Research

Publications

Below you can find a list of our published research.

8684 results

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 10, Issue 4, 24 4 2024, Pages 637-650 Multisize Electrode Field-of-View: Validation by High Resolution Gadolinium-Enhanced Cardiac Magnetic Resonance. Omara S, Glashan CA, Tofig BJ, Leenknegt L, Dierckx H, Panfilov AV, Beukers HKC, van Waasbergen MH, Tao Q, Stevenson WG, Nielsen JC, Lukac P, Kristiansen SB, van der Geest RJ, Zeppenfeld K

Background: Voltage mapping to detect ventricular scar is important for guiding catheter ablation, but the field-of-view of unipolar, bipolar, conventional, and microelectrodes as it relates to the extent of viable myocardium (VM) is not well defined. Objectives: The purpose of this study was to evaluate electroanatomic voltage-mapping (EAVM) with different-size electrodes for identifying VM, validated against high-resolution ex-vivo cardiac magnetic resonance (HR-LGE-CMR). Methods: A total of 9... Abstract

Cited 1 times since 2024 (0.7 per year) source: EuropePMC

Journal of bone and joint infection, Volume 9, Issue 1, 24 4 2024, Pages 9-16 Multiplex PCR test as an intra-operative diagnostic tool for periprosthetic joint infection in presumed aseptic revision hip and knee arthroplasty: a 1-year follow-up study of 200 cases. van Schaik TJA, Heesterbeek PJC, van Susante JLC, Rijnen WHC, Goosen JHM

Automated custom-made multiplex PCR techniques (mPCR) have become commercially available and are designed for intra-operative screening of concurrent periprosthetic joint infections (PJIs). The purpose of this study was to evaluate the value of a positive mPCR test in presumed aseptic revision total hip (THA) and knee (TKA) arthroplasties after a 1-year follow-up. In an earlier study, such an automated mPCR technique (Unyvero ITI G2; Curetis, Holzgerlingen, Germany) was tested on intra-operative... Abstract

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

Journal of the American Heart Association, Volume 13, Issue 3, 23 4 2024, Pages e033109 Myeloid PHD2 Conditional Knockout Improves Intraplaque Angiogenesis and Vascular Remodeling in a Murine Model of Venous Bypass Grafting. Sluiter TJ, Tillie RJHA, de Jong A, de Bruijn JBG, Peters HAB, van de Leijgraaf R, Halawani R, Westmaas M, Starink LIW, Quax PHA, Sluimer JC, de Vries MR

Background: Intraplaque angiogenesis occurs in response to atherosclerotic plaque hypoxia, which is driven mainly by highly metabolically active macrophages. Improving plaque oxygenation by increasing macrophage hypoxic signaling, thus stimulating intraplaque angiogenesis, could restore cellular function and neovessel maturation, and decrease plaque formation. Prolyl hydroxylases (PHDs) regulate cellular responses to hypoxia. We therefore aimed to elucidate the role of myeloid PHD2, the dominant... Abstract

Cited 1 times since 2024 (0.7 per year) source: EuropePMC

Vascular pharmacology, Volume 154, 23 4 2024, Pages 107279 Doxycycline induces mitochondrial dysfunction in aortic smooth muscle cells. Yap C, Wanga S, Wüst RCI, van Os BW, Pijls MME, Keijzer S, van Zanten E, Koolbergen DR, Driessen AHG, Balm R, Yeung KK, de Vries CJM, Houtkooper RH, Lindeman JHN, de Waard V

The antibiotic doxycycline is known to inhibit inflammation and was therefore considered as a therapeutic to prevent abdominal aortic aneurysm (AAA) growth. Yet mitochondrial dysfunction is a key-characteristic of clinical AAA disease. We hypothesize that doxycycline impairs mitochondrial function in the aorta and aortic smooth muscle cells (SMCs). Doxycycline induced mitonuclear imbalance, reduced proliferation and diminished expression of typical contractile smooth muscle cell (SMC) proteins.... Abstract

Cited 4 times since 2024 (2.9 per year) source: EuropePMC

The Journal of allergy and clinical immunology, Volume 153, Issue 4, 23 4 2024, Pages 1155-1161.e4 Influence of pathogenic filaggrin variants on dupilumab treatment in atopic dermatitis. Clabbers J, Boesjes C, Spekhorst L, van Gisbergen MW, Maas E, Marshall J, Janssen R, Janssen M, Zuithoff N, Steijlen P, de Graaf M, van Geel M, de Bruin-Weller M, Gostyński A

