Research

Publications

Below you can find a list of our published research.

7971 results

Cited 3 times since 2024 (2.5 per year) source: EuropePMC

JTCVS open, Volume 19, 19 3 2024, Pages 68-90 Current definitions of hemodynamic structural valve deterioration after bioprosthetic aortic valve replacement lack consistency. Velders BJJ, Vriesendorp MD, Asch FM, Reardon MJ, Dagenais F, Moront MG, Sabik Iii JF, Groenwold RHH, Klautz RJM

Objective: New echocardiographic definitions have been proposed for hemodynamic structural valve deterioration. We aimed to study their consistency in classifying structural valve deterioration after surgical aortic valve replacement. Methods: Data were used of patients undergoing surgical aortic valve replacement in a multicenter, prospective cohort study with a 5-year follow-up. All patients received the same stented bioprosthesis. Echocardiographic parameters were assessed by an independent c... Abstract

Cited 2 times since 2024 (1.7 per year) source: EuropePMC

Frontiers in cellular and infection microbiology, Volume 14, 19 3 2024, Pages 1282183 Vaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria. van Schaik EJ, Fratzke AP, Gregory AE, Dumaine JE, Samuel JE

Obligate intracellular bacteria have remained those for which effective vaccines are unavailable, mostly because protection does not solely rely on an antibody response. Effective antibody-based vaccines, however, have been developed against extracellular bacteria pathogens or toxins. Additionally, obligate intracellular bacteria have evolved many mechanisms to subvert the immune response, making vaccine development complex. Much of what we know about protective immunity for these pathogens has... Abstract

Cited 1 times since 2024 (0.8 per year) source: EuropePMC

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, Volume 37, Issue 7, 19 3 2024, Pages 666-673 Prognostic Value of Follow-up Measures of Left Ventricular Global Longitudinal Strain in Patients With ST-Segment Elevation Myocardial Infarction. Caunite L, Myagmardorj R, Galloo X, Laenens D, Stassen J, Nabeta T, Yedidya I, Meucci MC, Kuneman JH, van den Hoogen IJ, van Rosendael SE, Wu HW, van den Brand VM, Giuca A, Trusinskis K, van der Bijl P, Bax JJ, Ajmone Marsan N

Introduction: After ST-segment elevation myocardial infarction (STEMI), follow-up imaging is currently recommended only in patients with left ventricular ejection fraction (LVEF) 7% remained independently associated with the end point (hazard ratio, 2.5 [95% CI, 1.5-4.1]; P Abstract

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Volume 50, Issue 6, 19 3 2024, Pages 108278 Staging laparoscopy in gastric cancer patients: From a Dutch nationwide Delphi consensus towards a standardized protocol. van der Sluis K, Guchelaar NAD, Triemstra L, Mathijssen RHJ, Ruurda JP, Wijnhoven BPL, van Sandick JW, Collaborators

Background: Staging laparoscopy is a common diagnostic tool in gastric cancer, but its performance varies widely. The aim of this study was to gain Dutch nationwide consensus regarding the indications for and execution of staging laparoscopy in patients with gastric cancer. Methods: All surgeons in the Netherlands specialized in gastric cancer surgery (n = 52) were asked to participate in a Delphi consensus study. The study involved an initial questionnaire with a 3-point Likert scale, an online... Abstract

Cited 1 times since 2024 (0.8 per year) source: EuropePMC

Clinical pharmacology and therapeutics, Volume 116, Issue 3, 18 3 2024, Pages 690-702 Nonlinear Mixed-Effects Model of Z-Endoxifen Concentrations in Tamoxifen-Treated Patients from the CEPAM Cohort. Mc Laughlin AM, Helland T, Klima F, Koolen SLW, van Schaik RHN, Mathijssen RHJ, Neven P, Swen JJ, Guchelaar HJ, Dalenc F, White-Koning M, Michelet R, Mikus G, Schroth W, Mürdter T, Brauch H, Schwab M, Søiland H, Mellgren G, Thomas F, Kloft C, Hertz DL, CYP2D6 Endoxifen Percentage Activity Model (CEPAM) Consortium

Tamoxifen is widely used in patients with hormone receptor-positive breast cancer. The polymorphic enzyme CYP2D6 is primarily responsible for metabolic activation of tamoxifen, resulting in substantial interindividual variability of plasma concentrations of its most important metabolite, Z-endoxifen. The Z-endoxifen concentration thresholds below which tamoxifen treatment is less efficacious have been proposed but not validated, and prospective trials of individualized tamoxifen treatment to ach... Abstract

