6205 results
Radiation and environmental biophysics,
Volume 64, Issue 2, 4 1 2025, Pages 275-289
Commissioning and performance assessment of diodes and MOSFETs in in-vivo dosimetry for external beam radiation therapy.
Al Kharusi O, Al Mamari R, Al Hosni B, Al Amri I, Al Fishawy M, Boulassel MR, Bouchareb Y
The precision of radiation therapy treatment depends on several calibration and quality assurance processes. In-vivo dosimetry (IVD) is used in external beam radiotherapy to evaluate the delivered versus planned dose as a patient-specific quality assurance verification procedure. This study aimed at assessing the performance of diodes (EDP-103G and EDP-203G) and metal oxide semiconductor field-effect transistors (MOSFETs) and corresponding correction factors followed by IVD evaluation in differe...
Abstract
Cited 1 times since 2025 (4.5 per year)
source: EuropePMC
Nature genetics,
Volume 57, Issue 4, 4 1 2025, Pages 815-828
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes.
Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS, Zheng SL, Malarstig A, Gratton J, Bond I, Roselli C, Miller D, Chopade S, Schmidt AF, Abner E, Adams L, Andersson C, Aragam KG, Ärnlöv J, Asselin G, Raja AA, Backman JD, Bartz TM, Biddinger KJ, Biggs ML, Bloom HL, Boersma E, Brandimarto J, Brown MR, Brunak S, Bruun MT, Buckbinder L, Bundgaard H, Carey DJ, Chasman DI, Chen X, Cook JP, Czuba T, de Denus S, Dehghan A, Delgado GE, Doney AS, Dörr M, Dowsett J, Dudley SC, Engström G, Erikstrup C, Esko T, Farber-Eger EH, Felix SB, Finer S, Ford I, Ghanbari M, Ghasemi S, Ghouse J, Giedraitis V, Giulianini F, Gottdiener JS, Gross S, Guðbjartsson DF, Gui H, Gutmann R, Hägg S, Haggerty CM, Hedman ÅK, Helgadottir A, Hemingway H, Hillege H, Hyde CL, Aagaard Jensen B, Jukema JW, Kardys I, Karra R, Kavousi M, Kizer JR, Kleber ME, Køber L, Koekemoer A, Kuchenbaecker K, Lai YP, Lanfear D, Langenberg C, Lin H, Lind L, Lindgren CM, Liu PP, London B, Lowery BD, Luan J, Lubitz SA, Magnusson P, Margulies KB,
Heart failure (HF) is a major contributor to global morbidity and mortality. While distinct clinical subtypes, defined by etiology and left ventricular ejection fraction, are well recognized, their genetic determinants remain inadequately understood. In this study, we report a genome-wide association study of HF and its subtypes in a sample of 1.9 million individuals. A total of 153,174 individuals had HF, of whom 44,012 had a nonischemic etiology (ni-HF). A subset of patients with ni-HF were st...
Abstract
ERJ open research,
Volume 11, Issue 2, 3 1 2025, Pages 619-2024
Enzymatic therapy <i>versus</i> video-assisted thoracoscopic surgery for pleural infections: a systematic review and meta-analysis.
de Jonge WR, Smits B, Ket JCF, Altenburg J, Annema J, Daniels JMA, Dickhoff C, van Dorp M, Braun J, Korevaar DA, Heineman DJ
Aims: Parapneumonic pleural infections are frequently encountered, but the optimal treatment regimen remains controversial. The aim of this systematic review was to investigate whether immediate video-assisted thoracoscopic surgery (VATS) has advantages over intrapleural enzymatic therapy (IET). Methods: We searched MEDLINE, Embase and Web of Science Core Collection till November 2023 and included studies comparing IET and VATS in adult patients with parapneumonic pleural infections. Primary out...
Abstract
Frontiers in medicine,
Volume 12, 3 1 2025, Pages 1492596
Quality assessment of a training program for undergraduate sonography peer tutors: paving the future way for peer-assisted learning in medical ultrasound education.
Weimer J, Yilmaz D, Ille C, Weinmann-Menke J, Müller L, Büchner H, Buggenhagen H, Stäuber M, Neubauer R, Winter L, Weimer A, Dirks K, Künzel J, Rink M, Dionysopoulou A, Lorenz L, Kloeckner R, Recker F, Schiestl L
Introduction: Peer tutoring has been increasingly used to support university sonography teaching, necessitating well-qualified tutors. This study aims to evaluate the quality of a training program for sonography peer tutors developed and implemented at a university hospital. Materials and methods: A training program consisting of 11 modules was developed and subsequently evaluated for success with two subjective and two objective assessments of peer-tutoring quality. The two subjective assessmen...
