7528 results
Cited 1 times since 2024 (1.1 per year)
source: EuropePMC
Heart rhythm,
Volume 22, Issue 2, 31 5 2024, Pages 536-543
ECTOPIC trial: The efficacy of flEcainide Compared To metOprolol in reducing Premature ventrIcular Contractions: A randomized open-label crossover study in pediatric patients.
Bertels RA, Kammeraad JAE, van Geloven N, Filippini LH, van der Palen RLF, Tak RO, Frerich S, Vanagt W, Rehbock JJB, Knobbe I, Kuipers IM, de Riva M, Zeppenfeld K, Blom NA
Background: Frequent premature ventricular contractions (PVCs) in children are usually considered benign. Symptoms and left ventricular dysfunction are indications for treatment with antiarrhythmic drugs. Objective: This study aimed to evaluate the efficacy of flecainide vs metoprolol in reducing PVCs in children. Methods: A randomized open-label crossover trial was conducted of children with a PVC burden of >15% on Holter monitoring successively treated with metoprolol and flecainide, or vic...
Abstract
International archives of allergy and immunology,
Volume 185, Issue 11, 30 5 2024, Pages 1074-1082
Dog Allergy in Children: A Single-Centered Study.
Büyük Yaytokgil Ş, Alim Aydın S, Yilmaz D, Şengül Emeksiz Z, Gülseren SC, Toyran M, Civelek E, Dibek Misirlioğlu E
Introduction: Dogs are among the most commonly allergenic pets for children. Data on risk factors for the development of dog allergy are scarce. This study aimed to evaluate the characteristics of children with dog allergy and identify predictors of symptom development with dog exposure. Methods: The study included children with dog allergen sensitization demonstrated by skin prick test (SPT) between September 1, 2019, and December 1, 2022. Demographic, clinical, and laboratory data were collect...
Abstract
Cited 3 times since 2024 (3.1 per year)
source: EuropePMC
JACC. Cardiovascular interventions,
29 5 2024, Pages S1936-8798(24)00913-0
Real-World Implementation of a Genotype-Guided P2Y<sub>12</sub> Inhibitor De-Escalation Strategy in Acute Coronary Syndrome Patients.
Azzahhafi J, van den Broek WWA, Chan Pin Yin DRPP, van der Sangen NMR, Sivanesan S, Bofarid S, Peper J, Claassens DMF, Janssen PWA, Harmsze AM, Walhout RJ, Tjon Joe Gin M, Nicastia DM, Langerveld J, Vlachojannis GJ, van Bommel RJ, Appelman Y, van Schaik RHN, Henriques JPS, Kikkert WJ, Ten Berg JM
Background: CYP2C19 genotype-guided de-escalation from ticagrelor or prasugrel to clopidogrel may optimize the balance between ischemic and bleeding risk in patients with acute coronary syndrome (ACS). Objectives: This study sought to compare bleeding and ischemic event rates in genotyped patients vs standard care. Methods: Since 2015, ACS patients in the multicenter FORCE-ACS (Future Optimal Research and Care Evaluation in Patients with Acute Coronary Syndrome) registry received standard dual a...
Abstract
Cited 2 times since 2024 (2.1 per year)
source: EuropePMC
FEBS open bio,
Volume 14, Issue 10, 28 4 2024, Pages 1668-1681
Daily rhythms in metabolic and locomotor behaviour of prematurely ageing PolgA mice.
Singh A, Yilmaz D, Wehrle E, Kuhn GA, Müller R
Ageing is an inherent and intricate biological process that takes place in living organisms as time progresses. It involves the decline of multiple physiological functions, leading to body structure and overall performance modifications. The ageing process differs among individuals and is influenced by various factors, including lifestyle, environment and genetic makeup. Metabolic changes and reduced locomotor activity are common hallmarks of ageing. Our study focuses on exploring these phenomen...
Abstract
Cited 1 times since 2024 (1 per year)
source: EuropePMC
Journal of clinical lipidology,
Volume 18, Issue 6, 27 4 2024, Pages e915-e925
The impact of statin use on sepsis mortality.
