Research

Publications

Below you can find a list of our published research.

8684 results

Cited 65 times since 2014 (5.7 per year) source: EuropePMC

Arthritis research & therapy, Volume 16, Issue 1, 22 4 2014, Pages R19 Adiposity and hand osteoarthritis: the Netherlands Epidemiology of Obesity study. Visser AW, Ioan-Facsinay A, de Mutsert R, Widya RL, Loef M, de Roos A, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M, NEO Study Group

Introduction: Obesity, usually characterized by the body mass index (BMI), is a risk factor for hand osteoarthritis (OA). We investigated whether adipose tissue and abdominal fat distribution are associated with hand OA. Methods: The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort aged 45 to 65 years, including 5315 participants (53% women, median BMI 29.9 kg/m²). Fat percentage and fat mass (FM) (kg) were estimated using bioelectrical impedance analysis. The waist-t... Abstract

Cited 34 times since 2014 (3 per year) source: EuropePMC

Environmental science & technology, Volume 48, Issue 3, 22 4 2014, Pages 1753-1761 Chromium(III) complexation to natural organic matter: mechanisms and modeling. Gustafsson JP, Persson I, Oromieh AG, van Schaik JW, Sjöstedt C, Kleja DB

Chromium is a common soil contaminant, and it often exists as chromium(III). However, limited information exists on the coordination chemistry and stability of chromium(III) complexes with natural organic matter (NOM). Here, the complexation of chromium(III) to mor layer material and to Suwannee River Fulvic Acid (SRFA) was investigated using EXAFS spectroscopy and batch experiments. The EXAFS results showed a predominance of monomeric chromium(III)-NOM complexes at low pH ( 5 there were polynuc... Abstract

Cited 50 times since 2014 (4.4 per year) source: EuropePMC

PloS one, Volume 9, Issue 1, 22 4 2014, Pages e85197 Mobile HIV screening in Cape Town, South Africa: clinical impact, cost and cost-effectiveness. Bassett IV, Govindasamy D, Erlwanger AS, Hyle EP, Kranzer K, van Schaik N, Noubary F, Paltiel AD, Wood R, Walensky RP, Losina E, Bekker LG, Freedberg KA

Background: Mobile HIV screening may facilitate early HIV diagnosis. Our objective was to examine the cost-effectiveness of adding a mobile screening unit to current medical facility-based HIV testing in Cape Town, South Africa. Methods and findings: We used the Cost Effectiveness of Preventing AIDS Complications International (CEPAC-I) computer simulation model to evaluate two HIV screening strategies in Cape Town: 1) medical facility-based testing (the current standard of care) and 2) addition... Abstract

Cited 33 times since 2014 (2.9 per year) source: EuropePMC

Advances in health sciences education : theory and practice, Volume 19, Issue 4, 22 4 2014, Pages 565-580 Interpretation of radiological images: towards a framework of knowledge and skills. van der Gijp A, van der Schaaf MF, van der Schaaf IC, Huige JC, Ravesloot CJ, van Schaik JP, Ten Cate TJ

The knowledge and skills that are required for radiological image interpretation are not well documented, even though medical imaging is gaining importance. This study aims to develop a comprehensive framework of knowledge and skills, required for two-dimensional and multiplanar image interpretation in radiology. A mixed-method study approach was applied. First, a literature search was performed to identify knowledge and skills that are important for image interpretation. Three databases, PubMed... Abstract

Cited 22 times since 2014 (1.9 per year) source: EuropePMC

Heart rhythm, Volume 11, Issue 5, 22 4 2014, Pages 806-813 QRS fusion complex analysis using wave interference to predict reverse remodeling during cardiac resynchronization therapy. Sweeney MO, Hellkamp AS, van Bommel RJ, Schalij MJ, Borleffs CJ, Bax JJ

Background: Biventricular (BV) electrical wavefront fusion can induce improvement in left ventricular (LV) size and function during cardiac resynchronization therapy (CRT). Changes in BV wave propagation sequence and duration register in the QRS complex on the standard electrocardiogram. We developed a wave interference method for the characterization of BV fusion to predict LV reverse remodeling. Objective: To develop a simple electrocardiographic method for predicting reverse remodeling during... Abstract

