Research

Publications

Below you can find a list of our published research.

9618 results

Cited 70 times since 2009 (4.5 per year) source: EuropePMC

Journal of reconstructive microsurgery, Volume 26, Issue 1, 21 3 2009, Pages 59-65 Intraoperative near-infrared fluorescence imaging in perforator flap reconstruction: current research and early clinical experience. Lee BT, Matsui A, Hutteman M, Lin SJ, Winer JH, Laurence RG, Frangioni JV

Despite recent advances in perforator flap reconstruction, there can be significant variability in vessel size and location. Although preoperative evaluation may provide valuable information, real-time intraoperative methods have the potential to provide the greatest benefit. Our laboratory has developed the Fluorescence-Assisted Resection and Exploration (FLARE) near-infrared (NIR) fluorescence imaging system for intraoperative visualization of details of the underlying vasculature. The FLARE s... Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

The American journal of cardiology, Volume 105, Issue 3, 21 3 2009, Pages 302-305 Diagnostic accuracy of 64-slice multislice computed tomographic coronary angiography in patients with an intermediate pretest likelihood for coronary artery disease. van Werkhoven JM, Heijenbrok MW, Schuijf JD, Jukema JW, Boogers MM, van der Wall EE, Schreur JH, Bax JJ

Data on the diagnostic accuracy of multislice computed tomographic coronary angiography (CTA) have been mostly derived from patients with a high pretest likelihood of coronary artery disease. Systematic comparisons with invasive angiography in patients with an intermediate pretest likelihood are scarce. The purpose of the present study was to determine the diagnostic accuracy of CTA in patients without known coronary artery disease with an intermediate pretest likelihood. A total of 61 patients... Abstract

Cited 255 times since 2009 (16.3 per year) source: EuropePMC

Circulation, Volume 121, Issue 1, 21 3 2009, Pages 80-90 Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody. Arslan F, Smeets MB, O'Neill LA, Keogh B, McGuirk P, Timmers L, Tersteeg C, Hoefer IE, Doevendans PA, Pasterkamp G, de Kleijn DP

Background: Reperfusion therapy for myocardial infarction is hampered by detrimental inflammatory responses partly via Toll-like receptor (TLR) activation. Targeting TLR signaling may optimize reperfusion therapy and enhance cell survival and heart function after myocardial infarction. Here, we evaluated the role of TLR2 as a therapeutic target using a novel monoclonal anti-TLR2 antibody. Method and results: Mice underwent 30 minutes of ischemia followed by reperfusion. Compounds were administer... Abstract

Cited 23 times since 2009 (1.5 per year) source: EuropePMC

The American journal of cardiology, Volume 105, Issue 3, 21 3 2009, Pages 306-311 Impact of left ventricular dyssynchrony early on left ventricular function after first acute myocardial infarction. Nucifora G, Bertini M, Marsan NA, Delgado V, Scholte AJ, Ng AC, van Werkhoven JM, Siebelink HM, Holman ER, Schalij MJ, van der Wall EE, Bax JJ

The impact of left ventricular (LV) dyssynchrony after acute myocardial infarction (AMI) on LV ejection fraction (EF) is unknown. One hundred twenty-nine patients with a first ST-elevation AMI (58 + or - 11 years, 78% men) and QRS duration Abstract

Cited 50 times since 2009 (3.2 per year) source: EuropePMC

European heart journal, Volume 31, Issue 7, 16 3 2009, Pages 842-848 The yield of risk stratification for sudden cardiac death in hypertrophic cardiomyopathy myosin-binding protein C gene mutation carriers: focus on predictive screening. Christiaans I, Birnie E, van Langen IM, van Spaendonck-Zwarts KY, van Tintelen JP, van den Berg MP, Atsma DE, Helderman-van den Enden AT, Pinto YM, Hermans-van Ast JF, Bonsel GJ, Wilde AA

Aims: We investigated the presence of a clinical diagnosis of hypertrophic cardiomyopathy (HCM) and of risk factors for sudden cardiac death (SCD) at the first cardiological evaluation after predictive genetic testing in asymptomatic carriers of an MYBPC3 gene mutation. Methods and results: Two hundred and thirty-five mutation carriers were cardiologically evaluated on the presence of HCM and risk factors. A clinical diagnosis of HCM was made in 53 carriers (22.6%). Disease penetrance at 65 year... Abstract

Cited 15 times since 2009 (1 per year) source: EuropePMC

Respiratory medicine, Volume 104, Issue 5, 14 2 2009, Pages 690-696 Co-existence of COPD and left ventricular dysfunction in vascular surgery patients. Flu WJ, van Gestel YR, van Kuijk JP, Hoeks SE, Kuiper R, Verhagen HJ, Bax JJ, Sin DD, Poldermans D

Background: The co-existence between chronic obstructive pulmonary disease (COPD) and heart failure has been previously described. However, the co-existence between COPD and subclinical left ventricular (LV) dysfunction, without the presence of heart failure symptoms, is less well understood. This study determined the relationship and clinical relevance of COPD and subclinical LV dysfunction in vascular surgery patients. Methods: 1005 consecutive vascular surgery patients were included in which... Abstract

