8684 results
Cited 14 times since 2013 (1.2 per year)
source: EuropePMC
JMIR research protocols,
Volume 2, Issue 2, 17 3 2013, Pages e54
Evaluation of the Compliance, Acceptance, and Usability of a Web-Based eHealth Intervention for Parents of Children With Infantile Hemangiomas: Usability Study.
de Graaf M, Totte J, Breugem C, van Os-Medendorp H, Pasmans S
Background: Infantile hemangiomas (IH) are common benign vascular tumors in children. Recognition and timely referral of high risk IH to specialized centers is important. This might be achieved by involving parents in the care for IH by means of an eHealth intervention. Objective: The objective of our study was to evaluate parent compliance, acceptance, and usability of an open access, Web-based eHealth intervention (including e-learning and e-consult) designed to increase parents' knowledg...
Abstract
Cited 52 times since 2013 (4.5 per year)
source: EuropePMC
Drug discovery today,
Volume 19, Issue 7, 17 3 2013, Pages 859-868
Data-driven medicinal chemistry in the era of big data.
Lusher SJ, McGuire R, van Schaik RC, Nicholson CD, de Vlieg J
Science, and the way we undertake research, is changing. The increasing rate of data generation across all scientific disciplines is providing incredible opportunities for data-driven research, with the potential to transform our current practices. The exploitation of so-called 'big data' will enable us to undertake research projects never previously possible but should also stimulate a re-evaluation of all our data practices. Data-driven medicinal chemistry approaches have the potenti...
Abstract
Cited 21 times since 2013 (1.8 per year)
source: EuropePMC
Journal of medical genetics,
Volume 51, Issue 2, 16 3 2013, Pages 122-131
A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.
Oei L, Hsu YH, Styrkarsdottir U, Eussen BH, de Klein A, Peters MJ, Halldorsson B, Liu CT, Alonso N, Kaptoge SK, Thorleifsson G, Hallmans G, Hocking LJ, Husted LB, Jameson KA, Kruk M, Lewis JR, Patel MS, Scollen S, Svensson O, Trompet S, van Schoor NM, Zhu K, Buckley BM, Cooper C, Ford I, Goltzman D, González-Macías J, Langdahl BL, Leslie WD, Lips P, Lorenc RS, Olmos JM, Pettersson-Kymmer U, Reid DM, Riancho JA, Slagboom PE, Garcia-Ibarbia C, Ingvarsson T, Johannsdottir H, Luben R, Medina-Gómez C, Arp P, Nandakumar K, Palsson ST, Sigurdsson G, van Meurs JB, Zhou Y, Hofman A, Jukema JW, Pols HA, Prince RL, Cupples LA, Marshall CR, Pinto D, Sato D, Scherer SW, Reeve J, Thorsteinsdottir U, Karasik D, Richards JB, Stefansson K, Uitterlinden AG, Ralston SH, Ioannidis JP, Kiel DP, Rivadeneira F, Estrada K
Background: Osteoporosis is a systemic skeletal disease characterised by reduced bone mineral density and increased susceptibility to fracture; these traits are highly heritable. Both common and rare copy number variants (CNVs) potentially affect the function of genes and may influence disease risk. Aim: To identify CNVs associated with osteoporotic bone fracture risk. Method: We performed a genome-wide CNV association study in 5178 individuals from a prospective cohort in the Netherlands, inclu...
Abstract
Cited 175 times since 2013 (15.2 per year)
source: EuropePMC
EMBO reports,
Volume 15, Issue 1, 15 3 2013, Pages 62-69
Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion.
Snippert HJ, Schepers AG, van Es JH, Simons BD, Clevers H
The concept of 'field cancerization' describes the clonal expansion of genetically altered, but morphologically normal cells that predisposes a tissue to cancer development. Here, we demonstrate that biased stem cell competition in the mouse small intestine can initiate the expansion of such clones. We quantitatively analyze how the activation of oncogenic K-ras in individual Lgr5(+) stem cells accelerates their cell division rate and creates a biased drift towards crypt clonality. K-r...
Abstract
Cited 18 times since 2013 (1.6 per year)
source: EuropePMC
The Journal of infectious diseases,
Volume 209, Issue 11, 13 2 2013, Pages 1781-1791
Streptococcus pneumoniae arginine synthesis genes promote growth and virulence in pneumococcal meningitis.
