Research

Publications

Below you can find a list of our published research.

6196 results

Cited 12 times since 2012 (0.9 per year) source: EuropePMC

Current opinion in cardiology, Volume 27, Issue 2, 1 1 2012, Pages 111-117 Mitral valve surgery in low ejection fraction, severe ischemic mitral regurgitation patients: should we repair them all? Braun J, Klautz RJ

Purpose of review: The optimal surgical treatment of chronic ischemic mitral regurgitation still is the subject of much debate in the surgical and cardiological communities. Although combined restrictive mitral annuloplasty and revascularization has demonstrated good results with regard to improvement of clinical status, low rates of recurrent mitral regurgitation and sustained left ventricular reverse remodeling, a survival benefit still has not been demonstrated. In addition, not all patients... Abstract

Cited 29 times since 2012 (2.2 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 3, 1 1 2012, Pages 423-425 Practices of cardiac implantable electronic device follow-up: results of the European Heart Rhythm Association survey. Marinskis G, van Erven L, Bongiorni MG, Lip GY, Pison L, Blomström-Lundqvist C, Scientific Initiative Committee, European Heart Rhythm Association

This survey analyses some details of follow-up of patients with cardiac implantable electronic devices (CIEDs) in 40 centres-the members of the European Heart Rhythm Association (EHRA) research network. Results of this survey show that practices of CIED follow-up are not homogeneous between EHRA research network centres, and recommended clinical evaluation of the patients regarding possible device up-grade is not always performed. Remote device monitoring appears to be an evolving practice, most... Abstract

Postgraduate medical journal, Volume 88, Issue 1037, 1 1 2012, Pages 176-184 Republished article: Pharmacogenetics of antiplatelet therapy: ready for clinical application? Verschuren JJ, Jukema JW

Abstract

Cited 10 times since 2012 (0.8 per year) source: EuropePMC

Histology and histopathology, Volume 27, Issue 3, 1 1 2012, Pages 387-396 Visualizing TGF-β and BMP signaling in human atherosclerosis: a histological evaluation based on Smad activation. van Dijk RA, Engels CC, Schaapherder AF, Mulder-Stapel A, Ten Dijke P, Hamming JF, Lindeman JH

Background: The TGF-β superfamily members transforming growth factor-β (TGF-β/Activin) and bone morphogenetic proteins (BMP) have been implicated in the pathogenesis of atherosclerosis. However, their role in human disease remains controversial. In this study we used Smad phosphorylation as a read out for TGF-β and BMP signaling during the initiation, progression and (de)stabilization of human atherosclerotic disease. Material and methods: A systematic analysis was performed in 114 peri-renal ao... Abstract

Cited 4 times since 2012 (0.3 per year) source: EuropePMC

Investigative radiology, Volume 47, Issue 3, 1 1 2012, Pages 189-196 Tissue-velocity magnetic resonance imaging and tissue Doppler imaging to assess regional myocardial diastolic velocities at the right ventricle in corrected pediatric Tetralogy of Fallot patients. van der Hulst AE, Westenberg JJ, Delgado V, Kroft LJ, Holman ER, Blom NA, Bax JJ, de Roos A, Roest AA

Objectives: In patients with corrected Tetralogy of Fallot (cToF), pulmonary regurgitation and subsequent increased right ventricular (RV) end-diastolic volume are diastolic parameters related to adverse outcome. In addition, abnormalities of the RV outflow tract (RVOT) independently promote RV dilatation in cToF patients. Tissue Doppler imaging (TDI) and tissue-velocity magnetic resonance imaging (TV-MRI) enable quantitative assessment of regional diastolic performance by measuring myocardial v... Abstract

Cited 15 times since 2012 (1.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 3, 1 1 2012, Pages 94-101 Early mitral valve repair versus watchful waiting in patients with severe asymptomatic organic mitral regurgitation; rationale and design of the Dutch AMR trial, a multicenter, randomised trial. Tietge WJ, de Heer LM, van Hessen MW, Jansen R, Bots ML, van Gilst W, Schalij M, Klautz RJ, Van den Brink RB, Van Herwerden LA, Doevendans PA, Chamuleau SA, Kluin J