Cited 103 times since 2014 (9 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 100, Issue 12, 21 3 2014, Pages 960-968 Significant lead-induced tricuspid regurgitation is associated with poor prognosis at long-term follow-up. Höke U, Auger D, Thijssen J, Wolterbeek R, van der Velde ET, Holman ER, Schalij MJ, Bax JJ, Delgado V, Marsan NA

Background: Although the presence of an RV lead is a potential cause of tricuspid regurgitation (TR), the clinical impact of significant lead-induced TR is unknown. Objective: To evaluate the effect of significant lead-induced TR on cardiac performance and long-term outcome after cardioverter-defibrillator (ICD) or pacemaker implantation. Methods: A retrospective cohort of 239 ICD (n=191) or pacemaker (n=48) recipients (age 60±14 years, 77% male) from a tertiary care university hospital, with an... Abstract

Cited 17 times since 2014 (1.5 per year) source: EuropePMC

Critical care (London, England), Volume 18, Issue 1, 20 3 2014, Pages R18 Neurofilaments as a plasma biomarker for ICU-acquired weakness: an observational pilot study. Wieske L, Witteveen E, Petzold A, Verhamme C, Schultz MJ, van Schaik IN, Horn J

Introduction: Early diagnosis of intensive care unit - acquired weakness (ICU-AW) using the current reference standard, that is, assessment of muscle strength, is often hampered due to impaired consciousness. Biological markers could solve this problem but have been scarcely investigated. We hypothesized that plasma levels of neurofilaments are elevated in ICU-AW and can diagnose ICU-AW before muscle strength assessment is possible. Methods: For this prospective observational cohort study, neuro... Abstract

Cited 22 times since 2014 (1.9 per year) source: EuropePMC

Kidney international, Volume 85, Issue 6, 15 3 2014, Pages 1444-1453 Genetic and in vivo determinants of glucocorticoid sensitivity in relation to clinical outcome of childhood nephrotic syndrome. Teeninga N, Kist-van Holthe JE, van den Akker EL, Kersten MC, Boersma E, Krabbe HG, Knoers NV, van der Heijden AJ, Koper JW, Nauta J

Following initial glucocorticoid treatment, the clinical course in children with nephrotic syndrome is highly variable. Intrinsic sensitivity to glucocorticoids might be a determinant of this variability. Functional polymorphisms of the glucocorticoid receptor gene NR3C1 have been associated with either relatively impaired (GR-9β) or increased (BclI) glucocorticoid sensitivity. Here, in a prospective, well-defined cohort of children with nephrotic syndrome, we evaluated both carriage of GR-9β+Tt... Abstract

Cited 23 times since 2014 (2 per year) source: EuropePMC

Pharmacology, biochemistry, and behavior, Volume 121, 15 3 2014, Pages 184-188 The 5-HT₁A receptor C(1019)G polymorphism influences the intravaginal ejaculation latency time in Dutch Caucasian men with lifelong premature ejaculation. Janssen PK, van Schaik R, Zwinderman AH, Olivier B, Waldinger MD

Introduction: Lifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 min, and has been postulated as a neurobiological dysfunction related to diminished serotonergic neurotransmission with 5-HT₁A receptor hyperfunction and 5-HT₂C hypofunction. Aim: To investigate the relationship between 5-HT₁A receptor gene (HTR₁A)-C(1019)G promoter polymorphism and IELT in men with LPE. This polymorphism is known to increase 5-HT1A rece... Abstract

Cited 27 times since 2014 (2.4 per year) source: EuropePMC

The Journal of thoracic and cardiovascular surgery, Volume 148, Issue 4, 15 3 2014, Pages 1490-1497 Exercise capacity in children after total cavopulmonary connection: lateral tunnel versus extracardiac conduit technique. Bossers SS, Helbing WA, Duppen N, Kuipers IM, Schokking M, Hazekamp MG, Bogers AJ, Ten Harkel AD, Takken T