Piet JR, Geldhoff M, van Schaik BD, Brouwer MC, Valls Seron M, Jakobs ME, Schipper K, Pannekoek Y, Zwinderman AH, van der Poll T, van Kampen AH, Baas F, van der Ende A, van de Beek D
Streptococcus pneumoniae (pneumococcus) is a major human pathogen causing pneumonia, sepsis and bacterial meningitis. Using a clinical phenotype based approach with bacterial whole-genome sequencing we identified pneumococcal arginine biosynthesis genes to be associated with outcome in patients with pneumococcal meningitis. Pneumococci harboring these genes show increased growth in human blood and cerebrospinal fluid (CSF). Mouse models of meningitis and pneumonia showed that pneumococcal strain...
Abstract
Cited 12 times since 2013 (1 per year)
source: EuropePMC
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Volume 55, Issue 1, 12 2 2013, Pages 50-57
Additional diagnostic value of integrated analysis of cardiac CTA and SPECT MPI using the SMARTVis system in patients with suspected coronary artery disease.
Kirişli HA, Gupta V, Shahzad R, Al Younis I, Dharampal A, Geuns RJ, Scholte AJ, de Graaf MA, Joemai RM, Nieman K, van Vliet L, van Walsum T, Lelieveldt B, Niessen WJ
Unlabelled: CT angiography (CTA) and SPECT myocardial perfusion imaging (MPI) are complementary imaging techniques to assess coronary artery disease (CAD). Spatial integration and combined visualization of SPECT MPI and CTA data may facilitate correlation of myocardial perfusion defects and subtending coronary arteries and thus offer additional diagnostic value over either stand-alone or side-by-side interpretation of the respective datasets from the 2 modalities. In this study, we investigated...
Abstract
Cited 44 times since 2013 (3.8 per year)
source: EuropePMC
Osteoarthritis and cartilage,
Volume 22, Issue 2, 12 2 2013, Pages 197-202
The role of fat mass and skeletal muscle mass in knee osteoarthritis is different for men and women: the NEO study.
Visser AW, de Mutsert R, Loef M, le Cessie S, den Heijer M, Bloem JL, Reijnierse M, Rosendaal FR, Kloppenburg M, NEO Study Group
Objective: To investigate if the amount of fat mass (FM) or skeletal muscle mass (SMM) is more strongly associated with knee osteoarthritis (OA), in both men and women. Methods: The Netherlands Epidemiology of Obesity (NEO) study is a population-based cohort aged 45-65 years, including 5313 participants (53% female, median body mass index (BMI) 29.9 kg/m(2)). FM (kg), fat percentage, SMM (kg) and skeletal muscle (SM) percentage were estimated using bioelectrical impedance analysis (BIA). Clinica...
Abstract
Cited 632 times since 2013 (55 per year)
source: EuropePMC
European urology,
Volume 65, Issue 4, 12 2 2013, Pages 778-792
EAU guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2013 guidelines.
Witjes JA, Compérat E, Cowan NC, De Santis M, Gakis G, Lebret T, Ribal MJ, Van der Heijden AG, Sherif A, European Association of Urology
Context: The European Association of Urology (EAU) guidelines panel on Muscle-invasive and Metastatic bladder cancer (BCa) updates its guidelines yearly. This updated summary provides a synthesis of the 2013 guidelines document, with emphasis on the latest developments. Objective: To provide graded recommendations on the diagnosis and treatment of patients with muscle-invasive BCa (MIBC), linked to a level of evidence. Evidence acquisition: For each section of the guidelines, comprehensive liter...
Abstract
Cited 58 times since 2013 (5 per year)
source: EuropePMC
International journal of cancer,
Volume 134, Issue 11, 12 2 2013, Pages 2663-2673
Intraoperative fluorescence delineation of head and neck cancer with a fluorescent anti-epidermal growth factor receptor nanobody.
van Driel PB, van der Vorst JR, Verbeek FP, Oliveira S, Snoeks TJ, Keereweer S, Chan B, Boonstra MC, Frangioni JV, van Bergen en Henegouwen PM, Vahrmeijer AL, Lowik CW
Intraoperative near-infrared (NIR) fluorescence imaging is a technology with high potential to provide the surgeon with real-time visualization of tumors during surgery. Our study explores the feasibility for clinical translation of an epidermal growth factor receptor (EGFR)-targeting nanobody for intraoperative imaging and resection of orthotopic tongue tumors and cervical lymph node metastases. The anti-EGFR nanobody 7D12 and the negative control nanobody R2 were conjugated to the NIR fluoroph...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
The American journal of cardiology,
Volume 113, Issue 5, 12 2 2013, Pages 772-778
Prognostic value of aortic and mitral valve calcium detected by contrast cardiac computed tomography angiography in patients with suspicion of coronary artery disease.
