6221 results
Cited 54 times since 1995 (1.8 per year)
source: EuropePMC
The American journal of cardiology,
Volume 76, Issue 9, 1 1 1995, Pages 40C-46C
Effect of pravastatin on progression and regression of coronary atherosclerosis and vessel wall changes in carotid and femoral arteries: a report from the Regression Growth Evaluation Statin Study.
de Groot E, Jukema JW, van Boven AJ, Reiber JH, Zwinderman AH, Lie KI, Ackerstaff RA, Bruschke AV
Few data are available about the potential benefit of serum cholesterol reduction in the broad range of patients with coronary atherosclerosis and normal to moderately elevated serum cholesterol levels. REGRESS is a double-blind, placebo-controlled, multicenter study to assess the effect of a 2-year treatment with the 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin on progression and regression of coronary atherosclerosis using quantitative coronary arteriography in 885 ma...
Abstract
Cited 53 times since 1995 (1.8 per year)
source: EuropePMC
The Journal of general virology,
Volume 76 ( Pt 9), 1 1 1995, Pages 2223-2233
Comparison of equine arteritis virus isolates using neutralizing monoclonal antibodies and identification of sequence changes in GL associated with neutralization resistance.
Glaser AL, de Vries AA, Dubovi EJ
Three murine monoclonal antibodies (MAbs) that neutralize equine arteritis virus (EAV) infectivity were identified and characterized. The antibodies, 93B, 74D(B) and 38F, recognized the major envelope glycoprotein (GL) encoded by open reading frame (ORF) 5 in immunoblots and by immunoprecipitation. All three MAbs were used to compare the Bucyrus isolate of EAV and MAb neutralization-resistant (NR) escape mutants with the vaccine virus and 19 independent field isolates of EAV by virus neutralizat...
Abstract
Cited 13 times since 1995 (0.4 per year)
source: EuropePMC
German journal of ophthalmology,
Volume 4, Issue 5, 1 1 1995, Pages 311-314
Microperimetry in patients with central serous retinopathy.
Toonen F, Remky A, Janssen V, Wolf S, Reim M
In patients with acute central serous retinopathy (CSR), evaluation of visual acuity alone may not represent visual function. In patients with acute CSR, visual function may be disturbed by localized scotomas, distortion, and waviness. For the assessment of localized light sensitivity and stability of fixation, patients with CSR were evaluated by fundus perimetry with a scanning laser ophthalmoscope (SLO 101, Rodenstock Instruments). In all, 21 patients with acute CSR and 19 healthy volunteers w...
Abstract
Cited 15 times since 1995 (0.5 per year)
source: EuropePMC
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
Volume 10, Issue 9, 1 1 1995, Pages 1374-1384
Regulation of plasminogen activation, matrix metalloproteinases and urokinase-type plasminogen activator-mediated extracellular matrix degradation in human osteosarcoma cell line MG63 by interleukin-1 alpha.
de Bart AC, Quax PH, Löwik CW, Verheijen JH
Plasmin-mediated extracellular proteolysis has been implicated in the degradation of bone in normal and pathological conditions. Normal and malignant osteoblasts can produce both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). We have used the osteosarcoma cell line MG63 to address the question of whether the enhanced bone turnover in osteosarcomas is mediated by t-PA or by u-PAA and to study the effect of the cytokine interleukin-1 alpha (IL-1 alpha), k...
Abstract
Cited 52 times since 1995 (1.7 per year)
source: EuropePMC
Journal of virology,
Volume 69, Issue 8, 1 1 1995, Pages 4668-4674
The two major envelope proteins of equine arteritis virus associate into disulfide-linked heterodimers.
de Vries AA, Post SM, Raamsman MJ, Horzinek MC, Rottier PJ
In a coimmunoprecipitation assay with monospecific antisera, the two major envelope proteins GL and M of equine arteritis virus were found to occur in heteromeric complexes in virions and infected cells. While the GL protein associated with M rapidly and efficiently, newly synthesized M protein was incorporated into complexes at a slower rate, which implies that it interacts with GL molecules synthesized earlier. Analysis under nonreducing conditions revealed that the GL/M complexes consist of d...
