Research

Publications

Below you can find a list of our published research.

9618 results

Cited 15 times since 2010 (1 per year) source: EuropePMC

International journal of cardiology, Volume 149, Issue 1, 6 1 2010, Pages 23-29 Simultaneous estimation of NT-proBNP on top to mitral flow Doppler echocardiography as an accurate strategy to diagnose diastolic dysfunction in HFNEF. Kasner M, Gaub R, Westermann D, Kaplan H, Akpulat S, Steendijk P, Schultheiss HP, Tschöpe C

Background: Conventional echocardiography has limited accuracy in detecting diastolic dysfunction and NT-proBNP is known to be a reliable biomarker to rule out heart failure. Therefore NT-proBNP on top to conventional mitral flow Doppler might improve the diagnostic of diastolic dysfunction in patients with heart failure despite normal EF (HFNEF) without using tissue Doppler. Methods and results: Diastolic function of 46 patients with HFNEF was determined by pressure-volume loop obtained by cond... Abstract

Cited 3 times since 2010 (0.2 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 12, Issue 3, 6 1 2010, Pages 378-384 Structured care for patients after acute myocardial infarction: sudden cardiac death prevention--data from the Leiden MISSION! AMI study. Atary JZ, Borleffs CJ, Liem SS, Bax JJ, van der Hoeven BL, Bootsma M, van der Wall EE, van Erven L, Schalij MJ

Aims: To assess the number of patients in daily clinical practice that meets criteria for implantation of an implantable cardioverter defibrillator (ICD) following acute myocardial infarction (AMI) when treated according to an aggressive treatment protocol. Methods and results: Patients were treated according to the MISSION! protocol. The protocol encompasses pre-hospital, in-hospital, and outpatient clinical framework for the acute and chronic treatment of AMI patients and the decision making r... Abstract

Cited 25 times since 2010 (1.6 per year) source: EuropePMC

The American journal of cardiology, Volume 105, Issue 4, 5 1 2010, Pages 480-486 Assessment with multi-slice computed tomography and gray-scale and virtual histology intravascular ultrasound of gender-specific differences in extent and composition of coronary atherosclerotic plaques in relation to age. Pundziute G, Schuijf JD, van Velzen JE, Jukema JW, van Werkhoven JM, Nucifora G, van der Kley F, Kroft LJ, de Roos A, Boersma E, Reiber JH, Schalij MJ, van der Wall EE, Bax JJ

Data evaluating gender- and age-specific differences in plaque observations on multislice computed tomography (MSCT) are scarce. Accordingly, the aim of this study was to evaluate coronary plaque patterns in men and women in relation to age using MSCT. The findings were compared to observations on grayscale intravascular ultrasound (IVUS) and virtual histology (VH) IVUS. In total, 93 patients (59 men, 34 women) underwent 64-slice MSCT followed by conventional coronary angiography with IVUS. Plaq... Abstract

Cited 142 times since 2010 (9.1 per year) source: EuropePMC

European heart journal, Volume 31, Issue 15, 4 1 2010, Pages 1908-1915 Diagnostic accuracy of 320-row multidetector computed tomography coronary angiography in the non-invasive evaluation of significant coronary artery disease. de Graaf FR, Schuijf JD, van Velzen JE, Kroft LJ, de Roos A, Reiber JH, Boersma E, Schalij MJ, Spanó F, Jukema JW, van der Wall EE, Bax JJ

Aims: Multidetector computed tomography coronary angiography (CTA) has emerged as a feasible imaging modality for non-invasive assessment of coronary artery disease (CAD). Recently, 320-row CTA systems were introduced, with 16 cm anatomical coverage, allowing image acquisition of the entire heart within a single heart beat. The aim of the present study was to assess the diagnostic accuracy of 320-row CTA in patients with known or suspected CAD. Methods and results: A total of 64 patients (34 mal... Abstract

Cited 1510 times since 2010 (96.6 per year) source: EuropePMC

Stem cell research, Volume 4, Issue 3, 4 1 2010, Pages 214-222 Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK

Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through large complexes of 50-100 nm. Here we show that these MSCs secreted 50- to 100-nm particles. These particles could be visualized by electron microscopy and were shown to be phospholipid vesicles consisting of cholesterol, sphingomyelin, and phosphatidylcholine. They contained coimmunoprecipitating exosome-associated proteins,... Abstract

Cited 31 times since 2010 (2 per year) source: EuropePMC

Journal of lipid research, Volume 51, Issue 1, 1 1 2010, Pages 202-209 Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial. Matthan NR, Resteghini N, Robertson M, Ford I, Shepherd J, Packard C, Buckley BM, Jukema JW, Lichtenstein AH, Schaefer EJ, PROSPER Group

Cholesterol homeostasis, defined as the balance between absorption and synthesis, influences circulating cholesterol concentrations and subsequent coronary heart disease (CHD) risk. Statin therapy targets the rate-limiting enzyme in cholesterol biosynthesis and is efficacious in lowering CHD events and mortality. Nonetheless, CHD events still occur in some treated patients. To address differences in outcome during pravastatin therapy (40 mg/day), plasma markers of cholesterol synthesis (desmoste... Abstract

Cited 20 times since 2010 (1.3 per year) source: EuropePMC

Disability and rehabilitation, Volume 32, Issue 2, 1 1 2010, Pages 142-147 Psychological intervention targets for people with visual impairments: the importance of cognitive coping and goal adjustment. Garnefski N, Kraaij V, De Graaf M, Karels L

Purpose: This study represents, to our knowledge, the first examination of the joint influence of cognitive coping strategies and goal-related coping on depressive symptoms in people with severe visual impairments with the aim of finding targets for intervention. Method: In total, data of 67 individuals with visual impairments were assembled by telephone interviews. Depressive symptomatology, cognitive coping strategies, and goal-related coping processes were measured. Relationships between thes... Abstract

Cited 1 times since 2010 (0.1 per year) source: EuropePMC

The American journal of the medical sciences, Volume 339, Issue 1, 1 1 2010, Pages 89-91 Do not put money where your mouth is! de Groot NM, Scholte AJ, Jongbloed MR, Schuijf JD, DeRuiter MC, Bax JJ, Schalij MJ

A 60-year-old woman presented with repolarization disorders on the electrocardiogram after a generalized seizure, which immediately disappeared after vomiting up a 20-eurocent coin. We did not find any evidence of coronary artery disease. Multislice computed tomography demonstrated no coronary atherosclerotic stenosis but a close relationship of the esophagus with the coronary arteries. This relation was further studied in detail in a human cadaver. From our findings, it is most likely that the... Abstract

Cited 2 times since 2010 (0.1 per year) source: EuropePMC

Disease markers, Volume 29, Issue 5, 1 1 2010, Pages 265-273 Matrix metalloproteinases 2 and 3 gene polymorphisms and the risk of target vessel revascularization after percutaneous coronary intervention: Is there still room for determining genetic variation of MMPs for assessment of an increased risk of restenosis? Verschuren JJ, Sampietro ML, Pons D, Trompet S, Ewing MM, Quax PH, de Knijff P, Zwinderman AH, de Winter RJ, Tio RA, de Maat MP, Doevendans PA, Jukema JW

Objective: Mixed results have been reported of matrix metalloproteinases (MMP) and their association with restenosis after percutaneous coronary intervention (PCI). The current study examines whether multiple single nucleotide polymorphisms (SNPs), covering the full genomic region of MMP2 and MMP3, were associated with restenosis in the GENDER study population. Methods and results: The GENetic DEterminants of Restenosis (GENDER) study enrolled 3104 consecutive patients after successful PCI. The... Abstract

Cited 27 times since 2010 (1.7 per year) source: EuropePMC

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, Volume 18, Issue 1, 1 1 2010, Pages 63-77 Why are we where we are? Understanding replication origins and initiation sites in eukaryotes using ChIP-approaches. Schepers A, Papior P