Background: Asymptomatic severe mitral valve (MV) regurgitation with preserved left ventricular function is a challenging clinical entity as data on the recommended treatment strategy for these patients are scarce and conflicting. For asymptomatic patients, no randomised trial has been performed for objectivising the best treatment strategy. Methods: The Dutch AMR (Asymptomatic Mitral Regurgitation) trial is a multicenter, prospective, randomised trial comparing early MV repair versus watchful w... Abstract

Cited 21 times since 2012 (1.6 per year) source: EuropePMC

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, Volume 37, Issue 2, 1 1 2012, Pages 214-224 Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl/6J mice. Louwe MC, van der Hoorn JW, van den Berg SA, van den Berg SA, Jukema JW, Romijn JA, van Dijk KW, Rensen PC, Smit JW, Steendijk P

Increased availability of fatty acids released from insulin-resistant adipose tissue may lead to excess fatty acid uptake in nonadipose organs, including the heart. Accumulation of toxic fatty acid intermediates may affect cardiac function. Our aim was to identify to which extent high-fat diet feeding leads to alterations in cardiac function and whether this depends on gender and (or) duration of high-fat diet feeding. Male and female C57Bl/6J mice (n = 8 per group) of 12 to 16 weeks old were fe... Abstract

Cited 5 times since 2012 (0.4 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 14, Issue 6, 29 5 2012, Pages 778-780 Ventricular tachycardia ablation in implantable cardioverter-defibrillator recipients: a need to catch up with current recommendations. Zeppenfeld K

Abstract

Cited 36 times since 2012 (2.7 per year) source: EuropePMC

Circulation. Cardiovascular genetics, Volume 5, Issue 2, 28 4 2012, Pages 202-209 Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study. Vaarhorst AA, Lu Y, Heijmans BT, Dollé ME, Böhringer S, Putter H, Imholz S, Merry AH, van Greevenbroek MM, Jukema JW, Gorgels AP, van den Brandt PA, Müller M, Schouten LJ, Feskens EJ, Boer JM, Slagboom PE

Background: Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD. Methods and results: Incident cases (n=742), that is, participants who developed CHD during a med... Abstract

Cited 7 times since 2012 (0.5 per year) source: EuropePMC

International journal of cardiology, Volume 167, Issue 3, 25 4 2012, Pages 827-832 Increased risk for ascending aortic dilatation in patients with complex compared to simple aortic coarctation. Luijendijk P, Franken RJ, Vriend JW, Zwinderman AH, Vliegen HW, Winter MM, Groenink M, Bouma BJ, Mulder BJ

Aims: Aortic coarctation (CoA) occurs as a "simple" isolated disorder, and in a more "complex" form, combined with associated congenital cardiac abnormalities. Long term outcome of all CoA patients may be complicated by dilatation of the thoracic aorta. The aim of this study was to quantify progressive aortic dilatation, and identify determinants for progressive aortic dilatation. Methods and results: Cardiovascular Magnetic Resonance Imaging (CMR) and echocardiographic data... Abstract

Cited 75 times since 2012 (5.7 per year) source: EuropePMC

Journal of lipid research, Volume 53, Issue 5, 24 4 2012, Pages 1000-1011 Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a). Deshmukh HA, Colhoun HM, Johnson T, McKeigue PM, Betteridge DJ, Durrington PN, Fuller JH, Livingstone S, Charlton-Menys V, Neil A, Poulter N, Sever P, Shields DC, Stanton AV, Chatterjee A, Hyde C, Calle RA, DeMicco DA, Trompet S, Postmus I, Ford I, Jukema JW, Caulfield M, Hitman GA

