6424 results
European heart journal. Cardiovascular Imaging,
8 2 2025, Pages jeaf336
Pitfalls and Solutions in the Imaging Follow-up of Valvular Heart Disease Devices.
Ternacle J, Turgeon PY, Hahn RT, Marsan NA, Pibarot P
Doppler-echocardiography is the primary imaging modality for the evaluation and follow-up of valvular heart devices. This article highlights the unique pitfalls associated with these devices, including imaging challenges and flow dynamics, which often push echocardiography to its limits. The use of a multimodality imaging approach including cardiac computed tomography (CT) and magnetic resonance, and positron emission tomography-CT is recommended to confirm the diagnosis of prosthetic valve dysf...
Abstract
Life (Basel, Switzerland),
Volume 15, Issue 12, 5 1 2025, Pages 1868
Standardized and Quantitative ICG Perfusion Assessment: Feasibility and Reproducibility in a Multicentre Setting.
Feitsma E, Schouw H, Hoffman T, van Dijk S, Heeman W, Vonk J, Tange F, Koetje J, Jansen L, Schepers A, van Ginhoven T, Kelder W, van Dam G, Szymanski W, Noltes M, Kruijff S
Indocyanine green near-infrared fluorescence (ICG-NIRF) imaging is widely used to assess tissue perfusion, yet its subjective interpretation limits correlation with postoperative parathyroid function. To address this, the Workflow model for ICG-angiography integrating Standardization and Quantification (WISQ) was developed. This exploratory prospective multicenter study evaluated the reproducibility of WISQ in adults undergoing total thyroidectomy at two Dutch university centres. Patients with c...
Abstract
ESMO open,
Volume 10, Issue 12, 5 1 2025, Pages 105923
Pathological complete response and survival after neoadjuvant chemotherapy in patients with stage I TNBC: a registry-based study.
de Graaf M, Gielen RCAM, Balduzzi S, Siesling S, Linn SC, Kok M
Background: Pathological complete response (pCR) after neoadjuvant chemotherapy (NACT) is a strong prognostic factor in patients with early-stage triple-negative breast cancer (TNBC). One-third of all patients with early-stage TNBC have stage I disease. Chemotherapy is recommended for most patients with stage I TNBC with an increasing use in the neoadjuvant setting supported by recent guidelines. However, little is known on the chemotherapy benefit for stage I TNBC, in particular the likelihood...
Abstract
Circulation. Cardiovascular imaging,
4 1 2025, Pages e018862
Global Longitudinal Strain for Prognostic Staging in Wild-Type Transthyretin Cardiac Amyloidosis.
Debonnaire P, L'Hoyes W, Donal E, Verheyen N, Vervloet D, Dujardin K, Pouleur AC, Dulgheru R, Sarli Issa V, Droogmans S, Jurcut R, Regeer M, Dupont M, Bondue A, Timmermans P, Bohyn A, Christiaen E, Wyseure N, Bezard M, Zach D, Schwegel N, Knapen R, Buytaert L, de Marneffe N, Adam R, Ajmone Marsan N, Tavernier R, Buysschaert I, Trenson S
Background: A formal prognostic staging system in wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM), based on echocardiographic imaging, is lacking. We evaluated the prognostic performance of global longitudinal strain (GLS) staging in a large ATTRwt-CM patient cohort, including under tafamidis treatment and relative to National Amyloidosis Center (NAC) biomarker staging. Methods: A multicentric, international ATTRwt-CM patient cohort with baseline GLS (distribution quartiles), evaluate...
Abstract
Journal of the American Heart Association,
Volume 14, Issue 24, 3 1 2025, Pages e046283
Anrep Effect in the Right Ventricle: Evidence From Systolic Duration Analysis.
Reil JC, Sequeira V, Wink J, Federspiel JM, Reil GH, Steendijk P
Abstract
Annals of hepatology,
3 1 2025, Pages 102170
Genetic risk factors for MASLD/MASH and cardiovascular disease in elderly individuals.
