Research

Publications

Below you can find a list of our published research.

7429 results

Cited 26 times since 2015 (2.7 per year) source: EuropePMC

Heart and vessels, Volume 31, Issue 5, 1 1 2015, Pages 795-806 Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy? Grewal N, Franken R, Mulder BJ, Goumans MJ, Lindeman JH, Jongbloed MR, DeRuiter MC, Klautz RJ, Bogers AJ, Poelmann RE, Groot AC

Patients with bicuspid aortic valve (BAV) and patients with Marfan syndrome (MFS) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common and distinct pathways of clinical relevance, we compared the histopathological substrates of aortopathy. Ascending aortic wall biopsies were divided in five groups: BAV (n = 36) and TAV (n = 23) without and with dilation and non-dilated MFS (n = 8). General histologic featu... Abstract

Cited 422 times since 2015 (43.6 per year) source: EuropePMC

JAMA, Volume 314, Issue 1, 1 1 2015, Pages 52-60 Association of Cardiometabolic Multimorbidity With Mortality. Emerging Risk Factors Collaboration, Di Angelantonio E, Kaptoge S, Wormser D, Willeit P, Butterworth AS, Bansal N, O'Keeffe LM, Gao P, Wood AM, Burgess S, Freitag DF, Pennells L, Peters SA, Hart CL, Håheim LL, Gillum RF, Nordestgaard BG, Psaty BM, Yeap BB, Knuiman MW, Nietert PJ, Kauhanen J, Salonen JT, Kuller LH, Simons LA, van der Schouw YT, Barrett-Connor E, Selmer R, Crespo CJ, Rodriguez B, Verschuren WM, Salomaa V, Svärdsudd K, van der Harst P, Björkelund C, Wilhelmsen L, Wallace RB, Brenner H, Amouyel P, Barr EL, Iso H, Onat A, Trevisan M, D'Agostino RB, Cooper C, Kavousi M, Welin L, Roussel R, Hu FB, Sato S, Davidson KW, Howard BV, Leening MJ, Leening M, Rosengren A, Dörr M, Deeg DJ, Kiechl S, Stehouwer CD, Nissinen A, Giampaoli S, Donfrancesco C, Kromhout D, Price JF, Peters A, Meade TW, Casiglia E, Lawlor DA, Gallacher J, Nagel D, Franco OH, Assmann G, Dagenais GR, Jukema JW, Sundström J, Woodward M, Brunner EJ, Khaw KT, Wareham NJ, Whitsel EA, Njølstad I, Hedblad B, Wassertheil-Smoller S, Engström G

Importance: The prevalence of cardiometabolic multimorbidity is increasing. Objective: To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. Design, setting, and participants: Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689,300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest mortality follow-up: April 2013; 128,843 deaths). T... Abstract

Cited 104 times since 2015 (10.7 per year) source: EuropePMC

Nature, Volume 523, Issue 7561, 1 1 2015, Pages 459-462 Directional dominance on stature and cognition in diverse human populations. Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, Okada Y, Stančáková A, Faul JD, Zhao W, Bartz TM, Concas MP, Franceschini N, Enroth S, Vitart V, Trompet S, Guo X, Chasman DI, O'Connel JR, Corre T, Nongmaithem SS, Chen Y, Mangino M, Ruggiero D, Traglia M, Farmaki AE, Kacprowski T, Bjonnes A, van der Spek A, Wu Y, Giri AK, Yanek LR, Wang L, Hofer E, Rietveld CA, McLeod O, Cornelis MC, Pattaro C, Verweij N, Baumbach C, Abdellaoui A, Warren HR, Vuckovic D, Mei H, Bouchard C, Perry JRB, Cappellani S, Mirza SS, Benton MC, Broeckel U, Medland SE, Lind PA, Malerba G, Drong A, Yengo L, Bielak LF, Zhi D, van der Most PJ, Shriner D, Mägi R, Hemani G, Karaderi T, Wang Z, Liu T, Demuth I, Zhao JH, Meng W, Lataniotis L, van der Laan SW, Bradfield JP, Wood AR, Bonnefond A, Ahluwalia TS, Hall LM, Salvi E, Yazar S, Carstensen L, de Haan HG, Abney M, Afzal U, Allison MA, Amin N, Asselbergs FW, Bakker SJL, Barr RG, Baumeister SE, Benjamin DJ, Bergmann S, Boerwinkle E, Bott