Li M, Noordam R, Trompet S, Winter EM, Jukema JW, Arbous MS, Rensen PCN, Kooijman S
Background: Statins exert pleiotropic anti-inflammatory and antioxidant effects in addition to their cholesterol-lowering properties. This study aimed to investigate whether statin use is associated with improved outcomes of sepsis. Methods: Data from patients with sepsis were extracted from the Medical Information Mart for Intensive Care IV database. Patients with a history of receiving prescriptions for statins (i.e., atorvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, or simvas...
Abstract
Cited 1 times since 2024 (1 per year)
source: EuropePMC
Annals of vascular surgery,
Volume 108, 25 4 2024, Pages 385-392
Prognostic Performance of the Maximal Systolic Acceleration at the Hallux in Healing of Foot Ulcers: A Retrospective Cohort Study.
Willems SA, Pruim JD, van der Vorst JR, van Schaik J, Schepers A, Hamming JF, Brouwers JJWM
Background: The accurate prediction of foot ulcer healing remains a major challenge in clinical practice. To date, no reliable bedside tests are available. The primary aim of this study was to determine the prognostic performance of the maximal systolic acceleration (ACCmax) to predict ulcer healing. Secondary objectives comprised the investigation of the prognostic accuracy in patients prone to medial arterial calcification and to assess the potential risk of amputation. Methods: A single-cente...
Abstract
Cited 11 times since 2024 (11.4 per year)
source: EuropePMC
Alzheimer's & dementia : the journal of the Alzheimer's Association,
Volume 20, Issue 9, 24 4 2024, Pages 5973-5995
A genome-wide association meta-analysis of all-cause and vascular dementia.
Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) consortium
Introduction: Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD. Methods: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritiz...
Abstract
Rheumatology (Oxford, England),
22 4 2024, Pages keae375
Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis.
Velauthapillai A, Bootsma MFR, Bruni C, Bergmann C, Matucci-Cerinic M, Launay D, Riemekastan G, Garzanova L, Airò P, Rezus E, da Silva JAP, Del Galdo F, Hunzelmann N, Chung LS, Krasowska D, Distler O, van den Ende CHM, Vonk MC, EUSTAR collaborators
Background: Hypothesizing that early treatment yields improved prognosis, we aimed to investigate how the timing of immunosuppressive treatment relates to interstitial lung disease (ILD) development and the course of pulmonary function in systemic sclerosis (SSc). Methods: A cohort was created using data from the EUSTAR database and Nijmegen Systemic Sclerosis cohort, including adult patients who started their first immunosuppressive treatment (ie mycophenolate mofetil, methotrexate, cyclophosph...
Abstract
Cited 4 times since 2024 (4.1 per year)
source: EuropePMC
Journal of cardiovascular medicine (Hagerstown, Md.),
Volume 25, Issue 9, 22 4 2024, Pages 715-716
Invasive evaluation of coronary artery compliance modification after intracoronary lithotripsy.
Oliveri F, Van Oort M, Al Amri I, Bingen B, Van der Kley F, Jukema W, Montero J
Abstract
Cardiovascular revascularization medicine : including molecular interventions,
Volume 70, 22 4 2024, Pages 85-91
Intravascular lithotripsy for the treatment of peri-stent calcific lesions in saphenous vein grafts: A case series report.
Meijer M, Oliveri F, van Oort MJH, Bingen BO, van der Kley F, Jukema JW, Al Amri I, Montero-Cabezas JM
Background: Coronary artery bypass grafting (CABG) is a cornerstone treatment for coronary artery disease, with the use of saphenous vein grafts (SVGs) being prevalent. However, SVGs are susceptible to high failure rates due to graft inflammation, intimal hyperplasia, and atherosclerosis, leading to a substantial number of patients requiring revascularization. Percutaneous coronary intervention (PCI) of SVGs poses unique challenges, including increased risk of distal embolization and perforation...
