Research

Publications

Below you can find a list of our published research.

8684 results

Cited 112 times since 2014 (9.9 per year) source: EuropePMC

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, Volume 16, Issue 5, 4 1 2014, Pages 681-688 Feasibility, safety, and short-term outcome of leadless ultrasound-based endocardial left ventricular resynchronization in heart failure patients: results of the wireless stimulation endocardially for CRT (WiSE-CRT) study. Auricchio A, Delnoy PP, Butter C, Brachmann J, Van Erven L, Spitzer S, Moccetti T, Seifert M, Markou T, Laszo K, Regoli F, Collaborative Study Group

Aims: Left ventricular (LV) endocardial pacing may address the limitations in the selection of an LV pacing site and provide improvements in cardiac resynchronization therapy (CRT) effectiveness. We report on the feasibility, the safety, and the short-term outcome of a leadless ultrasound-based technology for LV endocardial resynchronization in heart failure (HF) patients enroled into the Wireless Stimulation Endocardially for CRT (WiSE-CRT) study. Methods and results: Seventeen HF patients were... Abstract

Cited 14 times since 2014 (1.2 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 30, Issue 4, 4 1 2014, Pages 713-720 Impact of right ventricular dyssynchrony on left ventricular performance in patients with pulmonary hypertension. Haeck ML, Höke U, Marsan NA, Holman ER, Wolterbeek R, Bax JJ, Schalij MJ, Vliegen HW, Delgado V

Pulmonary hypertension has been associated with right ventricular (RV) dyssynchrony which may induce left ventricular (LV) dysfunction and dyssynchrony through ventricular interdependence. The present study evaluated the influence of RV dyssynchrony on LV performance in patients with pulmonary hypertension. One hundred and seven patients with pulmonary hypertension (age 63 ± 14 years, systolic pulmonary arterial pressure 60 ± 19 mmHg) and LV ejection fraction (EF) >35% were evaluated. Ventric... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 2, 1 1 2014, Pages 77-79 ST-segment elevation associated with allergic reaction to echocardiographic contrast agent administration. van Ginkel A, Sorgdrager B, de Graaf MA, Karalis I, Ajmone Marsan N

We report a case of an allergic reaction after the administration of an echocardiographic contrast agent which resulted in ST-segment elevation. Hypersensitivity and allergic reactions are known causes of acute cardiovascular events. However, only limited reports are available which suggest the exact mechanism of the occurrence of angina or myocardial infarction during severe allergic reactions. In our case, through invasive imaging (coronary angiography and IVUS) we have shown for the first tim... Abstract

Cited 411 times since 2014 (36.2 per year) source: EuropePMC

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Volume 20, Issue 2, 1 1 2014, Pages 123-129 The effects of clinical and statistical heterogeneity on the predictive values of results from meta-analyses. Melsen WG, Bootsma MC, Rovers MM, Bonten MJ

Variance between studies in a meta-analysis will exist. This heterogeneity may be of clinical, methodological or statistical origin. The last of these is quantified by the I(2) -statistic. We investigated, using simulated studies, the accuracy of I(2) in the assessment of heterogeneity and the effects of heterogeneity on the predictive value of meta-analyses. The relevance of quantifying I(2) was determined according to the likely presence of heterogeneity between studies (low, high, or unknown)... Abstract

Neurology, Volume 82, Issue 5, 1 1 2014, Pages e36-40 Clinical reasoning: a 76-year-old man remaining comatose after cardiopulmonary resuscitation. Li SC, de Graaf MT, Cherian PJ

A 76-year-old man was admitted to the hospital after having a "cardiac arrest" while riding his bicycle and subsequently falling into a canal. Thirty minutes after the accident, he was resuscitated by an ambulance crew. They detected a ventricular tachycardia, which responded to defibrillation. Thereafter, there was a sinus bradycardia, which was treated with atropine and adrenaline. After 30 minutes of resuscitation, there was return of spontaneous circulation (ROSC). At admission to... Abstract

Cited 16 times since 2014 (1.4 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 22, Issue 2, 1 1 2014, Pages 64-69 Antithrombotic therapy in patients undergoing TAVI: an overview of Dutch hospitals. Nijenhuis VJ, Stella PR, Baan J, Brueren BR, de Jaegere PP, den Heijer P, Hofma SH, Kievit P, Slagboom T, van den Heuvel AF, van der Kley F, van Garsse L, van Houwelingen KG, Van't Hof AW, Ten Berg JM