Objectives: In patients with univentricular heart disease, the total cavopulmonary connection (TCPC) is the preferred treatment. TCPC can be performed using the intra-atrial lateral tunnel (ILT) or extracardiac conduit (ECC) technique. The purpose of the present study was to evaluate exercise capacity in contemporary TCPC patients and compare the results between the 2 techniques. Methods: A total of 101 TCPC patients (ILT, n=42; ECC, n=59; age, 12.2±2.6 years; age at TCPC completion, 3.2±1.1 yea... Abstract

Cited 73 times since 2014 (6.4 per year) source: EuropePMC

International journal of epidemiology, Volume 43, Issue 3, 14 2 2014, Pages 878-886 Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers. Deelen J, Beekman M, Codd V, Trompet S, Broer L, Hägg S, Fischer K, Thijssen PE, Suchiman HE, Postmus I, Uitterlinden AG, Hofman A, de Craen AJ, Metspalu A, Pedersen NL, van Duijn CM, Jukema JW, Houwing-Duistermaat JJ, Samani NJ, Slagboom PE

Background: Human leukocyte telomere length (LTL) decreases with age and shorter LTL has previously been associated with increased prospective mortality. However, it is not clear whether LTL merely marks the health status of an individual by its association with parameters of immune function, for example, or whether telomere shortening also contributes causally to lifespan variation in humans. Methods: We measured LTL in 870 nonagenarian siblings (mean age 93 years), 1580 of their offspring and... Abstract

Cited 13 times since 2014 (1.1 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 27, Issue 3, 13 2 2014, Pages 239-248 Association between multilayer left ventricular rotational mechanics and the development of left ventricular remodeling after acute myocardial infarction. Abate E, Hoogslag GE, Leong DP, Bertini M, Antoni ML, Nucifora G, Joyce E, Holman ER, Siebelink HM, Schalij MJ, Bax JJ, Delgado V, Ajmone Marsan N

Background: The identification of patients at risk for developing left ventricular (LV) remodeling after acute myocardial infarction (AMI) has crucial prognostic implications. The aims of this study were (1) to investigate the relationship between peak subepicardial and subendocardial twist and infarct transmurality, as assessed using contrast-enhanced magnetic resonance imaging, and (2) to evaluate the association between peak subepicardial and subendocardial twist and LV remodeling 6 months af... Abstract

Cited 6 times since 2014 (0.5 per year) source: EuropePMC

Journal of vascular surgery, Volume 59, Issue 5, 11 2 2014, Pages 1315-22.e1 National variation in the utilization of alternative imaging in peripheral arterial disease. de Vos MS, Hawkins AT, Hevelone ND, Hamming JF, Nguyen LL

Objective: The value and cost-effectiveness of less invasive alternative imaging (AI) modalities (duplex ultrasound scanning, computed tomography angiography, and magnetic resonance angiography) in the care of peripheral arterial disease (PAD) has been reported; however, there is no consensus on their role. We hypothesized that AI utilization is low compared with angiography in the United States and that patient and hospital characteristics are both associated with AI utilization. Methods: The N... Abstract

Cited 15 times since 2014 (1.3 per year) source: EuropePMC

BMC genomics, Volume 15, 10 2 2014, Pages 16 Generation of SNP datasets for orangutan population genomics using improved reduced-representation sequencing and direct comparisons of SNP calling algorithms. Greminger MP, Stölting KN, Nater A, Goossens B, Arora N, Bruggmann R, Patrignani A, Nussberger B, Sharma R, Kraus RH, Ambu LN, Singleton I, Chikhi L, van Schaik CP, Krützen M

Background: High-throughput sequencing has opened up exciting possibilities in population and conservation genetics by enabling the assessment of genetic variation at genome-wide scales. One approach to reduce genome complexity, i.e. investigating only parts of the genome, is reduced-representation library (RRL) sequencing. Like similar approaches, RRL sequencing reduces ascertainment bias due to simultaneous discovery and genotyping of single-nucleotide polymorphisms (SNPs) and does not require... Abstract

Cited 6 times since 2014 (0.5 per year) source: EuropePMC

Public health, Volume 128, Issue 2, 10 2 2014, Pages 195-201 Democratizing the world health organization. van de Pas R, van Schaik LG

