Research

Publications

Below you can find a list of our published research.

9618 results

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 14, Issue 9, 1 1 2006, Pages 283-284 Do patients benefit from drug-eluting stents in acute myocardial infarction? Steens RF, Jukema JW, van der Wall EE

Abstract

Cited 136 times since 2006 (7.2 per year) source: EuropePMC

Stroke, Volume 37, Issue 10, 31 5 2006, Pages 2531-2534 Transesophageal echocardiography is superior to transthoracic echocardiography in management of patients of any age with transient ischemic attack or stroke. de Bruijn SF, Agema WR, Lammers GJ, van der Wall EE, Wolterbeek R, Holman ER, Bollen EL, Bax JJ

Background and purpose: The merits of transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) in the management of transient ischemic attack (TIA) and stroke patients remains matter of debate. Methods: Two hundred and thirty-one consecutive patients with a recent TIA or stroke for which no definite cause and indication for anticoagulation was assessed after standardized work-up underwent TTE and TEE. Echocardiographic findings were categorized into minor and major risk fa... Abstract

Cited 178 times since 2006 (9.4 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 26, Issue 11, 31 5 2006, Pages 2552-2559 Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice. Westerterp M, van der Hoogt CC, de Haan W, Offerman EH, Dallinga-Thie GM, Jukema JW, Havekes LM, Rensen PC

Objective: The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden (E3L) mice with a humanized lipoprotein profile. Methods and results: E3L mice were crossbred with human CETP transgenic mice. On a chow diet, CETP expression increased plasma total cholesterol (TC) (+43%; P Abstract

Cited 10 times since 2006 (0.5 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 23, Issue 2, 29 5 2006, Pages 159-165 Plasma natriuretic peptide levels reflect changes in heart failure symptoms, left ventricular size and function after surgical mitral valve repair. Feringa HH, Poldermans D, Klein P, Braun J, Klautz RJ, van Domburg RT, van der Laarse A, van der Wall EE, Dion RA, Bax JJ

Background and aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) has diagnostic and prognostic value in patients with heart failure. The present prospective study was designed to assess whether changes in NT-proBNP levels after surgical mitral valve repair reflect changes in heart failure symptoms and changes in left atrial size, left ventricular size and left ventricular function. Methods: The study population consisted of 22 patients (mean age: 62.8 +/- 14.2 years, 68% male) undergoin... Abstract

Cited 23 times since 2006 (1.2 per year) source: EuropePMC

Journal of neurology, Volume 253, Issue 12, 28 4 2006, Pages 1572-1580 Comparison of CMT1A and CMT2: similarities and differences. Bienfait HM, Verhamme C, van Schaik IN, Koelman JH, de Visser BW, de Haan RJ, Baas F, van Engelen BG, de Visser M

To evaluate the clinical and electrophysiological similarities and differences between two large groups of patients with Charcot-Marie-Tooth disease, i.e. CMT1A and CMT2, we performed a post hoc comparison of clinical and electrophysiological data. Most CMT1A and CMT2 patients had the classical CMT phenotype. Age of onset was significantly later in CMT2. Total areflexia was present in approximately half of the CMT1A patients whereas it was rare in CMT2. Foot deformities and weakness of knee exte... Abstract

Cited 35 times since 2006 (1.8 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 26, Issue 11, 24 4 2006, Pages 2560-2566 Dual PPARalpha/gamma agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice. Zadelaar AS, Boesten LS, Jukema JW, van Vlijmen BJ, Kooistra T, Emeis JJ, Lundholm E, Camejo G, Havekes LM

Objective: We investigated whether the dual PPARalpha/gamma agonist tesaglitazar has anti-atherogenic effects in ApoE*3Leiden mice with reduced insulin sensitivity. Methods and results: ApoE*3Leiden transgenic mice were fed a high-fat (HF) insulin-resistance-inducing diet. One group received a high-cholesterol (HC) supplement (1% wt/wt; HC group). A second group received the same HC supplement along with tesaglitazar (T) 0.5 micromol/kg diet (T group). A third (control) group received a low-chol... Abstract