Background: Pathogenic variants in filaggrin (FLG) are associated with an increased risk of atopic dermatitis (AD). Objective: We evaluated the influence of FLG variants on the effectiveness of dupilumab treatment in AD. Methods: This prospective observational study included adult AD patients treated with dupilumab from the BioDay registry. FLG was analyzed with single-molecule molecular inversion probe-targeted sequencing. Novel mutations were confirmed by Sanger sequencing. Eczema Area and Sev... Abstract

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

Children (Basel, Switzerland), Volume 11, Issue 1, 22 4 2024, Pages 134 Pathogens in Pediatric Septic Arthritis: A Multi-Center Study in Turkiye (PEDSART Study). Iseri Nepesov M, Kilic O, Sali E, Yesil E, Akar A, Kaman A, Metin Akcan O, Kilic Cil M, Ozlu C, Lacinel Gurlevik S, Ulusoy E, Cetin BS, Akici N, Cakir D, Uslu Aygun FD, Hancerli CO, Tekin Yilmaz A, Alkan G, Uygun H, Bucak IH, Bursal B, Celik T, Sutcu M, Oz FN, Gayretli Aydin ZG, Karbuz A, Akturk H, Kepenekli E, Emiroglu M, Oncel S, Nuhoglu C, Korucu IH, Incesu M, Kaya A, Bombaci H, Dinleyici M, Carman KB, Duman M, Turel O, Yilmaz D, Alabaz D, Belet N, Tanir G, Turgut M, Celebi S, Kuyucu N, Arisoy ES, Durmaz G, Kaya M, Kara A, Dinleyici EC

Objectives: Septic arthritis (SA) is a serious bacterial infection that must be treated efficiently and timely. The large number of culture-negative cases makes local epidemiological data important. Accordingly, this study aimed to evaluate the etiology, clinical characteristics, and therapeutic approach of SA in children in Turkiye, emphasizing the role of real-time polymerase chain reaction (PCR) techniques in the diagnosis. Methods: In this multi-center, prospective study, children hospitaliz... Abstract

Cited 2 times since 2024 (1.5 per year) source: EuropePMC

International journal of primatology, Volume 45, Issue 4, 20 3 2024, Pages 739-773 Play Behavior Varies with Age, Sex, and Socioecological Context in Wild, Immature Orangutans (<i>Pongo</i> spp.). Kunz JA, Falkner SS, Aprilinayati F, Duvot GJ, Fröhlich M, Willems EP, Atmoko SSU, van Schaik CP, Schuppli C, van Noordwijk MA

Play is thought to serve different purposes at different times during ontogeny. The nature and frequency of play are expected to change accordingly over the developmental trajectory and with socio-ecological context. Orangutans offer the opportunity to disentangle the ontogenetic trajectories of solitary and social play with their extended immature phase, and socio-ecological variation among populations and species. We evaluated the frequency of play in 39 immature individuals across two populat... Abstract

Dermatology (Basel, Switzerland), Volume 240, Issue 2, 16 3 2024, Pages 216-225 Mental Health of School-Aged Children Treated with Propranolol or Atenolol for Infantile Hemangioma and Their Parents. Hermans MM, Schappin R, de Laat PCJ, Mendels EJ, Breur JMPJ, Langeveld HR, Raphael MF, de Graaf M, Breugem CC, de Wildt SN, Okkerse JME, Pasmans SGMA, Rietman AB

Background: Infants with infantile hemangioma (IH) have been effectively treated with propranolol or atenolol. Concerns were raised about the mental health of these children at school age, due to central nervous system effects of propranolol and visible nature of IH. Objective: This study aimed to compare the mental health at school age of children treated with propranolol to children treated with atenolol for IHs and their parents. Methods: This two-centered cross-sectional study included child... Abstract

Reviews in cardiovascular medicine, Volume 25, Issue 1, 16 3 2024, Pages 29 Non-Invasive Assessment of Multivalvular Heart Disease: A Comprehensive Review. De Zan G, van der Bilt IAC, Broekhuizen LN, Cramer MJ, Danad I, van Osch D, Patti G, van Rosendael PJ, Teske AJ, van der Harst P, Guglielmo M

Multivalvular heart disease (MVD) implies the presence of concomitant valvular lesions on two or more heart valves. This condition has become common in the few last years, mostly due to population aging. Every combination of valvular lesions uniquely redefines the hemodynamics of a patient. Over time, this may lead to alterations in left ventricle (LV) dimensions, shape and, eventually, function. Since most of the echocardiographic parameters routinely used in the valvular assessment have been d... Abstract

Cited 1 times since 2024 (0.7 per year) source: EuropePMC

npj antimicrobials and resistance, Volume 2, Issue 1, 16 3 2024, Pages 2 Integration of vanHAX downstream of a ribosomal RNA operon restores vancomycin resistance in a susceptible Enterococcus faecium strain. McInnes RS, Snaith AE, Dunn SJ, Papangeli M, Hardy KJ, Hussain A, van Schaik W

