Research

Publications

Below you can find a list of our published research.

6266 results

Cited 31 times since 2021 (7.4 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 14, Issue 9, 19 3 2021, Pages 1724-1737 Prognostic Implications of Associated Cardiac Abnormalities Detected on Echocardiography in Patients With Moderate Aortic Stenosis. Amanullah MR, Pio SM, Ng ACT, Sin KYK, Marsan NA, Ding ZP, Leon MB, Généreux P, Delgado V, Ewe SH, Bax JJ

Objectives: This study aimed to evaluate the prevalence and prognostic value of the extent of extra-aortic valvular cardiac abnormalities in a large multicenter registry of patients with moderate AS. Background: The prognostic significance of a new classification system that incorporates the extent of cardiac injury (beyond the aortic valve) has been proposed in patients with severe aortic stenosis (AS). Whether this can be applied to patients with moderate AS is unclear. Methods: Based on the e... Abstract

Cited 5 times since 2021 (1.2 per year) source: EuropePMC

Journal of virological methods, Volume 297, 19 3 2021, Pages 114196 A luciferase-based approach for measuring HBGA blockade antibody titers against human norovirus. van Loben Sels JM, Meredith LW, Sosnovtsev SV, de Graaf M, Koopmans MPG, Lindesmith LC, Baric RS, Green KY, Goodfellow IG

Background: Noroviruses are the most common cause of viral gastroenteritis worldwide, yet there is a deficit in the understanding of protective immunity. Surrogate neutralization assays have been widely used that measure the ability of antibodies to block virus-like particle (VLP) binding to histo-blood group antigens (HBGAs). However, screening large sample sets against multiple antigens using the traditional HBGA blocking assay requires significant investment in terms of time, equipment, and t... Abstract

Cited 3 times since 2021 (0.7 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 163, Issue 3, 18 3 2021, Pages 1166-1175 Long-term outcomes of atrioventricular septal defect and single ventricle: A multicenter study. Arrigoni SC, IJsselhof R, Postmus D, Vonk JM, François K, Bové T, Hazekamp MG, Rijnberg FM, Meyns B, van Puyvelde J, Poncelet AJ, de Beco G, van de Woestijne PC, Bogers AJJC, Schoof PH, Ebels T

Objective: The study objective was to analyze survival and incidence of Fontan completion of patients with single-ventricle and concomitant unbalanced atrioventricular septal defect. Methods: Data from 4 Dutch and 3 Belgian institutional databases were retrospectively collected. A total of 151 patients with single-ventricle atrioventricular septal defect were selected; 36 patients underwent an atrioventricular valve procedure (valve surgery group). End points were survival, incidence of Fontan c... Abstract

Frontiers in cardiovascular medicine, Volume 8, 13 2 2021, Pages 658719 Editorial: Heart Valve Tissue Engineering: Are We Ready for Clinical Translation? Hjortnaes J, Mokhles MM, Takkenberg JJM, Bouten CVC

Abstract

Cited 10 times since 2021 (2.4 per year) source: EuropePMC

Journal of cardiovascular computed tomography, Volume 15, Issue 6, 12 2 2021, Pages 485-491 Prognostic value of noninvasive combined anatomic/functional assessment by cardiac CT in patients with suspected coronary artery disease - Comparison with invasive coronary angiography and nuclear myocardial perfusion imaging for the five-year-follow up of the CORE320 multicenter study. Dewey M, Rochitte CE, Ostovaneh MR, Chen MY, George RT, Niinuma H, Kitagawa K, Laham R, Kofoed K, Nomura C, Sakuma H, Yoshioka K, Mehra VC, Jinzaki M, Kuribayashi S, Laule M, Paul N, Scholte AJ, Cerci R, Hoe J, Tan SY, Rybicki FJ, Matheson MB, Vavere AL, Arai AE, Miller JM, Cox C, Brinker J, Clouse ME, Di Carli M, Lima JAC, Arbab-Zadeh A

Background: Few data exist on long-term outcome in patients undergoing combined coronary CT angiography (CTA) and myocardial CT perfusion imaging (CTP) as well as invasive coronary angiography (ICA) and single photon emission tomography (SPECT). Methods: At 16 centers, 381 patients were followed for major adverse cardiac events (MACE) for the CORE320 study. All patients underwent coronary CTA, CTP, and SPECT before ICA within 60 days. Prognostic performance according binary results (normal/abnor... Abstract

