Research

Publications

Below you can find a list of our published research.

7880 results

Cited 15 times since 2004 (0.7 per year) source: EuropePMC

Biochemical pharmacology, Volume 68, Issue 11, 1 1 2004, Pages 2273-2281 A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy. de Graaf M, Nevalainen TJ, Scheeren HW, Pinedo HM, Haisma HJ, Boven E

The glucuronide prodrug of doxorubicin, DOX-GA3, can be selectively activated in tumors by extracellular human beta-glucuronidase, resulting in a better therapeutic index than doxorubicin. DOX-GA3, however, is rapidly excreted by the kidney. We hypothesized that slow release of DOX-GA3 from its methylester, DOX-mGA3, by esterase activity in blood would result in improved circulation half-life (t(1/2)) of DOX-GA3. DOX-mGA3 was synthesized more efficiently with an overall yield of 60% as compared... Abstract

Cited 31 times since 2004 (1.5 per year) source: EuropePMC

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Volume 34, Issue 12, 1 1 2004, Pages 1827-1833 Serum surfactant protein D is elevated in allergic patients. Koopmans JG, van der Zee JS, Krop EJ, Lopuhaä CE, Jansen HM, Batenburg JJ

Background: There is evidence that surfactant protein (SP)-D is important in the innate, as well as in the adaptive pulmonary immune response. Serum concentrations of SP-D have been proposed as parameter of the integrity of the blood-airspace barrier in interstitial lung diseases. We hypothesized that serum SP-D concentrations are affected in allergic patients and correlate with changes in allergic airway inflammation. Objective: To determine levels of serum SP-D in allergic patients compared wi... Abstract

Cited 51 times since 2004 (2.5 per year) source: EuropePMC

Radiology, Volume 233, Issue 3, 1 1 2004, Pages 824-829 Right ventricular function after pulmonary valve replacement in patients with tetralogy of Fallot. van Straten A, Vliegen HW, Hazekamp MG, Bax JJ, Schoof PH, Ottenkamp J, van der Wall EE, de Roos A

Purpose: To assess the time course of right ventricular (RV) function improvement after pulmonary valve replacement (PVR) in patients 25.2 years +/- 7.0 after repair of tetralogy of Fallot. Materials and methods: The medical ethics committee approved this study, and informed consent was obtained. Cardiac magnetic resonance (MR) imaging was performed before, 7 months after, and 19 months after PVR in 25 consecutive patients with tetralogy of Fallot with a 1.5-T MR imager. RV function was assessed... Abstract

Cited 20 times since 2004 (1 per year) source: EuropePMC

Inorganic chemistry, Volume 43, Issue 26, 1 1 2004, Pages 8461-8469 Rare-earth quinolinates: infrared-emitting molecular materials with a rich structural chemistry. Van Deun R, Fias P, Nockemann P, Schepers A, Parac-Vogt TN, Van Hecke K, Van Meervelt L, Binnemans K

Near-infrared-emitting rare-earth chelates based on 8-hydroxyquinoline have appeared frequently in recent literature, because they are promising candidates for active components in near-infrared-luminescent optical devices, such as optical amplifiers, organic light-emitting diodes, .... Unfortunately, the absence of a full structural investigation of these rare-earth quinolinates is hampering the further development of rare-earth quinolinate based materials, because the luminescence output canno... Abstract

Cited 8 times since 2004 (0.4 per year) source: EuropePMC

Gene, Volume 343, Issue 1, 1 1 2004, Pages 91-97 Efficient somatic gene targeting in the lymphoid human cell line DG75. Feederle R, Delecluse HJ, Rouault JP, Schepers A, Hammerschmidt W

Among the different approaches used to define the function of a protein of interest, alteration and/or deletion of its encoding gene is the most direct strategy. Homologous recombination between the chromosomal gene locus and an appropriately designed targeting vector results in an alteration or knockout of the gene of interest. Homologous recombination is easily performed in yeast or in murine embryonic stem cells, but is cumbersome in more differentiated and diploid somatic cell lines. Here we... Abstract

