Research

Publications

Below you can find a list of our published research.

6205 results

JACC. Cardiovascular imaging, 29 5 2025, Pages S1936-878X(25)00138-X The Last Decade in Tricuspid Regurgitation: How Imaging Shaped a Field. Hahn RT, Badano L, Praz F, Muraru D, Agricola E, Ajmone Marsan N, Bartkowiak J, Delgado V, Dreyfus J, Hausleiter J, Lurz P, Maisano F, Margonato D, Messika-Zeitoun D, Enriquez-Sarano M, Cavalcante JL

The tricuspid valve has become a major focus of novel structural heart interventions, with the Conformité Européenne approval of 5 devices in Europe and the U.S. Food and Drug Administration approval of 2 devices in the United States. Multiple meta-analyses and large population-based registries have shown that although significant tricuspid regurgitation (TR) often accompanies left heart or pulmonary vascular diseases, it is associated with an increased risk of mortality and a reduced quality of... Abstract

Journal of cardiothoracic and vascular anesthesia, 29 5 2025, Pages S1053-0770(25)00272-1 Anesthesia Management for the Personalized External Aortic Root Support (PEARS) Procedure: A Single-Center Experience. Pandey AK, Kougioumtzoglou AM, Lam BCY, Kho E, Eberl S, Dilai J, Koolbergen DR, Hermanns H

Objective: To delineate anesthesia management during the personalized external aortic root support (PEARS) procedure, with a focus on the use of multimodal monitoring and deliberate profound hypotension. Design: A single-center retrospective cohort study. Setting: Tertiary academic hospital. Participants: Patients undergoing the PEARS procedure due to aortic aneurysm. Interventions: None. Methods: Patient characteristics and anesthesia management are described, with particular emphasis on multim... Abstract

The international journal of cardiovascular imaging, Volume 41, Issue 5, 29 5 2025, Pages 991-1000 Prognostic impact of left ventricular myocardial work in patients undergoing surgery for primary mitral regurgitation. Nabeta T, Peters F, Wu HW, Chua AP, Palmen M, Tomšič A, Marsan NA, Bax JJ, van der Bijl P

Purpose: Echocardiography-based, left ventricular myocardial work (LVMW) can assess LV function by incorporating LV afterload. This study aims to evaluate the prognostic value of LVMW indices in patients with primary mitral regurgitation (MR) undergoing mitral valve surgery. Methods and results: A total of 306 patients (mean age 63 ± 12 years, 68% male) with severe, primary MR who underwent surgery, were included. All patients underwent transthoracic echocardiography and LVMW indices were assess... Abstract

Clinical case reports, Volume 13, Issue 4, 28 4 2025, Pages e70282 A <i>PDLIM7</i> Variant in Familial Mitral Valve Prolapse: A Case Series. van Wijngaarden AL, Koopmann TT, Ruivenkamp CAL, Wu HW, Ajmone Marsan N, Barge-Schaapveld DQCM

In the presented case of familial mitral valve prolapse, whole exome sequencing was used to reveal a missense variant in the PDLIM7 gene. This gene is considered a possible novel candidate gene for familial MVP based on PDLIM7 knock-out mice and zebrafish showing mitral valve abnormalities. Abstract

European heart journal. Quality of care & clinical outcomes, 28 4 2025, Pages qcae106 Key priorities for the implementation of the 2023 ESC Guidelines for the management of endocarditis in low-resource settings. Borger MA, de Waha S, Marsan NA, Zühlke L, Mestres CA, Fosbol E, Bonaros N, Pizzi MN, Brida M, Sionis A, Delgado V, Members of the Task Force for the 2023 ESC Guidelines for the management of endocarditis

European Society of Cardiology (ESC) Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinician... Abstract

American heart journal plus : cardiology research and practice, Volume 53, 26 4 2025, Pages 100534 The clinical impact of prophylactic concomitant left atrial appendage occlusion during cardiac surgery: A systematic review and meta-analysis. Zhao C, Girdauskas E, Schoones JW, Klautz RJM, Palmen M, Tomšič A

Background: Recently, concomitant left atrial appendage occlusion (LAAO) has emerged as prophylactic treatment option for preventing thromboembolic events in patients undergoing cardiac surgery with no known history of atrial fibrillation. The efficacy of prophylactic LAAO remains unknown. Methods: PubMed, Embase, Web of Science, Emcare, and the Cochrane Library were searched for studies on prophylactic LAAO in patients undergoing cardiac surgery. The primary endpoints were postoperative thrombo... Abstract