Abstract
International journal of cardiology,
Volume 413, 22 4 2024, Pages 132387
Mitral valve repair with resection and non-resection techniques in Barlow's disease: A multi-center study.
Tomšič A, Holubec T, Sandoval E, Pham T, Castella M, Klautz RJM, Marsan NA, Pereda D, Palmen M
Background: Various mitral valve (MV) repair techniques are nowadays in use. Non-resection techniques, that rely exclusively on Gore-Tex® neochords and annuloplasty, have been popularized; however, their efficacy in Barlow's disease, characterized by large myxomatous leaflets, is yet unclear. Methods: Consecutive patients undergoing MV repair for Barlow's disease between 2011 and 2019 were selected on the basis of being eligible for resection and non-resection techniques. Study endpoin...
Abstract
Frontiers in bioengineering and biotechnology,
Volume 12, 22 4 2024, Pages 1435695
Biofilm mitigation in hybrid chemical-biological upcycling of waste polymers.
Stoddard H, Kulas D, Zolghadr A, Aloba S, Schaerer LG, Putman L, Valencia I, Lacey JA, Shonnard DR, Techtmann SM, Ong RG
Introduction: Accumulation of plastic waste in the environment is a serious global issue. To deal with this, there is a need for improved and more efficient methods for plastic waste recycling. One approach is to depolymerize plastic using pyrolysis or chemical deconstruction followed by microbial-upcycling of the monomers into more valuable products. Microbial consortia may be able to increase stability in response to process perturbations and adapt to diverse carbon sources, but may be more li...
Abstract
Cited 1 times since 2024 (1 per year)
source: EuropePMC
The Science of the total environment,
Volume 948, 20 3 2024, Pages 174907
Accumulation of airborne microplastics on leaves of different tree species in the urban environment.
Leitão IA, Van Schaik L, Iwasaki S, Ferreira AJD, Geissen V
Microplastics (MPs) are omnipresent in the environment and they are linked to ecosystem and human health problems. The atmospheric transport of MPs and the role of tree leaves in MP atmospheric deposition has not been adequately studied. MP concentrations on the leaves of different tree species in urban regions of the Netherlands and Portugal, along with related MP deposition, were investigated in this study. We collected leaves from cedar, eucalyptus, oak, pine and willow trees, together with m...
Abstract
Cited 1 times since 2024 (1 per year)
source: EuropePMC
Clinical chemistry and laboratory medicine,
Volume 62, Issue 12, 19 3 2024, Pages e255-e256
Is uracil enough for effective pre-emptive DPD testing?
Heersche N, Matic M, Mathijssen RHJ, Coenen MJH, van Schaik RHN
Abstract
Cited 5 times since 2024 (5.1 per year)
source: EuropePMC
Preventive veterinary medicine,
Volume 231, 19 3 2024, Pages 106289
The impact of the bluetongue serotype 3 outbreak on sheep and goat mortality in the Netherlands in 2023.
Santman-Berends IMGA, van den Brink KMJA, Dijkstra E, van Schaik G, Spierenburg MAH, van den Brom R
In September 2023, bluetongue virus serotype 3 (BTV-3) emerged in the Netherlands, infecting over five thousand livestock farms. In sheep, high morbidity and mortality rates were reported that were unlike previously described bluetongue outbreaks. This study aimed to quantify the impact of BTV-3 in the small ruminant population in the Netherlands in 2023. Sheep and goat movement census data and BTV-3 notification data were available from 2020 until the end of 2023. Data were aggregated to farm a...
Abstract
Journal of visualized experiments : JoVE,
Issue 209, 19 3 2024
Imaging and Quantification of the Hepatic Vasculature of Mice Using Ultrafast Doppler Ultrasound.