Kamperidis V, de Graaf MA, Broersen A, Ahmed W, Sianos G, Delgado V, Dijkstra J, Bax JJ, Scholte AJ
Aortic valve calcium (VC) detected on noncontrast cardiac computed tomography angiography (CCTA) is known to be associated with all-cause mortality in asymptomatic and primary prevention population. However, the clinical significance of aortic and mitral VC remains unknown in symptomatic patients with suspected coronary artery disease (CAD). The aim of the present study was to assess whether aortic and mitral VC is independently associated with cardiac events and all-cause mortality in symptomat...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
Journal of biomolecular screening,
Volume 19, Issue 2, 11 2 2013, Pages 287-296
A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels.
Baas R, Lelieveld D, van Teeffelen H, Lijnzaad P, Castelijns B, van Schaik FM, Vermeulen M, Egan DA, Timmers HT, de Graaf P
Posttranslational modifications of histones play an important role in the regulation of gene expression and chromatin structure in eukaryotes. The balance between chromatin factors depositing (writers) and removing (erasers) histone marks regulates the steady-state levels of chromatin modifications. Here we describe a novel microscopy-based screening method to identify proteins that regulate histone modification levels in a high-throughput fashion. We named our method CROSS, for Chromatin Regula...
Abstract
Cited 2 times since 2013 (0.2 per year)
source: EuropePMC
Neural computation,
Volume 26, Issue 3, 9 2 2013, Pages 472-496
Approximate, computationally efficient online learning in Bayesian spiking neurons.
Kuhlmann L, Hauser-Raspe M, Manton JH, Grayden DB, Tapson J, van Schaik A
Bayesian spiking neurons (BSNs) provide a probabilistic interpretation of how neurons perform inference and learning. Online learning in BSNs typically involves parameter estimation based on maximum-likelihood expectation-maximization (ML-EM) which is computationally slow and limits the potential of studying networks of BSNs. An online learning algorithm, fast learning (FL), is presented that is more computationally efficient than the benchmark ML-EM for a fixed number of time steps as the numbe...
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
Urology,
Volume 83, Issue 2, 9 2 2013, Pages 508.e7-12
The effect of intracavernosal avanafil, a newer phosphodiesterase-5 inhibitor, on neonatal type 2 diabetic rats with erectile dysfunction.
Yilmaz D, Bayatli N, Un O, Kadowitz PJ, Sikka SC, Gur S
Objective: To determine the effect of avanafil, a novel phosphodiesterase-5 inhibitor, on the treatment of erectile dysfunction associated with type 2 diabetes mellitus (T2DM). Methods: In 2-day-old rats, T2DM was induced by single intraperitoneal injection of 90 mg/kg of streptozotocin (STZ; i.p.). Erectile responses were evaluated after 10 weeks on intracavernosal injection of avanafil (1 μM) to anesthetized rats and data expressed as intracavernosal pressure (ICP)/mean arterial pressure and t...
Abstract
Cited 17 times since 2013 (1.5 per year)
source: EuropePMC
BMC nephrology,
Volume 14, 9 2 2013, Pages 273
Time of injury affects urinary biomarker predictive values for acute kidney injury in critically ill, non-septic patients.
de Geus HR, Fortrie G, Betjes MG, van Schaik RH, Groeneveld AB
Background: The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has been reported in the literature. We studied the influence of timing on the predictive values of tubular proteins, measured before the rise of serum creatinine (SCr) in critically ill, non-septic patients. Methods: Seven hundred adult critically ill patients were prospectively i...
Abstract
Cited 6 times since 2013 (0.5 per year)
source: EuropePMC
European journal of trauma and emergency surgery : official publication of the European Trauma Society,
Volume 40, Issue 3, 4 1 2013, Pages 373-378
The prognostic value of plasma Δ-copeptin levels in patients with isolated traumatic brain injury.