European heart journal. Cardiovascular Imaging, 25 4 2025, Pages jeaf093 CCTA-Derived Coronary Plaque Burden Offers Enhanced Prognostic Value Over CAC Scoring In Suspected CAD Patients. Dahdal J, Jukema RA, Maaniitty T, Nurmohamed NS, Raijmakers PG, Hoek R, Driessen RS, Twisk JWR, Bär S, Planken RN, van Royen N, Nijveldt R, Bax JJ, Saraste A, van Rosendael AR, Knaapen P, Knuuti J, Danad I

Aim: To assess the prognostic utility of coronary artery calcium (CAC) scoring and coronary computed tomography angiography (CCTA) - derived quantitative plaque metrics for predicting adverse cardiovascular outcomes. Methods and results: The study enrolled 2,404 patients with suspected CAD but without prior history of CAD. All participants underwent CAC scoring and CCTA, with plaque metrics quantified using an artificial intelligence (AI)-based tool (Cleerly, Inc). Percent atheroma volume (PAV)... Abstract

ESC heart failure, 23 4 2025 Prognostic implications of functional tricuspid regurgitation in asymptomatic degenerative mitral regurgitation. Tribouilloy C, Bohbot Y, Essayagh B, Benfari G, Bax JJ, Le Tourneau T, Topilsky Y, Antoine C, Rusinaru D, Grigioni F, Ajmone Marsan N, van Wijngaarden A, Hochstadt A, Roussel JC, Thapa P, Hector M, Enriquez-Sarano M

Aims: Functional tricuspid regurgitation (FTR) associated with degenerative mitral regurgitation (DMR) accentuates the severity of heart failure and is a marker of poor prognosis. Little is known about FTR associated with asymptomatic DMR. Methods and results: The study included 1249 asymptomatic patients with moderate or severe DMR from the Mitral Regurgitation International Database-Quantitative (MIDA-Q) registry (mean age 64 ± 15 years, 25% female). Despite the asymptomatic status, absent/tri... Abstract

Journal of the American Heart Association, Volume 14, Issue 7, 21 3 2025, Pages e037531 Blockade of YAP Mechanoactivation Prevents Neointima Formation and Adverse Remodeling in Arterialized Vein Grafts. Garoffolo G, Sluiter TJ, Thomas A, Piacentini L, Ruiter MS, Schiavo A, Salvi M, Saccu C, Zoli S, Chiesa M, Yokoyama T, Agrifoglio M, Soncini M, Fiore GB, Martelli F, Condorelli G, Madeddu P, Molinari F, Morbiducci U, Quax PHA, Spinetti G, de Vries MR, Pesce M

Background: Bypass surgery using saphenous vein (SV) grafts is commonly performed to revascularize the ischemic heart and lower limbs. These interventions have limited success due to adverse remodeling caused by overproliferation of smooth muscle cells in the intima layer, leading to progressive bypass stenosis. We previously showed that cyclic strain deriving from exposure to coronary flow induces the expression of the matricellular protein thrombospondin-1 in the human SV, promoting activation... Abstract

European journal of heart failure, 19 3 2025 Ventricular arrhythmias in acute heart failure. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), the European Heart Rhythm Association (EHRA) and the Heart Failure Association (HFA) of the ESC. Gorenek B, Wijnmaalen AP, Goette A, Mert GO, Porter B, Gustafsson F, Dan GA, Ector J, Stuehlinger M, Spartalis M, Gosau N, Amir O, Chioncel O

Patients presenting with or alerting emergency networks due to acute heart failure (AHF) form a diverse group with a plethora of symptoms, risks, comorbidities, and aetiologies. During AHF, there is an increased risk of destabilizing the functional substrate and modulatory adding to the risk of ventricular arrhythmias (VAs) already created by the structural substrate. New VAs during AHF have previously identified patients with higher in-hospital and 60-day morbidity and mortality. Risk stratific... Abstract

Annals of medicine and surgery (2012), Volume 87, Issue 4, 19 3 2025, Pages 1995-1999 Fostering an open surgical culture: strategies to eliminate inappropriate behavior in surgical practice. Blok JJ, Snijders HS, Huizing F, Schmitz RF, Kerstjens LJ, Sier VQ, Blok CC, Lijkwan MA, Schepers A