Cited 10 times since 2021 (2.4 per year) source: EuropePMC

Radiology, Volume 300, Issue 1, 11 2 2021, Pages 79-86 Association between Aortic Valve Calcification Progression and Coronary Atherosclerotic Plaque Volume Progression in the PARADIGM Registry. Lee SE, Sung JM, Andreini D, Al-Mallah MH, Budoff MJ, Cademartiri F, Chinnaiyan K, Choi JH, Chun EJ, Conte E, Gottlieb I, Hadamitzky M, Kim YJ, Lee BK, Leipsic JA, Maffei E, Marques H, de Araújo Gonçalves P, Pontone G, Shin S, Stone PH, Samady H, Virmani R, Narula J, Berman DS, Shaw LJ, Bax JJ, Lin FY, Min JK, Chang HJ

Background Aortic valve calcification (AVC) is a key feature of aortic stenosis, and patients with aortic stenosis often have coronary -artery disease. Therefore, proving the association between the progression of AVC and coronary atherosclerosis could improve follow-up and treatment strategies. Purpose To explore the association between the progression of AVC and the progression of total and plaque volume composition from a large multicenter registry of serial coronary CT angiographic examinati... Abstract

Cited 30 times since 2021 (7.1 per year) source: EuropePMC

Life (Basel, Switzerland), Volume 11, Issue 5, 11 2 2021, Pages 433 Perfusion Parameters in Near-Infrared Fluorescence Imaging with Indocyanine Green: A Systematic Review of the Literature. Goncalves LN, van den Hoven P, van Schaik J, Leeuwenburgh L, Hendricks CHF, Verduijn PS, van der Bogt KEA, van Rijswijk CSP, Schepers A, Vahrmeijer AL, Hamming JF, van der Vorst JR

(1) Background: Near-infrared fluorescence imaging is a technique capable of assessing tissue perfusion and has been adopted in various fields including plastic surgery, vascular surgery, coronary arterial disease, and gastrointestinal surgery. While the usefulness of this technique has been broadly explored, there is a large variety in the calculation of perfusion parameters. In this systematic review, we aim to provide a detailed overview of current perfusion parameters, and determine the perf... Abstract

Cited 9 times since 2021 (2.1 per year) source: EuropePMC

Journal of clinical medicine, Volume 10, Issue 10, 11 2 2021, Pages 2047 Outcome and Predictors for Mortality in Patients with Cardiogenic Shock: A Dutch Nationwide Registry-Based Study of 75,407 Patients with Acute Coronary Syndrome Treated by PCI. Karami M, Peters EJ, Lagrand WK, Houterman S, den Uil CA, Engström AE, Otterspoor LC, Ottevanger JP, Ferreira IA, Montero-Cabezas JM, Sjauw K, van Ramshorst J, Kraaijeveld AO, Verouden NJW, Lipsic E, Vlaar AP, Henriques JPS, On Behalf Of The Pci Registration Committee Of The Netherlands Heart Registration

It is important to gain more insight into the cardiogenic shock (CS) population, as currently, little is known on how to improve outcomes. Therefore, we assessed clinical outcome in acute coronary syndrome (ACS) patients treated by percutaneous coronary intervention (PCI) with and without CS at admission. Furthermore, the incidence of CS and predictors for mortality in CS patients were evaluated. The Netherlands Heart Registration (NHR) is a nationwide registry on all cardiac interventions. We u... Abstract

Cited 6 times since 2021 (1.4 per year) source: Scopus

Nature communications, Volume 12, Issue 1, 10 2 2021, Pages 2610 A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. Malinova TS, Angulo-Urarte A, Nüchel J, Tauber M, van der Stoel MM, Janssen V, de Haan A, Groenen AG, Tebbens M, Graupera M, Plomann M, Huveneers S

Angiogenic sprouting relies on collective migration and coordinated rearrangements of endothelial leader and follower cells. VE-cadherin-based adherens junctions have emerged as key cell-cell contacts that transmit forces between cells and trigger signals during collective cell migration in angiogenesis. However, the underlying molecular mechanisms that govern these processes and their functional importance for vascular development still remain unknown. We previously showed that the F-BAR protei... Abstract

Cited 7 times since 2021 (1.7 per year) source: EuropePMC

Atherosclerosis, Volume 328, 9 2 2021, Pages 144-152 Triglyceride-lowering LPL alleles combined with LDL-C-lowering alleles are associated with an additively improved lipoprotein profile. Ibi D, Blauw LL, Noordam R, Dollé MET, Jukema JW, Rosendaal FR, Christodoulides C, Neville MJ, Koivula R, Rensen PCN, Karpe F, van Dijk KW

