Research

Publications

Below you can find a list of our published research.

9462 results

Cited 19 times since 2012 (1.4 per year) source: EuropePMC

Injury, Volume 43, Issue 7, 6 1 2012, Pages 1107-1111 Below-elbow cast for metaphyseal both-bone fractures of the distal forearm in children: a randomised multicentre study. Colaris JW, Biter LU, Allema JH, Bloem RM, van de Ven CP, de Vries MR, Kerver AJ, Reijman M, Verhaar JA

Introduction: Minimally displaced metaphyseal both-bone fractures of the distal forearm in children are often treated with an above-elbow cast (AEC). Treatment with a below-elbow cast (BEC) could give more comfort, but might lead to fracture displacement reducing pronation and supination. Because this has not been systematically investigated, we set up a randomised multicentre study. The purpose of this study was to find out whether BEC causes equal limitation of pronation and supination but wit... Abstract

Cited 36 times since 2012 (2.6 per year) source: EuropePMC

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume 54, Issue 11, 4 1 2012, Pages 1618-1620 Successful Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections revisited. Gurieva T, Bootsma MC, Bonten MJ

In 2011 Jain et al reported a 62% reduction of healthcare-associated methicillin-resistant Staphylococcus aureus infections that resulted from an intervention bundle. Here we present a mathematical model and prove, using parameters from the study by Jain et al, that the universal screen and isolate strategy can have contributed only marginally to the reduction in infections. Abstract

Cited 8 times since 2012 (0.6 per year) source: EuropePMC

The Netherlands journal of medicine, Volume 70, Issue 3, 1 1 2012, Pages 155 Valproic acid-induced DRESS syndrome with acute liver failure. van Zoelen MA, de Graaf M, van Dijk MR, Bogte A, van Erpecum KJ, Rockmann H, Maarschalk-Ellerbroek LJ

Abstract

Cited 19 times since 2012 (1.4 per year) source: EuropePMC

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Volume 7, Issue 12, 1 1 2012, Pages 1396-1405 Pre-infarction angina predicts thrombus burden in patients admitted for ST-segment elevation myocardial infarction. Ahmed TA, Sorgdrager BJ, Cannegieter SC, van der Laarse A, Schalij MJ, Jukema W

Aims: In patients with ST-elevation myocardial infarction (STEMI), high thrombotic burden, subsequent distal embolisation and myocardial no-reflow remain a large obstacle that may negate the benefits of urgent coronary revascularisation. We aimed at assessing the predictors of: 1) thrombus grade in patients undergoing primary percutaneous coronary intervention (PPCI) and 2) infarct size, in order to optimise therapy to reduce thrombus burden. Methods and results: One-hundred and fifty-three cons... Abstract

Cited 29 times since 2012 (2.1 per year) source: EuropePMC

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation, Volume 20, Issue 4, 1 1 2012, Pages 167-175 Treatment options in end-stage heart failure: where to go from here? Haeck ML, Hoogslag GE, Rodrigo SF, Atsma DE, Klautz RJ, van der Wall EE, Schalij MJ, Verwey HF

Chronic heart failure is a major healthcare problem associated with high morbidity and mortality. Despite significant progress in treatment strategies, the prognosis of heart failure patients remains poor. The golden standard treatment for heart failure is heart transplantation after failure of medical therapy, surgery and/or cardiac resynchronisation therapy. In order to improve patients' outcome and quality of life, new emerging treatment modalities are currently being investigated, inclu... Abstract

Cited 19 times since 2012 (1.4 per year) source: EuropePMC

Circulation. Arrhythmia and electrophysiology, Volume 5, Issue 2, 1 1 2012, Pages e38-40 Bipolar ablation of ventricular tachycardia in a patient after atrial switch operation for dextro-transposition of the great arteries. Piers SR, Dyrda K, Tao Q, Zeppenfeld K