Abstract
Cited 35 times since 1995 (1.2 per year)
source: EuropePMC
Magnetic resonance in medicine,
Volume 34, Issue 2, 1 1 1995, Pages 161-169
Quantitative analysis of regional left ventricular function after myocardial infarction in the pig assessed with cine magnetic resonance imaging.
Holman ER, Vliegen HW, van der Geest RJ, Reiber JH, van Dijkman PR, van der Laarse A, de Roos A, van der Wall EE
To assess the accuracy of quantitative analysis of global and regional wall motion and wall thickening of the left ventricle with cine magnetic resonance (MR), images obtained in eight pigs before and after myocardial infarction were compared with those obtained using gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA)-enhanced multislice spin-echo MR imaging and determination of pathology. The region with abnormal wall motion and wall thickening, as determined with cine MR imaging, identifi...
Abstract
Cited 45 times since 1995 (1.5 per year)
source: EuropePMC
The Journal of general virology,
Volume 76 ( Pt 8), 1 1 1995, Pages 1989-1998
Equine arteritis virus-neutralizing antibody in the horse is induced by a determinant on the large envelope glycoprotein GL.
Chirnside ED, de Vries AA, Mumford JA, Rottier PJ
Complementary DNAs encoding ORFs 2 to 7 equine arteritis virus (EAV) have been cloned into the expression vector pGEX to produce glutathione-S-transferase fusion proteins. Recombinant proteins were affinity purified and screened in ELISA with equine sera to identify immunoreactive polypeptides. The large envelope glycoprotein (GL) was identified as the most reactive to EAV-positive equine sera and an immuno-dominant epitope was mapped between amino acids 55 and 98 by subcloning and expression. A...
Abstract
Cited 10 times since 1995 (0.3 per year)
source: EuropePMC
The Journal of thoracic and cardiovascular surgery,
Volume 110, Issue 1, 1 1 1995, Pages 248-257
In situ hybridization: a new technique to determine the origin of fibroblasts in cryopreserved aortic homograft valve explants.
Hazekamp MG, Koolbergen DR, Braun J, Sugihara H, Cornelisse CJ, Goffin YA, Huysmans HA
Tissue degeneration reduces the durability of cryopreserved homografts. Earlier studies indicated that the presence of fibroblasts in homograft leaflets may contribute to increased valve longevity. These fibroblasts may be of recipient origin or represent surviving donor cells. We developed a method, based on in situ hybridization, to determine the origin of fibroblasts in homograft explants. In young pigs we performed aortic valve replacement with a cryopreserved porcine aortic homograft. A mal...
Abstract
Cited 32 times since 1995 (1.1 per year)
source: EuropePMC
Journal of virological methods,
Volume 54, Issue 1, 1 1 1995, Pages 1-13
Development and evaluation of an ELISA using recombinant fusion protein to detect the presence of host antibody to equine arteritis virus.
Chirnside ED, Francis PM, de Vries AA, Sinclair R, Mumford JA
A recombinant glutathione-S-transferase fusion protein expressing amino acids 55-98 of equine arteritis virus (EAV) GL (rGL 55-98) was tested in an ELISA for its ability to detect serum antibodies to EAV. Host antibodies induced following EAV infection bound the recombinant antigen by ELISA. The ELISA specificity and sensitivity were determined with a panel of equine sera including postinfection and postvaccination samples. A good correlation existed between EAV neutralizing antibody titers and...
