Research

Publications

Below you can find a list of our published research.

9618 results

Cited 79 times since 2010 (5.2 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 56, Issue 3, 1 1 2010, Pages 225-233 Effects of hepatic triglyceride content on myocardial metabolism in type 2 diabetes. Rijzewijk LJ, Jonker JT, van der Meer RW, Lubberink M, de Jong HW, Romijn JA, Bax JJ, de Roos A, Heine RJ, Twisk JW, Windhorst AD, Lammertsma AA, Smit JW, Diamant M, Lamb HJ

Objectives: The purpose of this study was to investigate the relationship between hepatic triglyceride content and both myocardial function and metabolism in type 2 diabetes mellitus (T2DM). Background: Heart disease is the leading cause of mortality in T2DM. Central obesity and hepatic steatosis, both hallmark abnormalities in T2DM, have been related to increased risk of heart disease. Methods: Sixty-one T2DM patients underwent myocardial perfusion and substrate metabolism measurements by posit... Abstract

Cited 8 times since 2010 (0.5 per year) source: EuropePMC

American journal of nephrology, Volume 32, Issue 2, 1 1 2010, Pages 163-168 Elevated preoperative phosphorus levels are an independent risk factor for cardiovascular mortality. van Kuijk JP, Flu WJ, Chonchol M, Valentijn TM, Verhagen HJ, Bax JJ, Poldermans D

Background/aims: Serum phosphorus levels have been associated with adverse long-term outcome in several populations, however, no prior studies evaluated short-term postoperative outcome. The present study evaluated the predictive value of phosphorus levels on 30-day outcome after vascular surgery. Methods: The study included patients scheduled for major vascular surgery (aortic aneurysm repair, lower extremity revascularization or carotid surgery), divided into four quartiles based on the preope... Abstract

Current cardiology reports, Volume 12, Issue 4, 1 1 2010, Pages 286-294 Preoperative evaluation of patients with possible coronary artery disease. Flu WJ, van Kuijk JP, Hoeks S, Bax JJ, Poldermans D

During noncardiac surgery, patients may be at risk for developing cardiac events, related to underlying coronary artery disease. Therefore, perioperative cardiac complications remain an area of clinical interest and concern in patients undergoing noncardiac surgery. Over the years, perioperative risk assessment has evolved significantly to detect surgical patients with myocardium at risk due the coronary artery disease. In addition, many efforts have been made to reduce the cardiac risk of patie... Abstract

Cited 22 times since 2010 (1.5 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 1, 1 1 2010, Pages 73-77 Effect of cardiac resynchronization therapy on cerebral blood flow. van Bommel RJ, Marsan NA, Koppen H, Delgado V, Borleffs CJ, Ypenburg C, Bertini M, Schalij MJ, Bax JJ

Decreased cerebral blood flow is frequently observed in patients with heart failure, and this could be the result of impaired cardiac systolic function. Cardiac resynchronization therapy (CRT) improves cardiac function and heart failure symptoms in selected patients. The effects of CRT on cerebral blood flow have not been previously evaluated. In the present study, left ventricular systolic function and cerebral blood flow were assessed in 35 patients with heart failure, before and 6 months afte... Abstract

Cited 7 times since 2010 (0.5 per year) source: EuropePMC

Multidisciplinary respiratory medicine, Volume 5, Issue 3, 30 5 2010, Pages 168-172 Relationship between disease severity and D-dimer levels measured with two different methods in pulmonary embolism patients. Coskun F, Yilmaz D, Ursavas A, Uzaslan E, Ege E

Pulmonary embolism (PE) is diagnosed with increasing frequency nowadays due to advances in the diagnostic methods and the increased awareness of the disease. There is a tendency to use non invasive diagnostic methods for all diseases. D-dimer is a fibrin degradation product. We aimed to detect the relationship between disease severity and the D-dimer levels measured with two different methods. We compared D-dimer levels in cases of massive vs. non-massive PE. A total of 89 patients who were diag... Abstract

