7368 results
Cited 14 times since 2024 (12.7 per year)
source: EuropePMC
Age and ageing,
Volume 53, Issue 7, 1 1 2024, Pages afae129
A world-wide study on delirium assessments and presence of protocols.
Nydahl P, Liu K, Bellelli G, Benbenishty J, van den Boogaard M, Caplan G, Chung CR, Elhadi M, Gurjar M, Heras-La Calle G, Hoffmann M, Jeitziner MM, Krewulak K, Mailhot T, Morandi A, Nawa RK, Oh ES, Collet MO, Paulino MC, Lindroth H, von Haken R, WDAD Study Group
Background: Delirium is a common complication of older people in hospitals, rehabilitation and long-term facilities. Objective: To assess the worldwide use of validated delirium assessment tools and the presence of delirium management protocols. Design: Secondary analysis of a worldwide one-day point prevalence study on World Delirium Awareness Day, 15 March 2023. Setting: Cross-sectional online survey including hospitals, rehabilitation and long-term facilities. Methods: Participating clinician...
Abstract
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
Volume 66, Issue 1, 1 1 2024, Pages ezae275
Hybrid palliation to promote growth of left ventricle and left ventricular outflow tract.
Eising JB, Bökenkamp R, Schneider AW, Kuipers IM, Hazekamp MG
Objectives: In patients with borderline left hearts or a severe left ventricular outflow tract obstruction, hybrid palliation can be used to stabilize the patient and postpone biventricular repair (BVR). In this study, we analysed growth of left-sided structures and outcomes of these patients. Methods: We conducted a retrospective cohort study including patients who received hybrid palliation between January 2010 and September 2023. Echo measurements were collected at hybrid palliation, BVR and...
Abstract
Cited 2 times since 2024 (1.8 per year)
source: EuropePMC
Thoracic research and practice,
Volume 25, Issue 4, 1 1 2024, Pages 162-167
Evaluation of Long-Coronavirus Disease 2019 Cases Readmitted to Intensive Care Units Due to Acute Respiratory Failure: Point Prevalence Study.
Tunçay E, Moçin Ö, Ediboğdu Ö, Adıgüzel N, Güngör S, İşcanlı İ, Er B, Mendil NA, Usalan A, Yılmaz D, Keskin H, Dönmez GE, Yılmaz B, Kargın F, Saraçoğlu KT, Temel Ş, Dal HC, Turan S, Talan L, Hoşgün D, Aydemir S, Sungurtekin H
Objective: Coronavirus disease 2019 (COVID-19) caused morbidity and mortality worldwide. Besides the acute effects, subacute and long-term effects are defined as long-COVID causing morbidity. The intensive care unit (ICU) data of long-COVID-19 cases were evaluated with the participation of 11 centers. Material and methods: Study was designed by Turkish Thoracic Society Respiratory Failure and Intensive Care Working Group to evaluate long COVID-19 patients. All patients followed up in the ICU w...
Abstract
Cited 22 times since 2024 (20 per year)
source: EuropePMC
Clinical pharmacology and therapeutics,
Volume 116, Issue 4, 1 1 2024, Pages 939-947
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy.
Duarte JD, Thomas CD, Lee CR, Huddart R, Agundez JAG, Baye JF, Gaedigk A, Klein TE, Lanfear DE, Monte AA, Nagy M, Schwab M, Stein CM, Uppugunduri CRS, van Schaik RHN, Donnelly RS, Caudle KE, Luzum JA
Beta-blockers are widely used medications for a variety of indications, including heart failure, myocardial infarction, cardiac arrhythmias, and hypertension. Genetic variability in pharmacokinetic (e.g., CYP2D6) and pharmacodynamic (e.g., ADRB1, ADRB2, ADRA2C, GRK4, GRK5) genes have been studied in relation to beta-blocker exposure and response. We searched and summarized the strength of the evidence linking beta-blocker exposure and response with the six genes listed above. The level of eviden...