DNA replication initiates from origins of replication following a strict sequential activation programme and a conserved temporal order of activation. The number of replication initiation sites varies between species, according to the complexity of the genomes, with an average spacing of 100,000 bp. In contrast to yeast genomes, the location and definition of origins in mammalian genomes has been elusive. Historically, mammalian replication initiation sites have been mapped in situ by systematic... Abstract

Cited 59 times since 2010 (3.8 per year) source: EuropePMC

American heart journal, Volume 159, Issue 1, 1 1 2010, Pages 148-157 Incremental value of subclinical left ventricular systolic dysfunction for the identification of patients with obstructive coronary artery disease. Nucifora G, Schuijf JD, Delgado V, Bertini M, Scholte AJ, Ng AC, van Werkhoven JM, Jukema JW, Holman ER, van der Wall EE, Bax JJ

Background: Left ventricular (LV) diastolic dysfunction and subclinical systolic dysfunction may be markers of coronary artery disease (CAD). However, whether these markers are useful for prediction of obstructive CAD is unknown. Methods: A total of 182 consecutive outpatients (54 +/- 10 years, 59% males) without known CAD and overt LV systolic dysfunction underwent 64-slice multislice computed tomography (MSCT) coronary angiography and echocardiography. The MSCT angiograms showing atheroscleros... Abstract

Cited 6 times since 2010 (0.4 per year) source: EuropePMC

Current pharmaceutical design, Volume 16, Issue 2, 1 1 2010, Pages 231-237 Genetic techniques for pharmacogenetic analyses. van der Straaten T, van Schaik RH

With the exponential increase in publications on DNA markers explaining and/or predicting response to drug therapy, the potential of pharmacogenetic testing of individual patients to optimize drug treatment is expanding. For the identification of pharmacogenetic markers, several techniques can be used used. The specific method usually depends on the requirements of the study, ranging from determining one or two single nucleotide polymorphisms (SNPs) in one to ten patients, one or two SNPs in tho... Abstract

Cited 23 times since 2010 (1.5 per year) source: EuropePMC

Journal of dairy science, Volume 93, Issue 1, 1 1 2010, Pages 218-233 Therapeutic effects of antimicrobial treatment during lactation of recently acquired bovine subclinical mastitis: two linked randomized field trials. van den Borne BH, van Schaik G, Lam TJ, Nielen M

Two linked randomized field trials were performed on 39 herds in the Netherlands to 1) determine therapeutic effects of antimicrobial treatment of recently acquired subclinical mastitis (RASCM) during lactation, 2) evaluate the effect of duration of subclinical mastitis on therapeutic outcome, and 3) identify factors related to the therapeutic success of RASCM. Cows with a first elevated composite somatic cell count (CSCC) after 2 consecutive low CSCC measurements were eligible for enrollment in... Abstract

Cited 91 times since 2010 (5.8 per year) source: EuropePMC

Pharmacogenetics and genomics, Volume 20, Issue 1, 1 1 2010, Pages 38-44 Interaction between polymorphisms in the OCT1 and MATE1 transporter and metformin response. Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH

Objective: Metformin is transported into the hepatocyte by organic cation transporter 1 (OCT1) and out of the hepatocyte by multidrug and toxin extrusion 1 (MATE1). Recently, we discovered that polymorphisms rs622342 A>C in the SLC22A1 gene, coding for OCT1, and rs2289669 G>A in the SLC47A1 gene, coding for MATE1, are associated with the degree of glucose lowering by metformin. In this study, we assessed whether there exists an interaction between these two polymorphisms. Methods: We ident... Abstract

Cited 41 times since 2010 (2.6 per year) source: EuropePMC

Pharmacoepidemiology and drug safety, Volume 19, Issue 1, 1 1 2010, Pages 75-81 Influence of genetic variation in CYP3A4 and ABCB1 on dose decrease or switching during simvastatin and atorvastatin therapy. Becker ML, Visser LE, van Schaik RH, Hofman A, Uitterlinden AG, Stricker BH