A progressive erosion of the democratic space appears as one of the emerging challenges in global health today. Such delimitation of the political interplay has a particularly evident impact on the unique public interest function of the World Health Organization (WHO). This paper aims to identify some obstacles for a truly democratic functioning of the UN specialized agency for health. The development of civil society's engagement with the WHO, including in the current reform proposals, is... Abstract

Cited 33 times since 2014 (2.9 per year) source: EuropePMC

Journal of internal medicine, Volume 275, Issue 6, 9 2 2014, Pages 621-630 The cardiokine secreted Frizzled-related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure. Askevold ET, Aukrust P, Nymo SH, Lunde IG, Kaasbøll OJ, Aakhus S, Florholmen G, Ohm IK, Strand ME, Attramadal H, Fiane A, Dahl CP, Finsen AV, Vinge LE, Christensen G, Yndestad A, Gullestad L, Latini R, Masson S, Tavazzi L, GISSI-HF Investigators, Ueland T

Objectives: Experimental studies have shown involvement of Wnt signalling in heart failure (HF). We hypothesized that secreted frizzled-related protein 3 (sFRP3), a modulator of Wnt signalling, is related to the progression of HF. Design: Circulating sFRP3 was measured in 153 HF patients and compared with 25 healthy controls. The association of sFRP3 with mortality was evaluated in 1202 patients (GISSI-HF trial). sFRP3 mRNA expression was assessed in failing human and murine left ventricles (LV)... Abstract

Cited 13 times since 2014 (1.1 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 34, Issue 3, 9 2 2014, Pages 594-602 Absence of chemokine (C-x-C motif) ligand 10 diminishes perfusion recovery after local arterial occlusion in mice. van den Borne P, Haverslag RT, Brandt MM, Cheng C, Duckers HJ, Quax PH, Hoefer IE, Pasterkamp G, de Kleijn DP

Objective: In arteriogenesis, pre-existing anastomoses undergo enlargement to restore blood flow in ischemic tissues. Chemokine (C-X-C motif) ligand 10 (CXCL10) is secreted after Toll-like receptor activation. Toll-like receptors are involved in arteriogenesis; however, the role of CXCL10 is still unclear. In this study, we investigated the role for CXCL10 in a murine hindlimb ischemia model. Approach and results: Unilateral femoral artery ligation was performed in wild-type (WT) and CXCL10(-/-)... Abstract

Revista espanola de cardiologia (English ed.), Volume 67, Issue 2, 8 2 2014, Pages 157 Appropriate use criteria for cardiopulmonary exercise testing in patients with cardiac resynchronization devices. Response. de Riva-Silva M, López-Gil M, Fontenla-Cerezuela A, Arribas-Ynsaurriaga F

Abstract

Cited 25 times since 2014 (2.2 per year) source: EuropePMC

Human gene therapy, Volume 25, Issue 1, 7 1 2014, Pages 41-49 Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia. Lijkwan MA, Hellingman AA, Bos EJ, van der Bogt KE, Huang M, Kooreman NG, de Vries MR, Peters HA, Robbins RC, Hamming JF, Quax PH, Wu JC

In this study, we target the hypoxia inducible factor-1 alpha (HIF-1-alpha) pathway by short hairpin RNA interference therapy targeting prolyl hydroxylase-2 (shPHD2). We use the minicircle (MC) vector technology as an alternative for conventional nonviral plasmid (PL) vectors in order to improve neovascularization after unilateral hindlimb ischemia in a murine model. Gene expression and transfection efficiency of MC and PL, both in vitro and in vivo, were assessed using bioluminescence imaging (... Abstract

Cited 3 times since 2014 (0.3 per year) source: EuropePMC

International journal of cardiology, Volume 172, Issue 1, 4 1 2014, Pages e3-5 Confounding factors in the relation between high sensitivity cardiac troponin T levels in serum and infarct size of patients with first ST-elevation myocardial infarction. Cobbaert CM, Bootsma M, Boden H, Ahmed TA, Hoogslag GE, Romijn FP, Ballieux BE, Wolterbeek R, Hermens WT, Schalij MJ, van der Laarse A

Abstract