Cited 27 times since 2004 (1.3 per year) source: EuropePMC

European journal of radiology, Volume 52, Issue 3, 1 1 2004, Pages 240-245 The value of MR angiography techniques in the detection of head and neck paragangliomas. van den Berg R, Schepers A, de Bruïne FT, Liauw L, Mertens BJ, van der Mey AG, van Buchem MA

Objective: The objective of this study was to compare three-dimensional phase-contrast angiography (3D PCA), 2D time-of-flight (2D TOF), and 3D TOF magnetic resonance (MR) angiography and a proton density weighted technique in terms of their ability to detect head and neck paragangliomas. Materials and methods: 14 patients with 29 paragangliomas were examined at 1.5 T. Three MR angiography sequences (3D PCA, 2D TOF, and multi-slab 3D TOF) and a proton density (PD) weighted sequence were reviewed... Abstract

Cited 57 times since 2004 (2.8 per year) source: EuropePMC

Diabetes care, Volume 27, Issue 12, 1 1 2004, Pages 2887-2892 Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease. Beishuizen ED, van de Ree MA, Jukema JW, Tamsma JT, van der Vijver JC, Meinders AE, Putter H, Huisman MV

Objective: Cardiovascular disease (CVD) is the most important cause of mortality in patients with type 2 diabetes. We aimed to determine the effect of statin therapy versus placebo on the progression of carotid intima-media thickness (IMT) in type 2 diabetic patients without manifest CVD. Research design and methods: A randomized, placebo-controlled, double-blind clinical trial was performed in 250 patients with type 2 diabetes. Patients were given either 0.4 mg cerivastatin or placebo daily. In... Abstract

Cited 3 times since 2004 (0.1 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 27, Issue 12, 1 1 2004, Pages 1603-1609 Hypertensive stress increases dispersion of repolarization. Van Huysduynen BH, Swenne CA, Van Eck HJ, Kors JA, Schoneveld AL, Van De Vooren H, Schiereck P, Schalij MJ, Van Der Wall EE

Several electrocardiographic indices for repolarization heterogeneity have been proposed previously. The behavior of these indices under two different stressors at the same heart rate (i.e., normotensive gravitational stress, and hypertensive isometric stress) was studied. ECG and blood pressure were recorded in 56 healthy men during rest (sitting with horizontal legs), hypertensive stress (performing handgrip), and normotensive stress (sitting with lowered legs). During both stressors, heart ra... Abstract

Cited 56 times since 2004 (2.8 per year) source: EuropePMC

Journal of virology, Volume 78, Issue 23, 1 1 2004, Pages 13019-13027 Structural protein requirements in equine arteritis virus assembly. Wieringa R, de Vries AA, van der Meulen J, Godeke GJ, Onderwater JJ, van Tol H, Koerten HK, Mommaas AM, Snijder EJ, Rottier PJ

Equine arteritis virus (EAV) is an enveloped, positive-stranded RNA virus belonging to the family Arteriviridae of the order Nidovirales. EAV particles contain seven structural proteins: the nucleocapsid protein N, the unglycosylated envelope proteins M and E, and the N-glycosylated membrane proteins GP(2b) (previously named G(S)), GP(3), GP(4), and GP(5) (previously named G(L)). Proteins N, M, and GP(5) are major virion components, E occurs in virus particles in intermediate amounts, and GP(4),... Abstract

Cited 38 times since 2004 (1.9 per year) source: EuropePMC

Circulation, Volume 110, Issue 20, 8 2 2004, Pages 3187-3192 Left atrial tachycardia originating from the mitral annulus-aorta junction. Gonzalez MD, Contreras LJ, Jongbloed MR, Rivera J, Donahue TP, Curtis AB, Bailey MS, Conti JB, Fishman GI, Schalij MJ, Gittenberger-de Groot AC