Abstract
Cited 3 times since 2024 (2.7 per year)
source: EuropePMC
Clinical and translational allergy,
Volume 14, Issue 7, 1 1 2024, Pages e12381
Dupilumab induces a significant decrease of food specific immunoglobulin E levels in pediatric atopic dermatitis patients.
van der Rijst LP, Hilbrands MS, Zuithoff NPA, de Bruin-Weller MS, Knulst AC, Le TM, de Graaf M
Abstract
Cited 8 times since 2024 (7.3 per year)
source: EuropePMC
European heart journal. Cardiovascular pharmacotherapy,
Volume 10, Issue 4, 1 1 2024, Pages 342-352
Safety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation.
Goodman SG, Steg PG, Szarek M, Bhatt DL, Bittner VA, Diaz R, Harrington RA, Jukema JW, White HD, Zeiher AM, Manvelian G, Pordy R, Poulouin Y, Stipek W, Garon G, Schwartz GG, ODYSSEY OUTCOMES Investigators
The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The s...
Abstract
Interdisciplinary cardiovascular and thoracic surgery,
Volume 39, Issue 1, 1 1 2024, Pages ivae132
Quality of life improvement from thoracoscopic atrial fibrillation ablation in women versus men: a prospective cohort study.
Vos LM, Vos R, Nieuwkerk PT, Vos PWK, Hofman FN, Klautz RJM, Van Putte BP
Objectives: Thoracoscopic ablation has proven to be an effective and safe rhythm control strategy, especially for persistent atrial fibrillation. However, its impact on quality of life (QoL) and potential gender differences remains unclear. Methods: This prospective, single-centre observational study included consecutive patients with symptomatic atrial fibrillation undergoing thoracoscopic ablation. QoL was measured using the Short Form 36 (SF-36) and Atrial Fibrillation Effect on Quality-of-Li...
Abstract
Cited 21 times since 2024 (19 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 37, Issue 11, 29 5 2024, Pages 1038-1046
Left Atrioventricular Coupling Index: A Novel Diastolic Parameter to Refine Prognosis in Heart Failure.
Fortuni F, Biagioli P, Myagmardorj R, Mengoni A, Chua AP, Zuchi C, Sforna S, Bax J, Ajmone Marsan N, Ambrosio G, Carluccio E
Background: Left atrioventricular coupling index (LACI), an index coupling left atrial to left ventricular (LV) volume at end-diastole, has been shown to be associated with prognosis in different clinical settings. However, the relation between LACI and LV diastolic dysfunction (DD) remains to be established. The aims of the present study were to investigate the association between LACI and LV DD and to assess its prognostic value in patients with heart failure (HF). Methods: A total of 1,158 pa...
Abstract
Appetite,
Volume 205, 29 5 2024, Pages 107585
Interaction as the foundation for eating practices in shared mealtimes.
van der Heijden A, Wiggins S
Mealtimes shared with other people define how, what, how much, and with whom we eat. On such occasions, whether in private or public spaces, and as formal or informal events, our eating practices are inseparable from our interactions with other people. In this Editorial for the Special Issue on Interactional approaches to eating together and shared mealtimes, we provide an overview of the interdisciplinary field of research on eating together and shared mealtimes to illustrate the breadth and de...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Journal of gastrointestinal and liver diseases : JGLD,
Volume 33, Issue 2, 29 5 2024, Pages 203-211
Does Genetic Variation in PNPLA3, TM6SF2 and HSD17B13 have a Role in the Development or Prognosis of Hepatocellular Carcinoma in Turkish Patients with Hepatitis B?
Demirtas CO, Eren F, Yilmaz D, Ozdogan OC, Gunduz F
Background and aims: Progression to hepatocellular carcinoma (HCC) is restricted by viral suppression in chronic hepatitis B (CHB); however, some patients still progress despite antiviral therapy. Presence of single nucleotide polymorphisms (SNPs) such as PNPLA3 rs738409 and TM6SF2 rs58542926 are associated with the development and progression of steatotic liver disease to HCC, whereas a splice variant in HSD17B13 rs72613567:TA has been shown to be protective. We investigated the role of these S...
Abstract
The American journal of emergency medicine,
Volume 83, 27 4 2024, Pages 95-100
MIS-C Treatment: Is glucocorticoid monotherapy enough for mild cases?
