6265 results
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
The aging male : the official journal of the International Society for the Study of the Aging Male,
Volume 17, Issue 4, 5 1 2014, Pages 248-255
L-arginine and tetrahydrobiopterin, but not sodium nitrite partially restored erectile dysfunction in aged rats.
Un O, Yilmaz D, Bayatli N, Kaya E, Gur S
Aging is associated with erectile dysfunction (ED), in which nitric oxide synthase (NOS) activity and NO bioavailability are reduced due to deficiencies of NOS cofactor (tetrahydrobiopterin, BH(4)) and substrate (L-arginine). We determined whether the prolonged treatment with sodium nitrite (NaNO(2)) as a storage form of NO ameliorates ED in aged rats. Male Sprague-Dawley rats were divided: younger, aged and NaNO(2)-treated (20 mg/kg per day) aged groups. The erectile (intracavernosal pressure [...
Abstract
Cited 2 times since 2014 (0.2 per year)
source: EuropePMC
PloS one,
Volume 9, Issue 6, 4 1 2014, Pages e98820
The CD200-CD200 receptor inhibitory axis controls arteriogenesis and local T lymphocyte influx.
van den Borne P, Rygiel TP, Hoogendoorn A, Westerlaken GH, Boon L, Quax PH, Pasterkamp G, Hoefer IE, Meyaard L
The role of the CD200 ligand-CD200 receptor (CD200-CD200R) inhibitory axis is highly important in controlling myeloid cell function. Since the activation of myeloid cells is crucial in arteriogenesis, we hypothesized that disruption of the CD200-CD200R axis promotes arteriogenesis in a murine hindlimb ischemia model. Female Cd200-/- and wildtype (C57Bl/6J) mice underwent unilateral femoral artery ligation. Perfusion recovery was monitored over 7 days using Laser-Doppler analysis and was increase...
Abstract
Cited 5 times since 2014 (0.5 per year)
source: EuropePMC
Fetal diagnosis and therapy,
Volume 36, Issue 1, 4 1 2014, Pages 59-68
Bicuspid aortic valve morphology and associated cardiovascular abnormalities in fetal Turner syndrome: a pathomorphological study.
van Engelen K, Bartelings MM, Gittenberger-de Groot AC, Baars MJ, Postma AV, Bijlsma EK, Mulder BJ, Jongbloed MR
Introduction: Bicuspid aortic valve (BAV) is common in Turner syndrome (TS). In adult TS, 82-95% of BAVs have fusion of the right and left coronary leaflets. Data in fetal stages are scarce. The purpose of this study was to gain insight into aortic valve morphology and associated cardiovascular abnormalities in a fetal TS cohort with adverse outcome early in development. Material and methods: We studied post-mortem heart specimens of 36 TS fetuses and 1 TS newborn. Results: BAV was present in 28...
Abstract
Cited 30 times since 2014 (2.8 per year)
source: EuropePMC
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography,
Volume 27, Issue 8, 3 1 2014, Pages 817-825
Left ventricular functional recovery and remodeling in low-flow low-gradient severe aortic stenosis after transcatheter aortic valve implantation.
Kamperidis V, Joyce E, Debonnaire P, Katsanos S, van Rosendael PJ, van der Kley F, Sianos G, Bax JJ, Ajmone Marsan N, Delgado V
Background: Speckle-tracking-derived global longitudinal strain (GLS) is a more sensitive method of detecting left ventricular (LV) functional recovery after transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis. However, it remains unknown whether LV function improves in patients with low-flow, low-gradient severe aortic stenosis (LFLGSAS) after TAVI. The aim of the present was to evaluate LV functional recovery and remodeling after TAVI in patients with LFLGSAS...
Abstract
Cited 30 times since 2014 (2.8 per year)
source: EuropePMC
Stem cells (Dayton, Ohio),
Volume 32, Issue 6, 1 1 2014, Pages 1493-1502
Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm.
Engels MC, Rajarajan K, Feistritzer R, Sharma A, Nielsen UB, Schalij MJ, de Vries AA, Pijnappels DA, Wu SM
A thorough understanding of the developmental signals that direct pluripotent stem cells (PSCs) toward a cardiac fate is essential for translational applications in disease modeling and therapy. We screened a panel of 44 cytokines/signaling molecules for their ability to enhance Nkx2.5(+) cardiac progenitor cell (CPC) formation during in vitro embryonic stem cell (ESC) differentiation. Treatment of murine ESCs with insulin or insulin-like growth factors (IGF1/2) during early differentiation incr...