During the genomic characterisation of Enterococcus faecium strains (n = 39) collected in a haematology ward, we identified an isolate (OI25), which contained vanA-type vancomycin resistance genes but was phenotypically susceptible to vancomycin. OI25 could revert to resistance when cultured in the presence of vancomycin and was thus considered to be vancomycin-variable. Long-read sequencing was used to identify structural variations within the vancomycin resistance region of OI25 and to uncover... Abstract

Cited 2 times since 2024 (1.4 per year) source: EuropePMC

Behavioral ecology and sociobiology, Volume 78, Issue 1, 15 3 2024, Pages 12 Wild and captive immature orangutans differ in their non-vocal communication with others, but not with their mothers. Fröhlich M, van Noordwijk MA, Mitra Setia T, van Schaik CP, Knief U

Abstract: In many group-living species, individuals are required to flexibly modify their communicative behaviour in response to current social challenges. To unravel whether sociality and communication systems co-evolve, research efforts have often targeted the links between social organisation and communicative repertoires. However, it is still unclear which social or interactional factors directly predict communicative complexity. To address this issue, we studied wild and zoo-housed immature... Abstract

Cited 1 times since 2024 (0.7 per year) source: EuropePMC

Journal of the American Heart Association, Volume 13, Issue 2, 12 2 2024, Pages e031646 Acute Coronary Syndrome Subphenotypes Based on Repeated Biomarker Measurements in Relation to Long-Term Mortality Risk. de Bakker M, Scholte NTB, Oemrawsingh RM, Umans VA, Kietselaer B, Schotborgh C, Ronner E, Lenderink T, Aksoy I, van der Harst P, Asselbergs FW, Maas A, Oude Ophuis AJ, Krenning B, de Winter RJ, The SHK, Wardeh AJ, Hermans W, Cramer GE, van Schaik RH, de Rijke YB, Akkerhuis KM, Kardys I, Boersma E, BIOMArCS Investigators †

Background: We aimed to identify patients with subphenotypes of postacute coronary syndrome (ACS) using repeated measurements of high-sensitivity cardiac troponin T, N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and growth differentiation factor 15 in the year after the index admission, and to investigate their association with long-term mortality risk. Methods and results: BIOMArCS (BIOMarker Study to Identify the Acute Risk of a Coronary Syndrome) was an obser... Abstract

Rural and remote health, Volume 24, Issue 1, 12 2 2024, Pages 8306 The Murray-Darling Medical Schools Network Research Collaboration: protocol for a longitudinal, multi-university program of work to explore the effect of rurally based medical school programs in the Murray-Darling region. Turner B, Bullock S, Butler S, Ferrington L, Macartney M, Major L, Monrouxe L, Osuagwu UL, Southwell P, Van Schaik L, Luscombe GM

Introduction: There is now strong evidence to support the positive impact of place-based medical education on the recruitment and retention of the rural health workforce in Australia. Much of this work, however, has been undertaken in the context of 'extended rural clinical placement' - students undertaking part of their medical degree in a rural location. Until recently, there were only a few places in Australia in which students could undertake the entirety of their medical degree in... Abstract

Cited 13 times since 2024 (9.3 per year) source: EuropePMC

Nature communications, Volume 15, Issue 1, 12 2 2024, Pages 494 Global emergence of a hypervirulent carbapenem-resistant Escherichia coli ST410 clone. Ba X, Guo Y, Moran RA, Doughty EL, Liu B, Yao L, Li J, He N, Shen S, Li Y, van Schaik W, McNally A, Holmes MA, Zhuo C

Carbapenem-resistant Escherichia coli (CREC) ST410 has recently emerged as a major global health problem. Here, we report a shift in CREC prevalence in Chinese hospitals between 2017 and 2021 with ST410 becoming the most commonly isolated sequence type. Genomic analysis identifies a hypervirulent CREC ST410 clone, B5/H24RxC, which caused two separate outbreaks in a children's hospital. It may have emerged from the previously characterised B4/H24RxC in 2006 and has been isolated in ten other... Abstract

Cited 4 times since 2024 (2.9 per year) source: EuropePMC

Frontiers in immunology, Volume 14, 11 2 2024, Pages 1324618 Establishment and immune phenotyping of patient-derived glioblastoma models in humanized mice. Liu L, van Schaik TA, Chen KS, Rossignoli F, Borges P, Vrbanac V, Wakimoto H, Shah K

Glioblastoma (GBM) is the most aggressive and common type of malignant brain tumor diagnosed in adults. Preclinical immunocompetent mouse tumor models generated using mouse tumor cells play a pivotal role in testing the therapeutic efficacy of emerging immune-based therapies for GBMs. However, the clinical translatability of such studies is limited as mouse tumor lines do not fully recapitulate GBMs seen in inpatient settings. In this study, we generated three distinct, imageable human-GBM (hGBM... Abstract