Cavus UY, Yildirim S, Gurer B, Dibek K, Yilmaz D, Ozturk G, Buyukcam F, Sonmez E
Purpose: Traumatic brain injury (TBI) is one of the most common causes of death among trauma patients. Earlier prediction of possible poor neurological outcomes, even upon admission to the emergency department, may help to guide treatment. The aim of this prospective study was to assess the predictive value of plasma copeptin levels for early morbidity and mortality in patients with isolated TBI. Methods: This prospective study comprised 53 patients who were admitted to the emergency department...
Abstract
Cited 1 times since 2013 (0.1 per year)
source: EuropePMC
Revista espanola de cardiologia (English ed.),
Volume 67, Issue 1, 3 1 2013, Pages 1-2
Abstracts, articles, citations.
Bax JJ, Delgado V
Abstract
Cited 14 times since 2013 (1.2 per year)
source: EuropePMC
PloS one,
Volume 8, Issue 12, 2 1 2013, Pages e80619
Calf-level factors associated with bovine neonatal pancytopenia--a multi-country case-control study.
Jones BA, Sauter-Louis C, Henning J, Stoll A, Nielen M, Van Schaik G, Smolenaars A, Schouten M, den Uijl I, Fourichon C, Guatteo R, Madouasse A, Nusinovici S, Deprez P, De Vliegher S, Laureyns J, Booth R, Cardwell JM, Pfeiffer DU
Bovine neonatal pancytopenia (BNP), a high fatality condition causing haemorrhages in calves aged less than 4 weeks, was first reported in 2007 in Germany and subsequently observed at low incidence in other European countries and New Zealand. A multi-country matched case-control study was conducted in 2011 to identify calf-level risk factors for BNP. 405 BNP cases were recruited from 330 farms in Belgium, France, Germany and the Netherlands by laboratory confirmation of farmer-reported cases. Up...
Abstract
Cited 32 times since 2013 (2.8 per year)
source: EuropePMC
Journal of dairy science,
Volume 97, Issue 2, 2 1 2013, Pages 715-730
Exploring the value of routinely collected herd data for estimating dairy cattle welfare.
de Vries M, Bokkers EA, van Schaik G, Engel B, Dijkstra T, de Boer IJ
Routine on-farm assessment of dairy cattle welfare is time consuming and, therefore, expensive. A promising strategy to assess dairy cattle welfare more efficiently is to estimate the level of animal welfare based on herd data available in national databases. Our aim was to explore the value of routine herd data (RHD) for estimating dairy cattle welfare at the herd level. From November 2009 through March 2010, 7 trained observers collected data for 41 welfare indicators in a selected sample of 1...
Abstract
Cited 4 times since 2013 (0.3 per year)
source: EuropePMC
The International journal of angiology : official publication of the International College of Angiology, Inc,
Volume 22, Issue 4, 1 1 2013, Pages 213-222
The Use of Intra-aortic Balloon Pump in a Real-World Setting: A Comparison between Survivors and Nonsurvivors from Acute Coronary Syndrome Treated with IABP. The Jakarta Acute Coronary Syndrome Registry.
Dharma S, Dakota I, Firdaus I, Wardeh AJ, Jukema JW
Real-world data on acute coronary syndrome (ACS) patients who received intra-aortic balloon pump (IABP) support are limited. The objective of this study was to evaluate the characteristics of ACS patients who received IABP support from a real-world ACS registry. Patients with ACS (N = 121) who received IABP support were enrolled. Characteristics of survivors and nonsurvivors were compared at 30 days. Mortality rate of patients with ACS who received IABP was 47%. The survivors (N = 64) had less o...
Abstract
Cited 122 times since 2013 (10.6 per year)
source: EuropePMC
Annals of internal medicine,
Volume 159, Issue 12, 1 1 2013, Pages 815-823
Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial.
Meijer CA, Stijnen T, Wasser MN, Hamming JF, van Bockel JH, Lindeman JH, Pharmaceutical Aneurysm Stabilisation Trial Study Group
Background: Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans. Objective: To test whether doxycycline inhibits AAA progression in humans. Design: Randomized, placebo-controlled, double-blind trial. (Dutch Trial Registry: NTR 1345) SETTING: 14 Dutch hospitals. Patients: 286 patients with small AAAs between October 2008 and June 2011. Intervention: Daily d...
Abstract
