Research

Publications

Below you can find a list of our published research.

6139 results

Cited 17 times since 2013 (1.5 per year) source: EuropePMC

PloS one, Volume 8, Issue 7, 2 1 2013, Pages e67923 TLR accessory molecule RP105 (CD180) is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation. Karper JC, Ewing MM, de Vries MR, de Jager SC, Peters EA, de Boer HC, van Zonneveld AJ, Kuiper J, Huizinga EG, Brondijk TH, Jukema JW, Quax PH

Background: RP105 (CD180) is TLR4 homologue lacking the intracellular TLR4 signaling domain and acts a TLR accessory molecule and physiological inhibitor of TLR4-signaling. The role of RP105 in vascular remodeling, in particular post-interventional remodeling is unknown. Methods and results: TLR4 and RP105 are expressed on vascular smooth muscle cells (VSMC) as well as in the media of murine femoral artery segments as detected by qPCR and immunohistochemistry. Furthermore, the response to the TL... Abstract

Cited 1 times since 2013 (0.1 per year) source: EuropePMC

Iranian journal of basic medical sciences, Volume 16, Issue 7, 1 1 2013, Pages 813-821 Generation of Helper Plasmids Encoding Mutant Adeno-associated Virus Type 2 Capsid Proteins with Increased Resistance against Proteasomal Degradation. Ahmadiankia N, Neshati V, Neshati Z, Swildens J, de Vries AA

Objective(s): Adeno-associated virus type 2 (AAV2) vectors are widely used for both experimental and clinical gene therapy. A recent research has shown that the performance of these vectors can be greatly improved by substitution of specific surface-exposed tyrosine residues with phenylalanines. In this study, a fast and simple method is presented to generate AAV2 vector helper plasmids encoding capsid proteins with single, double or triple Y→F mutations. Materials and methods: A one-step, high-... Abstract

Cited 13 times since 2013 (1.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 7-8, 1 1 2013, Pages 347-353 Different value of coronary calcium score to predict obstructive coronary artery disease in patients with and without moderate chronic kidney disease. Yiu KH, de Graaf FR, van Velzen JE, Marsan NA, Roos CJ, de Bie MK, Tse HF, van der Wall EE, Schalij MJ, Bax JJ, Schuijf JD, Jukema JW

Purpose: The coronary calcium score (CCS) predicts significant coronary artery disease (CAD) in the general population. While moderate chronic kidney disease (CKD) is associated with high CCS, the use of CCS to predict significant CAD in these patients is unknown. Methods: A total of 704 patients underwent computed tomography coronary angiography for the assessment of CCS and CAD. Sixty-nine (10 %) patients had moderate CKD, defined by an estimated glomerular filtration rate (eGFR) between 30 an... Abstract

Cited 16 times since 2013 (1.4 per year) source: EuropePMC

Radiology, Volume 269, Issue 2, 25 4 2013, Pages 370-377 Aortic disease in patients with Marfan syndrome: aortic volume assessment for surveillance. den Hartog AW, Franken R, de Witte P, Radonic T, Marquering HA, van der Steen WE, Timmermans J, Scholte AJ, van den Berg MP, Zwinderman AH, Mulder BJ, Groenink M

Purpose: To assess the reproducibility of aortic volume estimates and to serially test their use in patients with Marfan syndrome. Materials and methods: The study was approved by the medical ethics committee and all subjects gave written informed consent. In 81 patients with Marfan syndrome and seven healthy control subjects, aortic volumes and diameters at baseline were estimated by means of contrast material-enhanced magnetic resonance (MR) imaging. At 3 years of follow-up, aortic expansion r... Abstract

Cited 1065 times since 2013 (90.8 per year) source: EuropePMC

European heart journal, Volume 34, Issue 29, 24 4 2013, Pages 2281-2329 2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC, Delgado V, Elliott PM, Gorenek B, Israel CW, Leclercq C, Linde C, Mont L, Padeletti L, Sutton R, Vardas PE, ESC Committee for Practice Guidelines (CPG), Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Document Reviewers, Kirchhof P, Blomstrom-Lundqvist C, Badano LP, Aliyev F, Bänsch D, Baumgartner H, Bsata W, Buser P, Charron P, Daubert JC, Dobreanu D, Faerestrand S, Hasdai D, Hoes AW, Le Heuzey JY, Mavrakis H, McDonagh T, Merino JL, Nawar MM, Nielsen JC, Pieske B, Poposka L, Ruschitzka F, Tendera M, Van Gelder IC, Wilson CM