Purpose: To assess current antithrombotic treatment strategies in the Netherlands in patients undergoing transcatheter aortic valve implantation (TAVI). Methods: For every Dutch hospital performing TAVI (n = 14) an interventional cardiologist experienced in performing TAVI was interviewed concerning heparin, aspirin, thienopyridine and oral anticoagulation treatment in patients undergoing TAVI. Results: The response rate was 100 %. In every centre, a protocol for antithrombotic treatment after T... Abstract

Cited 1 times since 2014 (0.1 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 63, Issue 6, 1 1 2014, Pages 570-602 Highlights of the year in JACC 2013. DeMaria AN, Adler ED, Bax JJ, Ben-Yehuda O, Feld GK, Greenberg BH, Hall JL, Hlatky MA, Lew WY, Lima JA, Mahmud E, Maisel AS, Narayan SM, Nissen SE, Sahn DJ, Tsimikas S

Abstract

Cited 156 times since 2014 (13.7 per year) source: EuropePMC

Clinical pharmacokinetics, Volume 53, Issue 2, 1 1 2014, Pages 123-139 The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation. Hesselink DA, Bouamar R, Elens L, van Schaik RH, van Gelder T

The calcineurin inhibitor tacrolimus is the backbone of immunosuppressive drug therapy after solid organ transplantation. Tacrolimus is effective in preventing acute rejection but has considerable toxicity and displays marked inter-individual variability in its pharmacokinetics and pharmacodynamics. The genetic basis of these phenomena is reviewed here. With regard to its pharmacokinetic variability, a single nucleotide polymorphism (SNP) in cytochrome P450 (CYP) 3A5 (6986A>G) has been consis... Abstract

Cited 12 times since 2014 (1.1 per year) source: EuropePMC

European journal of endocrinology, Volume 170, Issue 2, 1 1 2014, Pages 181-191 Cushing's disease and hypertension: in vivo and in vitro study of the role of the renin-angiotensin-aldosterone system and effects of medical therapy. van der Pas R, van Esch JH, de Bruin C, Danser AH, Pereira AM, Zelissen PM, Netea-Maier R, Sprij-Mooij DM, van den Berg-Garrelds IM, van Schaik RH, Lamberts SW, van den Meiracker AH, Hofland LJ, Feelders RA

Objective/methods: Cushing's disease (CD) is often accompanied by hypertension. CD can be treated surgically and, given the expression of somatostatin subtype 5 and dopamine 2 receptors by corticotroph pituitary adenomas, pharmacologically. Indeed, we recently observed that stepwise medical combination therapy with the somatostatin-analog pasireotide, the dopamine-agonist cabergoline, and ketoconazole (which directly suppresses steroidogenesis) biochemically controlled CD patients and lower... Abstract

Cited 59 times since 2014 (5.2 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 36, Issue 1, 1 1 2014, Pages 71-79 Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. Elens L, Hesselink DA, Bouamar R, Budde K, de Fijter JW, De Meyer M, Mourad M, Kuypers DR, Haufroid V, van Gelder T, van Schaik RH

Background: The P450 oxidoreductase (POR)*28 variant allele has been associated with altered cytochrome P450 3A enzyme activities. Both CYP3A5 and CYP3A4 are involved in the metabolism of calcineurin inhibitors and recent data show that POR*28 may explain part of the variability observed in tacrolimus (Tac) pharmacokinetics. The aim of this study was to investigate the impact of the POR*28 allele on Tac and cyclosporine A (CsA) immunosuppressive therapies. Methods: Kidney transplant recipients r... Abstract

Cited 11 times since 2014 (1 per year) source: EuropePMC

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, Volume 22, Issue 4, 1 1 2014, Pages 793-800 Radiographic prevalence of CAM-type femoroacetabular impingement after open reduction and internal fixation of femoral neck fractures. Mathew G, Kowalczuk M, Hetaimish B, Bedi A, Philippon MJ, Bhandari M, Simunovic N, Crouch S, Ayeni OR, FAITH Investigators

Purpose: The purpose of this study was to estimate the radiographic prevalence of CAM-type femoroacetabular impingement (FAI) in elderly patients (≥ 50 years) who have undergone internal fixation for femoral neck fracture. Methods: A total of 187 frog-leg lateral radiographs of elderly patients who underwent internal fixation for a femoral neck fracture were reviewed by two independent reviewers. The alpha angle, beta angle, and femoral head-neck offset ratio were calculated. The presence of two... Abstract