Sütçü M, Kara EM, Yıldız F, Gül D, Yıldız R, Yılmaz D, Atik F, Özkaya O
Background: The effectiveness of using only glucocorticoids (GCs) in mild multisystem inflammatory syndrome (MIS-C) cases was compared with combined treatment [GCs + Intravenous immune globulin (IVIG)]. Methods: This retrospective cohort study was conducted between June 1, 2020, and June 1, 2022, in a tertiary care center in Istanbul, Turkey. Clinical and investigational data of the MIS-C patients were analyzed. The patients were divided into two groups: those who received only GCs and those who...
Abstract
Cited 2 times since 2024 (1.8 per year)
source: EuropePMC
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
Volume 104, Issue 2, 26 4 2024, Pages 203-212
Current applications, procedural and 1-year outcomes of Rotatripsy for the treatment of calcified coronary lesions.
van Oort MJH, Al Amri I, Bingen BO, Oliveri F, Vilalta V, Jurado-Roman A, Pereira AR, Cordoba-Soriano JG, Rumiz González E, Fernández-Peregrina E, van der Kley F, Jukema JW, Montero-Cabezas JM
Background: Intravascular lithotripsy (IVL) combined with rotational atherectomy (RA), known as Rotatripsy, is used to treat severe coronary artery calcification (CAC), though data on efficacy, midterm safety and use sequence is limited. We aimed to identify indicators for Rotatripsy use and to assess its safety and success rates, both acutely and at 1-year follow-up. Methods: Patients undergoing Rotatripsy for severe CAC across six centers from May 2019 to December 2023 were included. Demograph...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
JACC. Cardiovascular imaging,
Volume 17, Issue 10, 26 4 2024, Pages 1149-1163
Reappraisal of the Concept and Implications of Pulmonary Hypertension in Degenerative Mitral Regurgitation.
Essayagh B, Benfari G, Antoine C, Grigioni F, Le Tourneau T, Roussel JC, Bax JJ, Ajmone Marsan N, Butcher SC, Tribouilloy C, Rusinaru D, Hochstadt A, Topilsky Y, El-Am E, Thapa P, Michelena HI, Enriquez-Sarano M
Background: European and U.S. clinical guidelines diverge regarding pulmonary hypertension (PHTN) in degenerative mitral regurgitation (DMR). Gaps in knowledge underpinning these divergences affect risk assessment and management recommendations attached to systolic pulmonary pressure (SPAP) in DMR. Objectives: This study sought to define PHTN links to DMR severity, prognostic thresholds, and independent outcome impact in a large quantitative DMR registry. Methods: This study gathered a large mul...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Structural heart : the journal of the Heart Team,
Volume 8, Issue 5, 26 4 2024, Pages 100333
Pulmonary Vein Systolic Flow Reversal and Outcomes in Patients From the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (COAPT) Trial.
Bohra C, Asch FM, Lerakis S, Little SH, Redfors B, Zhou Z, Li Y, Weissman NJ, Grayburn PA, Kar S, Lim DS, Abraham WT, Lindenfeld J, Mack MJ, Bax JJ, Stone GW
Background: The implications of pulmonary vein (PV) flow patterns in patients with heart failure (HF) and mitral regurgitation (MR) are uncertain. We examined PV flow patterns in the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (COAPT) trial (NCT01626079), in which patients with HF and moderate-to-severe or severe functional MR were randomized to transcatheter edge-to-edge repair (TEER) with the MitraClip...
Abstract
Cited 5 times since 2024 (4.5 per year)
source: EuropePMC
Molecular cell,
Volume 84, Issue 14, 26 4 2024, Pages 2785-2796.e4
A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria.
Vento JM, Durmusoglu D, Li T, Patinios C, Sullivan S, Ttofali F, van Schaik J, Yu Y, Wang Y, Barquist L, Crook N, Beisel CL
The bacterial world offers diverse strains for understanding medical and environmental processes and for engineering synthetic biological chassis. However, genetically manipulating these strains has faced a long-standing bottleneck: how to efficiently transform DNA. Here, we report imitating methylation patterns rapidly in TXTL (IMPRINT), a generalized, rapid, and scalable approach based on cell-free transcription-translation (TXTL) to overcome DNA restriction, a prominent barrier to transformat...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Frontiers in plant science,
Volume 15, 26 4 2024, Pages 1349209
Counting nematodes made easy: leveraging AI-powered automation for enhanced efficiency and precision.
