9618 results
Cited 6 times since 2023 (3.2 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 24, Issue 11, 1 1 2023, Pages 1536-1543
Impact of statins based on high-risk plaque features on coronary plaque progression in mild stenosis lesions: results from the PARADIGM study.
Park HB, Arsanjani R, Sung JM, Heo R, Lee BK, Lin FY, Hadamitzky M, Kim YJ, Conte E, Andreini D, Pontone G, Budoff MJ, Gottlieb I, Chun EJ, Cademartiri F, Maffei E, Marques H, Gonçalves PA, Leipsic JA, Lee SE, Shin S, Choi JH, Virmani R, Samady H, Chinnaiyan K, Stone PH, Berman DS, Narula J, Shaw LJ, Bax JJ, Min JK, Chang HJ
Aims: To investigate the impact of statins on plaque progression according to high-risk coronary atherosclerotic plaque (HRP) features and to identify predictive factors for rapid plaque progression in mild coronary artery disease (CAD) using serial coronary computed tomography angiography (CCTA). Methods and results: We analyzed mild stenosis (25-49%) CAD, totaling 1432 lesions from 613 patients (mean age, 62.2 years, 63.9% male) and who underwent serial CCTA at a ≥2 year inter-scan interval us...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 220, 30 5 2023, Pages 106030
Exploring the data divide through a social practice lens: A qualitative study of UK cattle farmers.
Doidge C, Palczynski L, Zhou X, Bearth A, van Schaik G, Kaler J
Appropriate management decisions are key for sustainable and profitable beef and dairy farming. Data-driven technologies aim to provide information which can improve farmers' decision-making practices. However, data-driven technologies have resulted in the emergence of a "data divide", in which there is a gap between the generation and use of data. Our study aims to further understand the data divide by drawing on social practice theory to recognise the emergence, linkages, and re...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Cellular and molecular biology (Noisy-le-Grand, France),
Volume 69, Issue 9, 30 5 2023, Pages 15-23
NLRX1 ligand, docosahexaenoic acid, ameliorates LPS-induced inflammatory hyperalgesia by decreasing TRAF6/IKK/IkB-a/NF-kB signaling pathway activity.
Yilmaz DE, Senol SP, Temiz-Resitoglu M, Sahan-Firat S, Tunctan B
The nucleotide-binding oligomerization domain-like receptor X1 (NLRX1) has been associated with various anti-inflammatory mechanisms. We investigated whether the NLRX1 ligand docosahexaenoic acid (DHA) ameliorates lipopolysaccharide (LPS)-induced inflammatory hyperalgesia by interacting with tumor necrosis factor receptor-associated factor 6 (TRAF6)/inhibitor of kB (IkB) kinase (IKK)/IkB-a/nuclear factor-κB (NF-κB) signaling pathway in the central nervous system. Reaction time to thermal stimuli...
Abstract
Cited 6 times since 2023 (3.2 per year)
source: EuropePMC
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association,
Volume 32, Issue 11, 29 5 2023, Pages 107388
Non-coding RNAs versus protein biomarkers to diagnose and differentiate acute stroke: Systematic review and meta-analysis.
Florijn BW, Leontien van der Bent M, Nguyen TMT, Quax PHA, Wermer MJH, Yaël Nossent A, Kruyt ND
Background: Stroke diagnosis is dependent on lengthy clinical and neuroimaging assessments, while rapid treatment initiation improves clinical outcome. Currently, more sensitive biomarker assays of both non-coding RNA- and protein biomarkers have improved their detectability, which could accelerate stroke diagnosis. This systematic review and meta-analysis compares non-coding RNA- with protein biomarkers for their potential to diagnose and differentiate acute stroke (subtypes) in (pre-)hospital...