We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the observational phase of ASCOT (n = 651), all of whom were prescribed atorvastatin 10 mg. Following genome-wide imputation, we combined data from the three studies in a meta-analysis. We found associations of LDL-c response to atorvastatin that reach... Abstract

Cited 73 times since 2012 (5.5 per year) source: EuropePMC

Circulation. Cardiovascular interventions, Volume 5, Issue 2, 21 3 2012, Pages 279-287 Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs. Arslan F, Houtgraaf JH, Keogh B, Kazemi K, de Jong R, McCormack WJ, O'Neill LA, McGuirk P, Timmers L, Smeets MB, Akeroyd L, Reilly M, Pasterkamp G, de Kleijn DP

Background: Toll-like receptor (TLR)-2 is an important mediator of innate immunity and ischemia/reperfusion-induced cardiac injury. We have previously shown that TLR2 inhibition reduces infarct size and improves cardiac function in mice. However, the therapeutic efficacy of a clinical grade humanized anti-TLR2 antibody, OPN-305, in a large-animal model remained to be addressed. Methods and results: Pigs (n=38) underwent 75 minutes ischemia followed by 24 hours of reperfusion. Saline or OPN-305 (... Abstract

Cited 65 times since 2012 (4.9 per year) source: EuropePMC

Science signaling, Volume 5, Issue 212, 21 3 2012, Pages pt2 TGF-β signaling in endothelial-to-mesenchymal transition: the role of shear stress and primary cilia. Ten Dijke P, Egorova AD, Goumans MJ, Poelmann RE, Hierck BP

Endothelial-to-mesenchymal transition (EndoMT) is an instrumental step in the development of valves in the embryonic heart. This process is driven by activation of transforming growth factor-β (TGF-β) signaling and is characterized by the loss of endothelial and gain of mesenchymal phenotype, and by delamination of cells from the surface into the underlying endocardial cushion matrix. The endothelial cells (ECs) overlying the cushions are typically exposed to high blood flow and concomitant shea... Abstract

Cited 17 times since 2012 (1.3 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 35, Issue 6, 21 3 2012, Pages 652-658 Update on small-diameter implantable cardioverter-defibrillator leads performance. van Rees JB, van Welsenes GH, Borleffs CJ, Thijssen J, van der Velde ET, van der Wall EE, van Erven L, Schalij MJ

Background: The performance of small diameter implantable cardioverter defibrillator (ICD) leads is questionable. However, data on performance during long-term follow-up are scarce. The aim of this study is to provide an update for the lead failure and cardiac perforation rate of Medtronic's Sprint Fidelis ICD lead (Medtronic Inc., Minneapolis, MN, USA) and St. Jude Medical's Riata ICD lead (St. Jude Medical Inc., St. Paul, MN, USA). Methods: Since 1996, all ICD system implantations at... Abstract

Cited 11 times since 2012 (0.8 per year) source: EuropePMC

Heart and vessels, Volume 28, Issue 2, 18 3 2012, Pages 166-172 The maximum necrotic core area is most often located proximally to the site of most severe narrowing: a virtual histology intravascular ultrasound study. de Graaf MA, van Velzen JE, de Graaf FR, Schuijf JD, Dijkstra J, Bax JJ, Reiber JH, Schalij MJ, van der Wall EE, Jukema JW

Previous angiographic studies have shown that almost two-thirds of vulnerable plaques are located in non-obstructive lesions. Possibly, the maximum necrotic core (Max NC) area is not always identical to the site of most severe stenosis. Therefore, the purpose of this study was to evaluate the potential difference in location between the maximum necrotic core area and the site of most severe narrowing as assessed by virtual histology intravascular ultrasound (VH IVUS). Overall, 77 patients (139 v... Abstract

Cited 142 times since 2012 (10.7 per year) source: EuropePMC

European heart journal, Volume 33, Issue 7, 16 3 2012, Pages 857-865 Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial. Lüscher TF, Taddei S, Kaski JC, Jukema JW, Kallend D, Münzel T, Kastelein JJ, Deanfield JE, dal-VESSEL Investigators

