GB, Schalij MJ, Nihoyannopoulos P, Steendijk P, Molhoek SG, van Erven L, Bootsma M, Holman ER, van der Wall EE, Bax JJ

Objectives: The purpose of this research was to evaluate right ventricular (RV) remodeling after six months of cardiac resynchronization therapy (CRT). Background: Cardiac resynchronization therapy is beneficial in patients with end-stage heart failure. The effect of CRT on RV size is currently unknown. Accordingly, the effects of CRT on RV size, severity of tricuspid regurgitation, and pulmonary artery pressure were evaluated. Methods: Fifty-six consecutive patients with end-stage heart failure... Abstract

Cited 284 times since 2005 (14.6 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 46, Issue 12, 1 1 2005, Pages 2153-2167 Cardiac resynchronization therapy: Part 1--issues before device implantation. Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JW, Garrigue S, Gorcsan J, Hayes DL, Kass DA, Knuuti J, Leclercq C, Linde C, Mark DB, Monaghan MJ, Nihoyannopoulos P, Schalij MJ, Stellbrink C, Yu CM

Cardiac resynchronization therapy (CRT) has been used extensively over the last years in the therapeutic management of patients with end-stage heart failure. Data from 4,017 patients have been published in eight large, randomized trials on CRT. Improvement in clinical end points (symptoms, exercise capacity, quality of life) and echocardiographic end points (systolic function, left ventricular size, mitral regurgitation) have been reported after CRT, with a reduction in hospitalizations for deco... Abstract

Cited 68 times since 2005 (3.5 per year) source: EuropePMC

Radiology, Volume 237, Issue 3, 1 1 2005, Pages 868-871 Corrected tetralogy of Fallot: delayed enhancement in right ventricular outflow tract. Oosterhof T, Mulder BJ, Vliegen HW, de Roos A

Purpose: To evaluate retrospectively the presence of fibrosis and largest diameter of the right ventricular outflow tract (RVOT) by using delayed enhancement magnetic resonance (MR) imaging in patients who had undergone initial correction for tetralogy of Fallot. Materials and methods: MR imaging was performed in 24 consecutive patients (16 male, eight female; mean age, 25 years; age range, 13-47 years) with corrected tetralogy of Fallot. The study protocol was approved by the local ethics commi... Abstract

Nederlands tijdschrift voor geneeskunde, Volume 149, Issue 50, 1 1 2005, Pages 2773-2774 [The availability of only one statin is inadequate]. Jukema JW

When looking at the history of the prescription of a new class of drugs e.g. the statin, it is clear that for optimal use with regard to efficacy, areas of indication and safety, the continuous development of new compounds within this class was very advantageous. Competition between compounds is essential for providing best patient care. Thus the availability of only one statin was and continues to be inadequate for this purpose. Abstract

Cited 57 times since 2005 (2.9 per year) source: EuropePMC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Volume 19, Issue 14, 1 1 2005, Pages 1998-2004 Tumor necrosis factor-alpha plays an important role in restenosis development. Monraats PS, Pires NM, Schepers A, Agema WR, Boesten LS, de Vries MR, Zwinderman AH, de Maat MP, Doevendans PA, de Winter RJ, Tio RA, Waltenberger J, 't Hart LM, Frants RR, Quax PH, van Vlijmen BJ, Havekes LM, van der Laarse A, van der Wall EE, Jukema JW

Genetic factors appear to be important in the restenotic process after percutaneous coronary intervention (PCI), as well as in inflammation, a pivotal factor in restenosis. TNFalpha, a key regulator of inflammatory responses, may exert critical influence on the development of restenosis after PCI. The GENetic DEterminants of Restenosis (GENDER) project included 3104 patients who underwent a successful PCI. Systematic genotyping for six polymorphisms in the TNFalpha gene was performed. The role o... Abstract

Cited 18 times since 2005 (0.9 per year) source: EuropePMC

Heart rhythm, Volume 2, Issue 12, 1 1 2005, Pages 1365-1368 Syndactyly and long QT syndrome (CaV1.2 missense mutation G406R) is associated with hypertrophic cardiomyopathy. Lo-A-Njoe SM, Wilde AA, van Erven L, Blom NA

Abstract

Cited 3 times since 2005 (0.2 per year) source: EuropePMC

Nederlands tijdschrift voor geneeskunde, Volume 149, Issue 51, 1 1 2005, Pages 2837-2840 [Percutaneous coronary intervention with stent placement versus bypass operation in symptomatic multiple-vessel disease; lessons from an observational study]. van der Hoeven BL, Schalij MJ, van der Wall EE

In a large observational study comparing percutaneous coronary intervention (PCI) using stent implantation with coronary-artery bypass grafting (CABG), 3-year survival was better after CABG than after PCI with stenting. This was particularly true in patients with triple-vessel disease, and for patients with two-vessel disease with involvement ofthe proximal left anterior descending artery (LAD). Potential explanations for this finding are that with CABG 'future' culprit lesions are byp... Abstract

Cited 189 times since 2005 (9.7 per year) source: EuropePMC

The American journal of cardiology, Volume 97, Issue 2, 28 4 2005, Pages 260-263 Clinical versus echocardiographic parameters to assess response to cardiac resynchronization therapy. Bleeker GB, Bax JJ, Fung JW, van der Wall EE, Zhang Q, Schalij MJ, Chan JY, Yu CM