Stripling K, Timmermans F, Décombas-Deschamps S, Thalgott JH, Lemonnier D, de Vries MR, Rabelink TJ, Tanter M, Deffieux T, Lebrin F
Non-invasive in vivo imaging of the vasculature is a powerful tool for studying disease mechanisms in rodents. To achieve high sensitivity imaging of the microvasculature using Doppler ultrasound methods, imaging modalities employing the concept of ultrafast imaging are preferred. By increasing the frame rate of the ultrasound scanner to thousands of frames per second, it becomes possible to improve the sensitivity of the blood flow down to 2 mm/s and to obtain functional information about the m...
Abstract
Cited 3 times since 2024 (3.1 per year)
source: EuropePMC
United European gastroenterology journal,
Volume 12, Issue 10, 19 3 2024, Pages 1367-1377
T1 colorectal cancer patients' perspective on information provision and therapeutic decision-making after local resection.
Dekkers N, Dang H, de Graaf M, Nobbenhuis K, Verhoeven DA, van der Kraan J, de Vos Tot Nederveen Cappel WH, Alkhalaf A, van Westreenen HL, Basiliya K, Peeters KCMJ, Westerterp M, Doornebosch PG, Hardwick JCH, Langers AMJ, Boonstra JJ
Background: Decision-making after local resection of T1 colorectal cancer (T1CRC) is often complex and calls for optimal information provision as well as active patient involvement. Objective: The aim was to evaluate the perceptions of patients with T1CRC on information provision and therapeutic decision-making. Methods: This multicenter cross-sectional study included patients who underwent endoscopic or local surgical resection as initial treatment. Information provision was assessed using the...
Abstract
Cited 16 times since 2024 (16.3 per year)
source: EuropePMC
The Journal of molecular diagnostics : JMD,
Volume 26, Issue 10, 18 3 2024, Pages 851-863
DPYD Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, American College of Medical Genetics and Genomics, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, Pharmacogenomics Knowledgebase, and Pharmacogene Variation Consortium.
Pratt VM, Cavallari LH, Fulmer ML, Gaedigk A, Hachad H, Ji Y, Kalman LV, Ly RC, Moyer AM, Scott SA, Turner AJ, van Schaik RHN, Whirl-Carrillo M, Weck KE
The goals of the Association for Molecular Pathology Clinical Practice Committee's Pharmacogenomics (PGx) Working Group are to define the key attributes of pharmacogenetic alleles recommended for clinical testing and a minimum set of variants that should be included in clinical PGx genotyping assays. This document series provides recommendations for a minimum set of variant alleles (tier 1) and an extended list of variant alleles (tier 2) that will aid clinical laboratories when designing a...
Abstract
Heart rhythm O2,
Volume 5, Issue 9, 17 3 2024, Pages 614-622
Remarkably high and accelerating failure rate of a widely used implantable cardioverter-defibrillator lead: A large-scale manufacturer-independent multicenter study with long accurate follow-up.
Oosterwerff EFJ, Theuns DAMJ, Maass AH, van Erven L
Background: A high annual failure rate of the Linox family defibrillator lead was reported in various small single-center studies. No independent multicenter long-term performance information exists for this lead. Objective: Our aim was to assess the longevity of the Linox family leads and to evaluate clinical variables and adverse events associated with failure. Methods: This 4-center study included adults >18 years of age who received Linox family leads for the prevention of sudden cardiac...
Abstract
Cited 1 times since 2024 (1 per year)
source: EuropePMC
Journal of vascular surgery,
Volume 80, Issue 5, 17 3 2024, Pages 1418-1424.e1
Urgent Candy-Plug technique for distal false lumen occlusion in chronic aortic dissection.
Eleshra A, Kölbel T, Haulon S, Bertoglio L, Rohlffs F, Dias N, Panuccio G, Tsilimparis N, Candy-Plug Collaborators
Objective: This study aimed to assess the impact of urgency on early and midterm outcomes of the Candy-Plug (CP) technique for distal false lumen (FL) occlusion in thoracic endovascular aortic repair for aortic dissection. Methods: The CP registry was reviewed, and patients were categorized into elective and urgent/emergent groups for analysis. End points included technical success, clinical success, early (30-day) computed tomography angiography findings, early (30-day) mortality, adverse event...
Abstract