Abstract
Interdisciplinary cardiovascular and thoracic surgery,
Volume 40, Issue 3, 1 1 2025, Pages ivaf071
The arterial switch operation for transposition of the great arteries with left ventricular outflow tract obstruction and ventricular septal defect: clinical outcomes and specimen study.
van der Palen RLF, den Ouden A, Knobbe I, Bouma BJ, Koolbergen DR, Jongbloed MRM, Hazekamp MG
Objectives: In selected patients with transposition of the great arteries (TGA), ventricular septal defect (VSD) and left ventricular outflow tract obstruction (LVOTO), the arterial switch operation (ASO) may be the procedure of choice. This study reviews the clinical outcomes of TGA-VSD-LVOTO patients after ASO and compares mechanisms of LVOTO in this patient group to a historical series of cardiac specimens. Methods: This retrospective analysis included all cases with TGA-VSD-LVOTO who underwe...
Abstract
European heart journal. Cardiovascular Imaging,
Volume 26, Issue 3, 1 1 2025, Pages 385-413
The role of multi-modality imaging for the assessment of left atrium and left atrial appendage: a clinical consensus statement of the European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC).
Sade LE, Faletra FF, Pontone G, Gerber BLM, Muraru D, Edvardsen T, Cosyns B, Popescu BA, Klein A, Marwick TH, Cameli M, Saric M, Thomas L, Ajmone Marsan N, Fontes-Carvalho R, Podlesnikar T, Fontana M, La Gerche A, Petersen SE, Moharem-Elgamal S, Bittencourt MS, Vannan MA, Glikson M, Peichl P, Cochet H, Stankovic I, Donal E, Thomas D, Marta RS
Structural, architectural, contractile, or electrophysiological alterations may occur in the left atrium (LA). The concept of LA cardiopathy is supported by accumulating scientific evidence demonstrating that LA remodelling has become a cornerstone diagnostic and prognostic marker. The structure and the function of the LA and left atrial appendage (LAA), which is an integral part of the LA, are key elements for a better understanding of multiple clinical conditions, most notably atrial fibrillat...
Abstract
Cited 1 times since 2025 (4.3 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 4, 1 1 2025, Pages euaf055
Epicardial ventricular arrhythmia ablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society, the Asian Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society.
Arya A, Di Biase L, Bazán V, Berruezo A, d'Avila A, Della Bella P, Enriquez A, Hocini M, Kautzner J, Pak HN, Stevenson WG, Zeppenfeld K, Sepehri Shamloo A, Meyer C, de Chillou C, Deneke T, de Riva M, Porta-Sanchez A, Sapp J, Schmidt B, Shivkumar K, Sommer P, Soejima K, Supple GE, Wilde A, Zucchelli G
Epicardial access during electrophysiology procedures offers valuable insights and therapeutic options for managing ventricular arrhythmias (VAs). The current clinical consensus statement on epicardial VA ablation aims to provide clinicians with a comprehensive understanding of this complex clinical scenario. It offers structured advice and a systematic approach to patient management. Specific sections are devoted to anatomical considerations, criteria for epicardial access and mapping evaluatio...
Abstract
Cited 5 times since 2025 (21.6 per year)
source: EuropePMC
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 4, 1 1 2025, Pages euae214
Patient selection, ventricular tachycardia substrate delineation, and data transfer for stereotactic arrhythmia radioablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society.
Zeppenfeld K, Rademaker R, Al-Ahmad A, Carbucicchio C, De Chillou C, Cvek J, Ebert M, Ho G, Kautzner J, Lambiase P, Merino JL, Merino JL, Lloyd M, Misra S, Pruvot E, Sapp J, Schiappacasse L, Sramko M, Stevenson WG, Zei PC, Wichterle D, Chrispin J, Siklody CH, Neuwirth R, Pelargonio G, Reichlin T, Robinson C, Tondo C
Stereotactic arrhythmia radioablation (STAR) is a novel, non-invasive, and promising treatment option for ventricular arrhythmias (VAs). It has been applied in highly selected patients mainly as bailout procedure, when (multiple) catheter ablations, together with anti-arrhythmic drugs, were unable to control the VAs. Despite the increasing clinical use, there is still limited knowledge of the acute and long-term response of normal and diseased myocardium to STAR. Acute toxicity appeared to be re...
Abstract
Cited 1 times since 2025 (4.3 per year)
source: EuropePMC
Journal of the American College of Cardiology,
Volume 85, Issue 10, 1 1 2025, Pages 1042-1055
Best Practices for Imaging of Transcatheter Valve Failure: An Update From the Heart Valve Collaboratory.