Theel WB, de Jong VD, Grobbee DE, Jukema JW, Trompet S, Cabezas MC
Introduction and objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, MASH, are closely related to obesity and lifestyle. From previous studies, MASLD is also known for its strong genetic background. This study aimed to investigate the association between previously reported genetic polymorphisms of MASLD/MASH and clinical outcomes in an elderly Western European population. Patients and methods: We performed an analysis of 5,244 participants (mea...
Abstract
Cardiovascular diabetology,
Volume 24, Issue 1, 2 1 2025, Pages 453
Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes.
Mäenpää M, Jukema RA, van Diemen P, Bär S, Raijmakers PG, Sprengers R, Driessen RS, Bax JJ, Knaapen P, Knuuti J, Danad I, Saraste A, Maaniitty T
Background: Coronary artery disease (CAD) is a major contributor to cardiovascular events in individuals with diabetes. Quantification of coronary atherosclerotic burden is now feasible from coronary computed tomography angiography (CTA) whereas positron emission tomography (PET) enables quantitative assessment of myocardial perfusion. We studied the prognostic implications of quantitatively measured coronary plaque burden and myocardial perfusion in diabetic vs. non-diabetic patients with suspe...
Abstract
Annals of vascular surgery,
Volume 124, 2 1 2025, Pages 174-182
Considerations with Respect to Elective Abdominal Aortic Aneurysm Repair in Older People.
Biemond MJ, Paping JHM, Bulder RMA, Hultgren R, Mooijaart SP, Hamming JF, Lindeman JH
Background: The epidemiology of abdominal aortic aneurysm (AAA) is changing, with progressively more older patients receiving repair. Advancing age associates with an increased procedural risk but also with a decreasing lifetime rupture risk. This national study aims to provide background information for decision-making in older people. Methods: National administrative data (Statistics Netherlands) were used to estimate time-varying trends in the age and sex distribution of patients who underwen...
Abstract
Circulation. Arrhythmia and electrophysiology,
Volume 18, Issue 12, 2 1 2025, Pages e014049
International Survey on Vein of Marshall Retrograde Ethanol Infusion.
De Becker B, Derval N, Amin R, El Haddad M, Pambrun T, Bouyer B, Francois C, De Smet M, Channan EM, Blankoff N, Krahnefeld O, Agdirlioglu T, Minois D, Andorin A, Bessiere F, Gardey K, Sesselberg HW, Leyton-Mange JS, Marchand H, Mariottini C, Miled M, Sebag FA, Lellouche N, Andronache M, Marchese P, Rossi A, Nesti M, Herzet JM, Rodríguez Manero M, Pavlović N, Anselme F, Chaumont C, Wijnmaalen AP, Piers SRD, Waktare JEP, Najm A, Almorad A, Sousa PA, Lepièce C, Badot D, Auquier N, Efremidis M, Lian E, Maslova V, Tavernier R, Duytschaever M, Le Polain de Waroux JB, Valderrabano M, Knecht S
Background: Retrograde ethanolization of the vein of Marshall (VOM) has been identified as an adjunct technique in the treatment of persistent atrial fibrillation (AF) and left atrial tachycardia, as stated in the last consensus statement on ablation of AF. However, there is a lack of high-volume data on the technique. Methods: Through the collection of data from worldwide centers, we performed this international survey that aims to analyze the safety and procedural characteristics of VOM ethano...
Abstract
Giornale italiano di cardiologia (2006),
Volume 26, Issue 12 Suppl. 1, 1 1 2025, Pages e1-e108
[2025 ESC/EACTS Guidelines for the management of valvular heart disease].
Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W, ESC/EACTS Scientific Document Group
Abstract
Journal of the European Academy of Dermatology and Venereology : JEADV,
Volume 39, Issue 12, 1 1 2025, Pages 2028-2029
Reading the palms: Palmar hyperlinearity and type 2 biomarkers as early predictors of atopic dermatitis onset in infancy?
Vroman F, de Graaf M
Abstract
Clinical cancer research : an official journal of the American Association for Cancer Research,
Volume 31, Issue 24, 1 1 2025, Pages 5306-5316
Prognosis and Biological Characteristics of ER-Low Metastatic Breast Cancer: Results from a Multicenter Cohort and the TONIC Trial.