Cited 18 times since 2010 (1.2 per year) source: EuropePMC

European journal of endocrinology, Volume 163, Issue 3, 29 5 2010, Pages 435-441 Abnormal cardiac contractility in long-term exogenous subclinical hyperthyroid patients as demonstrated by two-dimensional echocardiography speckle tracking imaging. Abdulrahman RM, Delgado V, Ng AC, Ewe SH, Bertini M, Holman ER, Hovens GC, Pereira AM, Romijn JA, Bax JJ, Smit JW

Background: Subclinical hyperthyroidism is associated with cardiovascular morbidity. Recent advances in echocardiography imaging have allowed sophisticated evaluation of myocardial tissue properties. Objective: To investigate the myocardial effects of long-term exogenous subclinical hyperthyroidism using two-dimensional speckle tracking echocardiography imaging (2D-STE). Design: Prospective, single-blinded, placebo-controlled randomized trial of 6 months duration with two parallel groups. Patien... Abstract

Cited 30 times since 2010 (2 per year) source: EuropePMC

Journal of neurology, neurosurgery, and psychiatry, Volume 81, Issue 12, 28 4 2010, Pages 1374-1379 Randomised controlled trial comparing two different intravenous immunoglobulins in chronic inflammatory demyelinating polyradiculoneuropathy. Kuitwaard K, van den Berg LH, Vermeulen M, Brusse E, Cats EA, van der Kooi AJ, Notermans NC, van der Pol WL, van Schaik IN, van Nes SI, Hop WC, van Doorn PA

Background: Different preparations of intravenous immunoglobulin (IVIg) are considered to have comparable clinical efficacy but this has never been formally investigated. Some patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) report that some IVIg brands are more effective than others. A liquid IVIg preparation is more user friendly and potentially can be infused at a faster rate. Objectives: The primary objective was to compare the efficacy of two different IVIg bra... Abstract

Cited 57 times since 2010 (3.8 per year) source: EuropePMC

The Journal of biological chemistry, Volume 285, Issue 34, 28 4 2010, Pages 26081-26087 Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress. Cao G, Lee KP, van der Wijst J, de Graaf M, van der Kemp A, Bindels RJ, Hoenderop JG

Mg(2+) is an essential ion for many cellular processes, including protein synthesis, nucleic acid stability, and numerous enzymatic reactions. Mg(2+) homeostasis in mammals depends on the equilibrium between intestinal absorption, renal excretion, and exchange with bone. The transient receptor potential melastatin type 6 (TRPM6) is an epithelial Mg(2+) channel, which is abundantly expressed in the luminal membrane of the renal and intestinal cells. It functions as the gatekeeper of transepitheli... Abstract

Cited 307 times since 2010 (20.3 per year) source: EuropePMC

European heart journal, Volume 31, Issue 17, 28 4 2010, Pages 2124-2132 Predictors of pregnancy complications in women with congenital heart disease. Drenthen W, Boersma E, Balci A, Moons P, Roos-Hesselink JW, Mulder BJ, Vliegen HW, van Dijk AP, Voors AA, Yap SC, van Veldhuisen DJ, Pieper PG, ZAHARA Investigators

Aims: Data regarding pregnancy outcome in women with congenital heart disease (CHD) are limited. Methods and results: In 1802 women with CHD, 1302 completed pregnancies were observed. Independent predictors of cardiac, obstetric, and neonatal complications were calculated using logistic regression. The most prevalent cardiac complications during pregnancy were arrhythmias (4.7%) and heart failure (1.6%). Factors independently associated with maternal cardiac complications were the presence of cy... Abstract

Cited 3 times since 2010 (0.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 27, Issue 1, 23 4 2010, Pages 123-126 Cardiac magnetic resonance imaging; gatekeeper in suspected CAD? van der Wall EE, Siebelink HM, Bax JJ, Schalij MJ