Abstract
The International journal of angiology : official publication of the International College of Angiology, Inc,
Volume 23, Issue 2, 1 1 2014, Pages 93-100
A Randomized Comparison between Everolimus-Eluting Stent and Cobalt Chromium Stent in Patients with Acute ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Using Routine Intravenous Eptifibatide: The X-MAN (Xience vs. Multi-Link Stent in Acute Myocardial Infarction) Trial, A Pilot Study.
Dharma S, Wardeh AJ, Soerianata S, Firdaus I, Jukema JW
The objective of this study is to determine the efficacy and safety of an everolimus-eluting stent (EES/Xience; Abbott Vascular, Santa Clara, CA) compared with a cobalt chromium stent (CoCr/Multi-Link Vision; Abbott Vascular) in patients with acute ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) with routine administration of eptifibatide infusion. This is a prospective, single center, randomized trial comparing EES (n = 75) and CoCr stent (...
Abstract
Cited 5 times since 2014 (0.5 per year)
source: EuropePMC
Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation,
Volume 22, Issue 6, 1 1 2014, Pages 309
Obstruction of distal left anterior descending artery by the right ventricular lead of an implantable cardiac defibrillator.
Karalis I, Bleeker GB, Schalij MJ
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
JAMA,
Volume 311, Issue 22, 1 1 2014, Pages 2335
Left atrial fibrosis and recurrent arrhythmia.
Tops LF, Schalij MJ
Abstract
Cited 27 times since 2014 (2.5 per year)
source: EuropePMC
American journal of physiology. Heart and circulatory physiology,
Volume 307, Issue 3, 30 5 2014, Pages H361-9
Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload.
Borgdorff MA, Bartelds B, Dickinson MG, van Wiechen MP, Steendijk P, de Vroomen M, Berger RM
Right ventricular (RV) function is an important determinant of prognosis in congenital heart diseases, pulmonary hypertension, and heart failure. Preventive sildenafil treatment has been shown to enhance systolic RV function and improve exercise capacity in a model of fixed RV pressure load. However, it is unknown whether sildenafil has beneficial effects when treatment is started in established RV dysfunction, which is clinically more relevant. Our aim was to assess the effects of sildenafil tr...
Abstract
Cited 16 times since 2014 (1.5 per year)
source: EuropePMC
Journal of cardiovascular electrophysiology,
Volume 25, Issue 9, 29 5 2014, Pages 998-1004
Chronic kidney disease and implantable cardioverter defibrillator related complications: 16 years of experience.
Buiten MS, DE Bie MK, VAN DER Heijden AC, Rotmans JI, Bootsma M, Marc Groeneveld JH, Wolterbeek R, Rabelink TJ, Jukema JW, Schalij MJ, VAN Erven L
Introduction: Implantable cardioverter defibrillator (ICD) implantation has become an accepted therapy for the prevention of sudden cardiac death. However, serious comorbidities such as chronic kidney disease (CKD) are influencing the beneficial effects of ICD therapy. In this study, the association between kidney function and the occurrence of ICD related complications was assessed. Methods: All patients receiving an ICD or cardiac resynchronization therapy-defibrillator between 1996 and 2012 w...
Abstract
Cited 17 times since 2014 (1.6 per year)
source: EuropePMC
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology,
Volume 21, Issue 5, 24 4 2014, Pages 913-920
I-123 mIBG and Tc-99m myocardial SPECT imaging to predict inducibility of ventricular arrhythmia on electrophysiology testing: a retrospective analysis.
Zhou Y, Zhou W, Folks RD, Manatunga DN, Jacobson AF, Bax JJ, Garcia EV, Chen J
Objectives: The purpose of this study is to assess mIBG uptake in scar border zone and its relation with ventricular arrhythmia (VA) inducibility on electrophysiology (EP) testing using I-123 mIBG SPECT and resting Tc-99m SPECT myocardial perfusion imaging (MPI). Methods: Forty-seven patients from a previous clinical trial were retrospectively analyzed. These patients underwent I-123 mIBG and resting Tc-99m tetrofosmin SPECT, and EP testing. Twenty-eight patients were positive (EP+) and 19 patie...
Abstract
Cited 348 times since 2014 (32.2 per year)
source: EuropePMC
Lab on a chip,
Volume 14, Issue 13, 23 4 2014, Pages 2202-2211
Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs.
Bertassoni LE, Cecconi M, Manoharan V, Nikkhah M, Hjortnaes J, Cristino AL, Barabaschi G, Demarchi D, Dokmeci MR, Yang Y, Khademhosseini A
Vascularization remains a critical challenge in tissue engineering. The development of vascular networks within densely populated and metabolically functional tissues facilitate transport of nutrients and removal of waste products, thus preserving cellular viability over a long period of time. Despite tremendous progress in fabricating complex tissue constructs in the past few years, approaches for controlled vascularization within hydrogel based engineered tissue constructs have remained limite...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 4, 22 4 2014, Pages 311-319
Diagnosis and treatment of pulmonary hypertension.