Cited 2 times since 2024 (1.7 per year) source: EuropePMC

Arthritis research & therapy, Volume 26, Issue 1, 16 3 2024, Pages 70 Sensitive B-cell receptor repertoire analysis shows repopulation correlates with clinical response to rituximab in rheumatoid arthritis. Pollastro S, Musters A, Balzaretti G, Niewold I, van Schaik B, Hässler S, Verhoef CM, Pallardy M, van Kampen A, Mariette X, de Vries N, ABIRISK Consortium

Background: Although B-cell depleting therapy in rheumatoid arthritis (RA) is clearly effective, response is variable and does not correlate with B cell depletion itself. Methods: The B-cell receptor (BCR) repertoire was prospectively analyzed in peripheral blood samples of twenty-eight RA patients undergoing rituximab therapy. Timepoints of achieved BCR-depletion and -repopulation were defined based on the percentage of unmutated BCRs in the repertoire. The predictive value of early BCR-depleti... Abstract

Heart rhythm, Volume 21, Issue 10, 16 3 2024, Pages 1779-1786 Comparing adolescent- and adult-onset unexplained cardiac arrest: Results from the Dutch Idiopathic VF Registry. Verheul LM, Hoeksema WF, Groeneveld SA, Mulder BA, Bootsma M, Alings M, Evertz R, Blank AC, Kammeraad JAE, Clur SB, Yap SC, Postema PG, Wilde AAM, Volders PGA, Hassink RJ

Background: Current cohorts of patients with idiopathic ventricular fibrillation (IVF) primarily include adult-onset patients. Underlying causes of sudden cardiac arrest vary with age; therefore, underlying causes and disease course may differ for adolescent-onset vs adult-onset patients. Objective: The purpose of this study was to compare adolescent-onset with adult-onset patients having an initially unexplained cause of VF. Methods: The study included 39 patients with an index event aged ≤19 y... Abstract

Cited 2 times since 2024 (1.7 per year) source: EuropePMC

European urology, Volume 85, Issue 6, 15 3 2024, Pages e180 Corrigendum to "European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2023 Guidelines" [Eur. Urol. 85 (2024) 17-31]. Alfred Witjes J, Bruins HM, Carrión A, Cathomas R, Compérat E, Efstathiou JA, Fietkau R, Gakis G, Lorch A, Martini A, Mertens LS, Meijer RP, Milowsky MI, Neuzillet Y, Panebiaco V, Redlef J, Rink M, Rouanne M, Thalmann GN, Sæbjørnsen S, Veskimäe E, Mariappan P, van der Heijden AG

Abstract

Cited 1 times since 2024 (0.8 per year) source: EuropePMC

ACS omega, Volume 9, Issue 12, 15 3 2024, Pages 14054-14062 Propolis-Loaded Poly(lactic-co-glycolic Acid) Nanofibers: An In Vitro Study. Geyik F, Kaya S, Yılmaz DE, Demirci H, Akmayan İ, Özbek T, Acar S

Nanofibers have high potential through their high porosity, small pore sizes, lightweight materials, and their ability to mimic the extracellular matrix structure for use in the manufacture of wound dressings for wound treatment. In this study, poly(lactic-co-glycolic acid) (PLGA) nanofibers were produced by electrospinning. Propolis was loaded into the PLGA nanofibers by the dropping method. The average diameters and effects of propolis loading on the morphology of 37.5, 50, and 100% propolis-l... Abstract

Cited 6 times since 2024 (4.9 per year) source: EuropePMC

Journal of dentistry, Volume 144, 14 2 2024, Pages 104941 Fabrication trueness and marginal quality of additively manufactured resin-based definitive laminate veneers with different restoration thicknesses. Çakmak G, Donmez MB, Yılmaz D, Yoon HI, Kahveci Ç, Abou-Ayash S, Yilmaz B

Objectives: To evaluate how restoration thickness (0.5 mm and 0.7 mm) affects the fabrication trueness of additively manufactured definitive resin-based laminate veneers, and to analyze the effect of restoration thickness and margin location on margin quality. Methods: Two maxillary central incisors were prepared either for a 0.5 mm- or 0.7 mm-thick laminate veneer. After acquiring the partial-arch scans of each preparation, laminate veneers were designed and stored as reference data. By using t... Abstract

Journal of dairy science, Volume 107, Issue 8, 14 2 2024, Pages 5754-5778 A Living Lab approach to understanding dairy farmers' technology and data needs to improve herd health: Focus groups from 6 European countries. Doidge C, Ånestad LM, Burrell A, Frössling J, Palczynski L, Pardon B, Veldhuis A, Bokma J, Carmo LP, Hopp P, Guelbenzu-Gonzalo M, Meunier NV, Ordell A, Santman-Berends I, van Schaik G, Kaler J