Abstract

Cited 33 times since 2010 (2.2 per year) source: EuropePMC

European heart journal, Volume 31, Issue 16, 20 3 2010, Pages 2006-2013 Time course of global left ventricular strain after acute myocardial infarction. Antoni ML, Mollema SA, Atary JZ, Borleffs CJ, Boersma E, van de Veire NR, Holman ER, van der Wall EE, Schalij MJ, Bax JJ

Aims: The purpose of the present study was to assess the evolution of left ventricular (LV) function after acute myocardial infarction (AMI) using global longitudinal peak systolic strain (GLPSS) during 1 year follow-up. In addition, patients were divided in groups with early, late, or no improvement of LV function and predictors of recovery of LV function were established. Methods and results: A total of 341 patients with AMI were evaluated. Two-dimensional echocardiography was performed at bas... Abstract

Cited 16 times since 2010 (1.1 per year) source: EuropePMC

Journal of neurology, neurosurgery, and psychiatry, Volume 81, Issue 8, 18 3 2010, Pages 828-833 Tripod pinch strength and thumb opposition are the major determinants of manual dexterity in Charcot-Marie-Tooth disease type 1A. Videler AJ, Beelen A, van Schaik IN, Verhamme C, van den Berg LH, de Visser M, Nollet F

Background: Clinical features of Charcot-Marie-Tooth disease type 1A (CMT1A) include slowly progressive distal muscle weakness, atrophy and sensory loss. Upper-limb involvement results in reduced manual dexterity interfering with the execution of daily activities. Objective: To identify which hand function impairments are determinants of manual dexterity in CMT1A. Methods: In a cross-sectional, observational study, hand function (strength, mobility and sensory function) and manual dexterity (Sol... Abstract

Cited 15 times since 2010 (1 per year) source: EuropePMC

Cardiovascular research, Volume 88, Issue 2, 17 3 2010, Pages 367-375 A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease. Eefting D, Seghers L, Grimbergen JM, de Vries MR, de Boer HC, Lardenoye JW, Jukema JW, van Bockel JH, Quax PH

Aims: Matrix metalloproteinases (MMP) and plasminogen activator (PA)/plasmin-mediated proteolysis, especially at the cell surface, play important roles in matrix degeneration and smooth muscle cell migration, which largely contributes to vein graft failure. In this study, a novel hybrid protein was designed to inhibit both protease systems simultaneously. MMP and plasmin activity were inhibited at the cell surface by this hybrid protein, consisting of the receptor-binding amino-terminal fragment... Abstract

Cited 9 times since 2010 (0.6 per year) source: EuropePMC

Cardiovascular therapeutics, Volume 29, Issue 6, 14 2 2010, Pages e43-53 Coronary artery calcium scoring in cardiovascular risk assessment. Nucifora G, Bax JJ, van Werkhoven JM, Boogers MJ, Schuijf JD

Identification of patients at risk of future coronary artery disease (CAD) events traditionally relies on scoring tools that take demographic and clinical characteristics into account (e.g., the Framingham risk score in the United States and the Heart Score in Europe). Although these scoring tools have been shown to have a good predictive value, they may still fail to recognize a proportion of patients with coronary atherosclerosis at risk for future CAD events. In order to improve risk stratifi... Abstract

Cited 34 times since 2010 (2.2 per year) source: EuropePMC

Journal of oncology, Volume 2010, 13 2 2010, Pages 865908 Outcome of colonic surgery in elderly patients with colon cancer. Hermans E, van Schaik PM, Prins HA, Ernst MF, Dautzenberg PJ, Bosscha K

Introduction. Colonic cancer is one of the most commonly diagnosed malignancies and most often occurs in patients aged 65 years or older. Aim. To evaluate the outcome of colonic surgery in the elderly in our hospital and to compare five-year survival rates between the younger and elderly patients. Methods. 207 consecutive patients underwent surgery for colon cancer. Patients were separated in patients younger than 75 and older than 75 years. Results. Elderly patients presented significantly more... Abstract

Cited 19 times since 2010 (1.3 per year) source: EuropePMC

Journal of neuroimmunology, Volume 226, Issue 1-2, 12 2 2010, Pages 147-149 HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes. de Graaf MT, de Beukelaar JW, Haasnoot GW, Levering WH, Rogemond V, Didelot A, Honnorat J, Gratama JW, Smitt PA