Abstract

Cited 11 times since 2013 (0.9 per year) source: EuropePMC

The Annals of thoracic surgery, Volume 96, Issue 2, 24 4 2013, Pages 629-636 Enhanced characterization of ventricular performance after coarctation repair in neonates and young children. Klitsie LM, Roest AA, Kuipers IM, Van der Hulst AE, Hazekamp MG, Blom NA, Ten Harkel AD

Background: Within the group of patients undergoing coarctectomy today, two subgroups can be identified: neonates with a critical coarctation and nonneonatal patients. We hypothesize that patients who have to undergo repair in the neonatal period will have more persistent impairment of ventricular performance postoperatively. Accordingly, we aimed to characterize biventricular performance after coarctectomy in neonatal and nonneonatal patients. Methods: Children (aged 0 to 17 years) undergoing a... Abstract

Cited 28 times since 2013 (2.4 per year) source: EuropePMC

European heart journal. Cardiovascular Imaging, Volume 15, Issue 1, 21 3 2013, Pages 41-47 Changes in multidirectional LV strain in asymptomatic patients with type 2 diabetes mellitus: a 2-year follow-up study. Roos CJ, Scholte AJ, Kharagjitsingh AV, Bax JJ, Delgado V

Aims: Asymptomatic patients with diabetes mellitus (DM) and normal left ventricular (LV) ejection fraction (EF) may have LV dysfunction as assessed with speckle tracking echocardiography. Whether this subtle LV dysfunction may progress or not over time remains unknown. The present evaluation assessed changes in LV function with two-dimensional (2D) speckle tracking analysis in asymptomatic clinically stable patients with type 2 DM and normal LVEF after 2-year follow-up. Methods and results: A to... Abstract

Cited 169 times since 2013 (14.4 per year) source: EuropePMC

Cancer, Volume 119, Issue 18, 21 3 2013, Pages 3411-3418 Near-infrared fluorescence-guided resection of colorectal liver metastases. van der Vorst JR, Schaafsma BE, Hutteman M, Verbeek FP, Liefers GJ, Hartgrink HH, Smit VT, Löwik CW, van de Velde CJ, Frangioni JV, Vahrmeijer AL

Background: The fundamental principle of oncologic surgery is the complete resection of malignant cells. However, small tumors are often difficult to find during surgery using conventional techniques. The objectives of this study were to determine if optical imaging, using a contrast agent already approved for other indications, could improve hepatic metastasectomy with curative intent, to optimize dose and timing, and to determine the mechanism of contrast agent accumulation. Methods: The high... Abstract

Cited 39 times since 2013 (3.3 per year) source: EuropePMC

Arteriosclerosis, thrombosis, and vascular biology, Volume 33, Issue 8, 20 3 2013, Pages 1902-1910 Lysine acetyltransferase PCAF is a key regulator of arteriogenesis. Bastiaansen AJ, Ewing MM, de Boer HC, van der Pouw Kraan TC, de Vries MR, Peters EA, Welten SM, Arens R, Moore SM, Faber JE, Jukema JW, Hamming JF, Nossent AY, Quax PH

Objective: Therapeutic arteriogenesis, that is, expansive remodeling of preexisting collaterals, using single-action factor therapies has not been as successful as anticipated. Modulation of factors that act as a master switch for relevant gene programs may prove more effective. Transcriptional coactivator p300-CBP-associated factor (PCAF) has histone acetylating activity and promotes transcription of multiple inflammatory genes. Because arteriogenesis is an inflammation-driven process, we hypot... Abstract

Cited 28 times since 2013 (2.4 per year) source: EuropePMC

PloS one, Volume 8, Issue 6, 19 3 2013, Pages e66467 Niacin Reduces Atherosclerosis Development in APOE*3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol. Kühnast S, Louwe MC, Heemskerk MM, Pieterman EJ, van Klinken JB, van den Berg SA, van den Berg SA, Smit JW, Havekes LM, Rensen PC, van der Hoorn JW, Princen HM, Jukema JW

Objective: Niacin potently lowers triglycerides, mildly decreases LDL-cholesterol, and largely increases HDL-cholesterol. Despite evidence for an atheroprotective effect of niacin from previous small clinical studies, the large outcome trials, AIM-HIGH and HPS2-THRIVE did not reveal additional beneficial effects of niacin (alone or in combination with laropiprant) on top of statin treatment. We aimed to address this apparent discrepancy by investigating the effects of niacin without and with sim... Abstract