Abstract

Cited 104 times since 2012 (7.5 per year) source: EuropePMC

Cold Spring Harbor perspectives in biology, Volume 4, Issue 4, 1 1 2012, Pages a007989 Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Schepers A, Clevers H

The Wnt signaling pathway was originally uncovered as one of the prototype developmental signaling cascades in invertebrates as well as in vertebrates. The first indication that Wnt signaling also plays a role in the adult animal came from the study of the intestine of Tcf-4 (Tcf7L2) knockout mice. The gastrointestinal epithelium continuously self-renews over the lifetime of an organism and is, in fact, the most rapidly self-renewing tissue of the mammalian body. Recent studies indicate that Wnt... Abstract

Cited 32 times since 2012 (2.3 per year) source: EuropePMC

Therapeutic drug monitoring, Volume 34, Issue 2, 1 1 2012, Pages 153-159 Associations between ABCB1, CYP2A6, CYP2B6, CYP2D6, and CYP3A5 alleles in relation to efavirenz and nevirapine pharmacokinetics in HIV-infected individuals. Heil SG, van der Ende ME, Schenk PW, van der Heiden I, Lindemans J, Burger D, van Schaik RH

Background: Human immunodeficiency virus (HIV)-infected individuals show large interindividual variation in response to antiretroviral therapy. Efavirenz (EFV) and nevirapine (NVP) are nonnucleoside reverse transcriptase inhibitors, which are prescribed in combination with other antiretroviral therapy in so-called highly active antiretroviral therapy. Recent studies provide evidence for the role of cytochrome P450 (CYP) genes, in particular CYP2B6, in relation to EFV and NVP pharmacokinetics. In... Abstract

Cited 39 times since 2012 (2.8 per year) source: EuropePMC

Molecular ecology, Volume 21, Issue 13, 30 5 2012, Pages 3173-3186 Heavily male-biased long-distance dispersal of orang-utans (genus: Pongo), as revealed by Y-chromosomal and mitochondrial genetic markers. Nietlisbach P, Arora N, Nater A, Goossens B, Van Schaik CP, Krützen M

Mating systems are thought to be an important determinant of dispersal strategies in most animals, including the great apes. As the most basal taxon of all great apes, orang-utans can provide information about the evolution of mating systems and their consequences for population structure in this Family. To assess the sex-specific population structure in orang-utans, we used a combination of paternally transmitted Y-chromosomal genetic markers and maternally transmitted mitochondrial DNA sequenc... Abstract

Cited 56 times since 2012 (4.1 per year) source: EuropePMC

PloS one, Volume 7, Issue 3, 30 5 2012, Pages e32963 Inflammation aggravates disease severity in Marfan syndrome patients. Radonic T, de Witte P, Groenink M, de Waard V, Lutter R, van Eijk M, Jansen M, Timmermans J, Kempers M, Scholte AJ, Hilhorst-Hofstee Y, van den Berg MP, van Tintelen JP, Pals G, Baars MJ, Mulder BJ, Zwinderman AH

Background: Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocular and skeletal systems, associated with large clinical variability. Numerous studies reveal an involvement of TGF-β signaling. However, the contribution of tissue inflammation is not addressed so far. Methodology/principal findings: Here we showed that both TGF-β and inflammation are up-regulated in patients with MFS. We analyzed transcriptome-wide gene expression in 55 MFS patients us... Abstract