Cited 15 times since 2006 (0.8 per year) source: EuropePMC

Pediatric cardiology, Volume 27, Issue 5, 23 4 2006, Pages 552-556 Surgical repair of aortopulmonary window: thirty-seven years of experience. Jansen C, Hruda J, Rammeloo L, Ottenkamp J, Hazekamp MG

An aortopulmonary window (APW) is a communication between the ascending aorta and the pulmonary trunk in the presence of two separate semilunar valves. In order to increase our understanding about the surgical management of this rare lesion and its long-term results, we describe our experience over a 37-year period. Between 1968 and 2005, 18 patients were diagnosed with APW. Seventeen underwent surgical correction. Age at operation ranged from 22 days to 22 years (median, 0.20 years). Follow-up... Abstract

Cited 40 times since 2006 (2.1 per year) source: EuropePMC

Vascular pharmacology, Volume 45, Issue 5, 22 4 2006, Pages 281-301 Murine models of myocardial and limb ischemia: diagnostic end-points and relevance to clinical problems. Madeddu P, Emanueli C, Spillmann F, Meloni M, Bouby N, Richer C, Alhenc-Gelas F, Van Weel V, Eefting D, Quax PH, Hu Y, Xu Q, Hemdahl AL, van Golde J, Huijberts M, de Lussanet Q, Struijker Boudier H, Couffinhal T, Duplaa C, Chimenti S, Staszewsky L, Latini R, Baumans V, Levy BI

Ischemic disease represents the new epidemic worldwide. Animal models of ischemic disease are useful because they can help us to understand the underlying pathogenetic mechanisms and develop new therapies. The present review article summarizes the results of a consensus conference on the status and future development of experimentation in the field of cardiovascular medicine using murine models of peripheral and myocardial ischemia. The starting point was to recognize the limits of the approach,... Abstract

Cited 137 times since 2006 (7.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 48, Issue 5, 17 3 2006, Pages 964-969 Should major vascular surgery be delayed because of preoperative cardiac testing in intermediate-risk patients receiving beta-blocker therapy with tight heart rate control? Poldermans D, Bax JJ, Schouten O, Neskovic AN, Paelinck B, Rocci G, van Dortmont L, Durazzo AE, van de Ven LL, van Sambeek MR, Kertai MD, Boersma E, Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echo Study Group

Objectives: The purpose of this study was to assess the value of preoperative cardiac testing in intermediate-risk patients receiving beta-blocker therapy with tight heart rate (HR) control scheduled for major vascular surgery. Background: Treatment guidelines of the American College of Cardiology/American Heart Association recommend cardiac testing in these patients to identify subjects at increased risk. This policy delays surgery, even though test results might be redundant and beta-blockers... Abstract

Cited 48 times since 2006 (2.5 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 93, Issue 2, 16 3 2006, Pages 226-231 Plasma N-terminal pro-B-type natriuretic peptide as long-term prognostic marker after major vascular surgery. Feringa HH, Schouten O, Dunkelgrun M, Bax JJ, Boersma E, Elhendy A, de Jonge R, Karagiannis SE, Vidakovic R, Poldermans D

Objective: To assess the long-term prognostic value of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) after major vascular surgery. Design: A single-centre prospective cohort study. Patients: 335 patients who underwent abdominal aortic aneurysm repair or lower extremity bypass surgery. Interventions: Prior to surgery, baseline NT-proBNP level was measured. Patients were also evaluated for cardiac risk factors according to the Revised Cardiac Risk Index. Dobutamine stress echocardio... Abstract

Cited 36 times since 2006 (1.9 per year) source: EuropePMC

Heart rhythm, Volume 3, Issue 12, 10 2 2006, Pages 1397-1403 Right ventricular pacing and the risk of heart failure in implantable cardioverter-defibrillator patients. Smit MD, Van Dessel PF, Nieuwland W, Wiesfeld AC, Tan ES, Anthonio RL, Van Erven L, Van Veldhuisen DJ, Van Gelder IC