Surgery is a demanding and stressful profession. Unfortunately, inappropriate behavior is still not banished from the daily surgical practice and we are dealing with the negative consequences (e.g. negative working environments or burn-out). To adequately treat this type of behavior we first have to acknowledge its existence and create a proper path to discuss it inside our own ranks. The only manner to achieve this, is through an open culture. An 'open surgical culture' is the key, as... Abstract

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 18 3 2025 Dupilumab-Associated Ocular Surface Disease in Paediatric Atopic Dermatitis Patients: Results From the BioDay Registry. van der Rijst LP, van Luijk CM, van der Kamp S, Zuithoff NPA, de Boer JH, de Bruin-Weller MS, de Graaf M

Background: Dupilumab-associated ocular surface disease (DAOSD) is a common side effect in paediatric atopic dermatitis (AD) patients treated with dupilumab. However, long-term real-world safety data is limited. Therefore, this study investigates the incidence of DAOSD in paediatric AD patients treated with dupilumab and identifies associated risk factors. Methods: This prospective study included paediatric AD patients (aged 3-17 years) treated with dupilumab. Ocular symptoms were assessed every... Abstract

International journal of cardiology. Heart & vasculature, Volume 58, 17 3 2025, Pages 101654 Association of indexed aortic dimensions with the presence and extent of coronary artery ectasia in patients with acute coronary syndrome. van Oort MJH, Oliveri F, de Lange FWJ, Regeer MV, Bingen BO, Jukema JW, van der Kley F, Al Amri I, Montero-Cabezas JM

Background: Conflicting findings have been reported on the potential association between CAE and aortic dilatation. This study aimed to investigate the relationship between CAE extent and aortic dimensions in patients with acute coronary syndrome (ACS). Methods: This retrospective cohort study included 448 adult patients who underwent coronary angiography for ACS between 2004 and 2015. The cohort was divided into 224 patients with CAE and 224 control patients without CAE, matched for age, sex, a... Abstract

Cited 1 times since 2025 (5 per year) source: EuropePMC

Pediatric cardiology, 13 2 2025 Fontan-Associated Liver Disease (FALD) in the EUROFontan Experience. An Insight into European Awareness. Gozzi A, Vedovelli L, Bergonzoni E, Cao I, Angeli E, Zanoni R, Biffanti R, Butera G, Dimopoulos K, Rocafort AG, Hazekamp MG, Kansky A, Lenoir M, Martens T, Meliota G, Meyns B, Nosal M, Napoleone CP, Rijnberg FM, Dolzer ES, Scrascia G, Vairo U, Van Puyvelde J, Di Salvo G, Montanaro C, Padalino MA

Fontan-Associated Liver Disease (FALD) is a dramatically emerging problem even if not precisely defined in term of debated diagnosis and surveillance protocols. We analyze FALD prevalence, clinical impact and implications in a European cohort of patients. It's a retrospective observational multicenter study including Fontan patients operated between 1990 and 2022. Anatomical, clinical, surgical and liver-related data were collected, defining FALD as a spectrum of time-related structural-fun... Abstract

Arteriosclerosis, thrombosis, and vascular biology, Volume 45, Issue 5, 13 2 2025, Pages 576-584 Role of Perivascular Adipose Tissue in Vein Remodeling. Kruit N, Sluiter TJ, de Vries MR

Perivascular adipose tissue (PVAT) plays a crucial, yet underexplored, role in vein remodeling, which occurs after bypass surgery using a venous graft or creation of arteriovenous fistulae for hemodialysis access. PVAT exhibits significant heterogeneity in phenotype and tissue composition depending on the vascular bed, as well as its anatomic location within the vasculature. Through the excretion of adipokines, cytokines, and chemokines, PVAT can shape the vascular response to local and systemic... Abstract

Journal of lipid research, Volume 66, Issue 4, 13 2 2025, Pages 100778 Potential causal evidence for an ApoB-independent and HDL-related risk profile associated with coronary artery disease. Ao L, van Heemst D, Jukema JW, Rensen PCN, Willems van Dijk K, Noordam R

Plasma 1H-NMR metabolomic measures have yielded significant insight into the pathophysiology of cardiometabolic disease, but their inter-related nature complicates causal inference and clinical interpretation. This study aimed to investigate the associations of unrelated 1H-NMR metabolomic profiles with coronary artery disease (CAD) and ischemic stroke (IS). Principal component (PC) analysis was performed on 168 1H-NMR metabolomic measures in 56,712 unrelated European participants from UK Bioban... Abstract