Abstract
Cited 28 times since 1995 (0.9 per year)
source: EuropePMC
Journal of virology,
Volume 69, Issue 6, 1 1 1995, Pages 3441-3448
The small envelope glycoprotein (GS) of equine arteritis virus folds into three distinct monomers and a disulfide-linked dimer.
de Vries AA, Raamsman MJ, van Dijk HA, Horzinek MC, Rottier PJ
The small membrane glycoprotein (GS) of equine arteritis virus (EAV) is a minor virion component but is abundantly expressed in EAV-infected cells. In this study, we have analyzed its membrane topology, folding, oligomerization, and intracellular transport. We show that GS is a class I integral membrane protein with one functional N-glycosylation site. Gel electrophoresis under nonreducing conditions revealed that GS occurs in EAV-infected cells in four monomeric conformations and as disulfide-l...
Abstract
Cited 4 times since 1995 (0.1 per year)
source: EuropePMC
Archives of biochemistry and biophysics,
Volume 319, Issue 2, 1 1 1995, Pages 350-354
Metabolic inhibition of cardiomyocytes causes an increase in sarcolemmal fluidity which may be due to loss of cellular cholesterol.
Bastiaanse EM, Atsma DE, Van der Valk LJ, Van der Laarse A
We examined whether metabolic inhibition (5 mM NaCN + 10 mM 2-deoxyglucose) affects sarcolemmal fluidity in cultured neonatal cardiomyocytes. As a measure of sarcolemmal fluidity we determined the fluorescence steady-state anisotropy (rss, which is reciprocally related to membrane fluidity) of cardiomyocytes labeled with 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene, p-toluenesulfonate. During metabolic inhibition, membrane fluidity increased progressively: after 30 min rss had fallen...
Abstract
Cited 58 times since 1995 (1.9 per year)
source: EuropePMC
Circulation research,
Volume 76, Issue 6, 1 1 1995, Pages 1071-1078
Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition.
Atsma DE, Bastiaanse EM, Jerzewski A, Van der Valk LJ, Van der Laarse A
Calcium-activated neutral protease (CANP), also known as calpain, has been implicated in the development of cell death in ischemic hearts. CANP is thought to be activated by the calcium overload that develops during ischemia. We studied the involvement of CANP in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition (5 mmol/L NaCN + 10 mmol/L 2-deoxyglucose). First, we isolated CANP using ion exchange and affinity chromatography. Then the efficacy of the CANP inhibitors...
Abstract
Cited 436 times since 1995 (14.5 per year)
source: EuropePMC
Circulation,
Volume 91, Issue 10, 1 1 1995, Pages 2528-2540
Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The Regression Growth Evaluation Statin Study (REGRESS).
Jukema JW, Bruschke AV, van Boven AJ, Reiber JH, Bal ET, Zwinderman AH, Jansen H, Boerma GJ, van Rappard FM, Lie KI
Background: Intensive lowering of serum cholesterol may retard progression of coronary atherosclerosis in selected groups of patients. However, few data are available on the potential benefit of serum cholesterol reduction in the broad range of patients with coronary atherosclerosis and normal to moderately elevated serum cholesterol levels who undergo various forms of treatment. The Regression Growth Evaluation Statin Study (REGRESS) addresses this group of patients. Methods and results: REGRES...
Abstract
Cited 19 times since 1995 (0.6 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 25, Issue 6, 1 1 1995, Pages 1428-1435
Interaction between afterload and contractility in the newborn heart: evidence of homeometric autoregulation in the intact circulation.
Klautz RJ, Teitel DF, Steendijk P, van Bel F, Baan J
Objectives: We undertook the present study to determine whether afterload and contractility interact in the hearts of newborn lambs. We specifically investigated whether stepwise increases in afterload increase contractility. Background: Several studies in the isolated and intact adult dog heart have shown that afterload and contractility are not independent determinants of cardiac performance; rather, they interact. Afterload and contractility are unlikely to interact in the newborn heart becau...
Abstract
Cited 2 times since 1995 (0.1 per year)
source: EuropePMC
Circulation,
Volume 91, Issue 8, 1 1 1995, Pages 2292-2293
Sympathovagal balance and graded orthostatic tilt.