Background: At the mitral annulus-aorta (MA-Ao) junction, the left atrium is continuous through the subaortic curtain with the musculature of the anterior mitral leaflet. Under experimental conditions, this region can generate abnormal electrical activity. In patients with left atrial tachycardia, we investigated whether this region could be the source of this arrhythmia. Methods and results: In 10 (28%) of 35 consecutive patients with left atrial tachycardia, the arrhythmia originated from the... Abstract

Cited 29 times since 2004 (1.4 per year) source: EuropePMC

Pediatric research, Volume 57, Issue 1, 5 1 2004, Pages 16-21 Systolic and diastolic ventricular function assessed by pressure-volume loops in the stage 21 venous clipped chick embryo. Stekelenburg-de Vos S, Steendijk P, Ursem NT, Wladimiroff JW, Delfos R, Poelmann RE

Cardiac pressure-volume relations enable quantification of intrinsic ventricular diastolic and systolic properties independent of loading conditions. The use of pressure-volume loop analysis in early stages of development could contribute to a better understanding of the relationship between hemodynamics and cardiac morphogenesis. The venous clip model is an intervention model for the chick embryo in which permanent obstruction of the right lateral vitelline vein temporarily reduces the mechanic... Abstract

Cited 703 times since 2004 (34.5 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 44, Issue 9, 1 1 2004, Pages 1834-1840 Left ventricular dyssynchrony predicts response and prognosis after cardiac resynchronization therapy. Bax JJ, Bleeker GB, Marwick TH, Molhoek SG, Boersma E, Steendijk P, van der Wall EE, Schalij MJ

Objectives: This study was designed to predict the response and prognosis after cardiac resynchronization therapy (CRT) in patients with end-stage heart failure (HF). Background: Cardiac resynchronization therapy improves HF symptoms, exercise capacity, and left ventricular (LV) function. Because not all patients respond, preimplantation identification of responders is needed. In the present study, response to CRT was predicted by the presence of LV dyssynchrony assessed by tissue Doppler imagin... Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 12, Issue Suppl 2, 1 1 2004, Pages 25-26 Caring for patients with type 2 diabetes - a responsibility to be shared between cardiologists and diabetologists: Munich, 30 August 2004. Beeres SL

Abstract

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 12, Issue Suppl 2, 1 1 2004, Pages 17-18 INTERHEART - a global study of risk factors for acute myocardial infarction in 52 countries: Munich, 29 August 2004. Beeres SL

Abstract

Cited 14 times since 2004 (0.7 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 11, Issue 6, 1 1 2004, Pages 689-696 Added value of attenuation-corrected Tc-99m tetrofosmin SPECT for the detection of myocardial viability: comparison with FDG SPECT. Slart RH, Bax JJ, Sluiter WJ, van Veldhuisen DJ, Jager PL

Background: The aim of this study was to evaluate the value of attenuation correction of technetium 99m tetrofosmin single photon emission computed tomography (SPECT) imaging for the detection of myocardial viability. Methods and results: A head-to-head comparison between resting Tc-99m tetrofosmin SPECT and fluorine 18 fluorodeoxyglucose (FDG) SPECT was performed. Both the noncorrected and attenuation-corrected Tc-99m tetrofosmin SPECT images were compared with the FDG images that served as the... Abstract

Cited 5 times since 2004 (0.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 44, Issue 9, 1 1 2004, Pages 1877-1882 Functional significance of stenoses in coronary artery bypass grafts. Evaluation by single-photon emission computed tomography perfusion imaging, cardiovascular magnetic resonance, and angiography. Salm LP, Bax JJ, Vliegen HW, Langerak SE, Dibbets P, Jukema JW, Lamb HJ, Pauwels EK, de Roos A, van der Wall EE