Abstract
Cited 7 times since 2023 (3.7 per year)
source: EuropePMC
Alimentary pharmacology & therapeutics,
Volume 58, Issue 11-12, 28 4 2023, Pages 1151-1162
Therapeutic drug monitoring of methotrexate in patients with Crohn's disease.
van de Meeberg MM, Fidder HH, Oldenburg B, Sundaresan J, Struys EA, Montazeri NSM, Mares WGN, Mahmmod N, van Asseldonk DP, Lutgens MWMD, Kuyvenhoven JP, Rietdijk ST, Nissen LHC, Koehestanie P, de Boer NKH, de Jonge R, Bouma G, Bulatović Ćalasan M, Dutch Initiative on Crohn and Colitis (ICC)
Background: Therapeutic drug monitoring (TDM) has the potential to improve efficacy and diminish side effects. Measuring methotrexate-polyglutamate (MTX-PG) in erythrocytes might enable TDM for methotrexate in patients with Crohn's disease (CD). Aim: To investigate the relationship between MTX-PGs and methotrexate drug survival, efficacy and toxicity METHODS: In a multicentre prospective cohort study, patients with CD starting subcutaneous methotrexate without biologics were included and fo...
Abstract
Cited 18 times since 2023 (9.5 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 109, Issue 20, 28 4 2023, Pages 1525-1532
Tolerability and beneficial effects of sacubitril/valsartan on systemic right ventricular failure.
Nederend M, Kiès P, Regeer MV, Vliegen HW, Mertens BJ, Robbers-Visser D, Bouma BJ, Tops LF, Schalij MJ, Jongbloed MRM, Egorova AD
Objective: Patients with a systemic right ventricle (sRV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are prone to sRV dysfunction. Pharmacological options for sRV failure remain poorly defined. This study aims to investigate the tolerability and effects of sacubitril/valsartan on sRV failure in adult patients with sRV. Methods: In this two-centre, prospective cohort study, all consecutive adult patients with symptomatic h...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
The British journal of general practice : the journal of the Royal College of General Practitioners,
Volume 73, Issue 735, 28 4 2023, Pages e752-e759
Identification of frailty in primary care: accuracy of electronically derived measures.
Swart KM, van der Heijden AA, Blom MT, Overbeek JA, Nijpels G, van Hout HP, Elders PJ, Herings RM
Background: Routinely collected clinical data based on electronic medical records could be used to define frailty. Aim: To estimate the ability of four potential frailty measures that use electronic medical record data to identify older patients who were frail according to their GP. Design and setting: This retrospective cohort study used data from 36 GP practices in the Dutch PHARMO Data Network. Method: The measures were the Dutch Polypharmacy Index, Charlson Comorbidity Index (CCI), Chronic D...
Abstract
Cited 7 times since 2023 (3.7 per year)
source: EuropePMC
European radiology,
Volume 34, Issue 4, 26 4 2023, Pages 2665-2676
Progression of non-obstructive coronary plaque: a practical CCTA-based risk score from the PARADIGM registry.
Pontone G, Rossi A, Baggiano A, Andreini D, Conte E, Fusini L, Gebhard C, Rabbat MG, Guaricci A, Guglielmo M, Muscogiuri G, Mushtaq S, Al-Mallah MH, Berman DS, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, de Araújo Gonçalves P, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Lee SE, Maffei E, Marques H, Samady H, Shin S, Sung JM, van Rosendael A, Virmani R, Bax JJ, Leipsic JA, Lin FY, Min JK, Narula J, Shaw LJ, Chang HJ
Objectives: No clear recommendations are endorsed by the different scientific societies on the clinical use of repeat coronary computed tomography angiography (CCTA) in patients with non-obstructive coronary artery disease (CAD). This study aimed to develop and validate a practical CCTA risk score to predict medium-term disease progression in patients at a low-to-intermediate probability of CAD. Methods: Patients were part of the Progression of AtheRosclerotic PlAque Determined by Computed Tomog...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists,
Volume 32, Issue 4, 25 4 2023, Pages 1009-1017
Perprocedural Heparinization in Non-cardiac Arterial Procedures: The Current Practice in the Netherlands.
Roosendaal LC, Hoebink M, Wiersema AM, Yeung KK, Blankensteijn JD, Jongkind V, ACTION-survey collaborators
Purpose: Heparin is the most widely-used anticoagulant to prevent thrombo-embolic complications during non-cardiac arterial procedures (NCAP). Unfortunately, there is a lack of evidence and consequently non-uniformity in guidelines on perprocedural heparin management. Detailed insight into the current practice of antithrombotic strategies during NCAP in the Netherlands is important, aiming to identify potential optimal protocols and local differences concerning perprocedural heparinization. Mate...