Background: Hypothetically, T cells are involved in the pathogenesis of paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS). Objective: To identify genetic risk factors for Hu-PNS and investigate the role of T cells. Methods: HLA-A, B, DRB1 and DQB1 alleles were compared in 53 Hu-PNS patients with 24 small-cell lung-cancer (SCLC) patients and 2440 healthy controls (HC). Results: The frequency of both HLA-DQ2 and HLA-DR3 was significantly higher in Hu-PNS patients than in... Abstract

Cited 32 times since 2010 (2.1 per year) source: EuropePMC

Preventive veterinary medicine, Volume 96, Issue 1-2, 11 2 2010, Pages 49-55 Variation in herd level mastitis indicators between primi- and multiparae in Dutch dairy herds. van den Borne BH, van Schaik G, Lam TJ, Nielen M

Composite somatic cell count data from the national test day recording and reported cases of farmer diagnosed clinical mastitis were used to estimate the occurrence of mastitis from July 2004 to June 2005 in primi- and multiparae in the Netherlands. Herds had to participate in the test day recording and had to have at least 50 cows. A random selection of 396 of these dairy herds provided composite somatic cell count data, while 205 dairy herds additionally reported on clinical mastitis cases. Pr... Abstract

Cited 12 times since 2010 (0.8 per year) source: EuropePMC

Microbiology (Reading, England), Volume 156, Issue Pt 9, 11 2 2010, Pages 2649-2659 Differential PilA pilus assembly by a hospital-acquired and a community-derived Enterococcus faecium isolate. Hendrickx APA, Schapendonk CME, van Luit-Asbroek M, Bonten MJM, van Schaik W, Willems RJL

Pili are hair-like structures protruding from the cell envelope of bacterial cells. Here, we describe the conditional and differential display of PilA-type pili, and PilE and PilF proteins, encoded from pilin gene cluster 1 at the surface of a hospital-acquired Enterococcus faecium bloodstream isolate (E1165) and a community-derived stool isolate (E1039), at two different temperatures. Both strains have virtually identical pilA gene clusters, as determined by sequencing. Western blotting and tra... Abstract

Cited 41 times since 2010 (2.7 per year) source: EuropePMC

The American journal of cardiology, Volume 106, Issue 2, 9 2 2010, Pages 198-203 Predictive value of total atrial conduction time estimated with tissue Doppler imaging for the development of new-onset atrial fibrillation after acute myocardial infarction. Antoni ML, Bertini M, Atary JZ, Delgado V, ten Brinke EA, Boersma E, Holman ER, van der Wall EE, Schalij MJ, Bax JJ, van de Veire NR

Patients who develop new-onset atrial fibrillation (AF) after acute myocardial infarction (AMI) show an increased risk for adverse events and mortality during follow-up. Recently, a novel noninvasive echocardiographic method has been validated for the estimation of total atrial activation time using tissue Doppler imaging of the atria (PA-TDI duration). PA-TDI duration has shown to be independently predictive of new-onset AF. However, whether PA-TDI duration provides predictive value for new-ons... Abstract

Cited 11 times since 2010 (0.7 per year) source: EuropePMC

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Volume 48, Issue 8-9, 9 2 2010, Pages 2443-2447 Evaluation of genotoxicity from Nilufer Stream (Bursa/Turkey) water using piscine micronucleus test. Summak S, Aydemir NC, Vatan O, Yilmaz D, Zorlu T, Bilaloğlu R

In the present study, the in vivo micronucleus (MN) test in fish erythrocytes was used to evaluate the genotoxic potentials of water samples collected from four different sites along the Nilufer Stream which empties into the Marmara Sea on the north-west of Turkey. Nilufer Stream receives discharges of industrial and domestic wastes resulting from industrialization and urbanization activities in Bursa city. Nile tilapias (Oreochromis niloticus) were exposed to collected water samples under labor... Abstract