Objectives: This study was designed to perform a head-to-head comparison between single-photon emission computed tomography (SPECT) and cardiovascular magnetic resonance (CMR) to evaluate hemodynamic significance of angiographic findings in bypass grafts. Background: The hemodynamic significance of a bypass graft stenosis may not always accurately be determined from the coronary angiogram. A variety of diagnostic tests (invasive or noninvasive) can further characterize the hemodynamic consequenc... Abstract

Cited 39 times since 2004 (1.9 per year) source: EuropePMC

The Journal of clinical endocrinology and metabolism, Volume 89, Issue 11, 1 1 2004, Pages 5828-5836 Involvement of membrane-type matrix metalloproteinases (MT-MMPs) in capillary tube formation by human endometrial microvascular endothelial cells: role of MT3-MMP. Plaisier M, Kapiteijn K, Koolwijk P, Fijten C, Hanemaaijer R, Grimbergen JM, Mulder-Stapel A, Quax PH, Helmerhorst FM, van Hinsbergh VW

In the endometrium, angiogenesis is a physiological process, whereas in most adult tissues neovascularization is initiated only during tissue repair or pathological conditions. Pericellular proteolysis plays an important role in angiogenesis being required for endothelial cell migration, invasion, and tube formation. We studied the expression of proteases by human endometrial microvascular endothelial cells (hEMVECs) and their involvement in the formation of capillary tubes and compared these re... Abstract

Cited 6 times since 2004 (0.3 per year) source: EuropePMC

Echocardiography (Mount Kisco, N.Y.), Volume 21, Issue 8, 1 1 2004, Pages 721-723 Transesophageal echocardiography-guided transvenous biopsy of an intracardiac tumor. Scholte AJ, Frissen PH, van der Wouw PA

Transesophageal echocardiography with simultaneous fluoroscopic guidance during a transvenous biopsy of an intracardiac tumor is a valuable technique. We present the case of a 67-year-old man with a metastasis in the right atrium from which histological examination of the tumor was indicated. The inaccessible location of the primary tumor in the liver and impaired hemostasis due to cirrhosis necessitated a transvenous biopsy of the metastasis. The procedure and the associated techniques are disc... Abstract

Cited 13 times since 2004 (0.6 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 11, Issue 6, 1 1 2004, Pages 704-709 Prognostic value of stress Tc-99m tetrofosmin SPECT in patients with previous myocardial infarction: impact of scintigraphic extent of coronary artery disease. Elhendy A, Schinkel AF, van Domburg RT, Bax JJ, Valkema R, Poldermans D

Background: Our objective was to assess the prognostic value of the scintigraphic extent of coronary artery disease on stress technetium 99m tetrofosmin single photon emission computed tomography in patients with previous myocardial infarction. Methods and results: We studied 383 patients (280 men and 103 women; mean age, 60 +/- 11 years) more than 3 months after an acute myocardial infarction by exercise bicycle or dobutamine (up to 40 mug . kg -1 . min -1 ) stress Tc-99m tetrofosmin myocardial... Abstract

Cited 49 times since 2004 (2.4 per year) source: EuropePMC

Circulation, Volume 110, Issue 19, 1 1 2004, Pages 3017-3022 Abnormal myocardial presynaptic norepinephrine recycling in patients with Brugada syndrome. Kies P, Wichter T, Schäfers M, Paul M, Schäfers KP, Eckardt L, Stegger L, Schulze-Bahr E, Rimoldi O, Breithardt G, Schober O, Camici PG

Background: Life-threatening ventricular tachyarrhythmias can occur in young patients without structural heart disease (idiopathic forms). In many patients, these are typically triggered by an increased sympathetic tone, eg, by physical or mental stress. In contrast, in Brugada syndrome, ventricular tachyarrhythmias more often occur during rest or sleep when the vagal tone is predominant. Furthermore, adrenergic agonists can reduce the level of ST-segment elevation, whereas it is increased by pa... Abstract