Miglietta F, De Graaf M, Vernieri C, Piacentini F, Cacciatore M, Botticelli A, Vingiani A, Fotia G, Nicolè L, Griguolo G, Giarratano T, Massa D, Pellegrini V, Schiavi F, Porra F, Fassan M, Pruneri G, Dei Tos AP, Guarneri V, Kok M, Dieci MV
Purpose: The purpose of this study was to assess prognosis of estrogen receptor (ER)-low expression and its dynamics in HER2- metastatic breast cancer and to compare sensitivity to nivolumab between ER-low and triple-negative breast cancer (TNBC). Experimental design: Two cohorts were analyzed: a multicenter cohort of 982 patients with HER2- metastatic breast cancer and one prospective cohort of 110 patients with ER
Abstract
Circulation,
Volume 152, Issue 24, 1 1 2025, Pages 1666-1678
Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes After Acute Coronary Syndrome.
Tsimikas S, Szarek M, Cobbaert CM, Romijn F, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Yuan C, Gong XM, Goodman SG, White HD, Witztum JL, Steg PG, Schwartz GG, ODYSSEY OUTCOMES Investigators
Background: Oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) reflect pro-inflammatory properties of Lp(a) (lipoprotein(a)). The effect of OxPL-apoB on major adverse cardiovascular events (MACE) in patients with acute coronary syndrome in recent the era is not known. Methods: OxPL-apoB levels and Lp(a) were measured in 11 630 participants before and 5185 participants 4 months after randomization to alirocumab or placebo in the ODYSSEY OUTCOMES trial. Proportional hazards models adjusted...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 12, 1 1 2025, Pages euaf252
Cardiac implantable electronic device upgrades and downgrades: a Clinical Consensus Statement of the European Heart Rhythm Association (EHRA) of the ESC, the Asia Pacific Heart Rhythm Association (APHRS), Canadian Heart Rhythm Society (CHRS), Heart Rhythm Society (HRS), and the Latin American Heart Rhythm Society (LAHRS).
Keene D, Nielsen JC, Burri H, Chavez-Gutierrez CA, Deharo JC, Drossart I, Ip JE, Israel CW, Johansen JB, Kosztin A, Lau CP, Levy S, Manlucu J, Marcantoni L, Pujol-Lopez M, Rao A, Starck C, Tolosana JM, Van Erven L, Vogler J, Kaza N
Cardiac implantable electronic device upgrade and downgrade procedures are increasingly being performed. Whilst the most appropriate guideline-recommended device may have been followed during a patient's initial procedure, the requirements of patients can change over time. This could be due to worsening of cardiac function due to detrimental effects of pacing itself or the diagnosis, development, or progression of another cardiac comorbidity. Device downgrades are also performed when a pati...
Abstract
JACC. Cardiovascular interventions,
Volume 18, Issue 23, 1 1 2025, Pages 2833-2845
Anatomical vs Physiological Lesion Characteristics in Prediction of Acute Coronary Syndrome.
Yang S, Chung JW, Park SH, Zhang J, Lee K, Hwang D, Lee KS, Na SH, Doh JH, Nam CW, Kim TH, Shin ES, Chun EJ, Choi SY, Kim HK, Hong YJ, Park HJ, Kim SY, Husic M, Lambrechtsen J, Jensen JM, Nørgaard BL, Andreini D, Maurovich-Horvat P, Merkely B, Penicka M, de Bruyne B, Ihdayhid A, Ko B, Tzimas G, Leipsic J, Sanz J, Rabbat MG, Katchi F, Shah M, Tanaka N, Nakazato R, Asano T, Terashima M, Takashima H, Amano T, Sobue Y, Matsuo H, Otake H, Kubo T, Takahata M, Akasaka T, Kido T, Mochizuki T, Yokoi H, Okonogi T, Kawasaki T, Nakao K, Sakamoto T, Yonetsu T, Kakuta T, Yamauchi Y, Taylor CA, Bax JJ, Shaw LJ, Stone PH, Narula J, Koo BK
Background: Acute coronary syndrome (ACS) arises from a complex interplay among luminal narrowing, plaque morphology, and hemodynamic environment. Objectives: The authors aimed to compare the effectiveness of anatomy- and physiology-based ACS risk assessment. Methods: In this international, multicenter, internal case-control study, 351 ACS patients who underwent coronary computed tomography angiography (CCTA) 1 month to 3 years before the event were analyzed. Lesions were classified as culprit o...