Currently, a clear definition of response to cardiac resynchronization therapy (CRT) is still lacking, and clinical and echocardiographic end points are used. It is also unclear whether patients with clinical responses also improve in echocardiographic end points (and vice versa). To better understand and define response to CRT, the relation between improvement in clinical and echocardiographic parameters was evaluated in 144 patients. Abstract

Cited 1 times since 2005 (0.1 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 22, Issue 2, 25 4 2005, Pages 167-169 Failure to decrease blood pressure during sleep: non-dippers are among us. Steendijk P

Abstract

Cited 144 times since 2005 (7.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 26, Issue 2, 23 4 2005, Pages 340-346 Lesional overexpression of matrix metalloproteinase-9 promotes intraplaque hemorrhage in advanced lesions but not at earlier stages of atherogenesis. de Nooijer R, Verkleij CJ, von der Thüsen JH, Jukema JW, van der Wall EE, van Berkel TJ, Baker AH, Biessen EA

Background: Matrix metalloproteinase-9 (MMP-9) is involved in atherosclerosis and elevated MMP-9 activity has been found in unstable plaques, suggesting a crucial role in plaque rupture. This study aims to assess the effect of MMP-9 on plaque stability in apolipoprotein E-deficient mice at different stages of plaque progression. Methods and results: Atherosclerotic lesions were elicited in carotid arteries by perivascular collar placement. MMP-9 overexpression in intermediate or advanced plaques... Abstract

Pulmonary pharmacology & therapeutics, Volume 19, Issue 6, 18 3 2005, Pages 397-403 Clinically masked increases in bronchial inflammation in guideline-treated persistent asthma. Koopmans JG, Lutter R, Jansen HM, van der Zee JS

Background: Current guidelines generally recommend a combination of inhaled corticosteroids and a Beta2-agonist for persistent asthma. The adjustment of anti-inflammatory therapy in persistent asthma is advised to be guided mainly by the presence of symptoms. Objective: To investigate whether clinically masked increases in bronchial inflammation occur in guideline-treated, persistent asthma following allergen exposure. Methods: After a 4-week steroid-run-in period (fluticasone 250 microg twice d... Abstract

Cited 21 times since 2005 (1.1 per year) source: EuropePMC

Basic research in cardiology, Volume 101, Issue 1, 11 2 2005, Pages 36-42 Suppression of physiological cardiomyocyte proliferation in the rat pup after neonatal glucocorticosteroid treatment. de Vries WB, Bal MP, Homoet-van der Kraak P, Kamphuis PJ, van der Leij FR, Baan J, Steendijk P, de Weger RA, van Bel F, van Oosterhout MF

Background: Glucocorticosteroids (mostly dexamethasone) are widely used to prevent chronic lung disease in premature infants. Neonatal rats treated with dexamethasone have been shown to have reduced cardiac mass and cardiomyocyte hypertrophy, suggesting a lower number of cardiomyocytes at adult age, and a severely reduced life expectancy. In the present study we tested the hypothesis that a lower number of cardiomyocytes in later life is caused by a reduced cardiomyocyte proliferation and/or by... Abstract

Cited 5 times since 2005 (0.3 per year) source: EuropePMC

Heart, lung & circulation, Volume 14 Suppl 2, 7 1 2005, Pages S8-13 Assessment of myocardial viability in ischemic cardiomyopathy. Bax JJ

The number of patients with ischemic cardiomyopathy has increased extensively over recent years. Therapies include medical treatment, cardiac transplantation, cardiac resynchronization therapy and surgery. In the diagnostic and prognostic work-up, the assessment of myocardial viability has become more important over time. In particular, patients with viable myocardium can improve in LV function after revascularization; this will not occur in patients without viable tissue. In view of the high ri... Abstract

Cited 78 times since 2005 (4 per year) source: EuropePMC

Circulation, Volume 112, Issue 20, 7 1 2005, Pages 3058-3065 Plasma lipoproteins and apolipoproteins as predictors of cardiovascular risk and treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Packard CJ, Ford I, Robertson M, Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, Gaw A, Hyland M, Jukema JW, Kamper AM, Macfarlane PW, Perry IJ, Stott DJ, Sweeney BJ, Twomey C, Westendorp RG, PROSPER Study Group

Background: Statins are important in vascular disease prevention in the elderly. However, the best method of selecting older patients for treatment is uncertain. We assessed the role of plasma lipoproteins as predictors of risk and of treatment benefit in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER). Method and results: The association of LDLc and HDLc with risk was examined in the 5804 70- to 82-year-old subjects of PROSPER. Baseline LDLc showed no relation to risk of t... Abstract

Cited 15 times since 2005 (0.8 per year) source: EuropePMC

The American journal of cardiology, Volume 97, Issue 1, 4 1 2005, Pages 1-6 Prognostic implications of a normal stress technetium-99m-tetrofosmin myocardial perfusion study in patients with a healed myocardial infarct and/or previous coronary revascularization. Schinkel AF, Elhendy A, Bax JJ, van Domburg RT, Huurman A, Valkema R, Biagini E, Rizzello V, Feringa HH, Krenning EP, Simoons ML, Poldermans D

Previous studies have shown a good outcome for patients who present with normal findings on stress myocardial perfusion imaging. Currently, the prognostic implications of a normal study in patients who have a history of coronary artery disease (CAD) are not clear. This study investigated the long-term prognosis after a normal finding on stress technetium-99m (Tc-99m)-tetrofosmin single-photon emission computed tomography in patients with a history of CAD. The study included 147 consecutive patie... Abstract