Cited 1 times since 2024 (0.7 per year) source: EuropePMC

JACC. Clinical electrophysiology, Volume 10, Issue 3, 10 2 2024, Pages 502-511 Ventricular Tachycardia Ablation in Patients With Desmoplakin Cardiomyopathy. Ghannam M, Liang JJ, Hoogendoorn J, Zeppenfeld K, Siontis KC, Asirvatham SJ, Sacher F, Maury P, Gandjbakhch E, Morady F, Bogun F

Background: Desmoplakin (DSP) pathogenic variants are rare causes of arrhythmogenic cardiomyopathy and often involve the right and left ventricles. Ventricular tachycardia (VT) ablations may be required in these patients, but procedural characteristics have not been reported. Objectives: In this study, the authors sought to report a multicenter experience of VT ablation in patients with DSP pathogenic variants. Methods: VT ablations performed in patients with known DSP pathogenic variants were a... Abstract

Cited 2 times since 2024 (1.4 per year) source: EuropePMC

Frontiers in immunology, Volume 14, 10 2 2024, Pages 1279055 TCRβ clones in muscle tissue share structural features in patients with idiopathic inflammatory myopathy and are associated with disease activity. Anang DC, Walter HAW, Lim J, Niewold ITG, van der Weele L, Aronica E, Eftimov F, Raaphorst J, van Schaik BDC, van Kampen AHC, van der Kooi AJ, de Vries N

Objectives: To characterize the T cell receptor (TCRβ) repertoire in peripheral blood and muscle tissues of treatment naïve patients with newly diagnosed idiopathic inflammatory myopathies (IIMs). Methods: High throughput RNA sequencing of the TCRβ chain was performed in peripheral blood and muscle tissue in twenty newly-diagnosed treatment-naïve IIM patients (9 DM, 5 NM/OM, 5 IMNM and 1 ASyS) and healthy controls. Results thereof were correlated with markers of disease activity. Results: Muscle... Abstract

Cited 3 times since 2024 (2.1 per year) source: EuropePMC

JACC. Advances, Volume 3, Issue 2, 5 1 2024, Pages 100814 Virtual Reality for Pain and Anxiety Management in Cardiac Surgery and Interventional Cardiology. El Mathari S, Hoekman A, Kharbanda RK, Sadeghi AH, de Lind van Wijngaarden R, Götte M, Klautz RJM, Kluin J

Pain and anxiety are common in patients undergoing cardiac surgery and percutaneous cardiac interventions. Virtual reality (VR) is an emerging non-pharmacological tool for pain and anxiety management. However, its application around cardiac procedures remains relatively unexplored. In this review, we perform a targeted non-systematic literature review to assess the current state-of-the-art of VR for pain and anxiety management in patients undergoing cardiac procedures. Contexts of interest were... Abstract

Cited 1 times since 2024 (0.7 per year) source: EuropePMC

European urology open science, Volume 60, 5 1 2024, Pages 15-23 Short-term Changes in Health-related Quality of Life of Patients Undergoing Radical Surgery for Upper Urinary Tract Urothelial Carcinoma: Results from a Prospective Phase 2 Clinical Trial. van Doeveren T, Remmers S, Atema V, van den Bergh RCN, Boevé ER, Cornel EB, van der Heijden AG, Hendricksen K, Cauberg ECC, Jacobs RAL, Kroon BK, Leliveld AM, Meijer RP, Merks B, Oddens JR, Roelofs L, Somford DM, de Vries P, Wijsman B, Windt WAKM, Zwaan PJ, van Leeuwen PJ, Boormans JL, Aben KKH

Background and objective: The possible negative impact of radical surgery on patients' health-related quality of life (HRQoL) plays an important role in preoperative counseling. Here, we analyzed the HRQoL of patients treated for upper urinary tract urothelial carcinoma (UTUC) in the context of a single-arm phase 2 multicenter study, in which the safety and efficacy of a single preoperative intravesical instillation with mitomycin C were investigated. Our objective was to investigate early... Abstract

Journal of experimental child psychology, Volume 240, 5 1 2024, Pages 105834 Children's expectations about the stability of others' knowledge and preference states. Kurupınar M, Serbest O, Yılmaz D, Soley G

It is a crucial ability to predict others' psychological states across time and contexts. Focusing on cultural inventions such as songs and stories, we contrasted children's attributions of stability with others' knowledge and preference states across time and space and whether these attributions change as a function of children's familiarity with the known/liked items. Children (91 4-year-olds and 97 6-year-olds) were introduced to characters who knew or liked a song, a stor... Abstract