For successful development and adoption of technology on dairy farms, farmers need to be included in the innovation process. However, the design of agricultural technologies usually takes a top-down approach with little involvement of end-users at the early stages. Living Labs offer a methodology that involve end-users throughout the development process and emphasize the importance of understanding users' needs. Currently, exploration of dairy farmers' technology needs has been limited... Abstract

Cited 2 times since 2024 (1.6 per year) source: EuropePMC

Frontiers in veterinary science, Volume 11, 14 2 2024, Pages 1337661 Review state-of-the-art of output-based methodological approaches for substantiating freedom from infection. Meletis E, Conrady B, Hopp P, Lurier T, Frössling J, Rosendal T, Faverjon C, Carmo LP, Hodnik JJ, Ózsvári L, Kostoulas P, van Schaik G, Comin A, Nielen M, Knific T, Schulz J, Šerić-Haračić S, Fourichon C, Santman-Berends I, Madouasse A

A wide variety of control and surveillance programmes that are designed and implemented based on country-specific conditions exists for infectious cattle diseases that are not regulated. This heterogeneity renders difficult the comparison of probabilities of freedom from infection estimated from collected surveillance data. The objectives of this review were to outline the methodological and epidemiological considerations for the estimation of probabilities of freedom from infection from surveil... Abstract

Communications biology, Volume 7, Issue 1, 13 2 2024, Pages 314 A platform-independent AI tumor lineage and site (ATLAS) classifier. Rydzewski NR, Shi Y, Li C, Chrostek MR, Bakhtiar H, Helzer KT, Bootsma ML, Berg TJ, Harari PM, Floberg JM, Blitzer GC, Kosoff D, Taylor AK, Sharifi MN, Yu M, Lang JM, Patel KR, Citrin DE, Sundling KE, Zhao SG

Histopathologic diagnosis and classification of cancer plays a critical role in guiding treatment. Advances in next-generation sequencing have ushered in new complementary molecular frameworks. However, existing approaches do not independently assess both site-of-origin (e.g. prostate) and lineage (e.g. adenocarcinoma) and have minimal validation in metastatic disease, where classification is more difficult. Utilizing gradient-boosted machine learning, we developed ATLAS, a pair of separate AI T... Abstract

Cited 1 times since 2024 (0.8 per year) source: EuropePMC

Kidney international reports, Volume 9, Issue 6, 13 2 2024, Pages 1849-1859 Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure. Ganji-Arjenaki M, Kamali Z, International Consortium of Blood Pressure, Sardari S, de Borst M, Snieder H, Vaez A

Introduction: Blood pressure (BP) is a highly heritable trait with over 2000 underlying genomic loci identified to date. Although the kidney plays a key role, little is known about specific cell types involved in the genetic regulation of BP. Methods: Here, we applied stratified linkage disequilibrium score (LDSC) regression to connect BP genome-wide association studies (GWAS) results to specific cell types of the mature human kidney. We used the largest single-stage BP genome-wide analysis to d... Abstract

Journal of cardiovascular development and disease, Volume 11, Issue 3, 13 2 2024, Pages 90 Incremental Value of Biventricular Strain in Patients with Severe Aortic Stenosis. Sarrazyn C, Galloo X, Meucci MC, Butcher SC, Hirsawa K, Myagmardorj R, van der Kley F, De Backer T, Bax JJ, Ajmone Marsan N

(1) Background: Left ventricular global longitudinal (LVGLS) and right ventricular free wall strain (RVFWS) demonstrated separate prognostic values in patients with severe aortic stenosis (AS). However, studies evaluating the combined assessment of LVGLS and RVFWS have shown contradictory results. This study explored the prognostic value of combining LVGLS and RVFWS in a large group of severe AS patients referred for transcatheter aortic valve implantation. (2) Methods: Patients were classified... Abstract

Cited 11 times since 2024 (9 per year) source: EuropePMC

JACC. Cardiovascular imaging, Volume 17, Issue 8, 13 2 2024, Pages 894-906 Development and Validation of a Quantitative Coronary CT Angiography Model for Diagnosis of Vessel-Specific Coronary Ischemia. Nurmohamed NS, Danad I, Jukema RA, de Winter RW, de Groot RJ, Driessen RS, Bom MJ, van Diemen P, Pontone G, Andreini D, Chang HJ, Katz RJ, Stroes ESG, Wang H, Chan C, Crabtree T, Aquino M, Min JK, Earls JP, Bax JJ, Choi AD, Knaapen P, van Rosendael AR, CREDENCE and PACIFIC-1 Investigators