Abstract
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology,
Volume 27, Issue 12, 1 1 2025, Pages euaf324
Management of patients with atrial tachycardia: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), and the Association for European Paediatric and Congenital Cardiology (AEPC).
Meyer C, Kahle AK, Dagres N, Derval N, Dewland TA, Drago F, Eckardt L, Frontera A, Gerstenfeld EP, Hardy C, Jais P, Kalman J, Kistler PM, Martin C, Pürerfellner H, Takigawa M, Wong T, Zeppenfeld K
Atrial tachycardias (AT) represent an increasingly recognized cause of morbidity and mortality. Over the past decade, the mechanistic understanding and therapeutic concepts guiding AT treatment have undergone rapid progress. Catheter ablation has become the most effective therapy for maintaining sinus rhythm in patients with regular AT, while mapping and ablation concepts and technologies have improved significantly. Accordingly, international cardiac electrophysiology professional societies aim...
Abstract
Nature communications,
Volume 16, Issue 1, 28 4 2025, Pages 10707
Unveiling the global urban virome through wastewater metagenomics.
Worp N, Nieuwenhuijse DF, Izquierdo-Lara RW, Schapendonk CME, Brinch C, Jensen EEB, Munk P, Hendriksen RS, Global Sewage Surveillance Consortium, Aarestrup F, Oude Munnink BB, Koopmans MPG, de Graaf M
Understanding global viral dynamics is critical for public health. Traditional surveillance focuses on individual pathogens and symptomatic cases, which may miss asymptomatic infections or newly emerging viruses, delaying detection and response. Wastewater-based epidemiology has been used to track pathogens through targeted molecular assays, but its reliance on predefined targets limits detection of the full viral spectrum. Here, we analyse longitudinal wastewater samples from 62 cities across s...
Abstract
The American journal of cardiology,
Volume 260, 27 4 2025, Pages 10-17
Intravascular Lithotripsy in Diabetic Patients Undergoing Percutaneous Coronary Intervention: Long-Term Outcomes from the BENELUX Registry.
Phagu AAS, van Oort MJH, Oliveri F, Bingen BO, Paradies V, Mincione G, Claessen BEPM, Dimitriu-Leen AC, Vossenberg TN, Kefer J, Mandurino-Mirizzi A, Sagris M, van der Kley F, Jukema JW, Al Amri I, Montero-Cabezas JM
Diabetes mellitus (DM) is associated with increased coronary calcification and adverse outcomes after percutaneous coronary intervention (PCI), yet the performance of intravascular lithotripsy (IVL) in this high-risk population remains insufficiently defined. This study, conducted within the all-comers BENELUX-IVL registry, evaluated the safety and efficacy of IVL-assisted PCI in patients with and without DM. The primary endpoint was major adverse cardiovascular events (MACE) at 1 and 2 years, d...
Abstract
Communications biology,
Volume 8, Issue 1, 26 4 2025, Pages 1684
Chromogranin A and catestatin regulate pancreatic islet homeostasis, endocrine function, and neurotransmitter signaling.
Muntjewerff EM, Epremidze D, Nezhyva M, Kal S, Rohm TV, Tang K, Singh K, Espes D, Jati S, Bootsma M, Mannaa AM, Ikebuchi H, Nilsson AM, Rajasekaran M, Andrén PE, Jansson ET, Mahata SK, Christoffersson G
Chromogranin A (CgA), a neuroendocrine pro-hormone, is proteolytically cleaved into bioactive peptides, most notably catestatin (CST) and pancreastatin (PST), which exert opposing effects on metabolic and inflammatory processes. Using CgA- and CST knockout (KO) mice, we investigated the roles of these peptides in pancreatic endocrine function, morphology, neurotransmitter dynamics, and systemic glucose homeostasis. CST-KO mice displayed impaired insulin secretion in vivo (but not ex vivo), disru...
Abstract
JAMA cardiology,
26 4 2025
Interventions for Tricuspid Regurgitation.
Praz F, Angellotti D, Ajmone Marsan N, Butler J
Abstract