Khalique OK, Zaid S, Tang GHL, Abdel-Wahab M, Akodad M, Bapat VN, Bax JJ, Blackman DJ, Blanke P, Bleiziffer S, Capodanno D, Cavalcante JL, Dasi LP, De Backer O, De Beuel M, Duncan A, Dweck MR, Fukui M, Gupta A, Hayashida K, Herrmann HC, Kaneko T, Karam N, Khan JM, Kovac J, Landes U, Leipsic JA, Leon MB, Mack MJ, Madhavan MV, Makar MM, Makkar RR, Al Mallah M, Meier D, Modine T, Okada A, Parikh RK, Parma R, Patel D, Pibarot P, Prendergast B, Quader N, Reardon MJ, Rogers T, Safi LM, Sellers SL, Skaf S, Tarantini G, Tchetche D, van Mieghem N, Wang DD, Webb JG, Windecker S, Yakubov SJ, Delgado V, Hahn RT, Jilaihawi H
This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic va...
Abstract
Cited 2 times since 2025 (8.6 per year)
source: EuropePMC
Interdisciplinary cardiovascular and thoracic surgery,
Volume 40, Issue 3, 1 1 2025, Pages ivaf009
Survival outcomes after surgery for type A aortic dissection: a contemporary Dutch nationwide registry study.
Timmermans PT, Velders BJJ, Groenwold RHH, Vos RJ, Roefs MM, Braun J, Klautz RJM, Mecozzi G, Hjortnaes J, Cardiothoracic Surgery Registration Committee and the Aortic Surgery Work Group of the Netherlands Heart Registration
Objectives: To describe the nationwide survival outcomes after surgery for type A aortic dissection. Methods: All patients who underwent surgery for type A aortic dissection in the Netherlands between 2018 and 2021 were identified in the Netherlands Heart Registration (NHR) database. The NHR data were linked to lifelong survival data from Statistics Netherlands (98% match). Time trends for in-hospital and mid-term mortality were described, and age- and sex-adjusted regression analysis was perfor...
Abstract
British journal of anaesthesia,
Volume 134, Issue 4, 28 4 2025, Pages 1009-1017
Regulation of cerebrovascular resistance below the lower limit of cerebral autoregulation during induced hypotension: an observational study.
Kho E, van den Dool REC, Mahes SS, Corsmit OT, Vlaar APJ, Koolbergen DR, Veelo DP, Sperna Weiland NH, Immink RV
Background: To maintain adequate perfusion, cerebral blood flow (CBF) is preserved by changes in cerebrovascular resistance (CVR) inversely related to fluctuations in mean arterial blood pressure (MAP). It has been hypothesised that during progressive hypotension, a lower limit of cerebral autoregulation (LLCA) is reached beyond which cerebrovascular dilation becomes exhausted and CBF starts to decrease together with BP. We tested this hypothesis by assessing CVR above and below the LLCA. Method...
Abstract
JACC. Advances,
Volume 4, Issue 3, 26 4 2025, Pages 101633
Developing a Systematic Approach for the Implementation of Medical Extended Reality Learning Modules in Cardiothoracic Health Care: Recommendations From an International Expert Group.
Mahtab EAF, Max SA, Braun J, Regeer MV, Kaufman B, Dunning J, Bibleraaj B, Andreas M, Rodríguez Lecoq R, Klinceva M, Rosalia R, Lorusso R, Bruining N, Egorova AD
Extended reality (XR) modalities in health care are quickly evolving. There is a lack of systematically described developmental process and the "how to" execute a business-case guidance. This article formulates a systematic approach on the technical developmental steps and generation of business-case to guide the iterative development of an XR tool. An international expert group was established and several available frameworks related to entrepreneurship and business-case development w...
Abstract
STAR protocols,
Volume 6, Issue 1, 26 4 2025, Pages 103679
Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes.
Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW
Abstract
European heart journal. Digital health,
Volume 6, Issue 3, 26 4 2025, Pages 496-507
The environmental impact of telemonitoring vs. on-site cardiac follow-up: a mixed-method study.
van Bree EM, Snijder LE, Ter Haak S, Atsma DE, Brakema EA
Aims: Digital health technologies are considered promising innovations to reduce healthcare's environmental footprint. However, this assumption remains largely unstudied. We compared the environmental impact of telemonitoring and care on site (CoS) in post-myocardial infarction (MI) follow-up and explored how it influenced patients' and healthcare professionals' (HPs) perceptions of using telemonitoring. Methods and results: We conducted a mixed-method study; a standardized life c...
Abstract
PloS one,
Volume 20, Issue 2, 26 4 2025, Pages e0317826
The value of vector ECG in predicting residual pulmonary hypertension in CTEPH patients after pulmonary endarterectomy.
Luijten D, Rodenburg T, Bogaard HJ, Kianzad A, Ruigrok D, Croon P, Smeele P, Vliegen HW, Vonk Noordegraaf A, Meijboom LJ, Klok FA
Introduction: Right heart catheterization (RHC) is the diagnostic standard for establishing residual pulmonary hypertension (PH) after pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH). A potential non-invasive alternative diagnostic test could be electrocardiography (ECG)-derived ventricular gradient optimized for right ventricular pressure overload (VG-RVPO). Methods: We studied 66 CTEPH patients who underwent PEA. A subgroup of 20 patients a...
