Research

Publications

Below you can find a list of our published research.

9618 results

Cited 180 times since 2007 (10.2 per year) source: EuropePMC

European journal of epidemiology, Volume 22, Issue 12, 19 3 2007, Pages 917-923 The Generation R Study Biobank: a resource for epidemiological studies in children and their parents. Jaddoe VW, Bakker R, van Duijn CM, van der Heijden AJ, Lindemans J, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Uitterlinden AG, Verhulst FC, Hofman A

The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. In total, 9,778 mothers were enrolled in the study. Prenatal and postnatal data collection is conducted by physical examinations, questionnaires, interviews, ultrasound examinations and biological samples. Major efforts have... Abstract

Cited 48 times since 2007 (2.7 per year) source: EuropePMC

Biochemical and biophysical research communications, Volume 366, Issue 4, 18 3 2007, Pages 910-916 Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity. Pols TW, Ottenhoff R, Vos M, Levels JH, Quax PH, Meijers JC, Pannekoek H, Groen AK, de Vries CJ

NR4A nuclear receptors are induced in the liver upon fasting and regulate hepatic gluconeogenesis. Here, we studied the role of nuclear receptor Nur77 (NR4A1) in hepatic lipid metabolism. We generated mice expressing hepatic Nur77 using adenoviral vectors, and demonstrate that these mice exhibit a modulation of the plasma lipid profile and a reduction in hepatic triglyceride. Expression analysis of >25 key genes involved in lipid metabolism revealed that Nur77 inhibits SREBP1c expression. Thi... Abstract

Cited 3 times since 2007 (0.2 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 35, Issue 3, 18 3 2007, Pages 687 Discrepancy between glucose metabolism and sympathetic nerve terminals in a patient with metastatic paraganglioma. Rahbar K, Kies P, Stegger L, Juergens KU, Weckesser M

Abstract

Cited 86 times since 2007 (4.9 per year) source: EuropePMC

Journal of human evolution, Volume 54, Issue 5, 18 3 2007, Pages 568-590 Life history costs and benefits of encephalization: a comparative test using data from long-term studies of primates in the wild. Barrickman NL, Bastian ML, Isler K, van Schaik CP

The correlation between brain size and life history has been investigated in many previous studies, and several viable explanations have been proposed. However, the results of these studies are often at odds, causing uncertainties about whether these two character complexes underwent correlated evolution. These disparities could arise from the mixture of wild and captive values in the datasets, potentially obscuring real relationships, and from differences in the methods of controlling for phylo... Abstract

Cited 308 times since 2007 (17.4 per year) source: EuropePMC

European heart journal, Volume 29, Issue 4, 15 3 2007, Pages 531-556 Cardiac computed tomography: indications, applications, limitations, and training requirements: report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology. Schroeder S, Achenbach S, Bengel F, Burgstahler C, Cademartiri F, de Feyter P, George R, Kaufmann P, Kopp AF, Knuuti J, Ropers D, Schuijf J, Tops LF, Bax JJ, Working Group Nuclear Cardiology and Cardiac CT, European Society of Cardiology, European Council of Nuclear Cardiology

As a consequence of improved technology, there is growing clinical interest in the use of multi-detector row computed tomography (MDCT) for non-invasive coronary angiography. Indeed, the accuracy of MDCT to detect or exclude coronary artery stenoses has been high in many published studies. This report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT (WG 5) of the European Society of Cardiology and the European Council of Nuclear Cardiology summarizes the present... Abstract

Cited 27 times since 2007 (1.5 per year) source: EuropePMC

Journal of applied physiology (Bethesda, Md. : 1985), Volume 104, Issue 2, 13 2 2007, Pages 446-450 Long-term cardiovascular effects of neonatal dexamethasone treatment: hemodynamic follow-up by left ventricular pressure-volume loops in rats. Bal MP, de Vries WB, van Oosterhout MF, Baan J, van der Wall EE, van Bel F, Steendijk P

Dexamethasone is clinically applied in preterm infants to treat or prevent chronic lung disease. However, concern has emerged about adverse side effects. The cardiovascular short-term side effects of neonatal dexamethasone treatment are well documented, but long-term consequences are unknown. Previous studies showed suppressed mitosis during dexamethasone treatment, leading to reduced ventricular weight, depressed systolic function, and compensatory dilatation in prepubertal rats. In addition, r... Abstract

Cited 55 times since 2007 (3.1 per year) source: EuropePMC

British journal of clinical pharmacology, Volume 65, Issue 4, 7 1 2007, Pages 558-564 Influence of the CYP2D6*4 polymorphism on dose, switching and discontinuation of antidepressants. Bijl MJ, Visser LE, Hofman A, Vulto AG, van Gelder T, Stricker BH, van Schaik RH

What is already known about this subject: * Most antidepressants are metabolized by CYP2D6. The variant allele CYP2D6*4 is the main polymorphism resulting in reduced enzyme activity in Caucasians. * Reduced enzyme activity potentially leads to increased toxicity of antidepressants, but the relevance of genotyping for clinical practice is unclear. Most clinical studies suffer from small numbers of patients. What this study adds: * This large population-based cohort study in 1198 elderly Dutch pat... Abstract