Homozygosity has long been associated with rare, often devastating, Mendelian disorders, and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness. However, the effect of the more distant parental relatedness that is common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity), which are inferr... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 23, Issue 7-8, 1 1 2015, Pages 366-367 Acute pontine infarction after percutaneous coronary intervention: a very rare but devastating complication. Arslan F, Mair J, Franz WM, Otten M, van Lelyveld L

A 64-year-old man suffering from an acute posterior wall myocardial infarction underwent primary percutaneous coronary intervention. After several aspiration attempts, tirofiban infusion and pre- and post-dilatation, a bare-metal stent was successfully implanted in the culprit right coronary artery. While the patient did not show any neurological symptoms before or during the procedure, he exhibited hemiplegia and loss of spontaneous speech. Additional magnetic resonance imaging showed an extens... Abstract

Cited 13 times since 2015 (1.3 per year) source: EuropePMC

PloS one, Volume 10, Issue 6, 26 4 2015, Pages e0129899 Assessment of Myocardial Fibrosis in Mice Using a T2*-Weighted 3D Radial Magnetic Resonance Imaging Sequence. van Nierop BJ, Bax NA, Nelissen JL, Arslan F, Motaal AG, de Graaf L, Zwanenburg JJ, Luijten PR, Nicolay K, Strijkers GJ

Background: Myocardial fibrosis is a common hallmark of many diseases of the heart. Late gadolinium enhanced MRI is a powerful tool to image replacement fibrosis after myocardial infarction (MI). Interstitial fibrosis can be assessed indirectly from an extracellular volume fraction measurement using contrast-enhanced T1 mapping. Detection of short T2* species resulting from fibrotic tissue may provide an attractive non-contrast-enhanced alternative to directly visualize the presence of both repl... Abstract

Cited 2 times since 2015 (0.2 per year) source: EuropePMC

Cardiovascular and interventional radiology, Volume 38, Issue 6, 24 4 2015, Pages 1674-1675 Testicular Embolism After Endovascular Aneurysm Repair: A Rare Complication of Endovascular Repair of Abdominal Aortic Aneurysms. Vervoort M, Hoencamp R, Eefting D

Abstract

Cited 27 times since 2015 (2.8 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 17, Issue 1, 9 2 2015, Pages 96-105 Tricuspid valve remodelling in functional tricuspid regurgitation: multidetector row computed tomography insights. van Rosendael PJ, Joyce E, Katsanos S, Debonnaire P, Kamperidis V, van der Kley F, Schalij MJ, Bax JJ, Ajmone Marsan N, Delgado V

Aims: Multidetector row computed tomography (MDCT) may help to understand the underlying mechanisms of functional tricuspid regurgitation (TR), a highly prevalent valve disease with novel transcatheter therapies under development. The purpose of the present study was to assess the geometrical changes of the tricuspid valve in patients with functional TR using MDCT and to correlate these changes with the TR grade assessed with echocardiography. Methods and results: In 114 patients undergoing tran... Abstract

Cited 14 times since 2015 (1.4 per year) source: EuropePMC

European journal of heart failure, Volume 17, Issue 10, 4 1 2015, Pages 1042-1049 Anaemia in patients with aortic stenosis: influence on long-term prognosis. Ng AC, Kong WK, Kamperidis V, Bertini M, Antoni ML, Leung DY, Marsan NA, Delgado V, Bax JJ

Aims: The prognostic implications of anaemia in patients with aortic stenosis (AS) remain unclear. Accordingly, the present study aimed to evaluate the prognostic implications of anaemia in AS patients before and after aortic valve replacement (AVR). Methods and results: A total of 856 AS patients (age 71 ± 12 years, 60.2% male, 47.4% severe AS) were included. The mean haemoglobin (Hb) level was 13.2 ± 1.8 g/dL, and the prevalence of anaemia (Hb Abstract

Cited 34 times since 2015 (3.5 per year) source: EuropePMC

Atherosclerosis, Volume 241, Issue 2, 3 1 2015, Pages 289-296 Mast cells mediate neutrophil recruitment during atherosclerotic plaque progression. Wezel A, Lagraauw HM, van der Velden D, de Jager SC, Quax PH, Kuiper J, Bot I

Aims: Activated mast cells have been identified in the intima and perivascular tissue of human atherosclerotic plaques. As mast cells have been described to release a number of chemokines that mediate leukocyte fluxes, we propose that activated mast cells may play a pivotal role in leukocyte recruitment during atherosclerotic plaque progression. Methods and results: Systemic IgE-mediated mast cell activation in apoE(-/-)μMT mice resulted in an increase in atherosclerotic lesion size as compared... Abstract