Swenne CA, Bootsma M
Abstract
Cited 3 times since 1995 (0.1 per year)
source: EuropePMC
American heart journal,
Volume 129, Issue 4, 1 1 1995, Pages 809-818
Magnetic resonance techniques for the assessment of myocardial viability: clinical experience.
Vliegen HW, de Roos A, Bruschke AV, van der Wall EE
Abstract
Cited 51 times since 1995 (1.7 per year)
source: EuropePMC
Circulation,
Volume 91, Issue 7, 1 1 1995, Pages 2010-2017
Beat-to-beat analysis of left ventricular pressure-volume relation and stroke volume by conductance catheter and aortic Modelflow in cardiomyoplasty patients.
Schreuder JJ, van der Veen FH, van der Velde ET, Delahaye F, Alfieri O, Jegaden O, Lorusso R, Jansen JR, van Ommen V, Finet G
Background: Since the clinical introduction of dynamic cardiomyoplasty, a discrepancy has been observed between unchanged measurements of cardiac function and improved clinical outcome. Methods and results: We performed a beat-to-beat analysis of cardiac performance at rest in nine cardiomyoplasty patients 6 to 24 months after operation. Conductance and micromanometer catheters were placed in left ventricle and aorta and used for measurements over a 15-second period, during which the wrapped lat...
Abstract
Cited 4 times since 1995 (0.1 per year)
source: EuropePMC
The Journal of investigative dermatology,
Volume 104, Issue 3, 1 1 1995, Pages 374-378
Differential regulation of plasminogen activation in normal keratinocytes and SCC-4 cells by fibroblasts.
Boxman IL, Quax PH, Löwik CW, Papapoulos SE, Verheijen J, Ponec M
The plasminogen activator (PA)/plasmin system is thought to be involved in processes such as tumor invasion and wound healing, during which epithelial and mesenchymal cells come close together. However, information on regulation of the PA/plasmin system during epithelial-mesenchymal interactions is scarce. Therefore, we examined the in vitro modulation of the production and activity of the components of the PA/plasmin system in squamous carcinoma cells (SCC-4) and normal human keratinocytes in r...
Abstract
Cited 62 times since 1995 (2 per year)
source: EuropePMC
Virology,
Volume 207, Issue 2, 1 1 1995, Pages 518-527
Identification of a neutralization site in the major envelope glycoprotein (GL) of equine arteritis virus.
Balasuriya UB, Maclachlan NJ, De Vries AA, Rossitto PV, Rottier PJ
A panel of six neutralizing monoclonal antibodies (MAbs), neutralization-resistant variant (escape mutant [EM]) viruses, and individual viral proteins derived from a vaccinia virus expression system were used to identify the neutralizing determinants of equine arteritis virus (EAV). The neutralizing MAbs recognize a single neutralization site on the 29-kDa envelope glycoprotein of EAV (U. B. R. Balasuriya et al., 1993, J. Gen. Virol., 74, 2525-2529). Vaccinia virus recombinants which express eit...
Abstract
Cited 131 times since 1995 (4.3 per year)
source: EuropePMC
Circulation research,
Volume 76, Issue 2, 1 1 1995, Pages 199-208
cGMP and nitric oxide modulate thrombin-induced endothelial permeability. Regulation via different pathways in human aortic and umbilical vein endothelial cells.
Draijer R, Atsma DE, van der Laarse A, van Hinsbergh VW
Previous studies have demonstrated that cGMP and cAMP reduce the endothelial permeability for fluids and macromolecules when the endothelial permeability is increased by thrombin. In this study, we have investigated the mechanism by which cGMP improves the endothelial barrier function and examined whether nitric oxide (NO) can serve as an endogenous modulator of endothelial barrier function. Thrombin increased the passage of macromolecules through human umbilical vein and human aortic endothelia...
Abstract