Abstract
European heart journal. Cardiovascular Imaging,
24 4 2025, Pages jeaf063
Mitral Valve Stretched to its Limit: A Case of an Aborted Sudden Cardiac Death with Extensive Fibrotic Ventricular Remodeling.
van Rosendael PJ, Biesbroek PS, Meijs TA, Gotte MJW, Hopman LHGA
Abstract
JACC. Clinical electrophysiology,
21 3 2025, Pages S2405-500X(25)00066-0
The Relevance of the Type of Ventricular Arrhythmia in Titin-Related Dilated Cardiomyopathy: A Multicenter Study.
Ebert M, de Riva M, Wijnmaalen AP, Barge-Schaapveld DQCM, Bootsma M, Hoogendoorn J, Husser D, van Tintelen JP, Jongbloed JDH, Richter S, Berruezo A, Hindricks G, Stevenson WG, Zeppenfeld K
Background: Truncating titin variants (TTNtvs) are the most prevalent cause of inherited dilated cardiomyopathy. Occurrence of different ventricular arrhythmia (VA) subtypes, including premature ventricular complexes (PVCs), nonsustained ventricular tachycardia (NSVT), and sustained monomorphic VT (SMVT), has been reported. Objectives: The aim of this study was to analyze the prognostic relevance of distinct VA subtypes among TTNtv carriers and their underlying arrhythmogenic substrates. Methods...
Abstract
Journal of cardiothoracic and vascular anesthesia,
Volume 39, Issue 6, 21 3 2025, Pages 1451-1463
Vasoplegia in Cardiac Surgery: A Systematic Review and Meta-analysis of Current Definitions and Their Influence on Clinical Outcomes.
Papazisi O, van der Schoot MM, Berendsen RR, Arbous SM, le Cessie S, Dekkers OM, Klautz RJM, Marczin N, Palmen M, de Waal EEC
Objectives: To identify differences in the reported vasoplegia incidence, intensive care unit (ICU) length of stay (LOS), and 30-day mortality rates as influenced by different vasoplegia definitions used in cardiac surgery studies. Design: A systematic review was performed covering the period 1977 to 2023 using PubMed/MEDLINE, Embase, Web of Science, Cochrane Library, and Emcare and a meta-analysis (PROSPERO: CRD42021258328) was performed. Setting and participants: One hundred studies defining v...
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 3, 20 3 2025, Pages e013099
Characteristics of Patients With the Arrhythmogenic Mitral Valve Prolapse Syndrome and Sudden Cardiac Arrest and Sustained Ventricular Arrhythmias.
Chakrabarti A, Giudicessi JR, Ezzeddine FM, Delling FN, Dixit S, Lee YJ, Muser D, Magnani S, Van Wijngaarden A, Ajmone Marsan N, Miller MA, Gandhi J, Trivieri MG, Font J, Martins R, McCaffrey JA, Santangeli P, Marchlinski FE, Chapagain H, Mathew D, Kancharla K, Syed FF, Abid A, Cerbin L, Tzou WS, Garg L, Della Rocca DG, Natale A, Mohanty S, Sheldon SH, Kuo L, Haugaa KH, Aabel EW, Enriquez A, Maeda S, Deshmukh A, Ghannam M, Bogun F, Ackerman MJ, Liang JJ
Background: Patients with arrhythmogenic mitral valve prolapse syndrome are at increased risk for life-threatening ventricular arrhythmias, but studies have been limited by small sample sizes. We sought to assemble an international arrhythmogenic mitral valve prolapse syndrome registry to delineate the clinical, imaging, and treatment characteristics of patients with arrhythmogenic mitral valve prolapse syndrome who survived sudden cardiac arrest (SCA) or had sustained ventricular tachycardia (V...
Abstract
Journal of cardiovascular development and disease,
Volume 12, Issue 2, 18 3 2025, Pages 78
Beyond Survival: Assessing Quality of Life, Activity Level, and Ethnic Diversity in Aortic Dissection Survivors.
Bacour N, van Erp O, Grewal S, Tirpan AU, Eberl S, Yeung KK, Balm R, Verwoert GC, Driessen AHG, Klautz RJM, Grewal N
Background: An acute aortic dissection (AAD) is a highly lethal condition that demands immediate medical intervention. Survivors often face significant long-term challenges. While immediate survival remains a critical focus in acute care settings, little is known about long-term results, especially with regard to activity levels, post-operative quality of life, and the impact of cultural and ethnic characteristics on recovery. Using data from the Dutch National Aortic Dissection Survivor's...
Abstract