Cited 153 times since 2007 (8.6 per year) source: EuropePMC

Proceedings of the National Academy of Sciences of the United States of America, Volume 104, Issue 50, 5 1 2007, Pages 19762-19766 Other-regarding preferences in a non-human primate: common marmosets provision food altruistically. Burkart JM, Fehr E, Efferson C, van Schaik CP

Human cooperation is unparalleled in the animal world and rests on an altruistic concern for the welfare of genetically unrelated strangers. The evolutionary roots of human altruism, however, remain poorly understood. Recent evidence suggests a discontinuity between humans and other primates because individual chimpanzees do not spontaneously provide food to other group members, indicating a lack of concern for their welfare. Here, we demonstrate that common marmoset monkeys (Callithrix jacchus)... Abstract

Cited 12 times since 2007 (0.7 per year) source: EuropePMC

Radiology, Volume 246, Issue 2, 4 1 2007, Pages 394-400 MR imaging of right ventricular function after the Ross procedure for aortic valve replacement: initial experience. Grotenhuis HB, de Roos A, Ottenkamp J, Schoof PH, Vliegen HW, Kroft LJ

Purpose: To prospectively assess right ventricular (RV) function after the Ross procedure by using magnetic resonance (MR) imaging. Materials and methods: The local ethics committee approved the study and informed consent was obtained from all participants prior to enrollment in the study. Seventeen patients (15 male, two female; mean age +/- standard deviation, 19 years +/- 3.9; imaging performed 8.3 years after surgery +/- 3.2) and 17 matched controls (15 male, two female; mean age +/- standar... Abstract

Cited 2 times since 2007 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 50, Issue 25, 1 1 2007, Pages 2421-2430 Highlights of the 2007 scientific sessions of the European Society of Cardiology Vienna, Austria, September 1-5, 2007. Kristensen SD, Baumgartner H, Drexler H, Eeckhout E, Filippatos G, Gitt AK, Linde C, Pierard LA, Poldermans D, Schunkert H, Sipido KR, van der Wall EE, Fox K, Bax JJ, European Society of Cardiology

Abstract

Cited 57 times since 2007 (3.2 per year) source: EuropePMC

Archives of internal medicine, Volume 167, Issue 22, 1 1 2007, Pages 2482-2489 A prognostic risk index for long-term mortality in patients with peripheral arterial disease. Feringa HH, Bax JJ, Hoeks S, van Waning VH, Elhendy A, Karagiannis S, Vidakovic R, Schouten O, Boersma E, Poldermans D

Background: Prognostic information in peripheral arterial disease (PAD) may provide the basis for optimal management strategies at an early stage. This study aimed to develop a prognostic risk index for long-term mortality in patients with PAD. Methods: In a single-center observational cohort study, 2642 patients with an ankle-brachial index of 0.90 or lower were randomly divided into derivation (n = 1332) and validation (n = 1310) cohorts. Cox regression analysis with stepwise backward eliminat... Abstract

Cited 5 times since 2007 (0.3 per year) source: EuropePMC

Coronary artery disease, Volume 18, Issue 8, 1 1 2007, Pages 645-651 Baseline natriuretic peptide levels in relation to myocardial ischemia, troponin T release and heart rate variability in patients undergoing major vascular surgery. Feringa HH, Vidakovic R, Karagiannis SE, de Jonge R, Lindemans J, Goei D, Schouten O, Bax JJ, Poldermans D

Background: This study was conducted to determine the association between baseline N-terminal pro-B-type natriuretic peptide (NT-proBNP) and myocardial ischemia, troponin T release and heart rate variability (HRV) in patients undergoing major vascular surgery. Methods: In a prospective study, 182 vascular surgery patients were evaluated by clinical risk factors, dobutamine stress echocardiography and baseline NT-proBNP levels. Myocardial ischemia was detected by continuous 12-lead electrocardiog... Abstract

Cited 41 times since 2007 (2.3 per year) source: EuropePMC

Current opinion in lipidology, Volume 18, Issue 6, 1 1 2007, Pages 645-649 Opportunities and challenges for mesenchymal stem cell-mediated heart repair. Atsma DE, Fibbe WE, Rabelink TJ

Purpose of review: Mesenchymal stem cells (or multipotent stromal cells) are emerging as a potent cell type for cardiac cell therapy. This review describes the potential of cardiac mesenchymal stem cell therapy, but also highlights some recently discovered less favorable mesenchymal stem cell characteristics. Recent findings: Mesenchymal stem cells exert a beneficial effect on cardiac function upon administration to the ischemic myocardium. The mode of action does not seem to involve differentia... Abstract

Cited 42 times since 2007 (2.4 per year) source: EuropePMC

Clinical orthopaedics and related research, Volume 465, 1 1 2007, Pages 23-32 The 2007 Otto Aufranc Award. Ceramic-on-metal hip arthroplasties: a comparative in vitro and in vivo study. Williams S, Schepers A, Isaac G, Hardaker C, Ingham E, van der Jagt D, Breckon A, Fisher J