Abstract
Cited 3 times since 2023 (1.6 per year)
source: EuropePMC
BMC medicine,
Volume 21, Issue 1, 25 4 2023, Pages 365
Diagnostic and societal impact of implementing the syncope guidelines of the European Society of Cardiology (SYNERGY study).
Ghariq M, van den Hout WB, Dekkers OM, Bootsma M, de Groot B, Groothuis JGJ, Harms MPM, Hemels MEW, Kaal ECA, Koomen EM, de Lange FJ, Peeters SYG, van Rossum IA, Rutten JHW, van Zwet EW, van Dijk JG, Thijs RD, SYNERGY Consortium
Background: Syncope management is fraught with unnecessary tests and frequent failure to establish a diagnosis. We evaluated the potential of implementing the 2018 European Society of Cardiology (ESC) Syncope Guidelines regarding diagnostic yield, accuracy and costs. Methods: A multicentre pre-post study in five Dutch hospitals comparing two groups of syncope patients visiting the emergency department: one before intervention (usual care; from March 2017 to February 2019) and one afterwards (fro...
Abstract
Cited 2 times since 2023 (1.1 per year)
source: EuropePMC
CJC open,
Volume 6, Issue 1, 23 4 2023, Pages 1-10
Blood and Imaging Biomarkers in the Long-term Follow-up of Bicuspid Aortic Valve Patients.
Keuning ZA, Hendriks PM, Duijnhouwer AL, Meccanici F, Siebelink HJ, van den Hoven AT, Geenen LW, Eindhoven JA, Baggen VJM, Cuypers JAAE, Kauling RM, Roos-Hesselink JW, van den Bosch AE
Background: Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as valve stenosis and regurgitation. This study aimed to investigate sex differences in blood and imaging biomarkers and to describe the long-term prognostic value of blood and echocardiographic biomarkers. Methods: Patients were included from 2 prospective observational cohort studies; they underwent venous blood sampling and transthoracic echocardiography...
Abstract
Cited 2 times since 2023 (1.1 per year)
source: EuropePMC
Genes,
Volume 14, Issue 10, 22 4 2023, Pages 1841
Implementation of Pharmacogenetics in First-Line Care: Evaluation of Its Use by General Practitioners.
van der Drift D, Simoons M, Koch BCP, Brufau G, Bindels P, Matic M, van Schaik RHN
Pharmacogenetics (PGx) can explain/predict drug therapy outcomes. There is, however, unclarity about the use and usefulness of PGx in primary care. In this study, we investigated PGx tests ordered by general practitioners (GPs) in 2021 at Dept. Clinical Chemistry, Erasmus MC, and analyzed the gene tests ordered, drugs/drug groups, reasons for testing and single-gene versus panel testing. Additionally, a survey was sent to 90 GPs asking about their experiences and barriers to implementing PGx. In...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 36, Issue 11, 22 4 2023, Pages 1178-1180
Refining the Detection of Systemic Congestion in Severe Tricuspid Regurgitation: Echocardiography May Be the Key.
Fortuni F, Ajmone Marsan N
Abstract
Irish journal of medical science,
Volume 193, Issue 2, 22 4 2023, Pages 1073-1077
Investigation of the effect of Ramadan fasting on serum levels of melatonin, cortisol, and serotonin: the case of Turkey.
Şentürk E, Yıldız M, Şentürk M, Varol E, Yildirim MS, Yilmaz DA, Atay ME
Introduction: The aim of this study is to examine the effects of Ramadan fasting on melatonin, cortisol, and serotonin levels. Methods: In this study, the blood of 19 healthy male individuals between the ages of 26 and 51, registered in Agri (Turkey) Family Health Center and fasting during Ramadan, was studied. The study was carried out in 2021-2022. The SPSS-22 package program was used in the analysis of the data. Wilcoxon analysis was used in the study. Results: It was determined that the pre-...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
EJVES vascular forum,
Volume 60, 21 3 2023, Pages 82-83
Calcified Pseudocoarctation After Thoracic Endovascular Aortic Repair: A Hard Case to Crack.
van der Vorst JR, Teraa M
Abstract
Musculoskeletal science & practice,
Volume 67, 21 3 2023, Pages 102861
Measurement properties of a computer adaptive device, the Senscoordination 3D Cervical Trainer, to assess cervical range of motion in people with neck pain.