Cited 4 times since 2009 (0.3 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 26, Issue 2, 12 2 2009, Pages 249-252 Fingertip digital thermal monitoring: a fingerprint for cardiovascular disease? van der Wall EE, Schuijf JD, Bax JJ, Jukema JW, Schalij MJ

Abstract

Cited 28 times since 2009 (1.8 per year) source: EuropePMC

Environmental microbiology, Volume 12, Issue 3, 3 1 2009, Pages 730-745 A novel hybrid kinase is essential for regulating the sigma(B)-mediated stress response of Bacillus cereus. de Been M, Tempelaars MH, van Schaik W, Moezelaar R, Siezen RJ, Abee T

A common bacterial strategy for monitoring environmental challenges is to use two-component systems, which consist of a sensor histidine kinase (HK) and a response regulator (RR). In the food-borne pathogen Bacillus cereus, the alternative sigma factor sigma(B) is activated by the RR RsbY. Here we present strong indications that the PP2C-type phosphatase RsbY receives its input from the multi-sensor hybrid kinase BC1008 (renamed RsbK). Genome analyses revealed that, across bacilli, rsbY and rsbK... Abstract

Cited 94 times since 2009 (6 per year) source: EuropePMC

American journal of respiratory and critical care medicine, Volume 181, Issue 5, 3 1 2009, Pages 501-506 Patient outcomes after acute pulmonary embolism. A pooled survival analysis of different adverse events. Klok FA, Zondag W, van Kralingen KW, van Dijk AP, Tamsma JT, Heyning FH, Vliegen HW, Huisman MV

Rationale: There is a lack of information on the long-term prognosis of patients with acute pulmonary embolism (PE). Objectives: To assess the long-term risk for adverse events after PE. Methods: Consecutive patients diagnosed with PE between January 2001 and July 2007, and patients in whom PE was ruled out from a previous study were followed until July 2008 for the occurrence of adverse clinical events: mortality, symptomatic recurrent venous thromboembolism, cancer, arterial cardiovascular eve... Abstract

Cited 25 times since 2009 (1.6 per year) source: EuropePMC

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, Volume 17, Issue 2, 1 1 2009, Pages 225-231 Assessment of global left ventricular function and volumes with 320-row multidetector computed tomography: A comparison with 2D-echocardiography. de Graaf FR, Schuijf JD, van Velzen JE, Nucifora G, Kroft LJ, de Roos A, Schalij MJ, Jukema JW, van der Wall EE, Bax JJ

Background: Multidetector computed tomography (MDCT) has been demonstrated as a feasible imaging modality for noninvasive assessment of coronary artery disease and left ventricular (LV) function. Recently, 320-row systems have become available with 16 cm anatomical coverage allowing image acquisition of the entire heart within a single heartbeat. The purpose of this study was to evaluate the accuracy of 320-row MDCT in the assessment of global LV function compared to two-dimensional (2D) echocar... Abstract

Cited 2 times since 2009 (0.1 per year) source: EuropePMC

Endocrine reviews, Volume 30, Issue 7, 1 1 2009, Pages 927-928 Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach. Welsh P, Polisecki E, Robertson M, Jahn S, Buckley BM, de Craen AJ, Ford I, Jukema JW, Macfarlane PW, Packard CJ, Stott DJ, Westendorp RG, Shepherd J, Hingorani AD, Smith GD, Schaefer E, Sattar N

Abstract

Cited 13 times since 2009 (0.8 per year) source: EuropePMC

Pacing and clinical electrophysiology : PACE, Volume 33, Issue 4, 1 1 2009, Pages 431-436 Implementation of lead safety recommendations. VAN Rees JB, Borleffs CJ, Bax JJ, Nagtegaal EM, VAN DER Velde ET, VAN Erven L, Schalij MJ

Background: The Medtronic Sprint Fidelis (SF) implantable cardioverter defibrillator (ICD; Medtronic Inc., Minneapolis, MN, USA) lead has a higher than expected failure rate. Because of patient safety, Medtronic announced two advisories consisting of (1) adjustments in device settings (October 2007) and (2) installation of a lead integrity algorithm (May 2008). The objective of this study was to evaluate the effect of Medtronic's announcements on patient safety. Methods: To comply with the... Abstract

Cited 57 times since 2009 (3.6 per year) source: EuropePMC

American journal of physical anthropology, Volume 140, Issue 4, 1 1 2009, Pages 700-715 Fallback foods of temperate-living primates: a case study on snub-nosed monkeys. Grueter CC, Li D, Ren B, Wei F, Xiang Z, van Schaik CP

Only a few primate species thrive in temperate regions characterized by relatively low temperature, low rainfall, low species diversity, high elevation, and especially an extended season of food scarcity during which they suffer from dietary stress. We present data of a case study of dietary strategies and fallback foods in snub-nosed monkeys (Rhinopithecus bieti) in the Samage Forest, Northwest Yunnan, PRC. The snub-nosed monkeys adjusted intake of plant food items corresponding with changes in... Abstract