Aims: High-density lipoprotein cholesterol (HDL-C) is inversely associated with cardiovascular (CV) events and thus an attractive therapeutic target. However, in spite of marked elevations in HDL-C, the first cholesterol transport protein (CETP) inhibitor torcetrapib raised blood pressure (BP), impaired endothelial function, and increased CV mortality and morbidity. Dalcetrapib is a novel molecule acting on CETP with a different chemical structure to torcetrapib. As HDL stimulates nitric oxide (... Abstract

Cited 21 times since 2012 (1.6 per year) source: EuropePMC

Nature reviews. Cardiology, Volume 9, Issue 6, 14 2 2012, Pages 333-346 Multimodality imaging in interventional cardiology. van der Hoeven BL, Schalij MJ, Delgado V

'Multimodality' imaging--the side-by-side interpretation of data obtained from various noninvasive imaging techniques, such as echocardiography, radionuclide techniques, multidetector CT (MDCT), and MRI--allows anatomical, morphological, and functional data to be combined, increases diagnostic accuracy, and improves the efficacy of cardiovascular interventions and clinical outcomes. During the past decade, advances in software and hardware have allowed co-registration of various imagin... Abstract

Cited 22 times since 2012 (1.7 per year) source: EuropePMC

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Volume 42, Issue 3, 13 2 2012, Pages 520-523 Arterial switch in the first hours of life: no need for Rashkind septostomy? Nevvazhay T, Chernogrivov A, Biryukov E, Biktasheva L, Karchevskaya K, Sulejmanov S, Kalinicheva J, Artemiev N

Objectives: We describe our experience of arterial switch operation (ASO) in the first hours of life in children with D-transposition of the great arteries (TGA) intact ventricular septum and restrictive patent foramen ovale (PFO) with severe metabolic disorders. The Rashkind procedure is the usual strategy to stabilize critically ill patient before surgery. We assume that primary ASO is also the safe option. Methods: Between 2008 and 2010, 44 neonates underwent ASO. Of these, eight with simple... Abstract

Cited 12 times since 2012 (0.9 per year) source: EuropePMC

Magma (New York, N.Y.), Volume 25, Issue 5, 11 2 2012, Pages 369-379 Quantitative T 2* assessment of acute and chronic myocardial ischemia/reperfusion injury in mice. Aguor EN, Arslan F, van de Kolk CW, Nederhoff MG, Doevendans PA, van Echteld CJ, Pasterkamp G, Strijkers GJ

Object: Imaging of myocardial infarct composition is essential to assess efficacy of emerging therapeutics. T (2) (*) mapping has the potential to image myocardial hemorrhage and fibrosis by virtue of its short T (2) (*) . We aimed to quantify T (2) (*) in acute and chronic myocardial ischemia/reperfusion (I/R) injury in mice. Materials and methods: I/R-injury was induced in C57BL/6 mice (n = 9). Sham-operated mice (n = 8) served as controls. MRI was performed at baseline, and 1, 7 and 28 days a... Abstract

Cited 40 times since 2012 (3 per year) source: EuropePMC

Archives of orthopaedic and trauma surgery, Volume 132, Issue 6, 7 1 2012, Pages 823-830 Risk factors for failure to return to the pre-fracture place of residence after hip fracture: a prospective longitudinal study of 444 patients. Vochteloo AJ, van Vliet-Koppert ST, Maier AB, Tuinebreijer WE, Röling ML, de Vries MR, Bloem RM, Nelissen RG, Pilot P

Introduction: Long-term place of residence after hip fracture is not often described in literature. The goal of this study was to identify risk factors, known at admission, for failure to return to the pre-fracture place of residence of hip fracture patients in the first year after a hip fracture. Methods: This is a prospective longitudinal study of 444 consecutive admissions of hip fracture patients aged ≥ 65 years. Place of residence prior to admission, at discharge, after 3 and 12 months was... Abstract