Cited 2524 times since 2013 (214.7 per year) source: EuropePMC

European heart journal, Volume 34, Issue 28, 14 2 2013, Pages 2159-2219 2013 ESH/ESC guidelines for the management of arterial hypertension: the Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaarsma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM, Schmieder RE, Sirnes PA, Sleight P, Viigimaa M, Waeber B, Zannad F, Redon J, Dominiczak A, Narkiewicz K, Nilsson PM, Burnier M, Viigimaa M, Ambrosioni E, Caufield M, Coca A, Olsen MH, Schmieder RE, Tsioufis C, van de Borne P, Zamorano JL, Achenbach S, Baumgartner H, Bax JJ, Bueno H, Dean V, Deaton C, Erol C, Fagard R, Ferrari R, Hasdai D, Hoes AW, Kirchhof P, Knuuti J, Kolh P, Lancellotti P, Linhart A, Nihoyannopoulos P, Piepoli MF, Ponikowski P, Sirnes PA, Tamargo JL, Tendera M, Torbicki A, Wijns W, Windecker S, Clement DL, Coca A, Gillebert TC, Tendera M, Rosei EA, Ambrosioni E, Anker SD, Bauersachs J, Hitij JB, Caulfield M, De Buyzere M, De Geest S, Derumeaux GA, Erdine S, Farsang C, Funck-Brentano C, Gerc V, Germano G, Gielen S, Haller H, Hoes AW, Jordan J, Kahan T, Komajda M, Lovic D

Abstract

Cited 46 times since 2013 (3.9 per year) source: EuropePMC

European heart journal, Volume 34, Issue 48, 11 2 2013, Pages 3699-3706 Mast cells in human carotid atherosclerotic plaques are associated with intraplaque microvessel density and the occurrence of future cardiovascular events. Willems S, Vink A, Bot I, Quax PH, de Borst GJ, de Vries JP, van de Weg SM, Moll FL, Kuiper J, Kovanen PT, de Kleijn DP, Hoefer IE, Pasterkamp G

Aims: Human autopsy, animal, and cell culture studies together have merged in a concept suggesting participation of mast cells (MCs) in the generation of atherosclerotic plaques. More specifically, these studies have suggested MC-induced intraplaque neovascularization as one mechanism by which MCs may render the plaques vulnerable. The present study was designed to assess the association between MC numbers and neovascularization in human atherosclerotic plaques, and to relate the abundance of pl... Abstract

Cited 14 times since 2013 (1.2 per year) source: Scopus

Interactive cardiovascular and thoracic surgery, Volume 17, Issue 3, 4 1 2013, Pages 523-530 Pre-existing endothelial cell activation predicts vasoplegia after mitral valve surgery. Kortekaas KA, Lindeman JH, Reinders ME, Palmen M, Klautz RJ, de Groot PG, Roest M

Objectives: Post-cardiac surgery vasoplegia is a common complication of cardiac surgery, characterized by profound loss of systemic vascular resistance. This results in severe hypotension, high cardiac output and metabolic acidosis reflecting inadequate tissue perfusion. The pathophysiological mechanisms underlying this syndrome remain unknown. We hypothesized that this vasoplegia reflects endothelial dysfunction, either as pre-existing condition or as a consequence of the surgical procedure. Me... Abstract

Cited 20 times since 2013 (1.7 per year) source: EuropePMC

Atherosclerosis, Volume 229, Issue 2, 1 1 2013, Pages 423-429 Abdominal adiposity largely explains associations between insulin resistance, hyperglycemia and subclinical atherosclerosis: the NEO study. Gast KB, Smit JW, den Heijer M, Middeldorp S, Rippe RC, le Cessie S, de Koning EJ, Jukema JW, Rabelink TJ, de Roos A, Rosendaal FR, de Mutsert R, NEO study group

Objective: The relative importance of insulin resistance and hyperglycemia to the development of atherosclerosis remains unclear. Furthermore, adiposity may be responsible for observed associations. Our aim was to study the relative contributions of adiposity, insulin resistance and hyperglycemia to subclinical atherosclerosis. Methods: In this cross-sectional analysis of the Netherlands Epidemiology of Obesity (NEO) study, a cohort of persons of 45-65 years, BMI, waist circumference (WC), fasti... Abstract

Cited 3 times since 2013 (0.3 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 21, Issue 6, 1 1 2013, Pages 266-267 NVVC/NHJ Durrer Prizes 2012. van der Wall EE, Schalij MJ, Umans VA