Saikai KK, Bresilla T, Kool J, de Ruijter NCA, van Schaik C, Teklu MG
Counting nematodes is a labor-intensive and time-consuming task, yet it is a pivotal step in various quantitative nematological studies; preparation of initial population densities and final population densities in pot, micro-plot and field trials for different objectives related to management including sampling and location of nematode infestation foci. Nematologists have long battled with the complexities of nematode counting, leading to several research initiatives aimed at automating this pr...
Abstract
Cited 4 times since 2024 (3.6 per year)
source: EuropePMC
Heart rhythm,
Volume 22, Issue 1, 25 4 2024, Pages 90-99
Cardiac stereotactic body radiotherapy to treat malignant ventricular arrhythmias directly affects the cardiomyocyte electrophysiology.
Mages C, Gampp H, Rahm AK, Hackbarth J, Pfeiffer J, Petersenn F, Kramp X, Kermani F, Zhang J, Pijnappels DA, de Vries AAF, Seidensaal K, Rhein B, Debus J, Ullrich ND, Frey N, Thomas D, Lugenbiel P
Background: Promising as a treatment option for life-threatening ventricular arrhythmias, cardiac stereotactic body radiotherapy (cSBRT) has demonstrated early antiarrhythmic effects within days of treatment. The mechanisms underlying the immediate and short-term antiarrhythmic effects are poorly understood. Objective: We hypothesize that cSBRT has a direct antiarrhythmic effect on cellular electrophysiology through reprogramming of ion channel and gap junction protein expression. Methods: After...
Abstract
Cited 2 times since 2024 (1.8 per year)
source: EuropePMC
European urology oncology,
Volume 8, Issue 1, 21 3 2024, Pages 105-110
Consistencies in Follow-up After Radical Cystectomy for Bladder Cancer: A Framework Based on Expert Practices Collaboratively Developed by the European Association of Urology Bladder Cancer Guideline Panels.
Mertens LS, Bruins HM, Contieri R, Babjuk M, Rai BP, Puig AC, Escrig JLD, Gontero P, van der Heijden AG, Liedberg F, Martini A, Masson-Lecomte A, Meijer RP, Mostafid H, Neuzillet Y, Pradere B, Redlef J, van Rhijn BWG, Rouanne M, Rouprêt M, Sæbjørnsen S, Seisen T, Shariat SF, Soria F, Soukup V, Thalmann G, Xylinas E, Mariappan P, Alfred Witjes J
Background and objective: There is no standardized regimen for follow-up after radical cystectomy (RC) for bladder cancer (BC). To address this gap, we conducted a multicenter study involving urologist members from the European Association of Urology (EAU) bladder cancer guideline panels. Our objective was to identify consistent post-RC follow-up strategies and develop a practice-based framework based on expert opinion. Methods: We surveyed 27 urologist members of the EAU guideline panels for no...
Abstract
Cited 1 times since 2024 (0.9 per year)
source: EuropePMC
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
Volume 211, 21 3 2024, Pages 111417
Removal of <sup>177</sup>Lu from radioactive wastewater using Montmorillonite clay.
Yılmaz D, Gürses A, Kalecik S, Maman A, Şahin E, Güneş K
Because radioactive 177Lu has a wide range of possible applications in radiopharmaceuticals, its removal from medical wastewater is particularly important. Montmorillonite clay was employed as an adsorbent in this study. Radioactive solutions were prepared with dilutions of the solution containing 177Lu at various concentrations, in which it was present as Lu3+. ULEGe detector in gamma spectrometer was used to measure 177Lu gamma rays emitted from the radioactive aqueous solutions. The results o...
Abstract
Cited 3 times since 2024 (2.7 per year)
source: EuropePMC
Med (New York, N.Y.),
Volume 5, Issue 9, 20 3 2024, Pages 1083-1095.e6
SMIM1 absence is associated with reduced energy expenditure and excess weight.
Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S, DBDS Genetic Consortium, Chen J, MAGIC, Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M
Background: Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing to an interplay of lifestyle, environmental, and genetic factors. Obesity has a polygenic genetic architecture; however, single genetic variants with large effect size are etiological in a minority of c...
Abstract