Background: Noninvasive stress testing is commonly used for detection of coronary ischemia but possesses variable accuracy and may result in excessive health care costs. Objectives: This study aimed to derive and validate an artificial intelligence-guided quantitative coronary computed tomography angiography (AI-QCT) model for the diagnosis of coronary ischemia that integrates atherosclerosis and vascular morphology measures (AI-QCTISCHEMIA) and to evaluate its prognostic utility for major adver... Abstract

Cited 3 times since 2024 (2.5 per year) source: EuropePMC

iScience, Volume 27, Issue 4, 12 2 2024, Pages 109496 Oleic acid triggers metabolic rewiring of T cells poising them for T helper 9 differentiation. Reilly NA, Sonnet F, Dekkers KF, Kwekkeboom JC, Sinke L, Hilt S, Suleiman HM, Hoeksema MA, Mei H, van Zwet EW, Everts B, Ioan-Facsinay A, Jukema JW, Heijmans BT

T cells are the most common immune cells in atherosclerotic plaques, and the function of T cells can be altered by fatty acids. Here, we show that pre-exposure of CD4+ T cells to oleic acid, an abundant fatty acid linked to cardiovascular events, upregulates core metabolic pathways and promotes differentiation into interleukin-9 (IL-9)-producing cells upon activation. RNA sequencing of non-activated T cells reveals that oleic acid upregulates genes encoding key enzymes responsible for cholestero... Abstract

Cited 7 times since 2024 (5.7 per year) source: EuropePMC

Circulation. Cardiovascular imaging, Volume 17, Issue 3, 12 2 2024, Pages e016143 Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFRCT, and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry. Dundas J, Leipsic J, Fairbairn T, Ng N, Sussman V, Guez I, Rosenblatt R, Hurwitz Koweek LM, Douglas PS, Rabbat M, Pontone G, Chinnaiyan K, de Bruyne B, Bax JJ, Amano T, Nieman K, Rogers C, Kitabata H, Sand NPR, Kawasaki T, Mullen S, Huey W, Matsuo H, Patel MR, Norgaard BL, Ahmadi A, Tzimas G

Background: Luminal stenosis, computed tomography-derived fractional-flow reserve (FFRCT), and high-risk plaque features on coronary computed tomography angiography are all known to be associated with adverse clinical outcomes. The interactions between these variables, patient outcomes, and quantitative plaque volumes have not been previously described. Methods: Patients with coronary computed tomography angiography (n=4430) and one-year outcome data from the international ADVANCE (Assessing Dia... Abstract

Cited 5 times since 2024 (4.1 per year) source: EuropePMC

FEMS microbes, Volume 5, 9 2 2024, Pages xtae009 Interactions between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of Enterococcus faecium. Wagner TM, Pöntinen AK, Fenzel CK, Engi D, Janice J, Almeida-Santos AC, Tedim AP, Freitas AR, Peixe L, van Schaik W, Johannessen M, Hegstad K

Enterococcus faecium (Efm) is a versatile pathogen, responsible for multidrug-resistant infections, especially in hospitalized immunocompromised patients. Its population structure has been characterized by diverse clades (A1, A2, and B (reclassified as E. lactis (Ela)), adapted to different environments, and distinguished by their resistomes and virulomes. These features only partially explain the predominance of clade A1 strains in nosocomial infections. We investigated in vitro interaction of... Abstract

Cited 4 times since 2024 (3.2 per year) source: EuropePMC

Gastrointestinal endoscopy, Volume 100, Issue 4, 8 2 2024, Pages 703-709.e4 Interobserver agreement of current and new proposed endoscopic scores for postoperative recurrence in Crohn's disease. Bak MTJ, Hammoudi N, Allez M, Silverberg MS, Schellekens IM, Erler NS, Dijkstra G, Romberg-Camps M, de Boer NKH, Jansen SV, van der Marel S, Horjus CS, Visschedijk MC, Goetgebuer RL, van Dop WA, Hoekstra J, Bodelier AGL, Molendijk I, Derikx LAAP, van Schaik FDM, West RL, Duijvestein M, Janneke van der Woude C, van Ruler O, de Vries AC, Dutch Initiative on Crohn and Colitis and the RAP-CD study group

Background and aims: The modified Rutgeerts score (mRS) is widely used for the assessment of endoscopic postoperative recurrence (ePOR) in Crohn's disease (CD) after ileocolic resection to guide therapeutic decisions. To improve the validity and prognostic value of this endoscopic assessment, 2 new scores have been proposed. This study assessed the interobserver agreement of the current score (mRS) and the new endoscopic score for ePOR in CD. Methods: Sixteen Dutch academic and nonacademic... Abstract