The performance of novel ceramic-on-metal bearing couples has been compared with metal-on-metal and ceramic-on-ceramic bearing couples in laboratory and short-term clinical studies. Laboratory studies compared ceramic-on-metal with metal-on-metal and ceramic-on-ceramic bearings with diameters of 28 and 36 mm under standard conditions and under adverse conditions with head loading on the rim of the cup. Clinical studies compared metal ion levels in ceramic-on-metal with metal-on-metal, ceramic-on... Abstract

Cited 44 times since 2007 (2.5 per year) source: EuropePMC

Journal of clinical pharmacology, Volume 47, Issue 12, 1 1 2007, Pages 1555-1569 A randomized, placebo-controlled trial to evaluate the efficacy, safety, and pharmacodynamic interaction of coadministered amlodipine and atorvastatin in 1660 patients with concomitant hypertension and dyslipidemia: the respond trial. Preston RA, Harvey P, Herfert O, Dykstra G, Jukema JW, Sun F, Gillen D

Guidelines stress the importance of the simultaneous management of multiple cardiovascular risk factors. This can in part be achieved by coadministration of lipid-lowering and antihypertensive treatments. Potential pharmacodynamic interaction between drugs should be investigated as part of developing single-pill combinations. The Respond trial assessed whether combining amlodipine to treat hypertension and atorvastatin to treat dyslipidemia affected the action of either monotherapy. A total of 1... Abstract

Cited 22 times since 2007 (1.2 per year) source: EuropePMC

Journal of hypertension, Volume 25, Issue 12, 1 1 2007, Pages 2454-2462 Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice. van der Hoorn JW, Kleemann R, Havekes LM, Kooistra T, Princen HM, Jukema JW

Aim: This study was designed to investigate the effect of the angiotensin II receptor blocker olmesartan alone, or in combination with standard treatment with a statin, pravastatin, on atherosclerosis development in APOE*3Leiden transgenic mice. Methods and results: Four groups of 15 mice received an atherogenic diet alone (plasma cholesterol 17.4 +/- 2.7 mmol/l) or supplemented with either 0.008% (w/w) olmesartan (9.3 mg/kg per day) (plasma cholesterol 16.4 +/- 3.9 mmol/l), 0.03% (w/w) pravasta... Abstract

Clinical nuclear medicine, Volume 32, Issue 12, 1 1 2007, Pages 927-929 Intermittent ST-segment depressions during adenosine stress test. van der Hiel B, Scholte AJ, Stokkel MP

ST-segment depression during adenosine stress testing is usually a 1-time event during or after the test and is often related to ischemia due to severe 3-vessel disease. In this case report we describe a patient with severe 3-vessel disease who had intermittent ST-segment depression on the electrocardiogram during a myocardial perfusion stress test with adenosine. These intermittent ST depressions could be explained by possible adenosine-induced coronary spasm. Abstract

Cited 16 times since 2007 (0.9 per year) source: EuropePMC

Microbiology (Reading, England), Volume 153, Issue Pt 12, 1 1 2007, Pages 4234-4239 The stringent response of Bacillus anthracis contributes to sporulation but not to virulence. van Schaik W, Prigent J, Fouet A

The Gram-positive, spore-forming pathogen Bacillus anthracis is the aetiological agent of anthrax. Its main virulence factors are two toxins and an anti-phagocytic capsule. When B. anthracis is grown in laboratory culture, the highest expression of the anthrax toxin genes occurs during entry into stationary phase, suggesting that nutrient limitation is an environmental cue which induces toxin production. A common bacterial response to starvation is the so-called stringent response, in which the... Abstract

Cited 6 times since 2007 (0.3 per year) source: EuropePMC

IEEE transactions on biomedical circuits and systems, Volume 1, Issue 4, 1 1 2007, Pages 278-288 An address-event vision sensor for multiple transient object detection. Chan V, Jin C, van Schaik A

We present a vision sensor chip designed to detect multiple transient objects - objects that either move or change in light intensity - and output their locations using address-event representation. The sensor uses a novel onset detector to detect transient objects and a dynamically-wired winner-takes-all circuit to group pixels and select the brightest pixel in each object. This paper describes the circuits and also presents measurements that characterize the performance of the sensor chip. Abstract

Cited 27 times since 2007 (1.5 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 48, Issue 12, 1 1 2007, Pages 2001-2010 Nuclear imaging in cardiac resynchronization therapy. Henneman MM, van der Wall EE, Ypenburg C, Bleeker GB, van de Veire NR, Marsan NA, Chen J, Garcia EV, Westenberg JJ, Schalij MJ, Bax JJ

Recently, cardiac resynchronization therapy (CRT) has become implemented in the treatment of patients with severe heart failure. Although the improvement in systolic function after CRT implantation can be considerable, 20%-30% of patients do not respond to CRT. Evidence is accumulating that the presence of left ventricular (LV) dyssynchrony is mandatory for a response to CRT. Since the early 1980s attempts have been made to assess cardiac dyssynchrony with nuclear imaging, and it has been report... Abstract