Thoomes E, Cleland JA, Falla D, de Pauw R, Maissan F, de Graaf M
Introduction: Clinicians commonly assess cervical range of motion (ROM) in patients with neck pain. Recently, a new instrument has been developed, the Senscoordination 3D Cervical Trainer (SCT), designed to measure neck ROM in addition to joint position error, static and dynamic balance performance, and performance on a 'neuro muscular control test'. This study aims to assess the interrater reliability, concurrent validity, and responsiveness of the SCT using the CROM device as a compa...
Abstract
Clinical pediatrics,
Volume 63, Issue 2, 21 3 2023, Pages 208-213
Intravenous Magnesium Sulfate for Acute Bronchiolitis: Evaluation of the Effect on Clinical Course and Outcomes.
Şık N, Çitlenbik H, Öztürk A, Yılmaz D, Duman M
The aim of the present study was to assess the efficacy of intravenous (IV) magnesium sulfate (MgSO4) for children with bronchiolitis. A retrospective cohort study was performed at a pediatric emergency department. Aged between 1 and 24 months, children with moderate/severe bronchiolitis according to the Modified Respiratory Distress Assessment Instrument (mRDAI) score were included. Patients who received 40 mg/kg/dose of IV MgSO4 (group 1, n: 74) or not (group 2, n: 33) were compared. Respirato...
Abstract
Cited 7 times since 2023 (3.7 per year)
source: EuropePMC
Cell reports,
Volume 42, Issue 10, 20 3 2023, Pages 113124
Perturbations in 3D genome organization can promote acquired drug resistance.
Manjón AG, Manzo SG, Prekovic S, Potgeter L, van Schaik T, Liu NQ, Flach K, Peric-Hupkes D, Joosten S, Teunissen H, Friskes A, Ilic M, Hintzen D, Franceschini-Santos VH, Zwart W, de Wit E, van Steensel B, Medema RH
Acquired drug resistance is a major problem in the treatment of cancer. hTERT-immortalized, untransformed RPE-1 cells can acquire resistance to Taxol by derepressing the ABCB1 gene, encoding for the multidrug transporter P-gP. Here, we investigate how the ABCB1 gene is derepressed. ABCB1 activation is associated with reduced H3K9 trimethylation, increased H3K27 acetylation, and ABCB1 displacement from the nuclear lamina. While altering DNA methylation and H3K27 methylation had no major impact on...
Abstract
Cited 1 times since 2023 (0.5 per year)
source: EuropePMC
JTCVS open,
Volume 16, 20 3 2023, Pages 177-188
The robustness of the flow-gradient classification of severe aortic stenosis.
Velders BJJ, Vriesendorp MD, Asch FM, Moront MG, Dagenais F, Reardon MJ, Sabik Iii JF, Groenwold RHH, Klautz RJM
Objectives: A flow-gradient classification is used to determine the indication for intervention for patients with severe aortic stenosis (AS) with discordant echocardiographic parameters. We investigated the agreement in flow-gradient classification by stroke volume (SV) measurement at the left ventricular outflow tract (LVOT) and at the left ventricle. Methods: Data were used from a prospective cohort study and patients with severe AS (aortic valve area index ≤0.6 cm2/m2) with preserved ejectio...
Abstract
Cited 14 times since 2023 (7.3 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 17, Issue 1, 20 3 2023, Pages 79-95
Tricuspid Regurgitation: From Imaging to Clinical Trials to Resolving the Unmet Need for Treatment.
Grapsa J, Praz F, Sorajja P, Cavalcante JL, Sitges M, Taramasso M, Piazza N, Messika-Zeitoun D, Michelena HI, Hamid N, Dreyfus J, Benfari G, Argulian E, Chieffo A, Tchetche D, Rudski L, Bax JJ, Stephan von Bardeleben R, Patterson T, Redwood S, Bapat VN, Nickenig G, Lurz P, Hausleiter J, Kodali S, Hahn RT, Maisano F, Enriquez-Sarano M
Tricuspid regurgitation (TR) is a highly prevalent and heterogeneous valvular disease, independently associated with excess mortality and high morbidity in all clinical contexts. TR is profoundly undertreated by surgery and is often discovered late in patients presenting with right-sided heart failure. To address the issue of undertreatment and poor clinical outcomes without intervention, numerous structural tricuspid interventional devices have been and are in development, a challenging process...
Abstract