Background and aims: Mendelian randomization studies have shown that triglyceride (TG)- lowering lipoprotein lipase (LPL) alleles and low-density lipoprotein-cholesterol (LDL-C)-lowering alleles have independent beneficial associations on cardiovascular disease (CVD) risk. We aimed to provide further insight into this observation by applying Mendelian randomization analyses of genetically-influenced TG and LDL-C levels on plasma metabolomic profiles. Methods: We quantified over 100 lipoprotein m... Abstract

Cited 9 times since 2021 (2.1 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 34, Issue 9, 8 2 2021, Pages 955-965 Left Ventricular Global Longitudinal Strain as a Predictor of Outcomes in Patients with Heart Failure with Secondary Mitral Regurgitation: The COAPT Trial. Medvedofsky D, Milhorini Pio S, Weissman NJ, Namazi F, Delgado V, Grayburn PA, Kar S, Lim DS, Lerakis S, Zhou Z, Liu M, Alu MC, Kapadia SR, Lindenfeld J, Abraham WT, Mack MJ, Bax JJ, Stone GW, Asch FM, COAPT Investigators

Background: Left ventricular (LV) global longitudinal strain (GLS) is a sensitive marker of LV function and may help identify patients with heart failure (HF) and secondary mitral regurgitation who would have a better prognosis and are more likely to benefit from edge-to-edge transcatheter mitral valve repair with the MitraClip. The aim of this study was to assess the prognostic utility of baseline LV GLS during 2-year follow-up of patients with HF with secondary mitral regurgitation enrolled in... Abstract

Cited 13 times since 2021 (3.1 per year) source: EuropePMC

Heart rhythm, Volume 18, Issue 9, 3 1 2021, Pages 1539-1547 The precordial R' wave: A novel discriminator between cardiac sarcoidosis and arrhythmogenic right ventricular cardiomyopathy in patients presenting with ventricular tachycardia. Hoogendoorn JC, Venlet J, Out YNJ, Man S, Kumar S, Sramko M, Dechering DG, Nakajima I, Siontis KC, Watanabe M, Nakamura Y, Tedrow UB, Bogun F, Eckardt L, Peichl P, Stevenson WG, Zeppenfeld K

Background: Cardiac sarcoidosis (CS) with right ventricular (RV) involvement can mimic arrhythmogenic right ventricular cardiomyopathy (ARVC). Histopathological differences may result in disease-specific RV activation patterns detectable on the 12-lead electrocardiogram. Dominant subepicardial scar in ARVC leads to delayed activation of areas with reduced voltages, translating into terminal activation delay and occasionally (epsilon) waves with a small amplitude. Conversely, patchy transmural RV... Abstract

Cited 4 times since 2021 (0.9 per year) source: EuropePMC

ESC heart failure, Volume 8, Issue 3, 2 1 2021, Pages 1735-1737 Shear wave elastography to evaluate hepatic damage in heart failure. van der Bijl P, Delgado V, Bax JJ

Abstract

Cited 30 times since 2021 (7.1 per year) source: EuropePMC

ESC heart failure, Volume 8, Issue 4, 2 1 2021, Pages 2968-2981 Predictors and prognosis of right ventricular function in pulmonary hypertension due to heart failure with reduced ejection fraction. Schmeißer A, Rauwolf T, Groscheck T, Fischbach K, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Schäfer K, Steendijk P, Braun-Dullaeus RC

Aims: Failure of right ventricular (RV) function worsens outcome in pulmonary hypertension (PH). The adaptation of RV contractility to afterload, the RV-pulmonary artery (PA) coupling, is defined by the ratio of RV end-systolic to PA elastances (Ees/Ea). Using pressure-volume loop (PV-L) technique we aimed to identify an Ees/Ea cut-off predictive for overall survival and to assess hemodynamic and morphologic conditions for adapted RV function in secondary PH due to heart failure with reduced eje... Abstract

Cited 12 times since 2021 (2.8 per year) source: EuropePMC

European heart journal, Volume 42, Issue 19, 1 1 2021, Pages 1912-1925 Multimodality imaging in valvular heart disease: how to use state-of-the-art technology in daily practice. Reid A, Blanke P, Bax JJ, Leipsic J

Our understanding of the complexities of valvular heart disease (VHD) has evolved in recent years, primarily because of the increased use of multimodality imaging (MMI). Whilst echocardiography remains the primary imaging technique, the contemporary evaluation of patients with VHD requires comprehensive analysis of the mechanism of valvular dysfunction, accurate quantification of severity, and active exclusion extravalvular consequences. Furthermore, advances in surgical and percutaneous therapi... Abstract