Background: Right ventricular (RV) pacing in implantable cardioverter-defibrillator (ICD) patients may have detrimental effects on morbidity and mortality, in particular by inducing heart failure (HF). Objective: We investigated whether RV pacing increases the risk of HF in an asymptomatic ICD population. Methods: We evaluated all patients without symptomatic HF who received an ICD. The primary endpoint was the occurrence of HF, which was defined as new HF, hospitalization for HF, or death due t... Abstract

Cited 39 times since 2006 (2 per year) source: EuropePMC

Journal of human evolution, Volume 52, Issue 1, 8 2 2006, Pages 59-71 Variation in brain size and ecology in Pongo. Taylor AB, van Schaik CP

Numerous hypotheses have been advanced to explain relative increases in brain size in primates and other mammals. However, notably less attention has been directed towards addressing the biological limits to increasing brain size. Here we explore variation in brain size in orangutans. We evaluated both raw and size-adjusted cranial capacity (CC) in adult Pongo pygmaeus pygmaeus (n=147), P. p. wurmbii (n=24), P. p. morio (n=14), and P. abelii (n=36). Results demonstrate significant variation in C... Abstract

Cited 5 times since 2006 (0.3 per year) source: EuropePMC

Journal of pediatric gastroenterology and nutrition, Volume 43, Issue 2, 1 1 2006, Pages 265-266 Rhamnose and rhamnitol in dual sugar permeability tests. Malagon I, Onkenhout W, Klok M, van der Poel PF, Bovill JG, Hazekamp MG

Rhamnose is one of the sugars regularly used to conduct the dual sugar permeability test. For more than 30 years, it has been assumed that rhamnose is an inert sugar not metabolized by the human body and only fermented by some colonic bacteria into rhamnulose. While conducting an investigation on gut permeability in children undergoing cardiac surgery, increased concentrations of rhamnitol were found in the urine samples. The present report suggests that rhamnose is not an inert sugar and it is... Abstract

Cited 3 times since 2006 (0.2 per year) source: EuropePMC

Virus genes, Volume 33, Issue 1, 1 1 2006, Pages 59-68 The intraleader AUG nucleotide sequence context is important for equine arteritis virus replication. Archambault D, Kheyar A, de Vries AA, Rottier PJ

The 5(-terminal leader sequence of the equine arteritis virus (EAV) genome contains an open reading frame (ORF) with an AUG codon in a suboptimal context for initiation of protein synthesis. To investigate the significance of this intraleader ORF (ILO), an expression plasmid was generated carrying a DNA copy of the subgenomic mRNA7 behind a T7 promoter. Capped RNA transcribed from this construct was shown to direct, in an in vitro translation system, the synthesis of leader peptide as well as N... Abstract

Cited 7 times since 2006 (0.4 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 13, Issue 4, 1 1 2006, Pages 468-475 Roentgen stereophotogrammetric analysis: an accurate tool to assess stent-graft migration. Koning OH, Oudegeest OR, Valstar ER, Garling EH, van der Linden E, Hinnen JW, Hamming JF, Vossepoel AM, van Bockel JH

Purpose: To evaluate in an in vitro model the feasibility and accuracy of Roentgen stereophotogrammetric analysis (RSA) versus computed tomography (CT) for the ability to detect stent-graft migration. Methods: An aortic model was constructed from a 22-mm-diameter Plexiglas tube with 6-mm polytetrafluoroethylene inlays to mimic the renal arteries. Six tantalum markers were placed in the wall of the aortic tube proximal to the renal arteries. Another 6 markers were added to a Gianturco stent, whic... Abstract

Cited 34 times since 2006 (1.8 per year) source: EuropePMC

European journal of neurology, Volume 13, Issue 8, 1 1 2006, Pages 809-818 European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. European Federation of Neurological Societies, Peripheral Nerve Society, Hadden RD, Nobile-Orazio E, Sommer C, Hahn A, Illa I, Morra E, Pollard J, Hughes RA, Bouche P, Cornblath D, Evers E, Koski CL, Léger JM, Van den Bergh P, van Doorn P, van Schaik IN