The Pediatric infectious disease journal, Volume 44, Issue 4, 10 2 2025, Pages 281-286 The Prevalence, Serogroup Distribution and Risk Factors of Meningococcal Carriage in Children, Adolescents and Young Adults in Turkey Meningo-Carr-TR Study PART 3: COVID-19 Pandemic Situation. Kizil MC, Kara Y, Karbuz A, Oz FN, Ciftci E, Kurugol Z, Iseri Nepesov M, Celebi S, Cetin BS, Yilmaz D, Dinleyici M, Kizmaz Isancli D, Kilicaslan O, Ozdemir H, Inceli BH, Penezoglu DN, Dortkardesler B, Sezer Yamanel RG, Aksoy FD, Tekin Can S, Agrali Eröz N, Kaya M, Kilic O, Dinleyici EC

Background: The prevalence of meningococcal carriage and serogroup distribution is crucial for assessing the epidemiology of invasive meningococcal disease, forecasting outbreaks and formulating potential immunization strategies. Following the meningococcal carriage studies conducted in Turkey in 2016 and 2018, we planned to re-evaluate meningococcal carriage in children, adolescents and young adults during the COVID-19 pandemic period. Methods: In the MENINGO-CARR-3 study, we collected nasophar... Abstract

Cited 2 times since 2025 (9.2 per year) source: EuropePMC

Nature genetics, Volume 57, Issue 3, 6 1 2025, Pages 539-547 Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases. Roselli C, Surakka I, Olesen MS, Sveinbjornsson G, Marston NA, Choi SH, Holm H, Chaffin M, Gudbjartsson D, Hill MC, Aegisdottir H, Albert CM, Alonso A, Anderson CD, Arking DE, Arnar DO, Barnard J, Benjamin EJ, Braunwald E, Brumpton B, Campbell A, Chami N, Chasman DI, Cho K, Choi EK, Christophersen IE, Chung MK, Conen D, Crijns HJ, Cutler MJ, Czuba T, Damrauer SM, Dichgans M, Dörr M, Dudink E, Duong T, Erikstrup C, Esko T, Fatkin D, Faul JD, Ferreira M, Freitag DF, Ganesh SK, Gaziano JM, Geelhoed B, Ghouse J, Gieger C, Giulianini F, Graham SE, Gudnason V, Guo X, Haggerty C, Hayward C, Heckbert SR, Hveem K, Ito K, Johnson R, Jukema JW, Jurgens SJ, Kääb S, Kane JP, Kany S, Kardia SLR, Kavousi M, Khurshid S, Kamanu FK, Kirchhof P, Kleber ME, Knight S, Komuro I, Krieger JE, Launer LJ, Li D, Lin H, Lin HJ, Loos RJF, Lotta L, Lubitz SA, Lunetta KL, Macfarlane PW, Magnusson PKE, Malik R, Mantineo H, Marcus GM, März W, McManus DD, Melander O, Melloni GEM, Meyre PB, Miyazawa K, Mohanty S, Monfort LM, Müller-Nurasyid M,

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development and cell-cell communication at 139 loci. Furthermore, we assayed chromatin accessibility using assay f... Abstract

JACC. Clinical electrophysiology, 5 1 2025, Pages S2405-500X(25)00086-6 Impact of Anterior Right Ventricular Outflow Tract Conduction Block on QRS Morphology in Repaired Tetralogy of Fallot. Moore JP, Zeppenfeld K

Abstract

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Volume 105, Issue 6, 4 1 2025, Pages 1418-1426 Clinical and Technical Predictors of Treatment Success After Coronary Intravascular Lithotripsy in Calcific Coronary Lesions. van Oort MJH, Bingen BO, Oliveri F, Al Amri I, Phagu AAS, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Girgis H, van der Kley F, Jukema JW, Montero-Cabezas JM

Background: Intravascular lithotripsy (IVL) is increasingly used to treat coronary artery calcification (CAC). This study aimed to identify clinical and procedural factors associated with IVL treatment success. Methods: This retrospective analysis included 454 patients (73 ± 9 years, 75% male) treated with IVL from the multicenter BENELUX-IVL registry (May 2019 to February 2024). Treatment success was defined as achieving residual coronary diameter stenosis Abstract