Cited 5 times since 2009 (0.3 per year) source: EuropePMC

Clinical and experimental immunology, Volume 158 Suppl 1, 1 1 2009, Pages 60-67 6th International Immunoglobulin Symposium: poster presentations. Fernandez-Cruz E, Kaveri SV, Peter HH, Durandy A, Cantoni N, Quinti I, Sorensen R, Bussel JB, Danieli MG, Winkelmann A, Bayry J, Käsermann F, Späth P, Helbert M, Salama A, van Schaik IN, Yuki N

The posters presented at the 6th International Immunoglobulin Symposium covered a wide range of fields and included both basic science and clinical research. From the abstracts accepted for poster presentation, 12 abstracts were selected for oral presentations in three parallel sessions on immunodeficiencies, autoimmunity and basic research. The immunodeficiency presentations dealt with novel, rare class-switch recombination (CSR) deficiencies, attenuation of adverse events following IVIg treatm... Abstract

Cited 38 times since 2009 (2.4 per year) source: EuropePMC

American journal of physical anthropology, Volume 140, Issue 4, 1 1 2009, Pages 716-726 Foraging and ranging behavior during a fallback episode: Hylobates albibarbis and Pongo pygmaeus wurmbii compared. Vogel ER, Haag L, Mitra-Setia T, van Schaik CP, Dominy NJ

Periodic episodes of food scarcity may highlight the adaptive value of certain anatomical traits, particularly those that facilitate the acquisition and digestion of exigent fallback foods. To better understand the selective pressures that favored the distinctive dental and locomotor morphologies of gibbons and orangutans, we examined the foraging and ranging behavior of sympatric Hylobates albibarbis and Pongo pygmaeus wurmbii during an episode of low fruit availability at Tuanan, Kalimantan Te... Abstract

Cited 54 times since 2009 (3.4 per year) source: EuropePMC

Brain : a journal of neurology, Volume 132, Issue Pt 12, 1 1 2009, Pages 3252-3262 The natural history of Charcot-Marie-Tooth type 1A in adults: a 5-year follow-up study. Verhamme C, van Schaik IN, Koelman JH, de Haan RJ, de Visser M

Charcot-Marie-Tooth type 1A is the most prevalent hereditary demyelinating polyneuropathy. The aim of this study was to investigate the natural history of the disease in adults during a 5-year follow-up and to compare the changes over time with those found in normal ageing. In a cohort of 46 adult Charcot-Marie-Tooth type 1A patients, impairments and physical disability were scored at baseline and at 1, 3 and 5 years. Standardized nerve conduction studies and electromyography were performed at b... Abstract

Cited 35 times since 2009 (2.2 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 2, Issue 12, 1 1 2009, Pages 1425-1435 Role of left ventricular twist mechanics in the assessment of cardiac dyssynchrony in heart failure. Bertini M, Sengupta PP, Nucifora G, Delgado V, Ng AC, Marsan NA, Shanks M, van Bommel RJ, Schalij MJ, Narula J, Bax JJ

The authors discuss an incremental value of assessing left ventricular (LV) twist mechanics in patients with heart failure (HF) and its potential usefulness in characterizing response to cardiac resynchronization therapy (CRT) and reversal of LV remodeling at 6 months follow-up. They also underscore a critical relationship between LV lead position and changes in LV twist after CRT, and suggest that the reversal of LV remodeling in HF patients following CRT primarily results from restoration of t... Abstract

Cited 5 times since 2009 (0.3 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 54, Issue 25, 1 1 2009, Pages 2447-2458 Highlights of the 2009 scientific sessions of the European Society of Cardiology. Bax JJ, Casadei B, Di Mario C, Fagard R, Filippatos G, Fox KA, Metra M, Nihoyannopoulos P, Perk J, Rademakers F, Rosenhek R, Vardas PE, Pinto FJ, Ferrari R

Abstract

Cited 84 times since 2009 (5.3 per year) source: EuropePMC

European heart journal, Volume 30, Issue 24, 1 1 2009, Pages 3027-3036 Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure. Wachter R, Schmidt-Schweda S, Westermann D, Post H, Edelmann F, Kasner M, Lüers C, Steendijk P, Hasenfuss G, Tschöpe C, Pieske B

Aims: We tested the hypothesis that, in heart failure with normal ejection fraction (HFNEF), diastolic dysfunction is accentuated at increasing heart rates, and this contributes to impaired frequency-dependent augmentation of cardiac output. Methods and results: In 17 patients with HFNEF (median age 69 years, 13 female) and seven age-matched control patients, systolic and diastolic function was analysed by pressure-volume loops at baseline heart rate and during atrial pacing to 100 and 120 min(-... Abstract

Cited 1 times since 2009 (0.1 per year) source: EuropePMC

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists, Volume 16, Issue 6, 1 1 2009, Pages 690-693 Remote ischemic preconditioning in vascular surgery patients: the additional value to medical treatment. van Kuijk JP, Flu WJ, Verhagen HJ, Bax JJ, Poldermans D

Abstract