Cited 163 times since 2012 (11.8 per year) source: EuropePMC

PLoS genetics, Volume 8, Issue 3, 29 5 2012, Pages e1002584 Genome-wide association and functional follow-up reveals new loci for kidney function. Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster MC, O'Seaghdha CM, Glazer N, Isaacs A, Liu CT, Smith AV, O'Connell JR, Struchalin M, Tanaka T, Li G, Johnson AD, Gierman HJ, Feitosa M, Hwang SJ, Atkinson EJ, Lohman K, Cornelis MC, Johansson Å, Tönjes A, Dehghan A, Chouraki V, Holliday EG, Sorice R, Kutalik Z, Lehtimäki T, Esko T, Deshmukh H, Ulivi S, Chu AY, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, CARDIoGRAM Consortium, ICBP Consortium, CARe Consortium, Wellcome Trust Case Control Consortium 2 (WTCCC2), Harris TB, Launer LJ, Aspelund T, Eiriksdottir G, Mitchell BD, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu FB, Demirkan A, Oostra BA, de Andrade M, Turner ST, Ding J, Andrews JS, Freedman BI, Koenig W, Illig T, Döring A, Wichmann HE, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler HE, Igl W, Zaboli G, Wild SH, Wright AF, Campbell H, Ellinghaus D, Nöthlings U, Jacobs G, Biffar R, Endlic

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte... Abstract

Cited 30 times since 2012 (2.2 per year) source: EuropePMC

The Journal of infectious diseases, Volume 205, Issue 10, 28 4 2012, Pages 1539-1543 Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals. van Velzen M, van Loenen FB, Meesters RJ, de Graaf M, Remeijer L, Luider TM, Osterhaus AD, Verjans GM

Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV(R)) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACV(S)) and multiple phylogenetic-related... Abstract

Cited 15 times since 2012 (1.1 per year) source: EuropePMC

Journal of internal medicine, Volume 271, Issue 6, 26 4 2012, Pages 521-536 Management of acute coronary syndrome: achievements and goals still to pursue. Novel developments in diagnosis and treatment. Boden H, van der Hoeven BL, Karalis I, Schalij MJ, Jukema JW

Acute coronary syndromes contribute a substantial part of the global disease burden. To realize a reduction in mortality and morbidity, the management of patients with these conditions involves the integration of several different approaches. Timely delivery of appropriate care is a key factor, as the beneficial effect of reperfusion is greatest when performed as soon as possible. Innovations in antithrombotic therapy have also contributed significantly to improvements in the prevention of ischa... Abstract

Cited 72 times since 2012 (5.2 per year) source: EuropePMC

Molecular genetics and metabolism, Volume 106, Issue 2, 24 4 2012, Pages 135-141 Small fiber neuropathy in Fabry disease. Biegstraaten M, Hollak CE, Bakkers M, Faber CG, Aerts JM, van Schaik IN

Previous studies have explicitly shown that small nerve fibers are affected in Fabry disease which is assumed to cause the severe neuropathic pain that patients may have from childhood on. Neuropathic pain and small fiber neuropathy characteristics have therefore been considered as appropriate study endpoints in studies on the efficacy of enzyme replacement therapy. However, the relationship between small fiber neuropathy characteristics and pain, as well as the course of small fiber neuropathy... Abstract

Cited 102 times since 2012 (7.4 per year) source: EuropePMC

The American journal of cardiology, Volume 109, Issue 11, 23 4 2012, Pages 1657-1663 Social burden and lifestyle in adults with congenital heart disease. Zomer AC, Vaartjes I, Uiterwaal CS, van der Velde ET, Sieswerda GJ, Wajon EM, Plomp K, van Bergen PF, Verheugt CL, Krivka E, de Vries CJ, Lok DJ, Grobbee DE, Mulder BJ

We aimed to evaluate how the presence and severity of congenital heart disease (CHD) influence social life and lifestyle in adult patients. A random sample (n = 1,496) from the CONgenital CORvitia (n = 11,047), the Dutch national registry of adult patients with CHD, completed a questionnaire on educational attainment, employment and marital statuses, and lifestyle (response 76%). The Utrecht Health Project provided a large reference group (n = 6,810) of unaffected subjects. Logistic regression m... Abstract

Cited 9 times since 2012 (0.7 per year) source: EuropePMC

The American journal of cardiology, Volume 109, Issue 12, 22 4 2012, Pages 1792-1796 Relation of prolonged tissue Doppler imaging-derived atrial conduction time to atrial arrhythmia in adult patients with congenital heart disease. van der Hulst AE, Roest AA, Holman ER, Vliegen HW, Hazekamp MG, Bax JJ, Blom NA, Delgado V