Cited 415 times since 2021 (97.5 per year) source: EuropePMC

European heart journal, Volume 42, Issue 19, 1 1 2021, Pages 1825-1857 Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research. VARC-3 WRITING COMMITTEE, Généreux P, Piazza N, Alu MC, Nazif T, Hahn RT, Pibarot P, Bax JJ, Leipsic JA, Blanke P, Blackstone EH, Finn MT, Kapadia S, Linke A, Mack MJ, Makkar R, Mehran R, Popma JJ, Reardon M, Rodes-Cabau J, Van Mieghem NM, Webb JG, Cohen DJ, Leon MB

Aims: The Valve Academic Research Consortium (VARC), founded in 2010, was intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of these endpoints for transcatheter and surgical aortic valve clinical trials. Rapid evolution of the field, including the emergence of new complications, expanding clinical indications, and novel therapy strategies have mandated further refinement and expansion of these definitions to ensure clinical relevance. This document provides... Abstract

Cited 29 times since 2021 (6.8 per year) source: EuropePMC

European journal of preventive cardiology, Volume 28, Issue 6, 1 1 2021, Pages 611-621 Anticoagulation in patients with atrial fibrillation and active cancer: an international survey on patient management. Boriani G, Lee G, Parrini I, Lopez-Fernandez T, Lyon AR, Suter T, Van der Meer P, Cardinale D, Lancellotti P, Zamorano JL, Bax JJ, Asteggiano R, Council of Cardio-Oncology of the European Society of Cardiology

Background: In patients with active cancer and atrial fibrillation (AF) anticoagulation, thrombotic and bleeding risk still entail uncertainty. Aim: We explored the results of an international survey examining the knowledge and behaviours of a large group of physicians. Methods and results: A web-based survey was completed by 960 physicians (82.4% cardiologists, 75.5% from Europe). Among the currently available anticoagulants for stroke prevention in patients with active cancer, direct oral anti... Abstract

Cited 3 times since 2021 (0.7 per year) source: EuropePMC

RMD open, Volume 7, Issue 2, 1 1 2021, Pages e001524 New risk model is able to identify patients with a low risk of progression in systemic sclerosis. van Leeuwen NM, Maurits M, Liem S, Ciaffi J, Ajmone Marsan N, Ninaber M, Allaart C, Gillet van Dongen H, Goekoop R, Huizinga T, Knevel R, De Vries-Bouwstra J

Objectives: To develop a prediction model to guide annual assessment of systemic sclerosis (SSc) patients tailored in accordance to disease activity. Methods: A machine learning approach was used to develop a model that can identify patients without disease progression. SSc patients included in the prospective Leiden SSc cohort and fulfilling the ACR/EULAR 2013 criteria were included. Disease progression was defined as progression in ≥1 organ system, and/or start of immunosuppression or death. U... Abstract

Cited 1 times since 2021 (0.2 per year) source: EuropePMC

Interactive cardiovascular and thoracic surgery, Volume 32, Issue 5, 1 1 2021, Pages 834-836 Repair of traumatic avulsion of the right bronchus in children using extracorporeal membrane oxygenation support. Ricciardi G, Putman LM, Hazekamp MG

Traumatic avulsion of the right main bronchus in children is usually caused by blunt trauma or traffic accidents. Primary repair by suturing is the preferred treatment. Lesions are life threatening and urgent or emergency surgical repair is indicated. We report our experience with 2 cases of traumatic avulsion of right bronchus in children successfully suture repaired with the use of extracorporeal membrane oxygenation. Abstract

Cited 35 times since 2021 (8.2 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 59, Issue 5, 1 1 2021, Pages 968-977 Long-term outcome after the arterial switch operation: 43 years of experience. van der Palen RLF, Blom NA, Kuipers IM, Rammeloo LAJ, Jongbloed MRM, Konings TC, Bouma BJ, Koolbergen DR, Hazekamp MG

Objectives: The objective of this study was to assess our 43-year experience with arterial switch operation (ASO) for transposition of the great arteries (TGA) by analysing cardiac outcome measures (hospital and late mortality, reoperations and catheter interventions, significant coronary artery obstruction) and to identify risk factors for reoperation and catheter interventions. Methods: A total of 490 patients who underwent ASO for TGA from 1977 to 2020 were included in this retrospective, sin... Abstract