Purpose: Simvastatin and atorvastatin are metabolized by the CYP3A4 enzyme and transported by the ABCB1 transporter. We studied whether the polymorphism CYP3A4*1B and the polymorphisms C1236T, G2677A/T and C3435T in the ABCB1 gene were associated with a decrease of the prescribed dose or a switch to another cholesterol lowering drug during simvastatin and atorvastatin therapy. These events may indicate that statin plasma levels were too high and resulted in an adverse drug reaction or a too stro... Abstract

Cited 34 times since 2010 (2.2 per year) source: EuropePMC

Alimentary pharmacology & therapeutics, Volume 31, Issue 1, 1 1 2010, Pages 150-159 A comparison of the acid-inhibitory effects of esomeprazole and pantoprazole in relation to pharmacokinetics and CYP2C19 polymorphism. Hunfeld NG, Touw DJ, Mathot RA, Mulder PG, VAN Schaik RH, Kuipers EJ, Kooiman JC, Geus WP

Background: Esomeprazole and pantoprazole are metabolized in the liver and the polymorphic CYP2C19 enzyme is involved in that process. This genetic polymorphism determines fast (70% of Caucasians), intermediate (25-30% of Caucasians) and slow (2-5% of Caucasians) metabolism of PPIs. Aim: To compare the acid-inhibitory effects of esomeprazole 40 mg and pantoprazole 40 mg at 4, 24 and 120 h after oral administration in relation to CYP2C19 genotype and pharmacokinetics. Methods: CYP2C19*2, *3, *4,... Abstract

Cited 12 times since 2010 (0.8 per year) source: EuropePMC

Studies in health technology and informatics, Volume 161, 1 1 2010, Pages 57-65 Wearable dry sensors with bluetooth connection for use in remote patient monitoring systems. Gargiulo G, Bifulco P, Cesarelli M, Jin C, McEwan A, van Schaik A

Cost reduction has become the primary theme of healthcare reforms globally. More providers are moving towards remote patient monitoring, which reduces the length of hospital stays and frees up their physicians and nurses for acute cases and helps them to tackle staff shortages. Physiological sensors are commonly used in many human specialties e.g. electrocardiogram (ECG) electrodes, for monitoring heart signals, and electroencephalogram (EEG) electrodes, for sensing the electrical activity of th... Abstract

Cited 12 times since 2010 (0.8 per year) source: EuropePMC

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, Volume 2010, 1 1 2010, Pages 6493-6496 Dry electrode bio-potential recordings. Gargiulo G, Bifulco P, McEwan A, Nasehi Tehrani J, Calvo RA, Romano M, Ruffo M, Shephard R, Cesarelli M, Jin C, Mohamed A, van Schaik A

As wireless bio-medical long term monitoring moves towards personal monitoring it demands very high input impedance systems capable to extend the reading of bio-signal during the daily activities offering a kind of "stress free", convenient connection, with no need for skin preparation. In particular we highlight the development and broad applications of our own circuits for wearable bio-potential sensor systems enabled by the use of an FET based amplifier circuit with sufficiently hig... Abstract

Cited 3 times since 2010 (0.2 per year) source: EuropePMC

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, Volume 2010, 1 1 2010, Pages 3109-3112 A comparison between compressed sensing algorithms in electrical impedance tomography. Nasehi Tehrani J, Jin C, McEwan A, van Schaik A

Electrical Impedance Tomography (EIT) calculates the internal conductivity distribution within a body using electrical contact measurements. Conventional EIT reconstruction methods solve a linear model by minimizing the least squares error, i.e., the Euclidian or L2-norm, with regularization. Compressed sensing provides unique advantages in Magnetic Resonance Imaging (MRI) [1] when the images are transformed to a sparse basis. EIT images are generally sparser than MRI images due to their lower s... Abstract

Cited 9 times since 2010 (0.6 per year) source: EuropePMC

Science (New York, N.Y.), Volume 327, Issue 5964, 1 1 2010, Pages 410; author reply 410-1 Studying extant species to model our past. Whiten A, McGrew WC, Aiello LC, Boesch C, Boyd R, Byrne RW, Dunbar RI, Matsuzawa T, Silk JB, Tomasello M, van Schaik CP, Wrangham R

Abstract