Cited 133 times since 2014 (11.7 per year) source: EuropePMC

European heart journal, Volume 35, Issue 22, 31 5 2014, Pages 1466-1478 The atrial fibrillation ablation pilot study: a European Survey on Methodology and results of catheter ablation for atrial fibrillation conducted by the European Heart Rhythm Association. Arbelo E, Brugada J, Hindricks G, Maggioni AP, Tavazzi L, Vardas P, Laroche C, Anselme F, Inama G, Jais P, Kalarus Z, Kautzner J, Lewalter T, Mairesse GH, Perez-Villacastin J, Riahi S, Taborsky M, Theodorakis G, Trines SA, Atrial Fibrillation Ablation Pilot Study Investigators

Aims: The Atrial Fibrillation Ablation Pilot Study is a prospective registry designed to describe the clinical epidemiology of patients undergoing an atrial fibrillation (AFib) ablation, and the diagnostic/therapeutic processes applied across Europe. The aims of the 1-year follow-up were to analyse how centres assess in routine clinical practice the success of the procedure and to evaluate the success rate and long-term safety/complications. Methods and results: Seventy-two centres in 10 Europea... Abstract

Cited 5 times since 2014 (0.4 per year) source: EuropePMC

The international journal of cardiovascular imaging, Volume 30, Issue 3, 31 5 2014, Pages 583-589 Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia. van Ramshorst J, Beeres SL, Rodrigo SF, Dibbets-Schneider P, Scholte AJ, Fibbe WE, Zwaginga JJ, Schalij MJ, Bax JJ, Atsma DE

Intramyocardial bone marrow cell injection has been associated with improvements in myocardial perfusion and left ventricular function. The current substudy of a randomized, placebo-controlled, double-blinded study, investigated the effect of intramyocardial bone marrow cell injection on myocardial sympathetic innervation in patients with chronic myocardial ischemia. In a total of 16 patients (64 ± 8 years, 13 men), early and late iodine-123 metaiodobenzylguanidine (MIBG) imaging was performed b... Abstract

Cited 18 times since 2014 (1.6 per year) source: EuropePMC

BMC evolutionary biology, Volume 14, 30 5 2014, Pages 18 The effect of host social system on parasite population genetic structure: comparative population genetics of two ectoparasitic mites and their bat hosts. van Schaik J, Kerth G, Bruyndonckx N, Christe P

Background: The population genetic structure of a parasite, and consequently its ability to adapt to a given host, is strongly linked to its own life history as well as the life history of its host. While the effects of parasite life history on their population genetic structure have received some attention, the effect of host social system has remained largely unstudied. In this study, we investigated the population genetic structure of two closely related parasitic mite species (Spinturnix myo... Abstract

Cited 100 times since 2014 (8.8 per year) source: EuropePMC

Journal of the American College of Cardiology, Volume 63, Issue 12, 30 5 2014, Pages 1200-1210 Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese. Lubitz SA, Lunetta KL, Lin H, Arking DE, Trompet S, Li G, Krijthe BP, Chasman DI, Barnard J, Kleber ME, Dörr M, Ozaki K, Smith AV, Müller-Nurasyid M, Walter S, Agarwal SK, Bis JC, Brody JA, Chen LY, Everett BM, Ford I, Franco OH, Harris TB, Hofman A, Kääb S, Mahida S, Kathiresan S, Kubo M, Launer LJ, MacFarlane PW, Magnani JW, McKnight B, McManus DD, Peters A, Psaty BM, Rose LM, Rotter JI, Silbernagel G, Smith JD, Sotoodehnia N, Stott DJ, Taylor KD, Tomaschitz A, Tsunoda T, Uitterlinden AG, Van Wagoner DR, Völker U, Völzke H, Murabito JM, Sinner MF, Gudnason V, Felix SB, März W, Chung M, Albert CM, Stricker BH, Tanaka T, Heckbert SR, Jukema JW, Alonso A, Benjamin EJ, Ellinor PT

Objectives: This study sought to identify nonredundant atrial fibrillation (AF) genetic susceptibility signals and examine their cumulative relations with AF risk. Background: AF-associated loci span broad genomic regions that may contain multiple susceptibility signals. Whether multiple signals exist at AF loci has not been systematically explored. Methods: We performed association testing conditioned on the most significant, independently associated genetic markers at 9 established AF loci usi... Abstract