At the annual Spring Congress of the NVVC the Durrer prizes were awarded to the authors of the best original/review articles published in the year 2012, one paper being more basically-oriented and one paper being more clinically-oriented. This annual tradition exists already since the year 2006. Abstract

Cited 17 times since 2013 (1.4 per year) source: EuropePMC

Anesthesiology, Volume 118, Issue 6, 1 1 2013, Pages 1385-1394 Xenon and isoflurane reduce left ventricular remodeling after myocardial infarction in the rat. Roehl AB, Funcke S, Becker MM, Goetzenich A, Bleilevens C, Rossaint R, Steendijk P, Hein M

Background: Xenon and isoflurane are known to have cardioprotective properties. We tested the hypothesis that these anesthetics positively influence myocardial remodeling 28 days after experimental perioperative myocardial infarction and compared their effects. Methods: A total of 60 male Sprague-Dawley rats were subjected to 60 min of coronary artery occlusion and 120 min of reperfusion. Prior to ischemia, the animals were randomized for the different narcotic regimes (0.6 vol% isoflurane, 70 v... Abstract

Cited 9 times since 2013 (0.8 per year) source: EuropePMC

European journal of preventive cardiology, Volume 20, Issue 2 Suppl, 1 1 2013, Pages 8-12 Remote monitoring of patients with implanted devices: data exchange and integration. Van der Velde ET, Atsma DE, Foeken H, Witteman TA, Hoekstra WH

Background: Remote follow-up of implanted implantable cardioverter defibrillators (ICDs) may offer a solution to the problem of overcrowded outpatient clinics, and may also be effective in detecting clinical events early. Data obtained from remote follow up systems, as developed by all major device companies, are stored in a central database system, operated and owned by the device company. A problem now arises that the patient's clinical information is partly stored in the local electronic... Abstract

Cited 35 times since 2013 (3 per year) source: EuropePMC

American journal of physiology. Heart and circulatory physiology, Volume 305, Issue 3, 31 5 2013, Pages H354-64 Distinct loading conditions reveal various patterns of right ventricular adaptation. Borgdorff MA, Bartelds B, Dickinson MG, Steendijk P, de Vroomen M, Berger RM

Right ventricular (RV) failure due to chronically abnormal loading is a main determinant of outcome in pulmonary hypertension (PH) and congenital heart disease. However, distinct types of RV loading have been associated with different outcomes. To determine whether the adaptive RV response depends on loading type, we compared hemodynamics, exercise, and hypertrophy in models of pressure overload due to pulmonary artery banding (PAB), pressure overload due to PH, combined pressure and volume over... Abstract

Cited 22 times since 2013 (1.9 per year) source: EuropePMC

Heart (British Cardiac Society), Volume 99, Issue 17, 30 5 2013, Pages 1244-1249 Gender-specific differences in clinical outcome of primary prevention implantable cardioverter defibrillator recipients. van der Heijden AC, Thijssen J, Borleffs CJ, van Rees JB, Höke U, van der Velde ET, van Erven L, Schalij MJ

Objective: To assess differences in clinical outcome of implantable cardioverter-defibrillator (ICD) treatment in men and women. Design: Prospective cohort study. Setting: University Medical Center. Patients: 1946 primary prevention ICD recipients (1528 (79%) men and 418 (21%) women). Patients with congenital heart disease were excluded for this analysis. Main outcome measures: All-cause mortality, ICD therapy (antitachycardia pacing and shock) and ICD shock. Results: During a median follow-up o... Abstract

Cited 3 times since 2013 (0.3 per year) source: EuropePMC

European journal of nuclear medicine and molecular imaging, Volume 40, Issue 8, 29 5 2013, Pages 1171-1180 Automated quantitative coronary computed tomography correlates of myocardial ischaemia on gated myocardial perfusion SPECT. de Graaf MA, El-Naggar HM, Boogers MJ, Veltman CE, Broersen A, Kitslaar PH, Dijkstra J, Kroft LJ, Al Younis I, Reiber JH, Bax JJ, Delgado V, Scholte AJ

Purpose: Automated software tools have permitted more comprehensive, robust and reproducible quantification of coronary stenosis, plaque burden and plaque location of coronary computed tomography angiography (CTA) data. The association between these quantitative CTA (QCT) parameters and the presence of myocardial ischaemia has not been explored. The aim of the present investigation was to evaluate the association between QCT parameters of coronary artery lesions and the presence of myocardial is... Abstract