Atrial arrhythmia (AA) is common in adult patients with congenital heart disease (CHD). To enable the prevention of AA or its complications, timely identification of adult patients with CHD at risk of AA is crucial. Long total atrial activation times have been related to AA. Tissue Doppler imaging (TDI) permits noninvasive evaluation of the total atrial conduction time (PA-TDI duration). The present study evaluated the association between the PA-TDI duration and the development of AA in adult pa... Abstract

Cited 1 times since 2012 (0.1 per year) source: EuropePMC

Early human development, Volume 88, Issue 9, 22 4 2012, Pages 711-716 Genetic variants associated with adult blood pressure and kidney function do not affect fetal kidney volume. The Generation R Study. Taal HR, van den Hil LC, Hofman A, van der Heijden AJ, Jaddoe VW

Background: Smaller kidneys with reduced number of nephrons in early life lead to impaired kidney function and risk for hypertension and chronic kidney disease. These associations might be partly explained by common genetic variation. Aims: To assess the associations between common genetic variants, which have recently shown to be associated with blood pressure or kidney function, with fetal kidney volume. Study design: A prospective population based cohort study in Rotterdam, The Netherlands. S... Abstract

Cited 32 times since 2012 (2.3 per year) source: EuropePMC

International psychogeriatrics, Volume 24, Issue 8, 22 4 2012, Pages 1242-1251 Contradictory effects for prevention of depression and anxiety in residents in homes for the elderly: a pragmatic randomized controlled trial. Dozeman E, van Marwijk HW, van Schaik DJ, Smit F, Stek ML, van der Horst HE, Bohlmeijer ET, Beekman AT

Background: The aim of this study was to evaluate the effectiveness of a stepped-care program to prevent the onset of depression and anxiety disorders in elderly people living in residential homes. Methods: A pragmatic randomized controlled trial was conducted to compare the intervention with usual care in 14 residential homes in the Netherlands. A total of 185 residents with a minimum score of 8 on the Centre for Epidemiologic Studies Depression Scale, who did not meet the diagnostic criteria f... Abstract

Cited 73 times since 2012 (5.3 per year) source: EuropePMC

Neurology, Volume 78, Issue 14, 21 3 2012, Pages 1079-1084 Long-term remission of CIDP after pulsed dexamethasone or short-term prednisolone treatment. Eftimov F, Vermeulen M, van Doorn PA, Brusse E, van Schaik IN, PREDICT

Objective: Achieving long-term remission after a limited more intense treatment period would prevent prolonged use of corticosteroids or IV immunoglobulin (IVIg) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). In this prospective cohort study we present long-term follow-up data on patients included in a multicenter randomized controlled trial comparing 6 monthly pulses of dexamethasone with 8 months of daily prednisolone. Methods: Treatment effect was assessed with the Infla... Abstract

Cited 6 times since 2012 (0.4 per year) source: EuropePMC

The American journal of cardiology, Volume 109, Issue 12, 20 3 2012, Pages 1738-1742 Comparison of lipid profiles and attainment of lipid goals in patients <65 years versus patients ≥65 years (from the Lipid Treatment Assessment Project [L-TAP] 2). Rodriguez F, Santos RD, Messig M, Tarasenko L, Ferrières J, Jukema JW, Chiang CW, Waters DD, Foody JM, L-TAP 2 Investigators

There is a well-established link between dyslipidemia and cardiovascular events, although this risk is modified by age. Little is known about how treatment of dyslipidemia and low-density lipoprotein (LDL) cholesterol goal attainment differ between older and younger patients. We obtained clinical data from 9,926 dyslipidemic patients across 9 countries in North and Latin America, Europe, and Asia from 2006 through 2007. Multivariate regressions were performed to determine predictors of lipid lev... Abstract