Cited 31 times since 2015 (3.2 per year) source: EuropePMC

Atherosclerosis, Volume 241, Issue 2, 3 1 2015, Pages 547-554 Individual contributions of visceral fat and total body fat to subclinical atherosclerosis: The NEO study. Gast KB, den Heijer M, Smit JW, Widya RL, Lamb HJ, de Roos A, Jukema JW, Rosendaal FR, de Mutsert R, NEO study group

Background: Both overall and abdominal adiposity are established risk factors for cardiovascular disease. Visceral adipose tissue (VAT) and total body fat (TBF) are strongly correlated and previous studies did not make this distinction. Objective: We aimed to distinguish individual contributions of TBF, VAT, and the ratio of VAT to abdominal subcutaneous adipose tissue (VAT/SAT) to subclinical atherosclerosis in men and women. Methods: In this cross-sectional analysis of the Netherlands Epidemio... Abstract

Cited 1785 times since 2015 (182.9 per year) source: EuropePMC

The New England journal of medicine, Volume 372, Issue 25, 3 1 2015, Pages 2387-2397 Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, Darius H, Lewis BS, Ophuis TO, Jukema JW, De Ferrari GM, Ruzyllo W, De Lucca P, Im K, Bohula EA, Reist C, Wiviott SD, Tershakovec AM, Musliner TA, Braunwald E, Califf RM, IMPROVE-IT Investigators

Background: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. Methods: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to... Abstract

Guang pu xue yu guang pu fen xi = Guang pu, Volume 35, Issue 6, 1 1 2015, Pages 1501-1505 Radiation Parameters of Some Potential Bioactive Compounds. Gedik Z, Tugrak M, Dastan A, Gul HI, Yilmaz D

In this study, we aimed to determine the radiation parameters of some potential bioactive compounds. 1-Aryl-3-dibenzylamino-propane-1-on hydrochloride type Mannich bases were synthesized via classical conventional heating method. Aryl part was changed as phenyl (C6H5), 4-methylphenyl (4-CH3C6H4), 4-fluorophenyl ( 4-FC6H4), 4-nitrophenyl (4-NO2C6H4), 4-chlorophenyl (4-ClC6H4), 4-bromophenyl (4-BrC6H4), and 2-thienyl (C4H3S-2-yl). Mass attenuation coefficient (μm), effective atomic number (Z(eff))... Abstract

Cited 52 times since 2015 (5.3 per year) source: EuropePMC

European heart journal, Volume 36, Issue 31, 1 1 2015, Pages 2087-2096 Low gradient severe aortic stenosis with preserved ejection fraction: reclassification of severity by fusion of Doppler and computed tomographic data. Kamperidis V, van Rosendael PJ, Katsanos S, van der Kley F, Regeer M, Al Amri I, Sianos G, Marsan NA, Delgado V, Bax JJ

Aims: Low gradient severe aortic stenosis (AS) with preserved left ventricular ejection fraction (LVEF) may be attributed to aortic valve area index (AVAi) underestimation due to the assumption of a circular shape of the left ventricular outflow tract (LVOT) with 2-dimensional echocardiography. The current study evaluated whether fusing Doppler and multidetector computed tomography (MDCT) data to calculate AVAi results in significant reclassification of inconsistently graded severe AS. Methods a... Abstract

Cited 7 times since 2015 (0.7 per year) source: EuropePMC

Journal of cardiovascular medicine (Hagerstown, Md.), Volume 16, Issue 6, 1 1 2015, Pages 465-471 B-type natriuretic peptide vs. cardiac risk scores for prediction of outcome following major orthopedic surgery. Katsanos S, Babalis D, Kafkas N, Mavrogenis A, Leong D, Parissis J, Varounis C, Makris K, van der Heijden A, Anastasiou-Nana M, Filippatos G

Aims: The clinical role of B-type natriuretic peptide (BNP) in preoperative evaluation is not clear. We designed a prospective study to investigate the predictive value of BNP in comparison with established clinical risk scores for the outcome of major orthopedic surgery. Methods: Overall 242 elderly patients [80 (74-85) years] undergoing orthopedic surgery were included. Inhospital cardiovascular events and 1-year mortality were the main endpoints. Results: In total 20 (8.3%) patients had major... Abstract

Cited 16 times since 2015 (1.6 per year) source: EuropePMC

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Volume 56 Suppl 4, 1 1 2015, Pages 25S-30S 123I-MIBG SPECT for Evaluation of Patients with Heart Failure. Dimitriu-Leen AC, Scholte AJ, Jacobson AF