Background: Paraprotein-associated neuropathies have heterogeneous clinical, neurophysiological, neuropathological and haematological features. Objectives. To prepare evidence-based and consensus guidelines on the clinical management of patients with both a demyelinating neuropathy and a paraprotein (paraproteinaemic demyelinating neuropathy, PDN). Methods: Search of MEDLINE and the Cochrane library, review of evidence and consensus agreement of an expert panel. Recommendations: In the absence o... Abstract

Cited 45 times since 2006 (2.4 per year) source: EuropePMC

European journal of neurology, Volume 13, Issue 8, 1 1 2006, Pages 802-808 European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy. European Federation of Neurological Societies, Peripheral Nerve Society, van Schaik IN, Bouche P, Illa I, Léger JM, Van den Bergh P, Cornblath DR, Evers EM, Hadden RD, Hughes RA, Koski CL, Nobile-Orazio E, Pollard J, Sommer C, van Doorn PA

Several diagnostic criteria for multifocal motor neuropathy have been proposed in recent years and a beneficial effect of intravenous immunoglobulin (IVIg) and various other immunomodulatory drugs has been suggested in several trials and uncontrolled studies. The objectives were to prepare consensus guidelines on the definition, investigation and treatment of multifocal motor neuropathy. Disease experts and a patient representative considered references retrieved from MEDLINE and the Cochrane Li... Abstract

Cited 92 times since 2006 (4.8 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 80, Issue 2, 1 1 2006, Pages 192-201 Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib. Gardner ER, Burger H, van Schaik RH, van Oosterom AT, de Bruijn EA, Guetens G, Prenen H, de Jong FA, Baker SD, Bates SE, Figg WD, Verweij J, Sparreboom A, Nooter K

Objective: Our objective was to explore the relationships between imatinib pharmacokinetics and 9 allelic variants in 7 genes coding for adenosine triphosphate-binding cassette transporters (ABCB1 and ABCG2) and enzymes (cytochrome P450 [CYP] 2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5) of putative relevance for imatinib. Methods: Imatinib transport in vitro was studied by use of human embryonic kidney 293 cells transfected with wild-type ABCG2 and an ABCG2 Q141K clone. Steady-state pharmacokinetic... Abstract

Cited 9 times since 2006 (0.5 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 47, Issue 8, 1 1 2006, Pages 1307-1311 Nitrate administration increases blood flow in dysfunctional but viable myocardium, leading to improved assessment of myocardial viability: A PET study. Slart RH, Agool A, van Veldhuisen DJ, Dierckx RA, Bax JJ

Unlabelled: SPECT with 99mTc-labeled agents is better able to detect viability after nitrate administration. Nitrates induce vasodilation and may increase blood flow to severely hypoperfused but viable myocardium, thereby enhancing tracer delivery and improving the detection of viability. Quantitative data on the changes in blood flow are lacking in SPECT but can be provided by PET. The aim of the present study was to use PET to evaluate whether nitrate administration increases blood flow to chr... Abstract

Cited 30 times since 2006 (1.6 per year) source: EuropePMC

Journal of vascular surgery, Volume 44, Issue 2, 1 1 2006, Pages 419-424 Statins for the prevention of perioperative cardiovascular complications in vascular surgery. Schouten O, Bax JJ, Dunkelgrun M, Feringa HH, van Urk H, Poldermans D

Perioperative cardiovascular complications in vascular surgery remain a significant problem despite recent advancements in perioperative care. This clinical update summarizes the results of recent studies on the effectiveness and safety of perioperative statin use for the prevention of these perioperative cardiovascular complications. Five studies in patients undergoing major noncardiac vascular surgery and two studies in patients undergoing carotid endarterectomy are described. All studies repo... Abstract