Cited 16 times since 2014 (1.4 per year) source: EuropePMC

Journal of virology, Volume 88, Issue 8, 29 5 2014, Pages 4595-4599 Novel avian-origin influenza A (H7N9) virus attachment to the respiratory tract of five animal models. Siegers JY, Short KR, Leijten LM, de Graaf M, Spronken MI, Schrauwen EJ, Marshall N, Lowen AC, Gabriel G, Osterhaus AD, Kuiken T, van Riel D

We determined the pattern of attachment of the avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs, and guinea pigs and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This information contributes to our knowledge of the different animal models for influenza. Abstract

Cited 8 times since 2014 (0.7 per year) source: EuropePMC

PloS one, Volume 9, Issue 1, 27 4 2014, Pages e86522 Leukotriene B4 levels in human atherosclerotic plaques and abdominal aortic aneurysms. van den Borne P, van der Laan SW, Bovens SM, Koole D, Kowala MC, Michael LF, Schoneveld AH, van de Weg SM, Velema E, de Vries JP, de Borst GJ, Moll FL, de Kleijn DP, Quax PH, Hoefer IE, Pasterkamp G

Background: Leukotriene B4 (LTB4) has been associated with the initiation and progression of atherosclerosis and abdominal aortic aneurysm (AAA) formation. However, associations of LTB4 levels with tissue characteristics and adverse clinical outcome of advanced atherosclerosis and AAA are scarcely studied. We hypothesized that LTB4 levels are associated with a vulnerable plaque phenotype and adverse clinical outcome. Furthermore, that LTB4 levels are associated with inflammatory AAA and adverse... Abstract

Cited 54 times since 2014 (4.7 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 148, Issue 4, 25 4 2014, Pages 1583-1590 Ascending aorta dilation in association with bicuspid aortic valve: a maturation defect of the aortic wall. Grewal N, Gittenberger-de Groot AC, Poelmann RE, Klautz RJ, Lindeman JH, Goumans MJ, Palmen M, Mohamed SA, Sievers HH, Bogers AJ, DeRuiter MC

Objective: Patients with a bicuspid aortic valve have increased susceptibility to the development of ascending aortic dilation and dissection compared with persons with a tricuspid valve. To unravel a possible different mechanism underlying dilation in bicuspidy and tricuspidy, a comparison of the structure of the aortic wall was made. Methods: Ascending aortic wall biopsies were divided into 4 groups: bicuspid (n=36) and tricuspid (n=23) without and with dilation. The expression of vascular smo... Abstract

Cited 19 times since 2014 (1.7 per year) source: EuropePMC

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, Volume 122, Issue 1, 24 4 2014, Pages 60-63 CYP2C9*2 allele increases risk for hypoglycemia in POR*1/*1 type 2 diabetic patients treated with sulfonylureas. Ragia G, Tavridou A, Elens L, Van Schaik RH, Manolopoulos VG

It is previously shown that carriers of the defective allele CYP2C9*3 that leads to impaired sulfonylurea metabolism are at increased sulfonylurea-induced hypoglycemia risk due to diminished drug metabolism, whereas no effect of CYP2C9*2 allele was found. Recently, a polymorphism in P450 oxidoreductase (POR) gene, assigned as POR*28 allele, was associated with increased CYP2C9 activity. The aim of this study was to assess i) the effect of POR*28 allele on sulfonylurea-induced hypoglycemia risk a... Abstract

Cited 91 times since 2014 (8 per year) source: EuropePMC

Lung cancer (Amsterdam, Netherlands), Volume 84, Issue 1, 23 4 2014, Pages 86-91 EGFR mutated non-small cell lung cancer patients: more prone to development of bone and brain metastases? Hendriks LE, Smit EF, Vosse BA, Mellema WW, Heideman DA, Bootsma GP, Westenend M, Pitz C, de Vries GJ, Houben R, Grünberg K, Bendek M, Speel EJ, Dingemans AM

Objectives: Both bone and brain are frequent sites of metastasis in non-small cell lung cancer (NSCLC). Conflicting data exist whether EGFR mutant (+) patients are more prone to develop brain metastases or have a better outcome with brain metastases compared to EGFR/KRAS wildtype (WT) or KRAS+ patients. For bone metastases this has not been studied. Methods: In this retrospective case-control study all EGFR+ (exons 19 and 21) patients diagnosed at two pathology departments were selected (2004/20... Abstract