Heart failure (HF) is characterized by activation of the sympathetic cardiac nerves. The condition of cardiac sympathetic nerves can be evaluated by (123)I-metaiodobenzylguanidine ((123)I-MIBG) imaging. Most cardiac (123)I-MIBG studies have relied on measurements from anterior planar images of the chest. However, it has become progressively more common to include SPECT imaging in clinical and research protocols. This review examines recent trends in (123)I-MIBG SPECT imaging and evidence that pr... Abstract

Cited 6 times since 2015 (0.6 per year) source: EuropePMC

The International journal of angiology : official publication of the International College of Angiology, Inc, Volume 24, Issue 2, 1 1 2015, Pages 127-132 Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction. Dharma S, Hapsari R, Siswanto BB, van der Laarse A, Jukema JW

We aim to test the hypothesis that blood leukocyte count adds prognostic information in patients with acute non-ST-elevation myocardial infarction (non-STEMI). A total of 585 patients with acute non-STEMI (thrombolysis in myocardial infarction risk score ≥ 3) were enrolled in this cohort retrospective study. Blood leukocyte count was measured immediately after admission in the emergency department. The composite of death, reinfarction, urgent revascularization, and stroke during hospitalization... Abstract

Cited 27 times since 2015 (2.8 per year) source: EuropePMC

Protein science : a publication of the Protein Society, Volume 24, Issue 8, 29 5 2015, Pages 1292-1300 Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment. Konijnenberg A, Bannwarth L, Yilmaz D, Koçer A, Venien-Bryan C, Sobott F

Here we study the intact stoichiometry and top-down fragmentation behavior of three integral membrane proteins which were natively reconstituted into detergent micelles: the mechano-sensitive ion channel of large conductance (MscL), the Kirbac potassium channel and the p7 viroporin from the hepatitis C virus. By releasing the proteins under nondenaturing conditions inside the mass spectrometer, we obtained their oligomeric sizes. Increasing the ion activation (collision energy) causes unfolding... Abstract

Cited 32 times since 2015 (3.3 per year) source: EuropePMC

European heart journal, Volume 36, Issue 30, 25 4 2015, Pages 1983-1989 The effect of QRS duration on cardiac resynchronization therapy in patients with a narrow QRS complex: a subgroup analysis of the EchoCRT trial. Steffel J, Robertson M, Singh JP, Abraham WT, Bax JJ, Borer JS, Dickstein K, Ford I, Gorcsan J, Gras D, Krum H, Sogaard P, Holzmeister J, Brugada J, Ruschitzka F

Aims: In EchoCRT, a randomized trial evaluating the effect of cardiac resynchronization therapy (CRT) in patients with a QRS duration of Abstract

Cited 40 times since 2015 (4.1 per year) source: EuropePMC

Heart rhythm, Volume 12, Issue 10, 22 4 2015, Pages 2106-2114 Myocardial scar predicts monomorphic ventricular tachycardia but not polymorphic ventricular tachycardia or ventricular fibrillation in nonischemic dilated cardiomyopathy. Piers SR, Everaerts K, van der Geest RJ, Hazebroek MR, Siebelink HM, Pison LA, Schalij MJ, Bekkers SC, Heymans S, Zeppenfeld K

Background: The relation between myocardial scar and different types of ventricular arrhythmias in patients with nonischemic dilated cardiomyopathy (NIDCM) is unknown. Objectives: The purpose of this study was to analyze the effect of myocardial scar, assessed by late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR), on the occurrence and type of ventricular arrhythmia in patients with NIDCM. Methods: Consecutive patients with NIDCM who underwent LGE-CMR and implantable cardio... Abstract

Cited 1 times since 2015 (0.1 per year) source: EuropePMC

World journal of experimental medicine, Volume 5, Issue 2, 20 3 2015, Pages 140-153 Barriers in contribution of human mesenchymal stem cells to murine muscle regeneration. de la Garza-Rodea AS, Boersma H, Dambrot C, de Vries AA, van Bekkum DW, Knaän-Shanzer S

Aim: To study regeneration of damaged human and murine muscle implants and the contribution of added xenogeneic mesenchymal stem cells (MSCs). Methods: Minced human or mouse skeletal muscle tissues were implanted together with human or mouse MSCs subcutaneously on the back of non-obese diabetic/severe combined immunodeficient mice. The muscle tissues (both human and murine) were minced with scalpels into small pieces (< 1 mm(3)) and aliquoted in portions of 200 mm(3). These portions were eith... Abstract