Haeck ML, Vliegen HW
Abstract
Cited 4 times since 2014 (0.4 per year)
source: EuropePMC
European heart journal. Cardiovascular Imaging,
Volume 15, Issue 10, 22 4 2014, Pages 1183
Helical flow pattern in the right pulmonary artery after Fontan palliation.
Houtzager JH, Westenberg JJ, de Koning PJ, Hazekamp MG, Roest AA
Abstract
Cited 13 times since 2014 (1.2 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 100, Issue 17, 16 3 2014, Pages 1360-1365
Persistent neo-aortic growth during adulthood in patients after an arterial switch operation.
van der Bom T, van der Palen RL, Bouma BJ, van Veldhuisen SL, Vliegen HW, Konings TC, Zwinderman AH, Blom NA, Koolbergen DR, Hazekamp MG, Mulder BJ
Objective: After the arterial switch operation (ASO), disproportional neo-aortic growth during childhood has been reported. Even though it has been suggested neo-aortic dilation will stabilise in adulthood, data are lacking. The aim of this study was to assess the change in neo-aortic dimensions, prevalence of neo-aortic dilation >40 mm and long-term outcome in adults who underwent ASO in childhood. Methods: All 116 ASO patients operated in a tertiary referral centre and born before 1995 were...
Abstract
American heart journal,
Volume 168, Issue 1, 14 2 2014, Pages e5
Response to the letter to the editor by Ariza-Solé et al.
Velders MA, James SK, Libungan B, Sarno G, Fröbert O, Carlsson J, Schalij MJ, Albertsson P, Lagerqvist B
Abstract
Cited 10 times since 2014 (0.9 per year)
source: EuropePMC
Experimental cell research,
Volume 327, Issue 2, 13 2 2014, Pages 297-306
Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones.
Dambrot C, Buermans HP, Varga E, Kosmidis G, Langenberg K, Casini S, Elliott DA, Dinnyes A, Atsma DE, Mummery CL, Braam SR, Davis RP
Recent methodological advances have improved the ease and efficiency of generating human induced pluripotent stem cells (hiPSCs), but this now typically results in a greater number of hiPSC clones being derived than can be wholly characterized. It is therefore imperative that methods are developed which facilitate rapid selection of hiPSC clones most suited for the downstream research aims. Here we describe a combination of procedures enabling the simultaneous screening of multiple clones to det...
Abstract
Cited 12 times since 2014 (1.1 per year)
source: EuropePMC
Circulation. Cardiovascular quality and outcomes,
Volume 7, Issue 3, 13 2 2014, Pages 437-444
Left ventricular reverse remodeling, device-related adverse events, and long-term outcome after cardiac resynchronization therapy in the elderly.
Höke U, Putter H, Van Der Velde ET, Schalij MJ, Delgado V, Bax JJ, Marsan NA
Background: Limited data are available on efficacy, safety, and long-term prognosis after cardiac resynchronization therapy (CRT) in elderly patients. We aimed at evaluating the effect of CRT, device-related adverse events, and long-term outcome after CRT among elderly patients. Methods and results: A total of 798 CRT recipients (208 elderly: age, ≥75 years; 590 nonelderly: age,
Abstract
Cited 7 times since 2014 (0.6 per year)
source: EuropePMC
The international journal of cardiovascular imaging,
Volume 30, Issue 6, 10 2 2014, Pages 1151-1159
Associations of atherosclerosis in the descending thoracic aorta on CTA with arterial stiffness and chronic kidney disease in asymptomatic patients with diabetes mellitus.
Roos CJ, Delgado V, de Koning EJ, Rabelink TJ, Jukema JW, Bax JJ, Scholte AJ
The relation between atherosclerosis in the descending thoracic aortic (DTA), arterial stiffness and chronic kidney disease (CKD) in patients with diabetes mellitus (DM) remains unclear. The current aim was to evaluate associations of DTA atherosclerosis with arterial stiffness and parameters of CKD in asymptomatic patients with DM. A total of 213 asymptomatic patients with diabetes (mean age 52 years, 56% men) underwent cardiovascular risk assessment including multi-slice computed tomography (f...
Abstract
Cited 1 times since 2014 (0.1 per year)
source: EuropePMC
Heart (British Cardiac Society),
Volume 101, Issue 3, 9 2 2014, Pages 230-239
Cardiac resynchronisation therapy in populations underrepresented in randomised controlled trials.
Höke U, Delgado V, Marsan NA, Bax JJ
Abstract
